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             \author[1]{Henrique Hollanda Larangeira, Tábata de Oliveira Silva, Rafaela da Silva Schottz, Ingrid Fabric Gouveia Lima, Lina Borges Cavalcante, Marcus Antonio Studart da Cunha Frota, Janaína Gomes da Rocha, Lorena de Sousa  Moura}

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\date{\small \em Received: 1 January 1970 Accepted: 1 January 1970 Published: 1 January 1970}

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\begin{abstract}
        


Introduction: Understanding that cancer is a pathology that is challenging to detect, treat, and comprehend is what makes the study of cancer so important. The goal of this case study is to show how a 20-year-old woman was affected by a variety of factors and symptoms that, when combined, raised suspicion of Ewing's sarcoma, the second most common primary tumor in children and young adults. Ewing's sarcoma has the characteristics of being an aggressive malignancy originating in the bones.

\end{abstract}


\keywords{ewing's sarcoma; chest wall tumor; oncology.}

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{{\textit{CrossRef DOI of original article:}} \underline{}}
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Abstract-Introduction: Understanding that cancer is a pathology that is challenging to detect, treat, and comprehend is what makes the study of cancer so important. The goal of this case study is to show how a 20-year-old woman was affected by a variety of factors and symptoms that, when combined, raised suspicion of Ewing's sarcoma, the second most common primary tumor in children and young adults.\par
Ewing's sarcoma has the characteristics of being an aggressive malignancy originating in the bones.\par
Methodology: The present research uses clinical trials to treat and address the epidemiological component, with the analysis of a case report serving as a guide. SciELO and PubMed data platforms were utilized to compile the foundation of a literature review. The research period ran from July 2023 to the end of 2023, and publications published in Portuguese and English between 2000 and 2023 that met the inclusion criteria were both online texts and complete texts. As strategies for better evaluation of the texts, the following health descriptors (DeCS) were used: "Ewing's sarcoma" and "Chest wall tumor".\par
Case Report: S.J.J., female, 20 years old, student She arrived at the hospital complaining of chest pain for 2 yearsintense pain-and did not present other respiratory symptoms. She denied a fever and weight loss. She reports childhood asthma and denies a cancer history. She denies alcoholism and smoking. She reports that her mother had breast cancer. On physical examination, she was in good general condition, afebrile, anicteric, and eupneic on room oxygenation; absence of palpable lymph nodes in the cervical, supraclavicular, and axillary regions; auscultation of the respiratory system showed bilateral physiological vesicular murmurs and no adventitious sounds; there was no palpable tumor in the region of the chest, and did not present a restriction to the mobilization of the upper limbs. Saturation was 98\% at the time of the initial consultation.\par
Discussion: Bone Ewing's Sarcoma is known to be an aggressive tumor that typically affects people in their second decade of life. Also take note of the radiographic appearance of a licit lesion with a periosteal reaction indicative of an aggressive lesion. Additionally, the immunohistochemistry study is required to distinguish and categorize the various Ewing family sarcoma kinds. Thus, the case shows the importance of investigating pathologies that have not yet been well elucidated since rare diseases are not part of the medical routine, so their diagnosis brings the opportunity to obtain more specialized treatments. 
\section[{Introduction}]{Introduction}\par
he main aspect in which a study on cancer is necessary is to understand that lives are transformed by a pathology that is difficult to diagnose, treat, and understand. The objective of this case report is to illustrate how a 20-year-old girl was affected by a whole set of factors and signs that, when compiling the main characteristic points, led to the suspicion of Ewing's Sarcoma, the second most common primary tumor in children and adolescents. Ewing's sarcoma has the characteristics of being an aggressive malignancy originating in the bones. 
\section[{II.}]{II.} 
\section[{Methodology}]{Methodology}\par
In this epidemiological study, the utilization of clinical trials to treat and address the epidemiological element is discussed using a case report as a guide. in conjunction with an assessment of the literature, whose sources came from the SciELO and PubMed data sources. The research was made in July 2023, meeting the inclusion criteria, which were articles from the years 2000 to 2023, in Portuguese and English, online texts, and full texts. As strategies for better evaluation of the texts, the following health descriptors (DeCS) were used: "Ewing's sarcoma" and "Chest wall tumor" . a) Case Report S.J.J., female, 20 years old, student She arrived at the hospital complaining of chest pain for 2 yearsintense pain-and did not present other respiratory symptoms. She denied a fever and weight loss. She reports childhood asthma and denies a cancer history. She denies alcoholism and smoking. She reports that her mother had breast cancer. On physical examination, she was in good general condition, afebrile, anicteric, and eupneic on room air; there were no palpable lymph nodes in the cervical, supraclavicular, and axillary regions; auscultation of the respiratory system showed bilateral physiological vesicular murmurs and no adventitious sounds; there was no palpable tumor in the region of the chest; and she did not present a restriction to the mobilization of the upper limbs. At the time of the first consultation, the saturation was 98\% in room air.\par
A biopsy and several computed tomography images of the chest were done simultaneously. The first separate scout had an expansive lung lesion in the right lower lobe. One characteristic that stands out when all the scouts are analyzed is the nodule development angle, which is larger than 90 degrees and indicates an extrapulmonary lesion. In addition, chest tomography revealed opacity and demarcation in the xiphosternal line. Finally, the immunohistochemical analysis identified a neoplasm as cells with rounded, regular nuclei, coarse chromatin, and scant cytoplasm. The round cells, which in turn present an organoid pattern and fibromyxoid stroma, raise suspicions about the origin of the tumor.\par
The upper segment of the right lower lobe contained a solid and homogeneous subpleural expansive lesion that measured 6.0 x 3.4 cm in the largest axial axes. This lesion was located using a second computed tomography scan of the chest for surgical planning. The anterior cortex of the corresponding fifth and sixth costal arches looked to be in close contact with it, and a minor remodeling of the bones was observed. There is no pleural effusion and normal lung parenchyma.\par
The patient underwent a treatment that included myocutaneous repair, free margins, and resection from the fourth to the seventh quadrant. Three months after the date of surgery, a computed tomography scan of the chest was performed, showing signs of surgical manipulation on the right chest wall and blurring of the posterior aspect of the fourth to seventh costal arches on that side, with no signs of tumor remaining in the analysis for this one. As a result of the third right costal arch fracture, there was an atelectatic band on the lingula, no pleural effusion, the heart volume was still normal, and the thoracic aorta had a normal course and diameter. The patient was advised to have chest resonance segmentation every six months; however, the patient did not return for follow-up.   
\section[{Results \& Discussion}]{Results \& Discussion}\par
In its initial aspect, Ewing's Sarcoma is a malignant bone tumor characterized by round, primitive cells without obvious differentiation. Localized pain, with the potential for a palpable mass depending on the location, characterizes the clinical presentation. Wide surgical resection is the primary form of treatment, possibly with radiotherapy.\par
Since chest wall tumors are cancerous tumors that can impair lung function, the issue was chosen because of its importance to society. In this regard, primary tumors of the chest wall make up 5\% of all tumors and impact bone tissue in roughly 55\% of cases. A distinct clinical picture, histological characteristics, specificity, and anatomical location preference. To confirm the diagnostic theory of Ewing's Sarcoma, tomography and biopsies must also be carried out.\par
Based on the retrospective analysis of prospective studies by the Cooperative Weichteilsarkom Studiengruppe (CWS), carried out with 60 patients from 1997 to 2015, the prevalence of Ewing's sarcoma in men was observed, with a ratio of 4 men to 1 woman. The average age of a person with this sarcoma is 14.5 years old. In addition, the intra-abdominal and retroperitoneal regions are affected in about 93\% of cases, with emphasis on the thoracic, paratesticular, and parotid gland regions. In 67\% of the cases, they had tumors larger than 10 cm, and 88\% had locally disseminated tumors; thus, in most cases, sarcoma was characterized by large and disseminated tumors. 10\% of patients had only a single, isolated tumor at the time of clinical presentation; 27\% had spread to nearby lymph nodes; and 63\% had extraperitoneal metastasis, of which 67\% underwent surgical resection. Regarding treatment, of the 60 patients, nine underwent high-dose chemotherapy, six received regional hyperthermia, and 20 received radiotherapy. As a result, 51 patients died, of whom 49 due to the disease and 2 due to abandonment of chemotherapy and peritonitis. Surgery with resection at R0 is the aim; radiotherapy was implemented in patients with extensive or unresectable disease. The VAIA chemotherapy regimen (ifosfamide, vincristine, adriamycin, and actinomycin D) produced the best results overall.\par
Additionally, 32\% of patients had relapsed, 26.7\% had disease-free time for three years, and 42\% of patients had complete disease remission. The investigation revealed that no risk factor was connected to the progression of the disease, tumor size did not affect mortality, and metastatic sites did not exhibit a statistically significant prevalence. Sarcoma has a proven bad prognosis; often, a patient with a good prognosis has limited extra-abdominal illness, no pleural effusion, has undergone surgery at R0, and has used CT VAIA.\par
It is possible to observe the proportion of the evolution of cases in several patients, making a general analysis and allowing a certain orientation, both for the immediate treatment and for the prognosis of the patients.\par
In this way, neuroendocrine tumors and Ewing's sarcoma have been combined into a family of sarcomas. Although the latter studies exhibit greater neuroectodermal differentiation than Ewing's sarcoma, this difference is not clinically relevant. Typically, Ewing's sarcoma invades the cortex, periosteum, and soft tissues. They have a sparse cytoplasm that seems cleaner, which is a result of the high glycogen content. They have a sparse cytoplasm that seems cleaner, which is a result of the high glycogen content. It is a sarcoma that primarily affects flat bones like the pelvis, ribs, and vertebrae, as well as the trunk when soft tissues are involved. Immunohistochemical analysis of the samples shows the existence of cells with rounded, regular nuclei, coarse chromatin, and sparse cytoplasm. The round cells themselves have a fibromyxoid stroma and an organoid pattern. As a result, similar characteristics to the reported case are confirmed.\par
It appears that bone Ewing's Sarcoma is an aggressive tumor, usually affecting individuals in the second decade of life. Note also the appearance of a licit lesion with a periosteal reaction typical of an aggressive lesion on X-RAY. Furthermore, the immunohistochemical study is necessary to differentiate and classify the types of sarcomas in the Ewing family. Thus, the case shows the importance of investigating pathologies that have not yet been well elucidated since rare diseases are not part of the medical routine, so their diagnosis brings the opportunity to obtain more specialized treatments.\par
IV. 
\section[{Conclusion}]{Conclusion}\par
In this way, the case highlights the need to research pathologies that have not yet been fully understood because rare diseases are not common and their diagnosis guarantees access to more specialized treatments.\begin{figure}[htbp]
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\end{bibitemlist}
 			 		 	 
\end{document}
