@incollection{,
	
					
					
					3A5D4EA0B71F27D5E59A194BD9D7D7F5
					,
	note={Type: Double Blind Peer Reviewed International Research Journal Publisher: Global Journals Inc. (USA)}
				,
	author={{FarahYousef} and {NadinYousef} and {Damascus University}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}1733137
}

@book{b0,
	
	
		,
	title={{Guanidineshistorical, biological, biochemical and clinical aspects of the naturally occurring guanidine compounds}}
		,
	author={{
			AMori
		} and {
			BDCohen
		} and {
			ALowenthal
		}}
		
		
		
			,
	year={1985}
			,
	publisher={Plenum Press}
			,
	address={London}
		
	

}

@incollection{b1,
	
	
		,
	title={{Traditional plant medicines as treatments for diabetes}}
		,
	author={{
			CJBailey
		} and {
			CDay
		}}
		
	
	
		,
	journal={{Diabetes Care}}
		
			12
			
			,
	year={1989}
		
	

}

@incollection{b2,
	
	
		,
	title={{}}
		,
	author={{
			CJBailey
		} and {
			NiddmBiguanides
		}}
		
	
	
		,
	journal={{Diabetes Care}}
		
			15
			
			,
	year={1992}
		
	

}

@book{b3,
	
	
		,
	author={{
			HLeclerc
		} and {
			Le Galega
		}}
		
		,
	title={{Presse Med}}
				Paris
		
			,
	year={22 Dec 1928}
		
	

}

@incollection{b4,
	
	
	
	
		,
	booktitle={{UK: British Herbal Medicine Association}}
				
			,
	year={1976}
		
	

}

@book{b5,
	
	
		,
	title={{Handbook of medicinal herbs}}
		,
	author={{
			JADuke
		}}
		
			,
	year={2002}
			,
	publisher={CRC Press}
			337
			,
	address={Boca Raton, Florida}
		
	
	,
	note={2nd edn}

}

@incollection{b6,
	
	
		,
	title={{}}
		,
	author={{
			HMuller
		} and {
			HRheinwein
		}}
		
	
	
		,
	journal={{Pharmacology of galegin. Arch Exp Path Pharmacol}}
		
			125
			
			,
	year={1927}
		
	

}

@book{b7,
	
	
		,
	title={{}}
		,
	author={{
			FBischoff
		} and {
			MSahyun
		} and {
			MLong
		} and {
			GuanidineStructure
		} and {
			Hypoglycemia
		}}
		
		
		
		
		
		
			,
	year={2017}
		
	

}

@incollection{b8,
	
	
		,
	title={{Pharmacological studies of a new oral hypoglycaemic drug}}
		,
	author={{
			GUngar
		} and {
			LFreedman
		} and {
			SLShapiro
		}}
		
		
	
	
		,
	journal={{Proc Soc Exp Biol Med}}
		
			100
			
			,
	year={1957}
		
	

}

@incollection{b9,
	
	
		,
	title={{Weitere Ergebnisse der diabetesbehandlung mit blutzuckersenkenden biguaniden}}
		,
	author={{
			HMehnert
		} and {
			WSeitz
		}}
		
	
	
		,
	journal={{Munch Med Wschr}}
		
			100
			
			,
	year={1958}
		
	

}

@incollection{b10,
	
	
		,
	author={{
			MDDean
		} and {
			SPocock
		} and {
			MD
		} and {
			ArthurKirchner
		} and {
			MDLos
		} and {
			Angeles
		}}
		
		
		
		
		
	
	
		,
	booktitle={{Lactic Acidosis with Recovery In Diabetes Mellitus On Phenformin Therapy Jorge H. Mestman}}
				
			,
	year={SEPTEMBER 1969 * II 3, 1969}
		
	

}

@book{b11,
	
	
		,
	title={{}}
		,
	author={{
			CWilliam
		} and {
			Gong
		}}
		
		
	

}

@incollection{b12,
	
	
		,
	title={{}}
		,
	author={{
			DonaldBKato
		}}
	
	
		,
	journal={{Phenformin Induced Lactic Acidosis, Drag Intelligence and Clinical Pharmacy}}
		
			9
			
		
	

}

@incollection{b13,
	
	
		,
	title={{}}
		,
	author={{
			MNattrass
		} and {
			KGAlberti
		} and {
			Biguanides
		}}
		
		
	
	
		,
	journal={{Diabetologia}}
		
			14
			
			,
	year={1978}
		
	

}

@incollection{b14,
	
	
		,
	title={{Pharmacology and mode of action of the hypoglycaemic guanidine derivatives}}
		,
	author={{
			JSterne
		}}
	
	
		,
	booktitle={{Oral hypoglycaemic agents. Campbell GD (ed)}}
				London
		
			,
	publisher={Academic Press}
			,
	year={1969}
			
		
	

}

@incollection{b15,
	
	
		,
	title={{Metformin: a review of history, pharmacodynamics and therapy}}
		,
	author={{
			LSHermann
		}}
	
	
		,
	journal={{Diabetes Metab Rev}}
		
			5
			
			,
	year={1979}
		
	

}

@incollection{b16,
	
	
		,
	title={{}}
		,
	author={{
			CJBailey
		} and {
			RCTurner
		} and {
			Metformin
		}}
		
		
	
	
		,
	journal={{N Engl J Med}}
		
			334
			
			,
	year={1996}
		
	

}

@incollection{b17,
	
	
		,
	title={{Bodmer m, Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia}}
		,
	author={{
			Meiter Ch
		}}
	
	
		,
	journal={{Diabetes care}}
		
			31
			
			,
	year={2008}
		
	

}

@incollection{b18,
	
	
		,
	title={{Implication of the united kingdome prospective diabetes study}}
	
	
		,
	journal={{Diabetes Care}}
		
			25
			52832
			,
	year={2002}
			,
	publisher={American Diabetes Association}
		
	

}

@incollection{b19,
	
	
		,
	title={{Synthesis and evaluation of 1-substituted-biguanide derivates as anti-diabetic agents for type II diabetes Insulin Resistant}}
		,
	author={{
			;El-Bayouki Kh
		} and {
			RAbdel-Rahman
		}}
		
	
	
		,
	journal={{Drug Res}}
		
			66
			
			,
	year={2016}
		
	

}

@incollection{b20,
	
	
		,
	title={{}}
		,
	author={{
			SLShapiro
		} and {
			VAParrino
		} and {
			LFreedman
		}}
		
		
	
	
		,
	journal={{J. Am. Chem. Soc}}
		
			3728
			,
	year={1959}
		
	

}

@incollection{b21,
	
	
		,
	title={{New Route to Metformin Hydrochloride (,-dimethylimidodicarbonimidic diamide hydrochloride) Synthesis}}
		,
	author={{
			AShalmalshi
		}}
		
	
	
		,
	journal={{Molbank}}
		
			,
	year={2008}
		
	

}

@incollection{b22,
	
	
		,
	title={{Metformin therapy and clinical uses}}
		,
	author={{
			JScarpello
		} and {
			HHowllet
		}}
		
	
	
		,
	journal={{Review}}
		
			5
			
			,
	year={2008}
		
	

}

@incollection{b23,
	
	
		,
	title={{Management of hyperglycemia in type 2 diabetes: A patient centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)}}
		,
	author={{
			SEInzucchi
		} and {
			RMBergenstal
		} and {
			JBBuse
		} and {
			MDiamant
		} and {
			EFerrannini
		} and {
			MNauck
		}}
		
		
		
		
		
	
	
		,
	journal={{Diabetes Care}}
		
			35
			136479
			,
	year={2012}
		
	

}

@incollection{b24,
	
	
		,
	title={{Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects with Type 2}}
		,
	author={{
			NicolasMMichael
		} and {
			FHirshman
		}}
		
	
	
		,
	journal={{Diabetes}}
		
			51
			
			,
	year={2002}
		
	
	,
	note={DIABETES}

}

@incollection{b25,
	
	
		,
	title={{AMPactivated protein kinase is required for the lipidlowering effect of metformin in insulinresistant human HepG2 cells}}
		,
	author={{
			MZang
		} and {
			AZuccollo
		} and {
			XHou
		} and {
			DNagata
		} and {
			KWalsh
		} and {
			HHerscovitz
		}}
		
		
		
		
		
	
	
		,
	journal={{J Biol Chem}}
		
			279
			47898905
			,
	year={2004}
		
	

}

@incollection{b26,
	
	
		,
	title={{Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i}}
		,
	author={{
			MYEl-Mir
		} and {
			VNogueira
		} and {
			EFontaine
		} and {
			NAveret
		} and {
			MRigoulet
		} and {
			XLeverve
		}}
		
		
		
		
		
	
	
		,
	journal={{J. Biol. Chem}}
		
			275
			
			,
	year={2000}
		
	

}

@incollection{b27,
	
	
		,
	title={{Metformin and cancer: From the old medicine cabinet to pharmacological pitfalls and prospects}}
		,
	author={{
			AEmami Riedmaier
		} and {
			PFisel
		} and {
			ATNies
		} and {
			ESchaeffeler
		} and {
			MSchwab
		}}
		
		
		
		
	
	
		,
	journal={{Trends Pharmacol. Sci}}
		
			34
			
			,
	year={2013}
		
	

}

@incollection{b28,
	
	
		,
	title={{Mitochondrial metabolism and type2 diabetes: A specific target of metformin}}
		,
	author={{
			XMLeverve
		} and {
			BGuigas
		} and {
			DDetaille
		} and {
			CBatandier
		} and {
			EAKoceir
		} and {
			CChauvin
		}}
		
		
		
		
		
	
	
		,
	journal={{Diabetes Metab}}
		
			29
			
			,
	year={2003}
		
	

}

@incollection{b29,
	
	
		,
	title={{Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain}}
		,
	author={{
			AHalestrap
		} and {
			Owen M
		}}
		
	
	
		,
	journal={{Biochemical society}}
		
			
			,
	year={2000}
		
	

}

@incollection{b30,
	
	
		,
	title={{Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP}}
		,
	author={{
			RAMiller
		} and {
			QChu
		} and {
			JXie
		} and {
			MForetz
		} and {
			BViollet
		} and {
			MJBirnbaum
		}}
		
		
		
		
		
		6S8894. 14
	
	
		,
	journal={{Diabetes Metab}}
		
			29
			25660
			,
	year={2003. 2013}
		
	
	,
	note={Nature}

}

@incollection{b31,
	
	
		,
	title={{Cellular and molecular mechanisms of metformin: an overview}}
		,
	author={{
			BViollet
		} and {
			BGuigas
		} and {
			SanzGarcia
		} and {
			NLeclerc
		} and {
			JForetz
		} and {
			MAndreelli
		} and {
			F
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Clin Sci}}
		
			122
			
			,
	year={2012}
		
	

}

@incollection{b32,
	
	
		,
	title={{Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5}}
		,
	author={{
			PWCaton
		} and {
			NKNayuni
		} and {
			JKieswich
		} and {
			NQKhan
		} and {
			MMYaqoob
		} and {
			RCorder
		}}
		
		
		
		
		
	
	
		,
	journal={{J Endocrinol}}
		
			205
			97106
			,
	year={2010}
		
	

}

@incollection{b33,
	
	
		,
	title={{Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein}}
		,
	author={{
			LHe
		} and {
			ASabet
		} and {
			SDjedjos
		}}
		
		
	
	
		,
	journal={{Cell}}
		
			137
			
			,
	year={2009}
		
	

}

@incollection{b34,
	
	
		,
	title={{Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state}}
		,
	author={{
			MForetz
		} and {
			SHébrard
		} and {
			JLeclerc
		} and {
			EZarrinpashneh
		} and {
			MSoty
		} and {
			GMithieux
		}}
		
		
		
		
		
	
	
		,
	journal={{J Clin Invest}}
		
			120
			235569
			,
	year={2010}
		
	

}

@incollection{b35,
	
	
		,
	title={{Clinical pharmacokinetics of metformin}}
		,
	author={{
			AJScheen
		}}
	
	
		,
	journal={{Clin Pharmacokinet}}
		
			30
			
			,
	year={1996}
		
	

}

@incollection{b36,
	
	
		,
	title={{Clinical pharmacokinetics of metformin}}
		,
	author={{
			JArora
		} and {
			MDay
		} and {
			RODoogue
		} and {
			MPDuong
		} and {
			JK
		}}
		
		
		
		
	
	
		,
	journal={{Clin Pharmacokinet}}
		
			50
			
			,
	year={2011}
		
	

}

@incollection{b37,
	
	
		,
	title={{American Diabetes Association: Summary of revisions to the 2011 clinical practice recommendations}}
	
	
		,
	journal={{Diabetes Care}}
		
			34
			S3
			,
	year={2011}
		
	
	,
	note={Suppl 1}

}

@incollection{b38,
	
	
		,
	title={{Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes: progressive requirement for multiple therapies (UKPDS 49)}}
		,
	author={{
			RCTurner
		} and {
			CACull
		} and {
			VFrighi
		} and {
			RRHolman
		}}
		
		
		
	
	
		,
	journal={{JAMA}}
		
			281
			
			,
	year={1999}
		
	

}

@incollection{b39,
	
	
		,
	title={{A risk-benefit assessment of metformin in type 2 diabetes mellitus}}
		,
	author={{
			HcsHowlett
		} and {
			CJBailey
		}}
		
	
	
		,
	journal={{Drug Safety}}
		
			20
			
			,
	year={1999}
		
	

}

@incollection{b40,
	
	
		,
	title={{Management of hyperglycaemia in type 2 diabetes: a patientcentered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)}}
		,
	author={{
			SEInzucchi
		} and {
			RMBergenstal
		} and {
			JBBuse
		} and {
			MDiamant
		} and {
			EFerrannini
		} and {
			MNauck
		}}
		
		
		
		
		
	
	
		,
	journal={{Diabetologia}}
		
			55
			
			,
	year={2012}
		
	

}

@incollection{b41,
	
	
		,
	title={{Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations}}
		,
	author={{
			WLBennett
		} and {
			NMMaruthur
		} and {
			SSingh
		} and {
			JBSegal
		} and {
			LMWilson
		} and {
			RChatterjee
		}}
		
		
		
		
		
	
	
		,
	journal={{Ann Intern Med}}
		
			154
			
			,
	year={2011}
		
	

}

@incollection{b42,
	
	
		,
	title={{Oral combination therapy: repaglinide plus metformin for treatment of type 2 diabetes}}
		,
	author={{
			PRaskin
		}}
	
	
		,
	journal={{Diabetes Obes Metab}}
		
			10
			
			,
	year={2008}
		
	

}

@book{b43,
	
	
		,
	title={{}}
		,
	author={{
			BCharbonnel
		} and {
			AKarasik
		} and {
			JLiu
		} and {
			MWu
		} and {
			GMeininger
		}}
		
		
		
		
		
	

}

@incollection{b44,
	
	
		,
	title={{Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone}}
	
	
		,
	journal={{Diabetes Care}}
		
			29
			
			,
	year={2006}
		
	
	,
	note={Sitagliptin Study 020 Group}

}

@incollection{b45,
	
	
		,
	title={{PRESERVEbeta: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin}}
		,
	author={{
			JGerich
		} and {
			PRaskin
		} and {
			LJean-Louis
		}}
		
		
	
	
		,
	journal={{Diabetes Care}}
		
			28
			
			,
	year={2005}
		
	

}

@incollection{b46,
	
	
		,
	title={{Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus}}
		,
	author={{
			MGonzález-Ortiza
		} and {
			JGuerrero-Romero
		} and {
			Violante-Ortiz
		} and {
			R
		}}
		
		
		
	
	
		,
	journal={{J Diabetes Complications}}
		
			23
			
			,
	year={2009}
		
	

}

@incollection{b47,
	
	
		,
	title={{Long-Term Effects of metformin and lifestyle modification on nonalcoholic fatty liver disease obese adolescents}}
		,
	author={{
			LTock
		} and {
			AD?amaso
		} and {
			ADe Piano
		} and {
			JCarnier
		}}
		
		
		
		ID 831901
	
	
		,
	journal={{J Obes}}
		
			831901
			6
			,
	year={2010}
		
	

}

@incollection{b48,
	
	
		,
	title={{Metformin for obesity in children and adolescents: a systematic review}}
		,
	author={{
			MPark
		} and {
			SKinra
		} and {
			KWard
		} and {
			BWhite
		} and {
			RViner
		}}
		
		
		
		
	
	
		,
	journal={{Diabetes Care}}
		
			32
			
			,
	year={2009}
		
	

}

@incollection{b49,
	
	
		,
	title={{Gastrointestinal tolerability of extended-release metformin tablets compared to immediaterelease metformin tablets: results of a retrospective cohort study}}
		,
	author={{
			LBlonde
		} and {
			GEDailey
		} and {
			SAJabbour
		} and {
			CAReasner
		} and {
			DJMills
		}}
		
		
		
		
	
	
		,
	journal={{Curr Med Res Opin}}
		
			20
			
			,
	year={2004}
		
	

}

@incollection{b50,
	
	
		,
	title={{Assessment of efficacy and tolerability of once daily extended release metformin in patients with type 2 diabetes mellitus}}
		,
	author={{
			JLevy
		} and {
			RACobas
		} and {
			MBGomes
		}}
		
		
	
	
		,
	journal={{Diabetol Metab Syndr}}
		
			2
			16
			,
	year={2010}
		
	

}

@incollection{b51,
	
	
		,
	title={{Safety and efficacy of novel extended release formulation of metformin in patients with type 2 diabetes}}
		,
	author={{
			IRaz
		} and {
			IDelaet
		} and {
			HGoyvaerts
		}}
		
		
	
	
		,
	journal={{Diabetes}}
		
			A363
			,
	year={2000}
		
	
	,
	note={Suppl 1}

}

@incollection{b52,
	
	
		,
	title={{Decreased mortality associated with the use of metformin compared with sulfonylurea Monotherapy in type 2 diabetes}}
		,
	author={{
			JAJohnson
		} and {
			SRMajumdar
		} and {
			SHSimpson
		}}
		
		
	
	
		,
	journal={{Diabetes Care}}
		
			25
			
			,
	year={2002}
		
	

}

@book{b53,
	
	
		,
	title={{}}
		,
	author={{
			AScheen
		}}
		
	

}

@incollection{b54,
	
	
		,
	title={{Metformin revisited: a critical review of the benefit/risk balance in "at risk" patients with type 2 diabetes}}
		,
	author={{
			NPaquot
		}}
	
	
		,
	journal={{Diabetes & Metabolism}}
		
			
		
	

}

@incollection{b55,
	
	
		,
	title={{Metforminassociated lactic acidosis}}
		,
	author={{
			DTHulisz
		} and {
			MFBonfiglio
		} and {
			RDMurray
		}}
		
		
	
	
		,
	journal={{J Am Board Fam Pract}}
		
			11
			
			,
	year={1998}
		
	

}

@incollection{b56,
	
	
		,
	title={{Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)}}
	
	
		,
	journal={{Lancet}}
		
			352
			
			,
	year={1998}
		
		
			UK Prospective Diabetes Study (UKPDS) Group
		
	

}

@incollection{b57,
	
	
		,
	title={{Prospective Diabetes Study (UKPDS) Group: Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)}}
	
	
		,
	journal={{Lancet}}
		
			352
			9131
			
			,
	year={1998}
		
	

}

@incollection{b58,
	
	
		,
	title={{Metformin for obese, insulintreated diabetic patients: improvement in glycaemic control and reduction of metabolic risk factors}}
		,
	author={{
			DGiugliano
		} and {
			AQuatraro
		} and {
			GConsoli
		}}
		
		
	
	
		,
	journal={{Eur J Clin Pharmacol}}
		
			44
			
			,
	year={1993}
		
	

}

@incollection{b59,
	
	
		,
	title={{The use of metformin in type 1 diabetes: a systematic review of efficacy}}
		,
	author={{
			SVella
		} and {
			LBuetow
		} and {
			PRoyle
		}}
		
		
	
	
		,
	journal={{Diabetologia}}
		
			53
			5
			
			,
	year={2010}
		
	

}

@incollection{b60,
	
	
		,
	title={{Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents}}
		,
	author={{
			SAbdelghaffar
		} and {
			AMAttia
		}}
		
	
	
		,
	journal={{Cochrane Database Syst Rev}}
		
			1
			D006691
			,
	year={2009}
		
	

}

@incollection{b61,
	
	
		,
	title={{Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity-a problem that is no longer restrited to minority groups}}
		,
	author={{
			SWiegand
		} and {
			UMaikowski
		} and {
			OBlankenstein
		} and {
			HBierbermann
		} and {
			PTarnow
		} and {
			AGrutes
		}}
		
		
		
		
		
	
	
		,
	journal={{Eur J Endocrinol}}
		
			151
			
			,
	year={2004}
		
	

}

@incollection{b62,
	
	
		,
	title={{Clinical presentation and treatment of type 2 diabetes in children}}
		,
	author={{
			OPinhas-Hamiel
		} and {
			PZeitler
		}}
		
	
	
		,
	journal={{Pediatr Diabetes}}
		
			8
			
			,
	year={2007}
		
	
	,
	note={Suppl. 9}

}

@incollection{b63,
	
	
		,
	title={{Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial}}
		,
	author={{
			KLJones
		} and {
			SArslanian
		} and {
			VAPeterokova
		} and {
			JSPark
		} and {
			MJTomlinson
		}}
		
		
		
		
	
	
		,
	journal={{Diabetes Care}}
		
			25
			
			,
	year={2002}
		
	

}

@incollection{b64,
	
	
		,
	title={{Evidence based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review}}
		,
	author={{
			SPalomba
		} and {
			AFalbo
		} and {
			FZullo
		} and {
			FOrioJr
		}}
		
		
		
	
	
		,
	journal={{Endocr Rev}}
		
			30
			150
			,
	year={2009}
		
	

}

@incollection{b65,
	
	
		,
	title={{Metformin: Nature's gift that keeps on giving more!}}
		,
	author={{
			MBalasubramanyam
		}}
	
	
		,
	journal={{J Obes Metab Res}}
		
			1
			
			,
	year={2014}
		
	

}

@incollection{b66,
	
	
		,
	title={{Metformin: Do we finally have an antiaging drug?}}
		,
	author={{
			VNAnisimov
		}}
	
	
		,
	journal={{Cell Cycle}}
		
			12
			34839
			,
	year={2013}
		
	

}

@incollection{b67,
	
	
		,
	title={{Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: A systematic review and metaanalysis}}
		,
	author={{
			MYin
		} and {
			JZhou
		} and {
			EJGorak
		} and {
			FQuddus
		}}
		
		
		
	
	
		,
	journal={{Oncologist}}
		
			18
			124855
			,
	year={2013}
		
	

}

@incollection{b68,
	
	
		,
	title={{Recent Advances in the Use of Metformin: Can Treating Diabetes Prevent Breast Cancer?}}
		,
	author={{
			DHatoum
		} and {
			Mcgowan E
		}}
		
	
	
		,
	journal={{BioMed Research International}}
		
			2015
			
		
	

}

@incollection{b69,
	
	
		,
	title={{Repositioning metformin in cancer: Genetics, drug targets, and new ways of delivery}}
		,
	author={{
			MAldea
		} and {
			LCraciun
		} and {
			CTomuleasa
		} and {
			IBerindan Neagoe
		} and {
			GKacso
		} and {
			ISFlorian
		}}
		
		
		
		
		
		10.1007/s 1327701416768
		
	
	
		,
	journal={{Tumour Biol}}
		
			1
			6768
			,
	year={2014}
		
	

}

@incollection{b70,
	
	
		,
	title={{National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)}}
		,
	author={{
			MKrempf
		} and {
			KGParhofer
		} and {
			GSteg
		}}
		
		
	
	
		,
	journal={{Third Report of the NationalCholesterol Education Program (NCEP) Expert Panel on Detection. Circulation}}
		
			106
			
			,
	year={2002}
		
	

}

@book{b71,
	
	
		,
	author={{
			AKooy
		} and {
			JJager
		} and {
			PLehert
		}}
		
		
		,
	title={{Long-term effects of metformin on metabolism and}}
				
	

}