@incollection{, 5BD7015C97C64C022BE24BE1DE4488FA , author={{Dr. PrabhuS} and {Dr. VimalBhardwaj} and {Dr. V. VijuWilben}}, journal={{Global Journal of Medical Research}}, journal={{GJMR}}2249-46180975-588810.34257/GJMR, address={Cambridge, United States}, publisher={Global Journals Organisation}2232334 } @incollection{b0, , title={{De Backer D Circulatory shock}} , author={{ JLVincent }} , journal={{N Engl J Med}} 369 , year={2013} } @incollection{b1, , title={{A positive fluid balance is an independent prognostic factor in patients with sepsis}} , author={{ AAcheampong } and { JLVincent }} , journal={{Crit Care}} 19 , year={2015} } @incollection{b2, , title={{Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality}} , author={{ JHBoyd } and { JForbes } and { TNakada }} , journal={{Crit Care Med}} 39 , year={2011} } @incollection{b3, , title={{Higher fluid balance increases the risk of death from sepsis: results from a large international audit}} , author={{ YSakr } and { PnrBirri } and { KKotfis }} , journal={{Crit Care Medicine}} 45 , year={2017} } @incollection{b4, , title={{Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock}} , author={{ MVarpula } and { SKarlsson } and { ERuokonen } and { VPettila }} , journal={{Intensive Care Med}} 32 , year={2006} } @incollection{b5, , title={{The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands}} , author={{ PVan Beest } and { JHofstra } and { MSchultz } and { EBoerma } and { PSpronk } and { MKuiper }} , journal={{Crit Care}} 12 R33 , year={2008} } @incollection{b6, , title={{Microcirculatory oxygenation and shunting in sepsis and shock}} , author={{ CInce } and { MSinaasappel }} , journal={{Crit Care Med}} 27 , year={1999} } @book{b7, , author={{ RCArnold } and { NIShapiro } and { AEJones } and { CSchorr } and { JPope } and { ECasner } and { JEParrillo } and { RPDellinger } and { TrzeciakSMulti }} , title={{Center Study of Early Lactate Clearance as a Determinant of Survival in Patients with Presumed Sepsis. Shock}} , year={2008} } @incollection{b8, , title={{Lactic acidosis}} , author={{ JAKraut } and { NEMadias }} , journal={{N Engl JMed}} 371 24 , year={2014} } @incollection{b9, , title={{Central venous-arterial pCO2 difference as a tool in resuscitation of septic patients}} , author={{ PAVan Beest } and { MCLont } and { NDHolman } and { BLoef } and { MAKuiper } and { ECBoerma }} , journal={{Intensive Care Med}} 39 , year={2013} } @incollection{b10, , title={{Resuscitation of patients with septic shock: please ''mind the gap}} , author={{ BVallet } and { MRPinsky } and { MCecconi }} , journal={{Intensive Care Med}} 39 , year={2013} } @incollection{b11, , title={{Venoarterial CO2 difference during regional ischemic or hypoxic hypoxia}} , author={{ BVallet } and { JLTeboul } and { SCain } and { SCurtis }} , journal={{J Appl Physiol}} 89 , year={2000} } @incollection{b12, , title={{Central venous-arterial carbon dioxide difference as an indicator of cardiac index}} , author={{ JCuschieri } and { EPRivers } and { MWDonnino } and { MKatilius } and { GJacobsen } and { HBNguyen } and { NPamukov } and { HMHorst }} , journal={{Intensive Care Med}} 31 , year={2005} } @book{b13, , title={{Central venous-toarterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock? Intensive care medicine}} , author={{ FVallée } and { BVallet } and { OMathe }} , year={2008} 34 } @book{b14, , title={{Experimental and Clinical Studies on Lactate and Pyruvate as Indicators of the Severity of Acute Circulatory Failure (Shock) Circulation}} , author={{ MWeil } and { AAAfifi }} , year={1970} 41 } @incollection{b15, , title={{Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial}} , author={{ TCJansen } and { JVan Bommel } and { FJSchoonderbeek } and { SleeswijkVisser } and { SJVan Der Klooster } and { JMLima } and { APWillemsen } and { SPBakker } and { J }} , journal={{Am J Respir Crit Care Med}} 182 6 , year={2010} } @incollection{b16, , title={{Lactate clearance versus central venous oxygen saturation as goals of early sepsis therapy}} , author={{ AEJones } and { NShapiro } and { STrzeciak }} , journal={{JAMA}} 303 8 , year={2010} } @incollection{b17, , title={{Persistent sepsis-induced hypotension without hyperlactatemia: Is it really septic shock}} , author={{ GHernandez } and { RCastro } and { CRomero }} , journal={{Journal of Critical Care}} 26 , year={2011} , note={e414} } @incollection{b18, , title={{Ratios of central venous-to-arterial carbon dioxide content or tension to arteriovenous oxygen content are better markers of global anaerobic metabolism than lactate in septic shock patients}} , author={{ JMallat } and { MLemyze } and { MMeddour }} 10.1186/s13613-016-0110-3 , journal={{Annals of Intensive Care}} 6 1 , year={2016} } @book{b19, , title={{Gas transport to the periphery: how gases are moved to the peripheral tissues?}} , author={{ JBWest }} , editor={West J. B.,} , year={1990} , address={Seattle, WA, USA: Amazon} , note={editor. Respiratory Physiology: The Essentials. 4th} } @incollection{b20, , title={{Comparison of exercise cardiac output by the fick principle using oxygen and carbon dioxide}} , author={{ X.-GSun } and { JEHansen } and { HTing }} 10.1378/chest.118.3.631 , journal={{Chest}} 118 3 , year={2000} } @incollection{b21, , title={{Difference in acid-base state between venous and arterial blood during cardiopulmonary resuscitation}} , author={{ MHWeil } and { ECRackow } and { RTrevino } and { WGrundler } and { JLFalk } and { MIGriffel }} , journal={{New England Journal of Medicine}} 315 3 , year={1986 Jul 17} } @book{b22, , title={{Arterial-venous carbon dioxide tension difference during severe hemorrhage and resuscitation. Critical care medicine}} , author={{ JPDucey } and { JMLamiell } and { GEGueller }} , year={1992 Apr 1} 20 } @incollection{b23, , title={{Persistently high venous-to-arterial carbon dioxide differences during early resuscitation are associated with poor outcomes in septic shock}} , author={{ GAOspina-Tascón } and { DFBautista-Rincón } and { MUmaña }} , journal={{Crit Care}} 17 R294 , year={2013} } @incollection{b24, , title={{Temporal Evolution of the PcvCO2-PaCO2/CaO2-CcvO2 Ratio vs Serum Lactate during Resuscitation in Septic Shock}} , author={{ SMadabhushi } and { ATrikha } and { RKAnand } and { RRamachandran } and { PMSingh } and { VRewari }} 10.5005/jp-journals-10071-24044 35027796 PMC8693105 , journal={{Indian J Crit Care Med}} 25 12 , year={2021 Dec} }