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}{% \vskip8pt \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt } \usepackage[absolute,overlay]{textpos} \makeatother \usepackage{lineno} \linenumbers \begin{document} \author[1]{Korelina V.E.} \author[2]{Gazizova I.R.,} \renewcommand\Authands{ and } \date{\small \em Received: 1 January 1970 Accepted: 1 January 1970 Published: 1 January 1970} \maketitle \begin{abstract} Primary open-angle glaucoma (POAG) remains one of the most controversial eye diseases. Ophthalmologists do not have a consensus on the etiology and pathogenesis of POAG. It is obvious that glaucoma is no longer considered as an exclusively ocular disease associated with impaired hydrodynamics. The search for the causes of the inexorable progression of optic neuropathy has taken researchers far from the eyeball. According to modern concepts, glaucoma is considered as a neurodegenerative disease, located on the border of the professional interests of neurologists and ophthalmologists. Experimental and clinical studies reveal degenerative processes in glaucoma not only in the retina and optic nerve, but throughout the entire visual pathway. Structural changes in the brain in POAG are similar to those in a number of neurodegenerative diseases, for example, Alzheimer?s and Parkinson?s diseases. These changes correlate with clinical characteristics and severity of glaucoma. More recent studies have shown that neurodegeneration in glaucoma is also associated with neuroinflammatory processes affecting both the retina and brain. Characteristic signs of central nervous system (CNS) degeneration may precede the death of optic nerve fibers. Can neurodegeneration in glaucoma be considered a top-down process, or do events begin to unfold in the retina and gradually move into the brain? \end{abstract} \keywords{glaucoma, retinal ganglion cells, neurodegenerative disease, neuroinflammation, neuroimaging.} \begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) \textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark} \end{textblock*} \begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) \textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}} \end{textblock*} \begin{textblock*}{10cm}(1.05cm,3cm) {{\textit{CrossRef DOI of original article:}} \underline{}} \end{textblock*}\let\tabcellsep& \section[{V.E. Korelina ? \& I.R. Gazizova ?}]{V.E. Korelina ? \& I.R. Gazizova ?}\par Abstract-Primary open-angle glaucoma (POAG) remains one of the most controversial eye diseases. Ophthalmologists do not have a consensus on the etiology and pathogenesis of POAG. It is obvious that glaucoma is no longer considered as an exclusively ocular disease associated with impaired hydrodynamics. The search for the causes of the inexorable progression of optic neuropathy has taken researchers far from the eyeball. According to modern concepts, glaucoma is considered as a neurodegenerative disease, located on the border of the professional interests of neurologists and ophthalmologists. Experimental and clinical studies reveal degenerative processes in glaucoma not only in the retina and optic nerve, but throughout the entire visual pathway. Structural changes in the brain in POAG are similar to those in a number of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. These changes correlate with clinical characteristics and severity of glaucoma. More recent studies have shown that neurodegeneration in glaucoma is also associated with neuroinflammatory processes affecting both the retina and brain. Characteristic signs of central nervous system (CNS) degeneration may precede the death of optic nerve fibers. Can neurodegeneration in glaucoma be considered a top-down process, or do events begin to unfold in the retina and gradually move into the brain? \hyperref[b31]{[31,}\hyperref[b41]{41,}\hyperref[b56]{54]}. \section[{Keywords}]{Keywords} \section[{?????????????????}]{?????????????????}\par ? ??????????? ???????????? ???????????? ?????????????? ???????? ??? ???????? ?? ?????? ? ???????? ? ?????????? ?????, ?? ? ?? ???? ?????????? ??????????? ????. \hyperref[b67]{[65,} {\ref 88,} {\ref 91,} {\ref 93]}.\par ??????????? ????????? ????????? ????? ??? ???Ð?" ?????????? ??????? ??? ???? ??????????????????? ???????????, ????????, ??????? ??????????? ? ?????????? \hyperref[b85]{[81,} {\ref 92]}. ??? ????????? ??????????? ? ???????????? ???????????????? ? ???????? ????????. ????? ??????? ???????????? ????????, ??? ???????????????? ??? ???????? ????? ??????? ? ???????????????????? ??????????, ?????????????? ??? ????????, ??? ? ???????? ???? \hyperref[b80]{[78]}. ??????????? ???????? ??????????? ??????????? ??????? ??????? (???) ????? ?????????????? ?????? ??????? ??????????? ????? {\ref [55]}. ????? ?? ??????? ???????????????? ??? ???????? ????????? ?????????? ??? ??????? ???????? ??????????????? ? ???????? ? ?????????? ???????????? ? ???????? ??????????? ???????? ????????. \section[{II.}]{II.} \section[{???????????????? ??? ????}]{???????????????? ??? ????} \section[{???????}]{???????}\par ??????????? (??) ? ??????? ?????????? (??) ???????? ???????? ????????????????? ???????????????????? ?????????????. ???????? ???????????????? ???????? ??? ?? ? ?? ????????? ?????????? ?????????????? ???????? ????????? ? ????????? ?????????? ?????: ??????????? (?-???) ??? ??, ???-????? (p-tau) ? ????????? (A?) ??? ?? \hyperref[b64]{[62]}.\par ?? ??????????????? ??????? ???????? ? ???????? ? ???? ????????? ?????, ??? ???????? ? ???????????? ????????, ??????????????? ?????? ?????? ? ????????. ?????????????? ?????????? ????? ??????????? ???????? ???????????? ????????? ???????????? (A?) ? ?????????????????? ????????? ??????????????????????? ???-????? (pTau). ??? ????????? ????? ?????????????? ? ???????? ? ?????????? ????? \hyperref[b69]{[67]}.\par ?? ???????????? ????? ??????????????????? ???????????? ???????????? ? ??????????????? ??????? ????????????????? ????????. ??? ?????????????? ?????????? ????? ????, ????????? ?? ????????? ???????????. ??? ?? ????? ???????????? ??????????? ????????????????? ?????? ???????? \hyperref[b60]{[58]}.\par Ð?"???????, ??????????????????? ??????????? ??????????? ?????, ??????????????? ??????? ??????????? ?????? ???????? (Ð?"??) ? ??????? ?????????? ??????? \hyperref[b90]{[85,} {\ref 95]}.\par ??? ?????????? ???, ????? ?????? ?? ?????? ??????, ???????????? ??-??????, ?????????????????? ??? ????????????????, ????? ?????????? ???????????????? ??????? ??????????????? ???????? ? ???????, ?????????? ?????? ?? ?????????. ??-??????, ?????? ????????????? ???? ???????? ? ????? ?????????? ????????? ?????? ? ?????????? ????????. ??? ??? ??????????? ????? ??????????? ??????? ? ????????? ?????????????????, ?????????? ? ?????? ???????. ?????????? ????? ?????????? ?????????????? ? ????????? \hyperref[b16]{[16,}\hyperref[b76]{74,}\hyperref[b85]{81,} {\ref 92]}.\par ? ????????? ? ???????? ??????????? ???????? ??????????? ? 5 ??? ????, ??? ? ?? ??????????? ?? ??????????? ??????. ???????????? ??? ???? ??????? ????? ?????? ???? ????????? ?????????? ?????????? \hyperref[b14]{[14,}\hyperref[b39]{39]}. \hyperref[b34]{[34,}\hyperref[b58]{56]}.\par ? ???? ????? ???????????? ??????????? ?????????? ????? ????? ???? ????? ???????? ?????? ??????????? ???????? \hyperref[b74]{[72]}.\par ???? ????? ????????? ??? ? ???????????? ??????? ??????????? ?? ??????? ???????? ? ???????? ??????????? \hyperref[b18]{[18]}, ?? ?????? ????????????? ????????, ??? ???????? ????????? ?????? ? ?????? ???????? ????? ???? ?????????? ??? ?? ?????? ??????? ?????????? ??????? \hyperref[b38]{[38]} \hyperref[b22]{[22]}.\par Ð?"??????????-????????? ???????????? (Ð?"??) ???????????? ????? ????? ???, ?????????? ?? ??????????? ???????? ??????? ???? ? ??????? ???????? ? ???????. ????????? ????????????? ???????? ??????????? ????????????? ? ??????in vivo.?????? ???????????? ??? ???????? ???????? ?????? ?????? ???????? ??????????? ???? ? ????????? ? ?????????. ???????????????? ???????? ?????????? ? ?????????? ?????, ?????????? ??????, ?????????? ?????????? ??????, ?????????? ?????????? ? ?????????? ???? ? ??????? ????????? \hyperref[b21]{[21]}.\par ????????????? ????? ??????? ???????????? ????????? ????????? ????? ??????, ?? ????????? ? ????????????? ??????????????????? ??????????????, ??????????? ???Ð?". \section[{III.}]{III.}\par ???????????????? Ð?"????????? ??? ???Ð?" ???? ???????????????? ?????????? ? ???????? ? ???????????????? ?????????? ?????????? ?????????? ??????? ??????????? ????????? ??????????? \hyperref[b26]{[26,}\hyperref[b27]{27]}. ?????? ???????????????? ???? ???????? ?????? ???????????? ???? ???????? ? ??????????? ????? ??? ???????? ??????? ???????? \hyperref[b37]{[37,}\hyperref[b89]{84]}. ????????? ??????????? ??? ???Ð?" ???? ???????? ? ????????????????? ? ??????????? ????????????? \hyperref[b23]{[23,}\hyperref[b53]{52]}. ?????????? ??????????? ????? ?????? ? ????? ??????????? ?????, ??? ??????????? ?????????? ???????????? ? ??? ?????? ? ??????? ?????????????? ??????????? \hyperref[b78]{[76]}. ?????? ??? ????? ??????????? ????? ???????? ??????? ? ??????????? ??????????? ?????? ?Ð?"Ð?".\par ????????????? ?????????????, ??? ???????????????? ?????????? ? ????????? ????? ???????? ????????????????? ???????? ? ???????? ???Ð?" \hyperref[b12]{[12,}\hyperref[b20]{20,}\hyperref[b35]{35,}\hyperref[b62]{60,}\hyperref[b73]{71]}. ????????, ??????? ???????????????? Ð?"?? (??Ð?"??) ? ??????? Ð?"??, ??????? ???????? ????? ????????? ???????????, ????? ????????? ? ????????? ????????? ? ??????? ???????????, ??? ????? ??????????? ???????? ? ???????????????? ???Ð?" \hyperref[b49]{[48]}.\par ???????????? ??????????? ???????? ???? ? ???????? ???????????????? ? ???????? ?????? ???????? ? ??????????? ????? ??? ????????.\par ???????????????? \hyperref[b11]{[11,}\hyperref[b33]{33,}\hyperref[b86]{82]}. ? ???????? ?? ???????? ??????? ???????? ?????????.\par ?? ?????? ?????? ???????, ? ???????? ??????????????? ???????? ???? ?????? ?????? ????????? \hyperref[b42]{[42,}\hyperref[b44]{44,}\hyperref[b82]{79]}. ??????? ??????????? ??????????? ?????????? ???????. ? ?????????? ???????? ?????? ????????, ????? ???????? ?? ???????? ?????????, ?????????? ?????????? ??????????? \hyperref[b70]{[68]}. ??? ????????? ?????????? ????????? ???????????? ? ???????????? ?????????? ???????? Ð?"?? ?? ????? ???????????. ????????? ??????????? ??????????? ?????, ?????????? ?????????? ? ?????????? ? ??????????. ??? ????????? ???????? ????????????? ?????????? ????????? ? ????????, ?????? ????? ?? ???????????? ??? ??????? ??????? ?????? \hyperref[b43]{[43]}. ?????????? ??? ?????? ???????? ????????, ????? ????????? ?????????? \hyperref[b45]{[45]} \hyperref[b63]{[61]}.\par ?????? ????????????? ???????? ?? ??????, ??? ????????? ?????-? ????????? ??? ???????? ???????????? ?????? Ð?"?? ? ???????? ????? ?? ?????? ??????? ??????????? ??????? ????? \hyperref[b71]{[69]}.\par ??? ??????????????????? ???????????? ??? (????????, ??, ??) ????? ??????? ????????? ?????-? ????????? ? ???????? ??????? ???????????????, ??? ????????? ??????? ? ???????? ??????????? \hyperref[b86]{[82]}.\par ???????? ???????? ????? ?????????? ????????, ??????????? ????????? ????????? ? ?????????????? ????? (??????, ??????????? ??????, ??????? ??????? ?????????????? ????????), ? ????? ???????????? ??????????????????? ??????????? ??????????? ? ??????? ??????????????? ?????? \hyperref[b59]{[57]}.\par ?????????? ??????? ?????????????? ???????? (?Ð?"Ð?") ?? ????????? ????????????????? ????????? ???????? ???Ð?" ?????????? ????? ????? ?????? ?? ???????? ?????, ?????? ? ??????????? ???????????, ????????????????? ? ????????????? ???????????? ??????????.\par ?????????, ??? ??????????? ????????? ?Ð?"Ð?" ???????? ? ?????????? ?? ? ?-??? ? 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There is no conflict of interests. ???????????????? 101. ?????????, ?.?. ???????-??????????????? ??????????? ??????????? ???? ??? ???????? ? ??? ??????? ???????????: ??????????? ???. ... ????????? ??????????? ????: 14.01.07 / Medical Research Volume XXIII Issue VIII Version I ( 90. ?. 116-121. -doi: 10.32364/2311-7729-2022-22-2-D D D D )}\\ Global Journal of Global Journal of\tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{??????????? ??????????? ?????. ????????? ????????? ?? ?????? ????? ?????? ???????? ????, ?? ? ??????????? ???????? ? ??? ??????????? ???????????? ??????, ??????????? ????????? ???????? ? ???????? ??????????? ??????????? ??? ??????. ?????? ??????????????? ?????????? ???????? ??? ????????? ???????? ? ??????? ??????????? /}\tabcellsep Global Journal of\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{???????????????? ??? ???????? ????????? ????????}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{?????????? ? ?????? ??????????????? ???????? ??}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{????????????? ?????. ?????? ????????? ???????}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{?????????? ????????? ?????? ???????? ???????}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{???????? ????????????? ?????????? ?????????????}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{??????????? ????????. ?????? ??????????? ????????}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{??????? ?????? ?????? ??????? ? ??????????????? ????}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{? ????????????? ??????????? ????????????.}\\ \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{??????????????? ???????? ????? ?? ????????}\\ \tabcellsep \tabcellsep \tabcellsep ????????\tabcellsep ?????????????\tabcellsep ?\tabcellsep ????????????????\\ \tabcellsep © 2023 Global Journ als © 2023 Global Journ als\tabcellsep \tabcellsep \end{longtable} \par \begin{quote} F © 2023 Global Journ als Glaucoma as a Neurodegenerative Disease\end{quote} \caption{\label{tab_5}}\end{figure} \label{foot_0}\footnote{\label{foot_0} Glaucoma as a Neurodegenerative Disease} \backmatter \begin{bibitemlist}{1} \bibitem[]{b8}\label{b8} \textit{}, \xref{http://dx.doi.org/10.1007/s00234-019-02347-1}{10.1007/s00234-019-02347-1}. p. . \bibitem[Microglia]{b44}\label{b44} \textit{}, Microglia . \xref{http://dx.doi.org/10.1007/s00401-015-1524-y}{10.1007/s00401-015-1524-y}. \bibitem[]{b55}\label{b55} \textit{}, \xref{http://dx.doi.org/10.3390/jcm9103172}{10.3390/jcm9103172}. 9 p. 3172. \bibitem[]{b81}\label{b81} \textit{}, \xref{http://dx.doi.org/10.3389/fnagi.2017.00214}{10.3389/fnagi.2017.00214}. p. 214. \bibitem[]{b84}\label{b84} \textit{}, \xref{http://dx.doi.org/10.1111/bph.13426}{10.1111/bph.13426}. p. . \bibitem[]{b87}\label{b87} \textit{}, \xref{http://dx.doi.org/10.1016/j.molmed.2018.11.005}{10.1016/j.molmed.2018.11.005}. 25 p. . \bibitem[Verkhratsky et al. 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