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\title{The Private or Public Hospital: Where One Should Present with Appendicitis: A Systematic Review}
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\begin{document}

             \author[1]{Dr. Matthew  Binks}

             \author[2]{Dr. Matthew  Binks}

             \author[3]{Dr. Matthew  Binks}

             \affil[1]{  University of Newcastle}

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\date{\small \em Received: 6 December 2017 Accepted: 4 January 2018 Published: 15 January 2018}

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\begin{abstract}
        


Introduction-Appendicectomy for appendicitis remains the second most common urgent gastrointestinal surgery in the United States and one of the most common worldwide [1,2]. Low socioeconomic status and a lack of private health insurance have been shown to have detrimental effects on the prognosis of patients with appendicitis [3-7]. Such patients experience higher rates of appendiceal perforation, which increases morbidity 10-fold. [8,9]. They also attend hospital later, have reduced access to laparoscopic surgery and confront extended hospital stays and prolonged periods absent from work [3][4][5][6][7].Private hospital emergency departments have helped offset the healthcare burden on public hospital emergency departments worldwide [10]. Patients presenting to private hospitals have the luxury of choosing and having better access to their treating surgeon and generally have access to a better-funded system of care. Previously it has been hypothesized that this will expedite diagnosis and therefore definitive care for conditions such as appendicitis through surgery [11]. Furthermore, privately-treated patients will more likely be operated upon by a specialist surgeon with more advanced equipment [4,8,11].

\end{abstract}


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\let\tabcellsep& 	 	 		 
\section[{Introduction}]{Introduction}\par
ppendicectomy for appendicitis remains the second most common urgent gastrointestinal surgery in the United States and one of the most common worldwide \hyperref[b0]{[1,}\hyperref[b1]{2]}. Low socioeconomic status and a lack of private health insurance have been shown to have detrimental effects on the prognosis of patients with appendicitis \hyperref[b2]{[3]}\hyperref[b3]{[4]}\hyperref[b4]{[5]}\hyperref[b5]{[6]}\hyperref[b6]{[7]}. Such patients experience higher rates of appendiceal perforation, which increases morbidity 10-fold. \hyperref[b7]{[8,}\hyperref[b8]{9]}. They also attend hospital later, have reduced access to laparoscopic surgery and confront extended hospital stays and prolonged periods absent from work \hyperref[b2]{[3]}\hyperref[b3]{[4]}\hyperref[b4]{[5]}\hyperref[b5]{[6]}\hyperref[b6]{[7]}.\par
Private hospital emergency departments have helped offset the healthcare burden on public hospital emergency departments worldwide \hyperref[b9]{[10]}. Patients presenting to private hospitals have the luxury of choosing and having better access to their treating surgeon and generally have access to a better-funded system of care. Previously it has been hypothesized that this will expedite diagnosis and therefore definitive care for conditions such as appendicitis through surgery \hyperref[b10]{[11]}. Furthermore, privately-treated patients will more likely be operated upon by a specialist surgeon with more advanced equipment \hyperref[b3]{[4,}\hyperref[b7]{8,}\hyperref[b10]{11]}.\par
We set out to test whether these perceived advantages play out in reality. The primary aim of this systematic review was to compare the outcomes of patients admitted to public and private hospitals with appendicitis. The secondary aims were to compare the patient characteristics and operative details, such as access to laparoscopic surgery, of these two patient groups. 
\section[{II.}]{II.} 
\section[{Methods}]{Methods} 
\section[{a) Search Strategy}]{a) Search Strategy}\par
Beginning on the 15 th February 2018, four databases were systematically searched by two reviewers (MB, TL) and involved articles up to and reviewers (MB, TL) and involved articles up to and including the 16 th of February, 2018. The search terms used were (1) (public OR university OR government) AND (private OR university) AND appendi*. We performed a manual reference check of each of the included studies. 
\section[{b) Inclusion Criteria}]{b) Inclusion Criteria}\par
Studies that compared appendicectomies performed in public and private hospitals were included in our piece. Assessment of paper eligibility was made by two researchers (MB, TL). There were no restrictions regarding country or language of publication. Consideration was given to all age groups. There was no limitation on study design. Published abstracts were considered for inclusion. 
\section[{c) Exclusion Criteria}]{c) Exclusion Criteria}\par
We excluded studies devoid of a control group. Unpublished data was deemed ineligible. 
\section[{d) Data Extraction}]{d) Data Extraction}\par
Pre-operative data such as demographics, clinical findings and investigations, operative findings such as duration and rates of laparoscopic approach and postoperative results such as complication rates and length of stay were extracted independently by two reviewers (MB, TL). 
\section[{III.}]{III.} 
\section[{Results}]{Results}\par
The initial search elicited 258 citations and the manual reference check a further six (Figure 1). Once duplicates were discarded and titles reviewed, fifty-four abstracts were analyzed. Fourteen papers were identified for full-text appraisal and of these, six met the inclusion criteria, with a combined 1112 patients \hyperref[b4]{[5,}\hyperref[b10]{[11]}\hyperref[b11]{[12]}\hyperref[b12]{[13]}\hyperref[b13]{[14]}\hyperref[b14]{[15]}. The articles were a mixture of prospective \hyperref[b13]{[14]} and retrospective \hyperref[b4]{[5,}\hyperref[b10]{[11]}\hyperref[b11]{[12]}\hyperref[b12]{[13]}\hyperref[b14]{15]}case-control trials. Two studies were produced in Brazil and the remaining four were carried out in Australia \hyperref[b11]{[12]}, South Africa \hyperref[b13]{[14]}, the USA \hyperref[b14]{[15]} and France \hyperref[b4]{[5]}, respectively (Table \hyperref[tab_0]{1}). One study was undertaken in pediatric facilities only \hyperref[b14]{[15]} and the remainder were conducted in majority adult facilities \hyperref[b4]{[5,}\hyperref[b10]{[11]}\hyperref[b11]{[12]}\hyperref[b12]{[13]}\hyperref[b13]{[14]}.\par
A   \hyperref[b11]{[12,}\hyperref[b12]{13]}. Mackrillet al., 2014,found that 12.2\% of public and 4.8\% of private patients were operated on greater than 24hrs after presentation \hyperref[b11]{[12]}.The authors also report that 111 of their 164 public cases (68\%)were performed outside of normal working hours (0800-1700), compared with 55 of 105 (52\%) private patients. 
\section[{b) Preoperative Characteristics}]{b) Preoperative Characteristics}\par
Three studies examined the preoperative clinical parameters of public and private patients to varying degrees. \hyperref[b10]{Coelho et al. (2010)} was the only study to compare the presenting symptoms of patients presenting to public and private hospitals \hyperref[b10]{[11]}. In their cohort out of Brazil, they found the public patients presented with significantly more diarrhea (19\% vs. 8\%; p<0.001), while suggestive abdominal pain, anorexia, nausea and vomiting were evenly distributed between the cohorts. Regarding signs, fever was significantly more prevalent in public patients (41\% vs. 15\%; p<0.001), whereas abdominal tenderness and rebound tenderness were present in equal measure \hyperref[b10]{[11]}. \hyperref[b13]{Yang et al. (2015)} found fever to exist equally amongst public and private patients presenting with appendicitis \hyperref[b13]{[14]}. Heart rate (99.6 vs. 85.5 beats/min; p=0.002) and diastolic blood pressure (76.6 vs. 72.8mmHg; p=0.030) were both higher in their public hospital cohort.\par
Coelho et al., 2010, found that a significantly larger number of public patients were reviewed by a physician prior to surgeon assessment (85 vs. 13; p<0.001). The authors argued that this was likely a significant factor in these patients' delay to operation and therefore perforation \hyperref[b10]{[11]}. 
\section[{c) Investigations}]{c) Investigations}\par
Both although imaging in some form was requested equally in public and private patients (77\% vs. 77\%), CT scans were significantly more prevalent in the public cohort (36\% vs. 21\%; p=0.02) \hyperref[b14]{[15]}. \hyperref[b10]{Coelho et al., 2010}, discovered that ultrasound scans were effected significantly more frequently in the public population (56\% vs. 30\%; p<0.001) \hyperref[b10]{[11]}. 
\section[{d) Operations}]{d) Operations}\par
Rates of laparoscopic vs. open surgeries were inconsistent amongst the included studies. Coelho et al., 2010 (22\% vs. 86\%; p<0.001) and Yang et al., 2015 (25\% vs. 48\%; p=0.003) found the laparoscopic approach was used more with private patients \hyperref[b10]{[11,}\hyperref[b13]{14]}. However, Zilbertet al., 2009 (76\% vs. 54\%; p=0.002) found that pubic patients underwent proportionally more laparoscopic surgeries than private patients \hyperref[b14]{[15]}. All patients in the piece by Mackrillet al., 2014, underwent laparoscopic surgery \hyperref[b11]{[12]}. In a search for factors predictive of the use of a laparoscopic approach in French appendicectomies, Lienhartet al., 2003, found that private patients had an adjusted odds ratio of 2.7 relative to public patients \hyperref[b4]{[5]}. Nine public patients of Yang et al.'s required conversion to an open procedure. None of their private patients required conversion \hyperref[b13]{[14]}.\par
Steinman (55.9\% vs. 46.5\%; p=0.011), Yang (41\% vs. 23\%; p=0.026), Mackrill (22\% vs. 10\%; p=0.008) and Coelho (37\% vs. 21\%; p=0.013) found significantly higher rates of appendiceal perforation in the public cohorts of their studies. Zilbert (19\% vs. 13\%) found no significant difference between cohorts.\par
Yang et al., 2015, were the only group to investigate differences in operation duration between the groups. They found public cases typically took more than half an hour longer to complete (1.7 vs. 1.1hrs; p<0.001). 
\section[{e) Negative appendicectomy rates}]{e) Negative appendicectomy rates}\par
Only one of each of Steinman et al.'s (2013) public (1\%) and private (1\%) patients had a negative appendicectomy \hyperref[b12]{[13]}. \hyperref[b13]{Yang et al., 2015}, found the rate of histologically normal appendices were similar between groups (13.9\% vs. 5.7\%; p=0.076) \hyperref[b13]{[14]} Abscess formation, incisional hernias, at electasis, urinary retention, urinary tract infections and thrombophlebitis were equal between groups \hyperref[b10]{[11]}. \hyperref[b13]{Yang et al., 2015}, deemed ileus more prevalent in the public cohort (7\% vs. 0\%; p=0.045). Wound infection, fistula formation and pneumonia were not different \hyperref[b13]{[14]}. Mackrillet al., 2014, found similar numbers of abscesses, wound infections and episodes of ileus and urinary retention between their public and private cohorts \hyperref[b11]{[12]}.\par
Two cases of appendicitis died during the course of the included studies. Both were public patients in the study by Yang et al, 2015 \hyperref[b13]{[14]}. 
\section[{g) Length of hospital stay, readmission and time to resumption of activities}]{g) Length of hospital stay, readmission and time to resumption of activities}\par
Public patients spent significantly longer periods in hospital than their private comparisons in each of the four studies that investigated the outcome \hyperref[b10]{[11,}\hyperref[b12]{[13]}\hyperref[b13]{[14]}\hyperref[b14]{[15]}. Coelho et al., 2010, found public patients stayed a day longer (3.5 vs. 2.5 days; p=0.002), as did Zilbertet al., 2009 (2 vs. 1 day; p<0.001) \hyperref[b10]{[11,}\hyperref[b14]{15]}. \hyperref[b12]{Steinman et al., 2013}, found public patient's length of stay was 2.2 days longer (4 vs. 1.8 days; p<0.001)and Yang et al., 2015 found theirs to be 2.4 days longer (5.3 vs. 2.9; p=0.036) \hyperref[b12]{[13,}\hyperref[b13]{14]}.\par
Coelho et al., 2010, had four readmissions in their public cohort and one in their private cohort (4\% vs. 1\%; p=0.174) \hyperref[b10]{[11]}. \hyperref[b13]{Yang et al., 2015}, had six public readmissions and three private (8.2\% vs. 4.9\%; p=0.344) \hyperref[b13]{[14]}.\par
Coelho et al., 2010, found public patients took 16.8 days longer than their private comparisons to resume normal daily activities (33.2 vs. 16.4 days; p<0.001). Similarly, Yang et al., 2015, found public patients returned to work after 23 days, against private patients' 12.1 days \hyperref[b3]{[4,}\hyperref[b7]{8,}\hyperref[b10]{11]}s (p<0.001). 
\section[{IV.}]{IV.} 
\section[{Discussion}]{Discussion}\par
Ours is the first systematic review comparing public and private hospital's care of patients with appendicitis. The published literature on this topic is sparse and conducted in variable healthcare systems. Nevertheless, the widespread utilization of private hospitals as emergency healthcare facilities necessitates an update on the state of care offered by them \hyperref[b15]{[16]}. Many of the trends in the data seem to transcend the heterogeneity of their original studies. From the included studies, it appears that patients presenting to and being cared for within public institutions present later and with more complicated disease. This presentation is the first in a series of steps in the patient's hospital journey that concludes with a prolonged stay and relative difficulty in returning to normal life. The intervening steps include delays in reaching the operating theatre, reduced access to laparoscopic surgery, prolonged theatre operating times and increased operative complication rates \hyperref[b4]{[5,}\hyperref[b10]{[11]}\hyperref[b11]{[12]}\hyperref[b12]{[13]}\hyperref[b13]{[14]}\hyperref[b14]{[15]}.\par
Previous investigations of the relationship between appendiceal perforation and health insurance status or socioeconomic status have varied in their conclusions. In a retrospective analysis of appendicitis presentations to hospitals in Canada and the USA, Krajewskiet al., 2009, found that uninsured Americans were more likely to present to hospital with a perforated appendix than those with insurance \hyperref[b3]{[4]}. They also found that risk of perforation had a significant and inverse relationship to income in the United States, the risk of perforation increasing with each reduction in income quintile. Conversely in Canada, where health insurance is universal, the authors discovered that poorer population groups were no more likely to present to hospital with complicated appendicitis than the richest quintile \hyperref[b3]{[4]}. In a study of Greek patients with appendicitis, Papaziogas et al., 2009, found no difference in perforation rate with varying insurance status \hyperref[b8]{[9]}. Similarly, in their study out of New York,  {\ref Bickell et al., 2006, found} no relationship between insurance status and perforation rates \hyperref[b16]{[17]}.\par
Despite this variation in the literature, our study's finding that as a group, public patients present more unwell and yet take longer to receive definitive care in the form of surgery, is particularly concerning. For instance, despite Steinman et al.'s (2015) public cohort experiencing 20\% more perforations at presentation, their private cohort underwent surgery three hours earlier \hyperref[b12]{[13]}. Such findings obviously require further investigation and if proven consistent, demand institutional and systemic redress.\par
Laparoscopic appendicectomy is safer than open surgery and allows patients a faster postoperative recovery \hyperref[b17]{[18]}\hyperref[b18]{[19]} {\ref [20]}. Complications such as wound infection and ileus are increased with open surgery \hyperref[b17]{[18,} {\ref 20]}. Laparoscopy being more expensive and requiring specialized equipment, uninsured, non-white patients, and those presenting to low-volume facilities are less likely to receive it  {\ref [2-4, 8, 11]}. We found that this disparity holds with regards to public and private hospitals, which will likely have contributed to the overall increase in complications in public hospital patients.\par
Our study is quite limited by the scarcity of published studies available for comparison and is a strong indicator that more data is required from more institutions. Our study crosses national boundaries and hence compares articles founded in different healthcare systems, limiting its value. The inclusion of pediatric data, while broadening the scope, similarly limits the comparability of the papers. Operative data offered by each paper was truncated, with no description of technique or laparoscopic equipment used. Each paper analysed had incomplete outcome data. The quality of the included studies is restricted, with five of the six being retrospective in nature and none of them being randomized.\par
V. 
\section[{Conclusion}]{Conclusion}\par
This is the first systematic review analyzing the outcomes of cases of appendicitis treated at public and private hospitals. Our study suggests that patients treated at public hospitals have more complicated disease, receive more basic care at a later time point and suffer more operative complications and a longer hospital stay. There is a concerning dearth of literature on this topic and this report highlights the need for further research. \begin{figure}[htbp]
\noindent\textbf{1} \par 
\begin{longtable}{P{0.15740740740740738\textwidth}P{0.07945326278659612\textwidth}P{0.2368606701940035\textwidth}P{0.053968253968253964\textwidth}P{0.026984126984126982\textwidth}P{0.11843033509700175\textwidth}P{0.10343915343915343\textwidth}P{0.07345679012345678\textwidth}}
Study\tabcellsep Nationality\tabcellsep Study type\tabcellsep Hospitals (pub/priv)\tabcellsep No. hosp priv\tabcellsep Period of study\tabcellsep Patient numbers (pub/priv)\tabcellsep Number female (pub/priv)\\
Coelho 2010 [11]\tabcellsep Brazil\tabcellsep Retrospective case control\tabcellsep 1\tabcellsep 1\tabcellsep 2007-2009\tabcellsep 100/100\tabcellsep 46/56\\
Yang 2015 [14]\tabcellsep South Africa\tabcellsep Prospective case control\tabcellsep 2\tabcellsep 3\tabcellsep 2013-2014\tabcellsep 73/61\tabcellsep 36/30\\
Steinman 2013 [13]\tabcellsep Brazil\tabcellsep Retrospective case control\tabcellsep 1\tabcellsep 1\tabcellsep 2010\tabcellsep 111/143\tabcellsep 44/74\\
Zilbert 2009 [15]\tabcellsep USA\tabcellsep Retrospective case control\tabcellsep 1\tabcellsep 1\tabcellsep 2004-2008\tabcellsep 100/155 (84/134)*\tabcellsep 31/84\\
Lienhart 2003 [5]\tabcellsep France\tabcellsep Retrospective cohort\tabcellsep Nation-wide\tabcellsep \tabcellsep 1996\tabcellsep 2847\tabcellsep \\
Mackrill 2014 [12]\tabcellsep Australia\tabcellsep Retrospective case control\tabcellsep 1\tabcellsep 1\tabcellsep 13-month specified period not\tabcellsep 164\tabcellsep 87/55\end{longtable} \par
  {\small\itshape [Note: *Analysis was performed on cohort following removal of cases of perforation© 2018 Global Journals K The Private or Public Hospital: Where One Should Present with Appendicitis: A Systematic Review a) Timing]} 
\caption{\label{tab_0}Table 1 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{} \par 
\begin{longtable}{}
\end{longtable} \par
 
\caption{\label{tab_1}}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{} \par 
\begin{longtable}{P{0.85\textwidth}}
al., 2014 (7\% vs. 9\%; p=0.817).\\
Regarding individual complications, Coelho et\\
al., 2010, found wound infections were significantly more\\
common in public patients (22\% vs. 11\%; p=0.036).\\
Volume XVIII Issue I Version I\\
D D D D )\\
(\\
. negative appendicectomies in their public cohort and 16\% in their Mackrillet al., 2014, had 13.4\% private cohort [12]. Medical Research\\
© 2018 Global Journals 1\end{longtable} \par
 
\caption{\label{tab_2}K}\end{figure}
 		 		\backmatter  			  				\begin{bibitemlist}{1}
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\end{document}
