Abstract

Diabetes mellitus DM induced hyperglycation of cellular and membrane proteins may result in altered ionic nature as well as an alteration in 3 dimensional structures of these molecules thus resulting in a possible functional variation Sialic acid SA a constituent of glomerular basement membrane GBM is a newly established potent indicator for the development of macro and microvascular complications in DM and its elevated levels are observed in DM patients with microalbuminuria and clinical proteinuria Probably this elevation in SA may be due to increased SA release from the renal GBM due to hyperglycation This biochemical alteration is the main initiating factor for the pathophysiology of diabetic complication nephropathy Diallyl disulphide DADS the principle compound of garlic oil is well known for its anti-diabetic properties Hence a study was undertaken to assess the anti-glycation properties of DADS and its usefulness in prevention of de-sialation of GBM in alloxan diabetic kidneys thereby to establish any beneficial effects of DADS in prevention of renal complications in DM The current study showed a significant decrease p 0 001 in kidney glycated proteins and plasma SA levels in DADS treated diabetic rats as compared to diabetic control rats Hence it can be concluded that DADS helps in preventing glycation of renal proteins and de-sialation of GBM which may be useful in prevention of diabetic nephropathy