@incollection{,
	
					
					
					3B548C0C2F374ADE3A0EC6EB1F67C80D
				,
	author={{R.P.Gomes} and {L.C.Carneiro}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}1731115
}

@incollection{b0,
	
	
		,
	title={{}}
		,
	author={{
			JMAmatruda
		} and {
			SWelle
		}}
		
	
	
		,
	journal={{Endocrinology and metabolismo. Felig}}
		
			,
	year={1995}
		
	

}

@book{b1,
	
	
		,
	title={{}}
		,
	author={{
			JDBaxter
		} and {
			LFrohman
		}}
		
		
			,
	publisher={Mc GrawHill}
			3
		
	

}

@incollection{b2,
	
	
		,
	title={{Studies on genotoxicity and carcinogenicity of antibacterial, antiviral, antimalarial and antifungal drugs}}
		,
	author={{
			GBrambilla
		} and {
			FMattioli
		} and {
			LRobbiano
		} and {
			AMartelli
		}}
		
		
		
	
	
		,
	journal={{Mutagenesis}}
		
			
			,
	year={2011}
		
	

}

@incollection{b3,
	
	
		,
	title={{Update of carcinogenicity studies in animals and humans of 535 marketed pharmaceuticals}}
		,
	author={{
			GBrambilla
		} and {
			FMattioli
		} and {
			LRobbiano
		} and {
			AMartelli
		}}
		
		
		
	
	
		,
	journal={{Mutation Research}}
		
			750
			
			,
	year={2012}
		
	

}

@incollection{b4,
	
	
		,
	title={{Genotoxicity of antiobesity drug orlista and effect of caffeine intervention: an in vitro study}}
		,
	author={{
			MChakrabart
		} and {
			IGhosh
		} and {
			AJana
		} and {
			MGhosh
		} and {
			AMukherjee
		}}
		
		
		
		
	
	
		,
	journal={{Drug and Chemical Toxicology}}
		
			
			,
	year={2016}
		
	

}

@incollection{b5,
	
	
		,
	title={{Sistema teste de Allium cepa como bioindicador da citogenotoxicidade de cursos d'água}}
		,
	author={{
			CCCuchiara
		} and {
			CSBorges
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			VLBobrowski
		}}
		
		
	
	
		,
	journal={{Tecnologia Ciência Agropecuária}}
		
			6
			
			,
	year={2012}
		
	

}

@book{b6,
	
	
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	title={{Efeito genotóxico e antiproliferativo de Mikania cordifolia (LF) Willd. (Asteraceae) sobre o ciclo celular de Allium cepa L. Revista brasileira plantas medicinais}}
		,
	author={{
			MGDias
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	year={2014}
			16
			
		
	

}

@incollection{b7,
	
	
		,
	title={{Lipase inhibition: a novel concept in the treatment of obesity}}
		,
	author={{
			MLDrent
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			EAVeen
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	journal={{International Journal of Obesity and Related Metabolic Disorders}}
		
			17
			
			,
	year={1993}
		
	

}

@incollection{b8,
	
	
		,
	title={{Orlistat (RO 18-0647), a lipase inhibitor , in the treatment of human obesity : a multiple dose study}}
		,
	author={{
			MLDrent
		}}
	
	
		,
	journal={{International Journal of Obesity}}
		
			19
			
			,
	year={1995}
		
	

}

@incollection{b9,
	
	
		,
	title={{Orlistat e sibutramina: bons coadjuvantes para perda e manutenção de peso?}}
		,
	author={{
			RCFortes
		} and {
			NGGuimarães
		} and {
			AHaack
		} and {
			AA LTorres
		} and {
			KM BCarvalho
		}}
		
		
		
		
	
	
		,
	journal={{Rev. Bras. Nutr. Clin}}
		
			21
			
			,
	year={2006}
		
	

}

@book{b10,
	
	
		,
	title={{Tratado de fisiologia médica}}
		,
	author={{
			ACGuyton
		} and {
			JEHall
		}}
		
		
			,
	year={1997}
			,
	publisher={Guanabara Koogan}
			9
			,
	address={Rio de Janeiro}
		
	

}

@incollection{b11,
	
	
		,
	title={{}}
		,
	author={{
			AHalpern
		} and {
			MCMancini
		}}
		
	
	
		,
	journal={{Obesidade. Jovem médico}}
		
			1
			
			,
	year={1999}
		
	

}

@incollection{b12,
	
	
		,
	title={{Experiência clínica com o uso conjunto de Sibutramina e Orlistat em pacientes obesos}}
		,
	author={{
			AHalpern
		} and {
			APMonegaglia
		} and {
			AB GOliva
		} and {
			MBeyruti
		} and {
			ZS CHalpern
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			MCMncini
		}}
		
		
		
		
		
	
	
		,
	journal={{Arq Bras Endocrinol Metab}}
		
			44
			
			,
	year={2000}
		
	

}

@incollection{b13,
	
	
		,
	title={{A one -year trial to asses the value of orlistat in the management of obesity}}
		,
	author={{
			WP TJames
		}}
	
	
		,
	journal={{International Journal of Obesity}}
		
			21
			
			,
	year={1997}
		
	

}

@book{b14,
	
	
		,
	title={{Análise da toxicidade e da genotoxicidade de agrotóxicos utilizados na agricultura utilizando bioensaios com Allium cepa}}
		,
	author={{
			RAKruger
		}}
		
			,
	year={2009}
			,
	address={Novo Hamburgo}
		
	
	,
	note={Dissertação de Mestrado em Qualidade Ambiental -Feevale}

}

@book{b15,
	
	
		,
	title={{Avaliação da mutagenicidade do Xenical (Orlistat) utilizando-se células da medula óssea de ratos Wistar, em tratamento agudo, via gavagem}}
		,
	author={{
			EFLopes
		} and {
			VE PVicentini
		}}
		
		
			,
	year={2002}
		
		
			XI Encontro de Iniciação Científica da Universidade Estadual de Maringá
		
	

}

@incollection{b16,
	
	
		,
	title={{Antitumoral actions of the anti-obesity drug orlistat (Xenical) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu(erb B-2) oncogene}}
		,
	author={{
			JAMenendez
		} and {
			LVellon
		} and {
			RLupu
		}}
		
		
	
	
		,
	journal={{Ann. Oncol}}
		
			16
			
			,
	year={2005}
		
	

}

@incollection{b17,
	
	
		,
	title={{Assessment of the mutagenic, recombinagenic and carcinogenic potential of orlistat in somatic cells of Drosophila melanogaster}}
		,
	author={{
			PCOrsolin
		} and {
			RGSilva-Oliveira
		} and {
			JCNepomuceno
		}}
		
		
	
	
		,
	journal={{Food and Chemical Toxicology}}
		
			50
			
			,
	year={2012}
		
	

}

@book{b18,
	
	
		,
	title={{Obesity. In: Cecil tratado de medicina interna}}
		,
	author={{
			FXPi-Sunyer
		}}
		,
	editor={Bennett, J.C. and Plum, F. 20 ed. Rio de Janeiro: Guanabara Koogan}
		
			,
	year={1997. 1997}
		
	

}

@book{b19,
	
	
		,
	title={{Global context of obesity. Handbook of Obesity Prevention}}
		,
	author={{
			BMPopkin
		}}
		
			,
	year={2007}
			
		
	

}

@book{b20,
	
	
		,
	title={{Atualização das diretrizes para o tratamento farmacológico da obesidade e do sobrepeso}}
		,
	author={{
			RBRadominski
		}}
		
			,
	year={2010}
			,
	publisher={ABESO}
		
	

}

@incollection{b21,
	
	
		,
	title={{A modified Allium test as a tool in the screening of genotoxicity of complex mixtures}}
		,
	author={{
			JRank
		} and {
			MHNielsen
		}}
		
	
	
		,
	journal={{Hereditas}}
		
			118
			
			,
	year={1993}
		
	

}

@incollection{b22,
	
	
		,
	title={{Técnicas e Métodos para Utilização Prática de Microscopia}}
		,
	author={{
			CA ORibeiro
		} and {
			HSReis Filho
		} and {
			SRGrotzner
		}}
		
		
	
	
		,
	journal={{GEN -Grupo Editorial Nacional, Editora Santos}}
		
			1
			440
			,
	year={2012}
		
	

}

@incollection{b23,
	
	
		,
	title={{Retrospective population based analysis of the dose response (fecal fat excretion) relationship of orlistat in normal and obese volunteers}}
		,
	author={{
			JZhi
		}}
	
	
		,
	journal={{Clinical Pharmacology & Therapeutics}}
		
			56
			
			,
	year={1994}
		
	

}

@incollection{b24,
	
	
		,
	title={{Review of limited systemic absorption of orlistat , a lipase inhibitor in a healthy human volunteers}}
		,
	author={{
			JZhi
		}}
	
	
		,
	journal={{J. Clin . Pharmacol}}
		
			35
			
			,
	year={1995}
		
	

}