@incollection{,
	
					
					
					761702C7F5282323136526EBF6420705
					,
	note={Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Inc. (USA)}
				,
	author={{Maysoon MohammedHassan} and {University of wasit}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}1711323
}

@incollection{b0,
	
	
		,
	title={{More than HMB: a review of the obstetric and gynecological manifestations of bleeding disorders}}
		,
	author={{
			AHJames
		}}
	
	
		,
	journal={{Hemophilia}}
		
			11
			
			,
	year={2005}
		
	

}

@incollection{b1,
	
	
		,
	title={{Molecular analysis of FVIII gene in severe HA patients of Costa Rica}}
		,
	author={{
			LSalazar-Sánchez
		} and {
			GJiménez-Cruz
		} and {
			MMendez
		} and {
			PChaverri
		} and {
			PAlvarado
		} and {
			WSchröder
		} and {
			KWulff
		} and {
			MSandoval
		} and {
			FHHerrmann
		} and {
			APavlova
		} and {
			JOldenburg
		}}
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Hamostaseologie}}
		
			30
			1
			
			,
	year={2010}
		
	

}

@book{b2,
	
	
		,
	author={{
			PFFogarty
		} and {
			CMKessler
		} and {
			Hemophilia
		}}
		
		
		,
	title={{Consultative Hemostasis and Thrombosis}}
				,
	editor={
			CSKitchens
			CMKessler
			BAKonkle
		}
		Philadelphia, PA
		
			,
	publisher={Elsevier Saunders}
			2013
			
		
	
	,
	note={3rd ed.}

}

@incollection{b3,
	
	
		,
	title={{Spectrum of molecular defects and mutation detection rate in patients with mild and moderate hemophilia A}}
		,
	author={{
			NBogdanova
		} and {
			AMarkoff
		} and {
			REisert
		} and {
			CWermes
		} and {
			HPollmann
		} and {
			ATodorova
		} and {
			MChlystun
		} and {
			Nowak-Göttlu
		} and {
			JHorst
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Human Mutation Journal}}
		
			28
			1
			
			,
	year={2007}
		
	

}

@incollection{b4,
	
	
		,
	title={{Clinical Advances in Hemophilia Management}}
		,
	author={{
			AAnjali
		} and {
			ManuelSharathkumar
		} and {
			Carcao
		}}
		
		
	
	
		,
	journal={{Pediator Blood Cancer}}
		
			57
			
			,
	year={2011}
		
	

}

@incollection{b5,
	
	
		,
	title={{Reconstitution of human factor VIII from isolated subunits}}
		,
	author={{
			PJFay
		}}
	
	
		,
	journal={{Archives of Biochemistry and Biophysics}}
		
			262
			2
			
			,
	year={1988}
		
	

}

@book{b6,
	
	
		,
	title={{}}
		,
	author={{
			PHBotton
		} and {
			KJMaggs
		} and {
			B
		} and {
			Lancet
		}}
		
		
		
		
			,
	year={2003 24. 2003}
			361
		
	

}

@book{b7,
	
	
		,
	title={{}}
		,
	author={{
			JGraw
		} and {
			HHBrackmann
		}}
		
		
			,
	address={Oldenburg, J.}
		
	

}

@incollection{b8,
	
	
		,
	title={{Hemophilia A: From mutation analysis to new therapies}}
		,
	author={{
			RSchneppenheim
		} and {
			MSpannagl
		} and {
			RSchwaab
		}}
		
		
	
	
		,
	journal={{Nat. Rev. Genet}}
		
			6
			
			,
	year={2005}
		
	

}

@book{b9,
	
	
		,
	title={{Genetics of Hemophilia A and B. An Introduction for Clinicians}}
		,
	author={{
			CKKasper
		} and {
			CHBuzin
		}}
		
		
			,
	year={2009. 2009}
			,
	publisher={Southland Publications}
			
			,
	address={Pasadena, CA, USA}
		
	
	,
	note={1st ed.}

}

@book{b10,
	
	
		,
	title={{Surveillance of female patients with inherited bleeding disorders in United States Haemophilia Treatment Centres}}
		,
	author={{
			VRByams
		} and {
			PAKouides
		} and {
			RKulkarni
		} and {
			JRBaker
		} and {
			DLBrown
		} and {
			JCGill
		} and {
			AMGrant
		} and {
			AHJames
		} and {
			BAKonkle
		} and {
			JMaahs
		} and {
			MMDumas
		} and {
			SMcalister
		} and {
			DNance
		} and {
			DNugent
		} and {
			CSPhilipp
		} and {
			JMSoucie
		} and {
			EStange
		}}
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
		
			,
	year={2011}
			17
		
	
	,
	note={Issue Supplement s1 Pages 1-45}

}

@incollection{b11,
	
	
		,
	title={{) the rate of spontaneous mutation of a human gene}}
		,
	author={{
			JB SHaldane
		}}
	
	
		,
	journal={{Journal of Genetics}}
		
			31
			
			,
	year={1935}
		
	

}

@book{b12,
	
	
		,
	title={{}}
		,
	author={{
			UllaHedner
		}}
		
	

}

@book{b13,
	
	
		,
	title={{}}
		,
	author={{
			DavidGinsburg
		}}
		
	

}

@book{b14,
	
	
		,
	title={{Congenital Hemorrhagic Disorders: New Insights into the Pathophysiology and Treatment of Hemophilia}}
		,
	author={{
			JeanneMLusher
		} and {
			;
		} and {
			KatherineA2000High
		}}
		
		
		
			,
	publisher={American Society of Hematology}
			
		
	

}

@incollection{b15,
	
	
		,
	title={{Characterization of the human factor VIII gene}}
		,
	author={{
			JGitschier
		} and {
			WIWood
		} and {
			TMGoralka
		} and {
			KLWion
		} and {
			EYChen
		} and {
			DHEaton
		} and {
			GAVehar
		} and {
			DJCapon
		} and {
			RMLawn
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Nature}}
		
			312
			
			,
	year={1984}
		
	

}

@book{b16,
	
	
		,
	title={{}}
		,
	author={{
			RD.; NBagnall
		} and {
			Waseem
		}}
		
		
	

}

@incollection{b17,
	
	
		,
	title={{recurrent inversion breaking intron 1 of the factor VIII gene is a frequent cause of severe hemophilia A}}
		,
	author={{
			PMGreen
		} and {
			; FGiannelli
		}}
		
	
	
		,
	journal={{Blood}}
		
			99
			1
			
			,
	year={2002}
		
	

}

@incollection{b18,
	
	
		,
	title={{Inversions disrupting the factor VIII gene are a common cause of severe haemophilia A}}
		,
	author={{
			DLakich
		} and {
			HHKazazianJr
		} and {
			SEAntonarakis
		} and {
			JGitschier
		}}
		
		
		
	
	
		,
	journal={{Nature Genetics}}
		
			5
			3
			
			,
	year={1993}
		
	

}

@incollection{b19,
	
	
		,
	title={{Factor VIII gene inversions causing severe hemophilia A originate almost exclusively in male germ cells}}
		,
	author={{
			JPRossiter
		} and {
			MYoung
		} and {
			MLKimberland
		} and {
			PHutter
		} and {
			RPKetterling
		} and {
			JGitschier
		} and {
			JHorst
		} and {
			MAMorris
		} and {
			DJSchaid
		} and {
			PDe Moerloose
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Hum. Mol. Genet}}
		
			3
			
			,
	year={1994}
		
	

}

@incollection{b20,
	
	
		,
	title={{Polymorphism and hemophilia A causing inversions in distal Xq28: a complex picture}}
		,
	author={{
			RD.; FBagnall
		} and {
			PMGiannelli
		} and {
			Green
		}}
		
		
	
	
		,
	journal={{J Thromb Haemost}}
		
			3
			11
			
			,
	year={2005}
		
	

}

@incollection{b21,
	
	
		,
	title={{Int22h-related inversions causing hemophilia A: a novel insight into their origin and a new more discriminant PCR test for their detection}}
		,
	author={{
			RD.; FBagnall
		} and {
			MGiannelli; P
		} and {
			Green
		}}
		
		
	
	
		,
	journal={{J Thromb Haemost}}
		
			4
			3
			
			,
	year={2006}
		
	

}

@book{b22,
	
	
		,
	title={{}}
		,
	author={{
			SEAntonarakis
		} and {
			JPRossiter
		} and {
			MYoung
		} and {
			JHorst
		} and {
			PDe Moerloose
		} and {
			SSSommer
		}}
		
		
		
		
		
		
			,
	year={1995}
		
	

}

@incollection{b23,
	
	
		,
	title={{Factor VIII gene inversions in severe haemophilia A: results of an international consortium study}}
	
	
		,
	journal={{Blood}}
		
			86
			
		
	

}

@incollection{b24,
	
	
		,
	title={{Molecular characteristics of the intron 22 homologs of the coagulation factor VIII gene: an update}}
		,
	author={{
			CDDe Brasi
		} and {
			DJBowen
		}}
		
	
	
		,
	journal={{J Thromb Haemost}}
		
			6
			10
			
			,
	year={2008}
		
	

}

@incollection{b25,
	
	
		,
	title={{Are int22h-mediated deletions a common cause of hemophilia?}}
		,
	author={{
			LilianaCarmenMiguel Martín Abelleyro
		} and {
			ClaudiaPamelaRossetti
		} and {
			MiguelRadic
		} and {
			Candela
		}}
		
		
		
	
	
		,
	journal={{Annals of Hematology}}
		,
	editor={Irene Beatriz Larripa, Carlos Daniel De Brasi.}
		
			91
			4
			
			,
	year={2012}
		
	

}

@incollection{b26,
	
	
		,
	title={{Recurrent mutations in hemophilia A give evidence for CpG mutation hotspots}}
		,
	author={{
			HYoussoufian
		} and {
			HHKazazian
		} and {
			DGPhillips
		} and {
			SAronis
		} and {
			GTsiftis
		} and {
			VABrown
		} and {
			SEAntonarakis
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Nature}}
		
			324
			6095
			
			,
	year={1986}
		
	

}

@incollection{b27,
	
	
		,
	title={{A transcribed gene in an intron of the human factor VIII gene}}
		,
	author={{
			BLevinson
		} and {
			SKenwrick
		} and {
			DLakich
		} and {
			GHammondsJr
		} and {
			JGitschier
		}}
		
		
		
		
	
	
		,
	journal={{Genomics}}
		
			7
			1
			
			,
	year={1990}
		
	

}

@incollection{b28,
	
	
		,
	title={{Evidencefor a third transcript from the human factor VIII gene}}
		,
	author={{
			BLevinson
		} and {
			SKenwrick
		} and {
			PGamel
		} and {
			KFisher
		} and {
			JGitschier
		}}
		
		
		
		
	
	
		,
	journal={{Genomics}}
		
			14
			3
			
			,
	year={1992}
		
	

}

@incollection{b29,
	
	
		,
	title={{1.6-Mb contig of yeast artificial chromosomes around the human factor VIII gene reveals three regions homologous to probes for the DXS115 locus and two for the DXYS64 locus}}
		,
	author={{
			DFreije
		} and {
			DASchlessinger
		}}
		
	
	
		,
	journal={{Am. J. Hum. Genet}}
		
			51
			
			,
	year={1992}
		
	

}

@incollection{b30,
	
	
		,
	title={{Isolation of a 40 k-Da Huntingtin -associated protein}}
		,
	author={{
			MFPeters
		} and {
			CARoss
		}}
		
	
	
		,
	journal={{J. Biol. Chem}}
		
			276
			
			,
	year={2001}
		
	

}

@incollection{b31,
	
	
		,
	title={{Human genetic variation and its contribution to complex traits}}
		,
	author={{
			KAFrazer
		} and {
			SSMurray
		} and {
			NJSchork
		} and {
			EJTopol
		}}
		
		
		
	
	
		,
	journal={{Nat Rev Genet}}
		
			10
			
			,
	year={2009}
		
	

}

@incollection{b32,
	
	
		,
	title={{Characteristic mRNA abnormality found in half the patients with severe haemophilia A is due to large DNA inversions}}
		,
	author={{
			JNaylor
		} and {
			ABrinke
		} and {
			SHassock
		} and {
			PMGreen
		} and {
			FGiannelli
		}}
		
		
		
		
	
	
		,
	journal={{Hum. Mol. Genet}}
		
			2
			
			,
	year={1993}
		
	

}

@incollection{b33,
	
	
		,
	title={{Mutations in Intron 1 and Intron 22 Inversion Negative Haemophilia A Patients from Western India}}
		,
	author={{
			SNPreethi
		} and {
			DSShrimati
		} and {
			SChandrakala
		} and {
			GKanjaksha
		}}
		
		
		
	
	
		,
	journal={{Plos}}
		
			9
			5
			
			,
	year={2014}
		
	

}

@incollection{b34,
	
	
		,
	title={{Frequency of intron 1 and 22 inversions of Factor VIII gene in Mexican patients with severe hemophilia A}}
		,
	author={{
			MantillaCapacho
		} and {
			JMBeltrán-Miranda
		} and {
			CPLuna-Záizar
		} and {
			HAguilar-López
		} and {
			LEsparza-Flores
		} and {
			MALópez-Guido
		} and {
			BTroyo-Sanromán
		} and {
			RJaloma-Cruz
		} and {
			AR
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{American Journal of Hematology}}
		
			82
			4
			
			,
	year={2007}
		
	

}

@incollection{b35,
	
	
		,
	title={{Characterization of the factor VIII defect in 147 patients with sporadic hemophilia A: family studies indicate a mutation type-dependent sex ratio of mutation frequencies}}
		,
	author={{
			JBecker
		} and {
			RSchwaab
		} and {
			AMöller-Taube
		} and {
			USchwaab
		} and {
			WSchmidt
		} and {
			HHBrackmann
		} and {
			TGrimm
		} and {
			KOlek
		} and {
			JOldenburg
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Am J Hum Genet}}
		
			58
			4
			
			,
	year={1996}
		
	

}

@incollection{b36,
	
	
		,
	title={{Factor VIII gene explains all cases of haemophilia A}}
		,
	author={{
			JANaylor
		} and {
			PMGreen
		} and {
			CRRizza
		} and {
			FGiannelli
		}}
		
		
		
	
	
		,
	journal={{Lancet}}
		
			340
			
			,
	year={1992}
		
	

}

@incollection{b37,
	
	
		,
	title={{Clinical and genetic findings in five female patients with haemophilia A: Identification of a novel missense mutation}}
		,
	author={{
			MMartín-Salces
		} and {
			AVenceslá
		} and {
			MTAlvárez-Román
		} and {
			IRivas
		} and {
			IFernandez
		} and {
			NButta
		} and {
			MBaena
		} and {
			PFuentes-Prior
		} and {
			EFTizzano
		} and {
			VJiménez-Yuste
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Thromb Haemost}}
		
			104
			4
			
			,
	year={2010}
		
	

}

@incollection{b38,
	
	
		,
	title={{The hemophilias from royal genes to gene therapy}}
		,
	author={{
			PMMannucci
		} and {
			EG DTuddenham
		}}
		
	
	
		,
	journal={{The New England Journal of Medicine}}
		
			344
			23
			
			,
	year={2001}
		
	

}

@incollection{b39,
	
	
		,
	title={{A framework for genetic service provision for haemophilia and other inherited bleeding disorders}}
		,
	author={{
			CALudlam
		} and {
			KJPasi
		} and {
			PBolton-Maggs
		} and {
			PWCollins
		} and {
			AMCumming
		} and {
			GDolan
		} and {
			AFryer
		} and {
			CHarrington
		} and {
			FGHill
		} and {
			IRPeake
		} and {
			DJPerry
		} and {
			HSkirton
		} and {
			MSmith
		}}
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Hemophilia}}
		
			11
			2
			
			,
	year={2005}
		
	

}

@incollection{b40,
	
	
		,
	title={{Attitudes towards and beliefs about genetic testing in the hemophilia community: a qualitativestudy}}
		,
	author={{
			SThomas
		} and {
			DHerbert
		} and {
			AStreet
		} and {
			CBarnes
		} and {
			JBoal
		} and {
			PKomesaroff
		}}
		
		
		
		
		
	
	
		,
	journal={{Haemophilia}}
		
			13
			
			,
	year={2007}
		
	

}

@incollection{b41,
	
	
		,
	title={{Identification and management of women with inherited bleeding disorders: a survey of obstetricians and gynaecologists in the United Kingdom}}
		,
	author={{
			CChi
		} and {
			NShiltagh
		} and {
			CEKingman
		} and {
			DLEconomides
		} and {
			CALee
		} and {
			RAKadir
		}}
		
		
		
		
		
	
	
		,
	journal={{Hemophilia}}
		
			12
			4
			
			,
	year={2006}
		
	

}

@incollection{b42,
	
	
		,
	title={{Bleeding in carriers of hemophilia}}
		,
	author={{
			IPlug
		} and {
			EPMauser-Bunschoten
		} and {
			AHBrocker-Vriends
		} and {
			HKVan Amstel
		} and {
			JGVan Der Bom
		} and {
			JEVan Diemen-Homan
		} and {
			JWillemse
		} and {
			FRRosendaal
		}}
		
		
		
		
		
		
		
	
	
		,
	journal={{Blood}}
		
			108
			
			,
	year={2006}
		
	

}

@incollection{b43,
	
	
		,
	title={{Preimplantation genetic diagnosis for hemophilia A using indirect linkage analysis and direct genotyping approaches}}
		,
	author={{
			ADLaurie
		} and {
			AMHill
		} and {
			JRHarraway
		} and {
			APFellowes
		} and {
			GTPhillipson
		} and {
			PSBenny
		} and {
			MPSmith
		} and {
			PMGeorge
		}}
		
		
		
		
		
		
		
	
	
		,
	journal={{Journals of Thrombosis and Hemostasis}}
		
			8
			4
			
			,
	year={2010}
		
	

}

@incollection{b44,
	
	
		,
	title={{Report of a joint WHO/WFH meeting on the control of haemophilia: carrier detection and prenatal diagnosis}}
		,
	author={{
			IRPeake
		} and {
			DPLillicrap
		} and {
			VBoulyjenkov
		} and {
			EBriët
		} and {
			VChan
		} and {
			EKGinter
		} and {
			EMKraus
		} and {
			RLjung
		} and {
			PMMannucci
		} and {
			KNicolaides
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Blood Coagulation and Fibrinolysis}}
		
			4
			2
			
			,
	year={1993}
		
	

}