@incollection{,
	
					
					
					D43E31135127E16A211BD6FFB636E095
				,
	author={{AlexandraValencakova} and {ElenaHatalova} and {University of Veterinary Medicine and Pharmacy}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}1632731
}

@incollection{b0,
	
	
		,
	title={{Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure}}
		,
	author={{
			RKJain
		} and {
			LTBaxter
		}}
		
	
	
		,
	journal={{Cancer Res}}
		
			48
			
			,
	year={1988}
		
	

}

@incollection{b1,
	
	
		,
	title={{Bacterialdirected enzyme prodrug therapy}}
		,
	author={{
			PLehouritis
		} and {
			CSpringer
		} and {
			MTangney
		}}
		
		
	
	
		,
	journal={{J Control. Release}}
		
			170
			1
			
			,
	year={2013}
		
	

}

@incollection{b2,
	
	
		,
	title={{Chemotherapeutic tumour targeting using clostridial spores}}
		,
	author={{
			NPMinton
		} and {
			MLMauchline
		} and {
			MJLemmon
		} and {
			JKBrehm
		} and {
			MFox
		} and {
			NPMichael
		} and {
			AGiaccia
		} and {
			JMBrown
		}}
		
		
		
		
		
		
		
	
	
		,
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			17
			
			,
	year={1995}
		
	

}

@incollection{b3,
	
	
		,
	title={{Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration}}
		,
	author={{
			RAMalmgren
		} and {
			CCFlanigan
		}}
		
	
	
		,
	journal={{Cancer Res}}
		
			7
			
			,
	year={1955}
		
	

}

@incollection{b4,
	
	
		,
	title={{Oncolysis by clostridia. V. Transplanted tumors of the hamster}}
		,
	author={{
			KEngelbart
		} and {
			DGericke
		}}
		
	
	
		,
	journal={{Cancer res}}
		
			24
			
			,
	year={1964}
		
	

}

@incollection{b5,
	
	
		,
	title={{Association of cancer of the breast and acute myelocytic leukemia}}
		,
	author={{
			RWCarey
		} and {
			JFHolland
		} and {
			PRSheehe
		} and {
			SGraham
		}}
		
		
		
	
	
		,
	journal={{Cancer}}
		
			20
			7
			
			,
	year={1967}
		
	

}

@incollection{b6,
	
	
		,
	title={{Oncolysis by clostridia. Ii. Experiments on a tumor spectrum with a variety of clostridia in combination with heavy metal}}
		,
	author={{
			DGericke
		} and {
			KEngelbart
		}}
		
	
	
		,
	journal={{Cancer Res}}
		
			24
			
			,
	year={1964}
		
	

}

@incollection{b7,
	
	
		,
	title={{Further progress with oncolysis due to apathogenic clostridia}}
		,
	author={{
			DGericke
		} and {
			FDietzel
		} and {
			WKönig
		} and {
			IRüster
		} and {
			LSchumacher
		}}
		
		
		
		
	
	
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			1
			
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	year={1979}
		
	

}

@book{b8,
	
	
		,
	title={{Intensification of the oncolysis by clostridia by means of radio-frequency hyperthermy in experiments on animals--dependence on dosage and on intervals}}
		,
	author={{
			FDietzel
		} and {
			DGericke
		}}
		
		
	

}

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		,
	title={{}}
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	author={{
			Strahlentherapie
		}}
		
			,
	year={1977}
			153
			
		
	

}

@incollection{b10,
	
	
		,
	title={{Combination bacteriolytic therapy for the treatment of experimental tumors}}
		,
	author={{
			LHDang
		} and {
			CBettegowda
		} and {
			DLHuso
		} and {
			KWKinzler
		} and {
			BVogelstein
		}}
		
		
		
		
	
	
		,
	journal={{Proc. Natl. Acad. Sci. USA}}
		
			26
			
			,
	year={2001}
		
	

}

@incollection{b11,
	
	
		,
	title={{Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria}}
		,
	author={{
			CBettegowda
		} and {
			LHDang
		} and {
			RAbrams
		} and {
			DLHuso
		} and {
			LDillehay
		} and {
			ICheong
		} and {
			NAgrawal
		} and {
			SBorzillary
		} and {
			JMMccaffery
		} and {
			ELWatson
		} and {
			KSLin
		} and {
			FBunz
		} and {
			KBaidoo
		} and {
			MGPomper
		} and {
			KWKinzler
		} and {
			BVogelstein
		} and {
			SZhou
		}}
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Proc. Natl. Acad. Sci. USA}}
		
			100
			25
			
			,
	year={2003}
		
	

}

@incollection{b12,
	
	
		,
	title={{Tumor-specific liposomal drug release mediated by liposomase}}
		,
	author={{
			ICheong
		} and {
			SZhou
		}}
		
	
	
		,
	journal={{Methods. Enzymol}}
		
			465
			
			,
	year={2009}
		
	

}

@incollection{b13,
	
	
		,
	title={{Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses}}
		,
	author={{
			NJRoberts
		} and {
			LZhang
		} and {
			FJanku
		} and {
			ACollins
		} and {
			RYBai
		} and {
			VStaedtke
		} and {
			AWRusk
		} and {
			DTung
		} and {
			MMiller
		} and {
			JRoix
		} and {
			KVKhanna
		} and {
			RMurthy
		} and {
			RSBenjamin
		} and {
			THelgason
		} and {
			ADSzvalb
		} and {
			JEBird
		} and {
			SRoy-Chowdhuri
		} and {
			HHZhang
		} and {
			YQiao
		} and {
			BKarim
		} and {
			JMcdaniel
		} and {
			AElpiner
		} and {
			ASahora
		} and {
			JLachowicz
		} and {
			BPhillips
		} and {
			ATurner
		} and {
			MKKlein
		} and {
			GPost
		} and {
			LADiazJr
		} and {
			GJRiggins
		} and {
			NPapadopoulos
		} and {
			KWKinzler
		} and {
			BVogelstein
		} and {
			CBettegowda
		} and {
			DLHuso
		} and {
			MVarterasian
		} and {
			SSaha
		} and {
			SZhou
		}}
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Sci. Transl. Med}}
		
			
			,
	year={20146}
		
	

}

@incollection{b14,
	
	
		,
	title={{Targeting vascular and avascular compartments of tumors with C. novyi-NT and antimicrotubule agents}}
		,
	author={{
			LHDang
		} and {
			CBettegowda
		} and {
			NAgrawal
		} and {
			ICheong
		} and {
			DHuso
		} and {
			PFrost
		} and {
			FLoganzo
		} and {
			LGreenberger
		} and {
			JBarkoczy
		} and {
			GRPettit
		} and {
			Smith
		} and {
			HGurulingappa
		} and {
			SKhan
		}}
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Cancer biology & therapy}}
		
			3
			3
			
			,
	year={2004}
		
	

}

@book{b15,
	
	
		,
	title={{Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicological sciences: an official journal of the Society of Toxicology}}
		,
	author={{
			LADiaz
		} and {
			Jr
		} and {
			ICheong
		} and {
			CAFoss
		} and {
			XZhang
		} and {
			BAPeters
		} and {
			NAgrawal
		} and {
			CBettegowda
		} and {
			BKarim
		} and {
			GLiu
		} and {
			KKhan
		} and {
			XHuang
		} and {
			MKohli
		} and {
			LHDang
		}}
		
		
		
		
		
		
		
		
		
		
		
		
		
		
			,
	year={2005}
			88
			
		
	

}

@incollection{b16,
	
	
		,
	title={{Repeated cycles of Clostridium-directed enzyme prodrug therapy resultin sustained antitumour effects in vivo}}
		,
	author={{
			JTheys
		} and {
			OPennington
		} and {
			LDubois
		}}
		
		
	
	
		,
	journal={{Br. J. Cancer}}
		
			95
			
			,
	year={2006}
		
	

}

@incollection{b17,
	
	
		,
	title={{Optimized clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104}}
		,
	author={{
			SCLiu
		} and {
			GOAhn
		} and {
			MKioi
		}}
		
		
	
	
		,
	journal={{Cancer Res}}
		
			68
			
			,
	year={2008}
		
	

}

@incollection{b18,
	
	
		,
	title={{Clostridium to treat cancer: dream or reality? Ann}}
		,
	author={{
			JTheys
		} and {
			PLambin
		}}
		
	
	
		,
	journal={{Transl. Med}}
		
			1
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			,
	year={2015}
		
	
	,
	note={Suppl}

}

@incollection{b19,
	
	
		,
	title={{Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo}}
		,
	author={{
			JTHeap
		} and {
			JTheys
		} and {
			MEhsaan
		}}
		
		
	
	
		,
	journal={{Oncotarget}}
		
			5
			
			,
	year={2014}
		
	

}

@incollection{b20,
	
	
		,
	title={{Tumor-targeted Salmonella. Highly selective delivery vectors}}
		,
	author={{
			DBermudes
		} and {
			BLow
		} and {
			JPawelek
		}}
		
		
	
	
		,
	journal={{Adv. Exp. Med. Biol}}
		
			465
			
			,
	year={2000}
		
	

}

@incollection{b21,
	
	
		,
	title={{Construction of VNP20009: a novel, genetically stable antibioticsensitive strain of tumor-targeting Salmonella for parenteral administration in humans}}
		,
	author={{
			KBLow
		} and {
			MIttensohn
		} and {
			XLuo
		} and {
			LMZheng
		} and {
			IKing
		} and {
			JMPawelek
		} and {
			DBermudes
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Methods Mol. Med}}
		
			90
			
			,
	year={2004}
		
	

}

@incollection{b22,
	
	
		,
	title={{Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo}}
		,
	author={{
			KBLow
		} and {
			MIttensohn
		} and {
			TLe
		} and {
			JPlatt
		} and {
			SSodi
		} and {
			MAmoss
		} and {
			OAsh
		} and {
			ECarmichael
		} and {
			AChakraborty
		} and {
			JFischer
		} and {
			SLLin
		} and {
			XLuo
		} and {
			SIMiller
		} and {
			LZheng
		} and {
			IKing
		} and {
			JMPawelek
		} and {
			DBermudes
		}}
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Nat. Biotechnol}}
		
			17
			1
			
			,
	year={1999}
		
	

}

@incollection{b23,
	
	
		,
	title={{Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma}}
		,
	author={{
			JFToso
		} and {
			VJGill
		} and {
			PHwu
		} and {
			FMMarincola
		} and {
			NPRestifo
		} and {
			DJSchwartzentruber
		} and {
			RMSherry
		} and {
			SLTopalian
		} and {
			JCYang
		} and {
			FStock
		} and {
			LJFreezer
		} and {
			KEMorton
		} and {
			CSeipp
		} and {
			LHaworth
		} and {
			SMavroukakis
		} and {
			DWhite
		} and {
			SMacdonald
		} and {
			JMao
		} and {
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		} and {
			SARosenberg
		}}
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{J. Clin. Oncol}}
		
			20
			1
			
			,
	year={2002}
		
	

}

@incollection{b24,
	
	
		,
	title={{Tumor amplified protein expression therapy: Salmonella as a tumor-selective protein delivery vector}}
		,
	author={{
			LMZheng
		} and {
			XLuo
		} and {
			MFeng
		} and {
			ZLi
		} and {
			TLe
		} and {
			MIttensohn
		} and {
			MTrailsmith
		} and {
			DBermudes
		} and {
			SLLin
		} and {
			ICKing
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Oncol. Res}}
		
			12
			3
			
			,
	year={2000}
		
	

}

@incollection{b25,
	
	
		,
	title={{Salmonella pathogenicity island-2 and anticancer activity in mice}}
		,
	author={{
			JMPawelek
		} and {
			SSodi
		} and {
			AKChakraborty
		} and {
			JTPlatt
		} and {
			SMiller
		} and {
			DWHolden
		} and {
			MHensel
		} and {
			KBLow
		}}
		
		
		
		
		
		
		
	
	
		,
	journal={{Cancer Gene Ther}}
		
			9
			10
			
			,
	year={2002}
		
	

}

@incollection{b26,
	
	
		,
	title={{Cancer immuno-therapy based on killing of Salmonella-infected tumor cells}}
		,
	author={{
			Avogadri F 1
		} and {
			CMartinoli
		} and {
			LPetrovska
		} and {
			CChiodoni
		} and {
			PTransidico
		} and {
			VBronte
		} and {
			RLonghi
		} and {
			MPColombo
		} and {
			GDougan
		} and {
			MRescigno
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Cancer Res}}
		
			65
			9
			
			,
	year={2005}
		
	

}

@incollection{b27,
	
	
		,
	title={{Containment of tumor-colonizing bacteria by host neutrophils}}
		,
	author={{
			KWestphal
		} and {
			SLeschner
		} and {
			JJablonska
		} and {
			HLoessner
		} and {
			SWeiss
		}}
		
		
		
		
	
	
		,
	journal={{Cancer Res}}
		
			8
			
			,
	year={2008}
		
	

}

@incollection{b28,
	
	
		,
	title={{Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing}}
		,
	author={{
			YBarak
		} and {
			FSchreiber
		} and {
			SHThorne
		} and {
			CHContag
		} and {
			DDebeer
		} and {
			AMatin
		}}
		
		
		
		
		
	
	
		,
	journal={{BMC Cancer}}
		
			146
			,
	year={2010}
		
	

}

@incollection{b29,
	
	
		,
	title={{Tumour targeting with systemically administered bacteria}}
		,
	author={{
			DMorrissey
		} and {
			GCO'sullivan
		} and {
			MTangney
		}}
		
		
	
	
		,
	journal={{Curr. Gene. Ther}}
		
			10
			1
			
			,
	year={2010}
		
	
	,
	note={Review}

}

@incollection{b30,
	
	
		,
	title={{Antibody directed enzymes revive anti-cancer prodrugs concept}}
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	author={{
			KDBagshawe
		}}
	
	
		,
	journal={{Br. J. Cancer}}
		
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	year={1987}
		
	

}

@incollection{b31,
	
	
		,
	title={{Antibody-directed enzyme/prodrug therapy (ADEPT)}}
		,
	author={{
			KDBagshawe
		}}
	
	
		,
	journal={{Biochem. Soc. Trans}}
		
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			5
			
			,
	year={1990}
		
	
	,
	note={Review}

}

@incollection{b32,
	
	
		,
	title={{Prodrugs for targeted tumor therapies: recent developments in ADEPT, GDEPT and PMT}}
		,
	author={{
			LFTietze
		} and {
			KSchmuck
		}}
		
	
	
		,
	journal={{Curr. Pharm. Des}}
		
			17
			32
			
			,
	year={2011}
		
	
	,
	note={Review}

}

@incollection{b33,
	
	
		,
	title={{Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions}}
		,
	author={{
			ANLukashev
		} and {
			VALashkevich
		} and {
			OEIvanova
		} and {
			GAKoroleva
		} and {
			AEHinkkanen
		} and {
			JIlonen
		}}
		
		
		
		
		
	
	
		,
	journal={{J. Gen. Virol}}
		
			86
			
			,
	year={2005}
		
	

}

@incollection{b34,
	
	
		,
	title={{PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-betalactamase and HPMA copolymer-C-Dox as a model combination}}
		,
	author={{
			RSatchi-Fainaro
		} and {
			HHailu
		} and {
			JWDavies
		} and {
			CSummerford
		} and {
			RDuncan
		}}
		
		
		
		
	
	
		,
	journal={{Bioconjug Chem}}
		
			14
			4
			
			,
	year={2003}
		
	

}

@incollection{b35,
	
	
		,
	title={{A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs}}
		,
	author={{
			RASpooner
		} and {
			FFriedlos
		} and {
			KMaycroft
		} and {
			SMStribbling
		} and {
			JRoussel
		} and {
			JBrueggen
		} and {
			BStolz
		} and {
			TO'reilly
		} and {
			JWood
		} and {
			AMatter
		} and {
			RMarais
		} and {
			CJSpringer
		}}
		
		
		
		
		
		
		
		
		
		
		
	
	
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	journal={{Br. J. Cancer}}
		
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	year={2003}
		
	

}

@book{b36,
	
	
		,
	title={{New prodrugs derived from 6-aminodopamine and 4-aminophenol as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT)}}
		,
	author={{
			SKnaggs
		} and {
			HMalkin
		} and {
			HMOsborn
		} and {
			NAWilliams
		} and {
			PYaqoob
		}}
		
		
		
		
		
	

}

@incollection{b37,
	
	
		,
	title={{}}
	
	
		,
	journal={{Org. Biomol. Chem}}
		
			3
			21
			
			,
	year={2005}
		
	

}

@incollection{b38,
	
	
		,
	title={{Duocarmycin-based prodrugs for cancer prodrug monotherapy}}
		,
	author={{
			LFTietze
		} and {
			HJSchuster
		} and {
			KSchmuck
		} and {
			ISchuberth
		} and {
			FAlves
		}}
		
		
		
		
	
	
		,
	journal={{Bioorg. Med. Chem}}
		
			12
			
			,
	year={2008}
		
	

}

@incollection{b39,
	
	
		,
	title={{Gene-directed enzyme prodrug therapy}}
		,
	author={{
			INiculescu-Duvaz
		} and {
			RSpooner
		} and {
			RMarais
		} and {
			CJSpringer
		}}
		
		
		
	
	
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	journal={{Bioconjug. Chem}}
		
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			1
			
			,
	year={1998}
		
	
	,
	note={Review}

}

@incollection{b40,
	
	
		,
	title={{Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy}}
		,
	author={{
			FLMoolten
		}}
	
	
		,
	journal={{Cancer Res}}
		
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	year={1986}
		
	

}

@incollection{b41,
	
	
		,
	title={{Improved retroviral suicide gene transfer in colon cancer celll ines after cell synchronization with methotrexate}}
		,
	author={{
			LFinzi
		} and {
			AKraemer
		} and {
			CCapron
		} and {
			SNoullet
		} and {
			DGoere
		} and {
			CPenna
		} and {
			BNordlinger
		} and {
			JLegagneux
		} and {
			JFEmile
		} and {
			RMalafosse
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{J. Exp. Clin. Cancer. Res}}
		
			92
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	year={2011}
		
	

}