Abstract

Methicillin-resistant Staphylococcusaureus (MRSA) infections are most medically threat, hard to treat infection among medical care units. MRSA isolates emerged from Staphylococcusaureus strain how carry mecA gene which confer their resistance to methicillin. The standard drug of choice to resolve MRSA infections is vancomycin which late replaced by teicoplanin due to their renal toxicity. During this study 20 MRSA isolates were obtained from the Central Laboratory of Babylon Health Directorate and previously diagnosed as MRSA using both phenotypic (by VITEK 2 compact system) and genotypic (mecA gene detection) diagnostics methods. Teicoplanin disk diffusion were achieved acc -ording to CLSI 2012.Well diffusion method was used to test the effects of mixture of Argan Oil and 1.5 % H2O2 with ratios: (1:1, 1:2, and 2:1 Argan oil: 1.5% H2O2). The effect of the mentioned mixtures in addition to the effect of 1.5% H2O2 alone and Argan oil alone were tested using well diffusion method according to CLSI 2012. The results of inhibition zone for mixture were recorded and compared with the inhibition of teicoplanin. The results revealed ability of argan oil: H2O2 mixture with ration 2:1 to inhibit growth 80% of MRSA isolates and give inhibition zone similar to those of teicoplanin #x2265; 14mm. This study concludes the satisfactoriness of use Argan oil as anti-MRSA medical oil with high level of safety and low level of uncomfortable effects.