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\def\makelabel##1{\upshape ##1}}% } {\end{list}\end{raggedright}} \newenvironment{specHead}[2]% {\vspace{20pt}\hrule\vspace{10pt}% \phantomsection\label{#1}\markright{#2}% \pdfbookmark[2]{#2}{#1}% \hspace{-0.75in}{\bfseries\fontsize{16pt}{18pt}\selectfont#2}% }{} \def\TheFullDate{1970-01-01 (revised: 01 January 1970)} \def\TheID{\makeatother } \def\TheDate{1970-01-01} \title{Thrombotic Complications in Children in the Postcovidae Period: Clinical Cases} \author{}\makeatletter \makeatletter \newcommand*{\cleartoleftpage}{% \clearpage \if@twoside \ifodd\c@page \hbox{}\newpage \if@twocolumn \hbox{}\newpage \fi \fi \fi } \makeatother \makeatletter \thispagestyle{empty} \markright{\@title}\markboth{\@title}{\@author} \renewcommand\small{\@setfontsize\small{9pt}{11pt}\abovedisplayskip 8.5\p@ plus3\p@ minus4\p@ \belowdisplayskip \abovedisplayskip \abovedisplayshortskip \z@ plus2\p@ \belowdisplayshortskip 4\p@ plus2\p@ minus2\p@ \def\@listi{\leftmargin\leftmargini \topsep 2\p@ plus1\p@ 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\textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt \textcolor{GJBlue}{\large\bfseries\abstractname\space} }{% \vskip8pt \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt } \usepackage[absolute,overlay]{textpos} \makeatother \usepackage{lineno} \linenumbers \begin{document} \author[1]{Guli Saatova} \author[2]{Bubalima Musurkulova} \author[3]{Ainura Bolotbekova} \author[4]{Regina Almazbekova} \author[5]{Alla Furtikova} \author[6]{Mairam Koshukeeva} \renewcommand\Authands{ and } \date{\small \em Received: 1 January 1970 Accepted: 1 January 1970 Published: 1 January 1970} \maketitle \begin{abstract} Resume-The high incidence of arterial thrombosis and venous thromboembolic complications in patients with SARS-CoV-2 coronavirus infection indicates the need for an in-depth study of the pathogenetic moments of procoagulant status and a more rational approach to preventive measures.The aim of the work was to study clinical cases of thrombotic complications in children with coronavirus infection to substantiate the principles of practical approach to treatment and prevention.This article presents clinical cases of thrombotic complications after COVID-19 in four children 12 months, 12, 16 and 3 years of age. \end{abstract} \keywords{children, COVID-19, thrombosis, hypercoagulability, blood vessels, post-Covidae syndrom.} \begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) \textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark} \end{textblock*} \begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) \textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}} \end{textblock*} \begin{textblock*}{10cm}(1.05cm,3cm) {{\textit{CrossRef DOI of original article:}} \underline{}} \end{textblock*}\let\tabcellsep& \section[{???????? ?????:}]{???????? ?????:}\par Ð?"???, COVID-19, ???????, ???????????????, ??????, ???????????? ???????, ?????????? ?????? ??????, ???????, ?????????????? ??????????, ????????????. Resume-The high incidence of arterial thrombosis and venous thromboembolic complications in patients with SARS-CoV-2 coronavirus infection indicates the need for an in-depth study of the pathogenetic moments of procoagulant status and a more rational approach to preventive measures.\par The aim of the work was to study clinical cases of thrombotic complications in children with coronavirus infection to substantiate the principles of practical approach to treatment and prevention.\par This article presents clinical cases of thrombotic complications after COVID-19 in four children 12 months, 12, 16 and 3 years of age.\par In the first and second cases of children with congenital heart disease after coronavirus pneumonia, thrombotic complications in the form of a thrombus in the right atrium and a thrombus in the hepatic segment of the inferior Author ?: e-mail: saatova@mail.ru vena cava were detected. In the third case, occlusive thrombosis of the common and external iliac veins on the left and the external iliac vein on the right was detected. In this case, the child was diagnosed with secondary antiphospholipid syndrome. In a clinical case, a 3-year-old child developed acute cerebral circulation disorder with ischemic stroke in the middle cerebral artery basin after a COVID-19 coronavirus infection. ??? ?????????? ??????? ?? 10.12.21?: ??????, ??????? ??????, ????????????? ??????, ?????????, ???????? ?????????????? ?????????. ??Ð?" ?? 13.12.21?: ???? ?????????, ??? 150 ?? ? ???., ????????????? ??? ?????? ????????? ??????. ????????? ??????????, ??????????? ??????? ?????????. ????Ð?" ?? 09.12.21?. ???: Ð?"??? (????????? ???). ????????? ??????????? ? ??????? ??????? ?????????? 1,7 ? 1,6 ??. ??????????????? ???????? (???. 1). \section[{Keywords}]{Keywords}\par ???? ????????? ???????: ????????????????? ??????? (?????????? 350?? ? 4 ?/???? ?6; ???????? 3,0 ?? 1 ?/???? ?11; ???????? 110 ?? ?/?), ???????????????? ??????? (??????? 500 ?Ð?" ?? 0,1 ? 4 ?/???? ?/? ? ??????????? ???????, ???????? 2,5?? ¼ ??? ?1/2 ? ?1/3 ? ? ????), ?????????? ????????? (?????????? ½ ??? ? 1 ?/????), ????????????????????? ??????? (?????? 3,0 ?? ? 2 ?/????).\par ????????? ?? ???? ??????? ?????????????????, ?????? ???, ????????? ?????????? ?? ?????? 93-96\%, ???????????? ?????????? ????????? ?????. ? ???????? ????????? ??????????? ? ??????? ??????? ?????????? ??????????? ? ?????????? ? ?????????? ?? 1,1 ? 1,0 ??. ???????? ?????????????? -«????????? ? ??????????? ???????????? ??????? ???». ????????? ???????? 2,5?? ?? 1/4 ??? ? 1 ??? ??????? ?????????. ??????? ? ??????????.\par ????????????? ????????? ?????? ????? ?? ???????????? ??????? ????? 4 ??? (???, ???, ???). ??????????? ?????? ????? 7 ????. ????Ð?" ? ?????? ? ?????????????? ????? 1 ?????. ? ????????? ????????? ???????: ??????????? 0,6 ?3 ?/? ?2 ? 0,6? 2 ?/? ?1 ?0,6 ?3 ?/? ?1 ? 0,6 ?2 ?/? ?1? 0,3 ?2 ?/? ?1? 0,3 ?1 ?/? ?1; ????? 500 ?? ? 1 ??? ? ???? ?6; ????? 8?? ?16?? ?8?? ?? ???.?-?? 100,0 ? ????????? ?? ?????? ? ?????????; ?????? 2,0 ?/? ???. ?5; ????????? 1 ???.? ???? ?19; ?????? ?????????? ? ????? ???????????; ?????? ???? (???????????? ??????????????) 0,4 ??/??(???????? ???? ? ??????? 5 ????); ???????? \begin{figure}[htbp] \noindent\textbf{} \par \begin{longtable}{P{0.42263941346367473\textwidth}P{0.0126527438347034\textwidth}P{0.0389024661186403\textwidth}P{0.047022883803599196\textwidth}P{0.0024550099977782716\textwidth}P{0.2957342812708287\textwidth}P{0.02813819151299711\textwidth}P{0.0022661630748722506\textwidth}P{0.0001888469229060209\textwidth}} \multicolumn{8}{l}{II. Ð?"??? ? ??????????? ???????? ?????? (???) ??????? 4: ???????????? ??????? ????? 2021 ?. ?? 24.11.21? ?????????????? ?? ?????? ??????????? ?????? ????? ?????????? ? ?????? ???????? ????? ? ?????? ??????????? COVID-19. ??? ?? ?????, ?????????? ?????????????? ?????????? ??????? ?????? (???) ? ??????? ????????? ??????????, ??????? ?????? ? ??? ??????????. a) ??????????? ?????? ???????????? ?????????????? ???????? ? ???????????? ???????????????? ?????????? ? ????????????? Ð?"??? ?????????????? ????? ?????????????? MNO ?????????? ?????? ?????????, Ð?"? II-III ???????. ???????: ?????????? 400?? 4?/????, ??????????? 600?? 13.12.21? 12,2" 109,8\% 10,9 1,36 ?/? 1?/????, 21.12.21 18,9" 73,1\% 1,3 1,30?/? ???????????? 4??+???????? 0,9 ?/? ????????, ??????? 28.12.21 12,8 110\% 0,9 1,42?/? 0,1??, ??????? 35??, ?????? 10 ?? ?/? ????????, 03.01.22 90,9 14,7\% 6,78 1,94?/? ???????? ?? 7 ???, ?????????? ½ ???. 13.01.22 21,1 61,2\% 1,63 5,58?/? 06.12.2021 ???? ??? ???????? ???????????? ?? ????Ð?" ???????? ??????????? ? ?????? ?????????? 17.01.22 53,0 25,2\% 3,95 3,38 ?/? ???????????????? ?????? ? ??????? ? ??? ????? (?????). ????????? ???????. ?????????? ???????? ? ???????????? SARS -?oV-2 ?? ???????????? COVID-19 ?????????????? ???????. ?????? ???????? ????????? 10.12.21? IgG -????????????? (??=16,5), IgM -??????? ?. ?. 04.01.2021 ???? ???????? (12 ???????). ???????, ?????????? ??????????????? ? ????? (?????Ð?"): 09.12.2021 87-96\%. ??? ???????????? ??? ??????? ??????? ????????????? ?????? ?????? ??????????? ? ??????? ???????????? ????????? ?????? ?? 64 ? ???. SpO 2 60-Ð?"??? ??????????? ? ????????? ?????????????????? ???????, ??????? ?????????, ????????? ???. ?????????????.}\\ \multicolumn{2}{l}{Ð?"??? ???????: 18.01.2022 ?}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{3}{l}{????????? ?????. Ð?"?????? ????????????? ?????????}\\ \multicolumn{5}{l}{??????????? ???????: ???. Ð?"????? ?????????????? ??????????? (Ð?"???). ?????? ???????????? ???????????? ?????????.????????? ????? ???????????? ?????????????? ????????. ????? ? ?????? ??????????. ? ??????? ? ???????? ?????????????? ???: ???????? ?????????? ?????? (???). Ð?"???. ???????? ???????????. ????? ?????? ??????????? ?????????????,}\tabcellsep \multicolumn{3}{l}{: hypercoagulability, children, blood syndrom, congenital heart disease, stroke, thrombotic COVID-19, thrombosis, vessels, post-Covidae complications, prevention. ??????? ????????? ? ???????????. ???? ?????? ?????????, ??????????, ????????????? ??? ? 3-4 ?????????? ????? ?? ???????. ??????? ????????? ?????????? (???) -170 ? ???. ????? ??????, ?????????????? ??? ?????????. ?????? ? ????????? ? ???????? ?????????? ?????. ?????? ???. ???? ? ?????????????? ??????????. Ð?"????? ????????????:}\\ \multicolumn{5}{l}{??????? ?????????????? ?? ?????? ?????????. ? 11.11.}\tabcellsep \tabcellsep I.\tabcellsep ????????\\ \tabcellsep \tabcellsep \multicolumn{6}{l}{????????? ?? ????????????? ??????? ????????? ??????? 1: ????? ?????? ?????}\\ Ð?"???\tabcellsep ?? ?10 12 /?\tabcellsep HB ?/?\tabcellsep ?? -10 9 /?\tabcellsep \multicolumn{2}{l}{???? -10 9 /?}\tabcellsep \multicolumn{2}{l}{??? COVID-19 ? ????? ?? ??? ?????????????, ??? ? ????????. ???? \% ?id\% ??? -Gran \% ??/?}\\ 10.12.21 14.12.21 21.12/21\tabcellsep 4,87 4.82 5.00\tabcellsep 146 140 142\tabcellsep 252 258 311\tabcellsep \tabcellsep \multicolumn{3}{l}{???????????? ????????? ? ???? ????????? ? 67,6 9.1 23.3 2 ????????? ?????????? ????????? ???????? ????? ?? 11,2 9.8 49.6 10.2 40.2 5 ???????? ?????? ?????? ??? COVID-19, ?????? ?? ?????? ??????????? ? ????? ????????????? ? ?????? 14.3 52.6 9.6 37.8 9}\\ 29.12/21\tabcellsep 4.98\tabcellsep 143\tabcellsep 309\tabcellsep \tabcellsep \multicolumn{2}{l}{????????????? ????????. 18.7 29.4 6.3}\tabcellsep 12.0\tabcellsep 2\\ 14.01.22\tabcellsep 4.93\tabcellsep 140\tabcellsep 319\tabcellsep \tabcellsep 10.5\tabcellsep \multicolumn{2}{l}{??????? ??????? ???????????? ????????? ? 49.5 8.3 42.2 11}\\ \tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{3}{l}{???????? ?????????????????? ??????????, ???????}\\ \multicolumn{4}{l}{??????? 2: 10.12.21 5,0 4,53 61,8 21.12.21 4,20 1,74 63,8 03.01.22 5,36 1,74 ?/?}\tabcellsep \tabcellsep \multicolumn{3}{l}{?????????? ?????????????? ????????? SARS-CoV-2, ???????? ?? ? ?????? ????????? ? ????? ?????????? ?????????????????? ???????, ??????????????? ? ????????????? ???????????? ???????? ???????????????? ???????? ???????????????? ??????? ? ????? ????????????? ??????? 38,5 4,57 69,3/43,4 2,85 ? ??/? ???????????????? ???????????? (Lim W. 2019). 60,80 9,37 0,22/0,24?? 3,47 ?????? ??????? ???????? ???????? ?????????????? ???/? ?????????? ? ????????????????COVID-19. ?????, ? ??????? ????? ???????????? ?????????????? ???/? ? ?????? ???????????? ??????????? ?????? 66,3 3,84 0,30/0,34?? 6,1}\\ \tabcellsep \tabcellsep \multicolumn{6}{l}{???????? ?????????????? ?????? ? ??????? ??????, ??????? 3: ????????????? ?????}\\ \tabcellsep Ð?"??? 10.12.21 14.12.21?\tabcellsep ??????? ??????/? 2,15 2,20\tabcellsep \multicolumn{5}{l}{???????????? ???????? ??? ?????? ???????????, ??????????? ??????? ??????? ?????. ??????????/? ??? ?? ?????? ???? ????????????: ??????? ??????????? ??????? ?/? ??? 9,9 ???. ?????????????? ?????????? ? ?????, ?????????? 5,0}\\ \tabcellsep 13.01.22\tabcellsep 1,78\tabcellsep \tabcellsep \tabcellsep \multicolumn{3}{l}{?????????????? ???????? ??? ??????????? ????????? ??? 12,9}\\ \tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{3}{l}{????????????? ??????? ? ??????? ? ????????????.}\end{longtable} \par \caption{\label{tab_0}????????????? ?????? ????? Ð?"??? ???.??? ??????/ ? ?????. ?????, ?? ???. ?????, ?/? ???????? ? ??????/? ????? ?????/? ???/??? ?????/? ???????? ?????/?}\end{figure} \begin{figure}[htbp] \noindent\textbf{} \par \begin{longtable}{P{0.007772644142843392\textwidth}P{0.8422273558571566\textwidth}} \tabcellsep Thrombotic Complications in Children in the Postcovidae Period: Clinical Cases\\ Year 2023 Global Journal of Medical Research 40 Volume XXIII Issue VIII Version I ( D D D D ) F\tabcellsep b) ??????????? ?????? ?????? ??????????? ???????? ?????? ????? ???? ? ??????? ? ??? ??????? ?.?.: 14.01.2009 ???? ????????. Ð?"??? ???????????: 14.06.2021 ??????????? ???????: ???. ???????? ???????? ??????????? ??????? (??) ? ???????????????? ??????????? ???????III ??????? (???????? ??????????? ???? ??). ??????? 5: ????? ?????? ????? ?????????? ????? 15.06.21 ?????????? * 10 12 /? 4,26 Hb, ?/? 123 ?? 0.8 ?????????? *10 9 /? 378 ????????? *10 9 /? 7,4 ??????????,\% 1 ?/?,\% 4 ?/?,\% 52 ?????????,\% 40 ????????,\% 3 ????????? ???????: ????????? ?? 1 ???. 2 ???? ? ???? ?8, ????????? ?? 1,5 ??. 2 ???? ? ???? ?/?, ?????????? ?? 1 ???. 2 ???? ? ????. ?????????? ?? 1 ??. 4 ???? ? ???? ?/? ???????, ?????????? ?? 60 ??. 2 ???? ? ???? ?/? ??????? ?8, ???????? ?? 1 ??????? 1 ??? ? ????, ???????? ?? 1 ???. 3 ???? ? ????, ????????? ?? 1 ??????? ????? ????? ???? ?1. Ð?"?????? ?? 800 ?? (0,2) 4 ???? ? ???? ?4, ????? ?? 1250 ?Ð?" (0,25) 4 ???? ? ???? ?/? ?????? ?????. ???????????? ???????? ????Ð?", ??Ð?" ????? ??????, ??? ??????? ??????? ??????? ????????? 24.06.2021, ????? ?? ???????????? ??????? ?????? 3 ???, ????? ?? ??????????????.?????????? ????? ??????????: ????????? ?? 1,5 ??. 2 ???? ? ???? ?/?, ?????????? ?? 1 ??. 4 ???? ? ???? ?/? ??????? ?????????????. ?? ???? ???????, ???????????? 22.06.21 4,25 125 0,9 386 7,6 1 2 53 41 3 ???????????????? ??????? ?? ?????? ?????? ?? ???????? ???????? ?? ??, ??? ??????? ????? ??????????? ??????? ?????????????. c) ??????????? ?????? ???????? ??????? ?????? ??????????? ? ???????????? ????????? ??????? ????? ???????????? ?????????????? ???????? COVID-19 ??????? ?.?.20.09.2005 ???? ????????, 16 ??? Ð?"??? ??????????? ? ????????? ??????????????????: 25.03.2022 ??????????? ???????: ???????????? ???????, ????????? ????????????????? ???????: ???????????? ??????? ????? ? ???????? ??????????? ??? ????? ? ???????? ??????????? ???? ??????????? Figure 4goes here. File name: Figure 4General blood test.gpeg ??????? 4. ?????????? ??????? ????? ??? (?? 28.03.21): ???? ???/??????, ??????????, ???.?????????-1020, ??????? ??????, ????? ???, ???????-???., ???? ??. 3-4-4, ????????? 2-3-4-4, ???? ????. +, ?????? ???? ?? ??????????? ????????? 2750 ??? (?? 12.04.21): ???? ???/??????, ??????????, ???.?????????-1013, ??????? ??????, ????? ???, ???????-???., ???? ??. ????., ????????? 1-1-3, ???? ????. + ?????? ??. ?????(?? 28.03.22): ??? -20,0 ??/?, ??? ?????????-8,45 ??????/?, ????????? ?????-2,43 ??, ????? ????? -77,1 ?/?, ???????? -4,51 ?????/?, ?????????-68,3 ??????/?, ????? ?????-5,52; ???-63,2, ???-99,5, ???? +, ?? -???., ?? -2,13, Fe -8,4 ?????/?, ?-1,29 (31.03.22): ??. ??????????? ?? ?? -????? -9'38", ???-14,3"; ???-85,7\%, ???-1,17, ???? -25,3", ?????????? -3,9\% (04.04.22): ???-12,7"; ???-98,4\%, ???-1,03, ???? -24,1", ?????????? -4,2 ?????? ??. ?????(?? 08.04.22): ??? ?????????-7,73 ??????/?, ????????? ?????-3,51 ??, ????? ????? -70 ?/?, ???????? -5,37 ?????/?, ?????????-77,4 ??????/?, ????? ?????-4,47; ???-15, ???-43,0, ?? -2,29, ? -1,43 ??????? 8: ???????????? ??????? ????? Figures Ð?"????? ???????????? ??? 4 4 ??????? 6: ???????????? ??????? ?????: ??? 16,7" ??? 77,8\% ??? 1,21 ?????????? 2,4 ????? ?????? ???? ?? 15.06.2021: ???? ?/?, ???????????? ??????, ???.????????? 1020, ??????? ??????, ???????-???., ????? 0,675 ?/?, ????????? 2-3-4 ? ???? ??????, ????????? 6-7-8 ? ???? ??????, ????????++; ?????? ???? ?? ???????????: ????????? 2,750,????????? 6,000 ????? ?????? ???? ?? 22.06.2021?.: ???? ?/?, ???????????? ??????, ???.????????? 1015, ??????? ??????, ???????-???., ????? ?????, ????.?????????., ????????? 1-3-4-4; ?????? ???? ?? ???????????: ????????? 2,500. ??????? 7: ????????????? ?????? ?????: ???????????????? ???????????? ??Ð?" ?? 15.06.2021: ????????????? ??? ?????? ????????? ??????. ???? ????????? ? ?????????? ? ??????????. ??Ð?" ???????? ??????????? ?????? ??????????, ????? ??????????. ? ??? ??????? ??????? ? ????? ?? 17.06.2021: ??????????? ??????. ???-???????? ????????, ??????????????????. ??????????? ??????????. ? ???-?? ?? 14.06.2021: ???. ???????? ???????? ?? ? ???????????????? ?? III??.(???????? ??????????? ???? ??). ?? ??????????? ???????????? ??????????. Ð?"???????? ???? ??????? ??????. ????????????? ??????????????? ?? -III??.??Ð?". ? ??? ?? 18.06.2021: ?????? ?? ????? ??????????? ???????? ?????? ????? ????, ?????????????, ????? (???.3). Figure 3 goes here. File name: Figure 3 Ultrasound from 18.06.2021.gpeg ???. ?????????, ??????/? 18,65 19,4 ????????? ?????, ?Ð?" 3,51 2,16 ????? ?????, ?/? 66,0 69,0 ????????, ?????/? 7,24 8,42 ?????????, ??????/? 70,0 59,0 ???,?Ð?"/? 59,0 36,0 ???, ?Ð?"/? 95,0 50,0 ????? 5,11 5,18 ?? 2,47 2,57 ?????? 1,48 1,67 ??? 13,0 (06:00,12:00,18:00,00:00), ?????????? ?? 1 ???. 2 ???? ? ???? ?????????, ???????? ?? 1 ??????? 1 ??? ? ????, ???????? ?? 1 ???. 3 ???? ? ????, ??????? ?? 1250 ?Ð?" (0,25) 4 ???? ? ???? ?/? ?????? ?????. ??????, ????????????? ????????? ???? ?????, ?????? Ð?"??? ???????????? ??? ??? ??? ???? ?????????? ??????? (??????????????? SARS-COV-2 ?????????). ????????? ????? ??????????? ????-??????? ?? 26.01.2022?. ??????? ??? -???????. 08.04.2022 13,1" 95,2\% 1,06 24,0" 4,2\% 12.04.2022 15,5" 76,1\% 1,28 38,0" 4,3\% ???. 3. ??? ?? 18.06.2021: ?????? ?? ????????????? ?? ???. ??????? -???????? ????? ????, ?????????????, ????? ???, ??? ? ??? ?????? ? ?????????? ????????? ???????????? ????? ??????????? ???????? ?????? ? ?????, ???? ????? ?????????? ????? 2021 ???? ??????? ??????? COVID-19 14.04.2022 15,6" 75,3\% 1,28 32,0" 3,9\% (??? +). ? ?????? 2022 ???? ????????? ? ???????? ? ???????? ??????? ???? ?????????????? ???????? ???????COVID-19, ?????????? ?????????. ? ????? ???????????? ??????????? (?? 06.02.2022): ????????????? ?? ??????????, ?????????????? ?? ???? (Karikalan S. 2022). ??????, ? ?????? ??????? ? ??? ????????? ????????? ??????, ???????????? ??????? ?????. ?? ??????????? ???????? ?????????????????? ???????? ????????? ? ??????? ???????? ??????? ?????????? ? ??????????? ???????? ?????? ????? ???? ? ?????, ?????????? ?????????????? ????????. ?????????????? ?????????, ????????? ? COVID-19, ???????????? ??????? ???????????????????? ?????????, ?????????????? ???? ????????????????? ??????????. ? ???? ????? ???????? ????????? ??? ???? ? ???????????? ???????, ? ??? ????? ????????? ? ???. ?????? ?? ?????????????? ??????????? ???????, ???????? ????? ? ????????????? ?????????? ????????????????? ???????????? ????????? ? ???? ????????? ?????? ?????, ?????????? COVID-19 ? ????????????? ?????????? ?? ???????????????? ??? ???????????????. ????????? ???, ?????????? ??????????????? ????????, ????????? ?????????? ?????????????? ????????! ?????? ??????? ????????? ?????, ?????? ??? ??????? ?????????? ????????? ??????? ?????????. ????? ?????????????? ????????? ?????? (???) ???????? ???????? ???????? ????? ???????????????? ?????? ??????? ????????? ???????????? ? ?????????, ??????????? ????? ?????????, ??? ?????????, ?????????, ????????? ??. ?????? ???? ??? ??????????? ????????????? ??????? ?????? ??????? ??? ??????.?Ð?" 18 ? ??? SpO2-99\%. ?? ???????????? ??????? ???, ??????? ???, ??????? ?????? ?? ?????????. ????????? ????????. ????? ?????? ?????????? ?????? ??????, ?Ð?" -110/70. ????? ??????, ???? ?????? ?????, ????-???????, ??? ? ???? ??????? ??????????, ??? ????????? ???? ??????????, ?????????, ??? 88-98 ? ???. 5. 06.04.22: ????????? ????? ??????????? ?????????? ? ?????????? ????? ?????????? ?? ??????????? ????? ??????, ??????? ???????????. ? implantation.gpeg ????????? ??????????.Ð?"???????? ???? ?? ?????????? Figure 5 goes here. File name: Figure 5State after ?????? (Bigdelian H. 2021; WHO 2021; KlokF.A. 2020). 26.01.2022 ???????? ??????????? ???? ??????. ???-180??/?, ?????????? ??? ?? ???? ? ?????????? ?? ???? ?????????? ????? ?????? ??????? (???.5). ????? ????????? ??? ?????????????? ???????. ?????????, ?????????????? ?? ???? ?????????? ?????Ð?" ??? ????????? ???????? ? ??????? ???????. ??????. ??????? -???????? ?????????????, ?? Ð?"???????????????? ? ????????? ?????????????????? ?????????????. ????????????? ? ??????? ?Ð?"? ? ?Ð?" 43??/?. ?????????????? ????? ?????????????, ??????? IgA???????? ? ??????? ??????, Ð?"-Ð?"???? 10000??/??, ???????? ? ?/? ???? ?/? ??????????, ????????, ??????? ??????; ?2 ????????????? IgM, IgG, ?????????? ?? ????. ?????? ?????? ??????????: ??????? ? ????????????IgM, IgG, IgA???????? ? ????????????? ?? ??????????, ?????????????? ?? ???? ??????????? ??????? ??? ? ???: ????????? ????????????? ?? ???. ??????? -???????? ????? ??????. ???, ??? ? ??? ?????? ? ?????????? ????????? ????? ???? ????????? ??????? ????????, ???? ????? ? ???????????? ??????? ???, ??????? ?????, ??????? ???????: ?????? ?????????????????? ?????????????. 23?18 ??. ????? ?????? ??????????: ?????? ?? ????????????????, ???????????????? ???????. ?? ???? ??????????? ????-??????? ? ??????? ??????? ????? ??? ????????????? ????-?????? ? ????????? ??????????? (?? 22.03.22): ????????? ????? ????????? ???????????, ? ????? ? ?????? ????????? ?????????????? ??????????? ????????? ??? ?????? ?? ??????? ?????????, ? ?????????? ??????? ???????, ???????????????????. ??????????????? ? ???. ?????, ????????????????? ? ????????? ?????? ??? ???????????. ??????? ??????????? ? ?????????????? ??????? ????? ? ???????? ??????????? ??? ????? ? Ð?"??????????? ???????????? (?? 08.02.22): ??????????? ??????? "??????" ? ?????????: ??????? ???-???????. ??????????? ???????????????? ? ??????? ???????? ?? ????????? ?????? ?ELP-2 -???????? ???? (???), ????? ????????? ???? (???) ?????. ? ????????????IgG -90,46, IgM-35,75, ??????????? ???? (???), ?????????? ??????? ?????? ??????????? ???????????? ??????????? (?? 31.03.2022): ???????? ?????? ???????????? ??????? ????? ??????????? ???????? ?????????, ????????????? ??????????? ?????? ???????????, ??? ??? ??????? ??????????? ??????????? ????????????? -1,23+ ?????????????? ????????? ? ????? ????? ??????????? ???????????? ???????? ????????? ??Ð?"Ð?" ??????? ?????????????? -580,0 ??/?? (????? 0-10); ????????????? COVID-19, ??????? ????????? ?? ?????? ?????????? ? ??????????? ???????, ? 890,0 ??/?? (????? 0-10); ???????? ? ????-2 ??? ?????? ???????? ????????? ??????? ???? ? ????? ????????????????? ??????? ?? ? ???????????? ?????????? ?? ????.\\ \tabcellsep © 2023 Global Journ als\end{longtable} \par \begin{quote} \par \par \par \par \par ????????????? ??????????????? ???????????????? ??????? (??)III ???????. ??????? ???????? ??????????? (??Ð?"). ???? I-II. ???????????? ?????????????????? ?????-????? (????? ? ?????? ????? ????).???????????? ???????.??????? ???????? ?? ?????? ? ?????, ????????, ??????? ????????????, ????? ?? ????, ???????????, ????????? ????????????.??? ??? ??????? ??????? 2020 ???? (? 11?????? ????????), ????? ???????? ???????? ?? ???????? ????????? ???????????????. ???????????? ??????? COVID-19 (??? lgGSARS-Cov-2???? 16,5).????????? ???????. ??Ð?": ??????? ?????.\end{quote} \caption{\label{tab_1}1 and 2 go here. File name: Figure 1 Echo Cardiogram from 09.12.2021.gpeg Figure 2 Echo Cardiogram from 09.12.2021.gpeg}\end{figure} \begin{figure}[htbp] \noindent\textbf{} \par \begin{longtable}{P{0.0066849034022909894\textwidth}P{0.40741579757223456\textwidth}P{0.43589929902547436\textwidth}} \tabcellsep ?? ???????????? ??????????? ????? ?????????????? ??????? ????? ? ????? ? ???????????????\tabcellsep ???????? ???????: ?????????????????, ????????????,\\ \tabcellsep ??????????, ?????? ?????? ????? ???? ??????????? ???????????? ?????.\tabcellsep ??????????? ? ???????????????? ???????. Ð?"??????? ??\\ \tabcellsep ??? ?????? ?????????, ??????? ????????????? ??????? ? ????? ????? ??????, ?????????????? ??????\tabcellsep ???????????, ????????? ??????? ?????????? ???????,\\ \tabcellsep ?????? (????????) ???? ???????? (Karikalan S. 2022). ?????? ??????????????? ??????????? ?? ?????????\tabcellsep ??????????? ???? ???? ? ???????? 37,7-38,5?.\\ Year 2023 Volume XXIII Issue VIII Version I Global Journal of D D D D ) F ( Medical Research\tabcellsep ??? ??????? ????? ???? ?????????? ? ??????????? ????????????????? ?????????. ???????????????? ????????????????? ??????? ??? ??????? ??????? COVID-19 ?? ????????? ??????????? ???????? ? ???????? ?????? ?? ?????????? ???????????, ??????? ????? ? ????? ?????????. d) ??????????? ?????? ??????? ????????? ????????? ?????????????? (????), ??????????? ??????? ? ???????? ??????? ???????? ??????? ? ??????? ????? ???????????? ?????????????? ???????? COVID-19 Ð?"?????? ?.?. 2017 ???? ???????? (3 ????). ???????? ???????: ????. ??????????? ??????? ? ???????? ??????? ???????? ??????? ??????, ? ????????? ?????????? ??????? ?????????, ?????????? ???????????? ?????????????? ????????. ????????????? ??????????. ?????????????: ??????????. ???????????-??????????????? ??????. ???????????????? ?????? ????????? ???????. ?????? ????????. Ð?"??????????? ????????????. ??????????? ??????????????? ??????????? ???????. ??????? ?? 6 ???????????? 5 ?????. ???????????? ????????? ?? ???? ????????? ?? 3-4 ???????, ????????? ???? ? 1 ?????????. ??????? ?? ????? ? 3 ??????. ??????? ?? ??? -?????????????. ?? ????? ???????????? ?? 2-3 ????????? ?????????? ?Ð?". ???? ? ????? 39 ??????, ??????????, ????? ?? ?? ??????? ????????? ?Ð?" ?? ??Ð?" 210 ?? ?? ??. ??? 3400 ??. ????????? ?????, ? ????? ????????? ?? 2 ????, ?????? ???????. ?????????? ???????? -?? ?????????. ???????????????? ?? ?????????. ??????????? ????? ????????. ?? ????? ???????????? ????????? ?????????, ??????, ???????? ???????. ??????? ??????? COVID-19 (?? 04.07.2020. ??? SARSCoV-2 ?????????????) 28.07.20 ????? ??????? ???? ?????, ???????????? ???????, ?????????? ?????? ??????????? ???????? ? ????? ???????????. ? ???? ?? ???? ?????????? ? ??????????? ?? ????? ??????????, ??? ??? ??????????? ??????? ??????? ?? ???? ?????????. ?????? ???????? ?/?, ??????? ??? ???????????????? ? ?????????? ?? ??????? ????????? ? ?????????? ????????, ? ???????? ??????? ??????-???????????? ????????? ? ??????? ????????, ?????????, ?? ???? ????????? ??????????? ???? ?? 39 ????????. ?????????????? ??????????? ???????? ? ????? ???????????????? ?????????? ? ???????????????? ???????????? ??? ? ???? ????????? ? ?????? Figure 8,9 goes here. File name: Figure 6 MRI Angiography from 07.08.2020.gpeg ???. 8, 9. ??? ??????????? ?? 07.08.2020? -??????? ????????? ???????? ?????? ??????? ? ?????? ???????? ??????? ? ????? ??????. Ð?"????????? ??????????? ?????? ????? ??? ????????? ????? -??????? ? ???? ?????? ??? ?Ð?"-??????????? ??????????????? ??????????? ???????, ??????????. ??Ð?"-???? ?????????. ??? 160 ??. ? ???. ??? ????????? ??????. ???????? ??????? ?????? ????? ????? Ð?"???. ?????????????? ??????? ??????? ??????: ???????????? ??????????? ?????????. ??????? ???????????????? (??????????????? ? ??????????????), ???????????????? (????, ??????????? ? ??????????????????). ????? ??????????? ??????? ?????????? ????????????? ????????: ???????? -30,84 ??/??; D-????? -0,53; ?????????? ? -4,6. ?? ?????????????? ??????? ??????? ?????? ? ???????? ???????????? ???????????? ? ????? ?????? ? ?????? ????????????. NIHSS (36 ???? ????????)-13 ?. Ð?"????? ??????????? ?????? ???????? ?????????????? ?????????? ????????? ????????? ?????????????? ?????????? ???????????? ????? ?????? ?????????? ???????????? ??? ?? ????????? ? ?????????????? ??????????? ? ???? ?????????, ?????????? ???????? COVID-19, ? ????? ?? ?????? ????????? ????????? ????????? ????? ??????????. ? ????? ? ???? ?????????? ?????????? ? ????????? ?????????? ???????????? ?????????????? ?????????? ? ????? ? ???????????? ????? ?????????????? ????????? ?????????? ?? ?? ???????. ?? ?????? ????? ??? ????????? ?????????? ????????? ???????????? ????????? ?? ????????? ? ?????????? ??????? ????????? ??????? ????????? ?????? ?????????, ??? ????? ??????? ? ????????????? ????? ????????????? ????????????????? ??????? ? ???????????? ???????????? ??????????, ????????????? ????????????? ???????? ?????????. ?????????????? ????????. ????????? ??? ? ?????? ?????? ????? ???? ?????????? ????????????????????? ????????, ??? ??????? ?????????? ????? ????????? ?????? ???????? ?????????. ??????????, ???????? ?????? ??????? ???????????? ???????? ? ?????, ????????, ????????????? ??????????? ???????. ???? ???? ????????? COVID-19 ????? ????????, ? ?????? ??????? ? ??? ??????????? ??????? ??????????????? ????????. ??? ??????? TheLancet, ? ????????? ???????? ????????, ???????????? ?OVID-19, ???????? ????????? ????????? ????? (?????? ?? ????????), ??????? ????? ? ???????????? (ReyesGil M. 2019; ESO 2023; Bowles L. 2020; HarzallahI. 2020) ???????????????? ??????? ?????????? ?????? ???? ???????????? ??????????? ??????? ????????????? ?????????? ?????, ?????????????? ?\tabcellsep 1 ½ ???. ????? ?9; ?????? 16?? ???.1 ???.,1 ??? ???? ????.1 ?5? 2 ??? ???.,1 ??? ????,1/2 ???????; ??????? ?????? 0,1 ???????; ????????? ½ ??? ? 2 ???? ? ???? ?4 ? ½ ????? ?2 ? ?????????? ??????? ????????? ???????? ??????????? ??????????, ??????? ??????? ?? ?????????, ?????????? ????????? ?? ??????? ????? ?????????? ???, ???? ??? ?????????? ??Ð?"Ð?" ??????? ???????? ???????? ???????????, ????????? ????????? ????????????? ???????. ? ?????? ??????????? ?????? COVID-19 ????????????? ???????? ????????????? ?????????, ????????? ??? ????????, ??????????? «COVID-19-?????????????? ??? -???????? ???????». ????????????????? ??????? -???????????? ???????????, ??????? ????????????? ??? ???????? ??? ???????????? ???????. ?????????????? ??????? ??????????? ??????? ??????????????? ??????: ???????? -???? (3 ? ?? ??Ð?"). ?? ?????? ?? ?????????. ?? ???????? ???????????? ?? ?????????. ????? ???????? ?????. ?? ??????. ?????? ????????? ??????? ????????, D=S, ??????? ??????? ?? ???? ???????????, D=S. Ð?"??????? ??????? ????? ???. ?????????? ???, ???????? ?? ????????. ???? ????????????. ???????? ????? ??????? ?? ??????????????? ???? ?? ???? ???????????, D