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\title{Quality of Life Assessment among Adult Epileptic Patients Taking Follow Up Care at Jimma University Medical Center, Jimma, South West Ethiopia: Using Quality of Life in Epilepsy Inventory-31instrument}
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             \author[1]{Daniel Shiferaw  Alemayehu}

             \affil[1]{  Mizan-Tepi University,}

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\date{\small \em Received: 10 December 2017 Accepted: 3 January 2018 Published: 15 January 2018}

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\begin{abstract}
        


Introduction: Epilepsy is neurological disorder which affects patient's quality of life and their close social networks. Thus, this study assessed quality of life and associated factors among adult epileptic patients taking follow up care at Jimma University Medical Center from March 1 -1 May, 2015.Methods: Institution based cross sectional study was used. A total of 314 epilepsy patients already receiving antiepileptic drugs for at least 3 months were randomly selected and interviewed. Quality of life in epilepsy inventory-31instrument was used to measure health quality of life. T-test, one way Anova and Pearson correlation were used to compare means and association between dependent and outcome variables. Multiple Linear regression analysis was performed to assess the association between health related quality of life and explanatory variables. P value < 0.05 was considered statistically significant in this study.

\end{abstract}


\keywords{Keywords: epilepsy, quality of life, qolie-31instrument, jumc.}

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\section[{Introduction}]{Introduction}\par
Epilepsy is public health problem in the world. It has been estimated that at least 70 million people suffer from epilepsy and epilepsy is responsible for 1\% contribution to the global burden of diseases while this contribution is 80\% in the developing countries \hyperref[b1]{[2,} {\ref 3]}. The incidence rate of epilepsy is generally higher in developing countries compared to developed countries which are figured in median as 43.4/100 000 people per year and 68.7/100, 00 people per year in developing countries  {\ref [4]}. In Ethiopia, crude incidence of epilepsy is 64 per 100,000 \hyperref[b2]{[5]}.\par
Epilepsy can be associated with profound physical, psychological and social consequences \hyperref[b3]{[6]}. It may interfere with social functioning by limiting educational opportunities, employability, and interpersonal relationships and also increase the risk of death \hyperref[b4]{[7]}.\par
Quality of Life (QOL) has been defined by the World Health Organization (WHO) as an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. It is a broad ranging concept incorporating in a complex way the person's physical health, psychological state, level of independence, social relationships, personal beliefs and their relationship to salient features of the environment \hyperref[b5]{[8]}.\par
Quality of Life Assessment among Adult Epileptic Patients Taking Follow Up Care at Jimma University Medical Center, Jimma, South West Ethiopia: Using Quality of Life in Epilepsy Inventory-31instrument pattern, Frequency of Anti Epileptic drugs (AEDs) taken/day, Side effect of the treatment, age of the patient when Anti Epileptic drugs started, current co-morbidities and Level of anxiety and depression was significantly associated with at least one of the seven domains of Quality of life score.\par
pilepsy is a neurologic disorder characterized by recurrent episode of seizure. The cause of epileptic seizure is often unknown but in some people the condition is inherited also it is caused by brain damage due to different causes \hyperref[b0]{[1]}. 
\section[{E}]{E}\par
Improving the diagnosis, treatment, prevention, and social acceptability are important factors in achieving the objective of the management of epilepsy. Quality of life is recognized as an important outcome in epilepsy treatment \hyperref[b6]{[9]}.\par
The investigator has come across a limited study done in Ethiopia addressing quality of life among epileptic patients. Thus main aim of this study was to determine cognitive, emotional, social, physical and psychological aspect of QOL by using Quality Of Life in Epilepsy Inventory-31(QOLIE-31) instrument among adult epileptic patients taking follow up care at Jimma University Medical Center (JUMC). 
\section[{II.}]{II.} 
\section[{Methods and Materials a) Study design and population b) Data collection instrument}]{Methods and Materials a) Study design and population b) Data collection instrument}\par
The questionnaire had 5 parts, HRQOL instruments (QOLIE-31), Hospital Anxiety and Depression Scale (HADS), Sociodemographic, medical and personal factors.\par
In this study HRQOL was measured based on total score of Quality Of Life in Epilepsy (QOLIE)-31questionner. A QOLIE-31questionner-containing 31 items categorized under seven domains covering the following concepts of health: overall quality of life, cognitive functioning, emotional well-being, social functioning, energy/fatigue, seizure worry and medication effects.\par
Energy/fatigue scale Assess feelings of tiredness, loss of energy and the overall impact of this issue on life Emotional well being (mood) scale assess the mood of the client such as feeling of nervousness, being calm and peaceful, happiness Social functioning domain assess how the Health limited social activities (such as visiting with friends or close relatives) Cognitive functioning scale used to assess mental activity such as thinking, reading, concentrating and memory problems Medication effects scale assess the physical and mental effect of AED, as well as worries about the medication taken Seizure worry scale assess impact of seizures such as bothering and worries about having another seizure, hurting from seizure, embracement or social problems resulting from having seizure next time. Overall quality of life scale considers the above all domains or scales.\par
The score corresponding to each scale as well as QOLIE-31 total score was calculated for each patient. Each item is scored on a scale of 0 to 100, with a score of zero equivalent to maximum disability or worst quality of life and a score of 100 equivalent to no disability or a high quality of life. However, possible categories or response sets for scoring vary across questions. Examples of response sets used include (i) 0, 25, 50, 75, 100; (ii) 0, 20, 40, 60, 80, 100; (iii) 0, 33,67, 100.\par
Questions on patient socio-demographics, personal factors such as (perceived stigma and sleeping pattern) and some clinical characteristics (such as partial or generalized epilepsy type) were also included in the integrated questionnaire. Medical records were reviewed to extract additional information pertaining to the date of initiation of AEDs, and type of therapy (poly-therapy or mono-therapy).\par
The questionnaire was administered by trained nurses hired from other hospitals and technical support was given by the Principal Investigator.\par
At time of data collection filled questionnaires was checked for completeness and consistency of information by the supervisor on daily basis and typing errors was manually edited.\par
Questionnaire was prepared in English and translated to local language. Questionnaire was pretested on 5\% of sample size a week before actual data collection period in other public (Shenen Gibe) hospital and after pre-test necessary modification was done.   
\section[{Data Analysis Procedure}]{Data Analysis Procedure}\par
The coded data was checked, cleaned and entered into Epi data version 3.1 and then analysed by SPSS window version 20.0.\par
Frequencies and percentages were used to summarize the Sociodemographic, personal factors and medical characteristics of the patients. A cross-sectional study was conducted in chronic illness clinics of JUMC between March 1/2015 -May1/ 2015. The study population was all people aged 18 years and above who had been on anti-epileptic drugs for at least 3 months with an expectation that patients would have a good experience on AEDs and possibly would knowledgeably describe seizure control features \hyperref[b7]{[10,}\hyperref[b22]{25]}. By using Single population formula a total of 314 samples were selected based on a study report which shows the proportion (P) of epileptic patients who are in lower Health Related Quality of Life (HRQOL) were 45.8\% \hyperref[b14]{[17]}. The estimated 5\% margin error of the true HRQOL (on 0-100 scale) with 95\% Confidence interval was used with 10\% non-response rate. The hospital gives follow up care for epileptic patients every Thursday, thus using systematic sampling, a sampling interval of 3 patients were enrolled and interviewed on a weekly basis for a period of 8 weeks.\par
Hospital Anxiety and Depression (HAD) Scale was used to measure patient's current comorbidity with anxiety and depression which may affect patient's quality of life \hyperref[b21]{[24]}.\par
Independent t test and one way Anova was done to compare means, and also Pearson correlation was done between the dependent and continuous independent variables. Then those variable with P<0.2 was selected for regression.\par
Linear regression was performed to assess the association between HRQOL and different explanatory variables. P value < 0.05 was considered statistically significant in this study.\par
Finally the result was presented using statement, tables and figures. 
\section[{Ethical Approval}]{Ethical Approval}\par
Before the data collection, ethical clearance letter was obtained from ethical review committee of Jimma University College of public health and medical sciences. The letter was submitted to the JUMC management and permission was obtained to interview as well as access patients and their medical records. The respondents were informed about the purpose of the study, and their oral consent was obtained. The respondents' right to refuse or withdraw from participating in the interview was fully maintained and the information provided by each respondent was kept strictly confidential by making each questionnaire coded and not sharing personal information of any patient to the third party.\par
IV. 
\section[{Result}]{Result}\par
From the total respondents, 100 (32.9\%) of the respondents have expressed perceived stigma due to the disease (epilepsy); 266 (87.5\%) of the respondents were reported they are compliant to self care and 259 (85.2 \%) perform daily activities (work) independently. Also 227 (74.7 \%) of clients have reported family support in their day to day life. Concerning substance abuse 66 (21.7\%) of the client ever used substance and 47 (15.5 \%) were using substances currently. Regular physical exercise and enjoying recreational activities are practiced among 52 (17.1\%) and 132 (43.4 \%) of the respondents. 237 (78\%) of clients get enough and regular sleep daily (Table \hyperref[tab_1]{2}).\par
According to Hospital Anxiety and depression scale (HAD scale, 106 (35\%) and 88 (29 \%) of patients has abnormal score of anxiety and depression respectively (Table \hyperref[tab_2]{3}).  
\section[{Socio-demographic, Clinical and Personal Characteristics of the respondents}]{Socio-demographic, Clinical and Personal Characteristics of the respondents}\par
From the total 314 study participants enrolled, 304 were interviewed. Of the total respondents, 177 (58.2\%) were male; the average age was 28 years and only 133 (43.8\%) were currently married. Majority of the participants, 198(65.1\%), at least able to read and right and 124 (40.8\%) of them were Farmers; 207(68.1\%) of them were Rural dwellers. Cost of treatment for epilepsy among 260 (85.5\%) participants was free.\par
Regarding the seizure type, 271 (89.1\%) subjects had generalized onset seizure and 33 (10.9\%) has focal onset (partial) seizure. 260 (85.5\%) respondents has at least one seizure per year and 44 (14.5\%) of them were seizure free at least for a year. The average age of the respondents when they get epilepsy and age of the pt when AEDs started was 18 and 21 years respectively. Concerning the type of AEDs, 191 (62.8\%) and 90 (29.9\%) respondents take one and two AEDs respectively. Also 165 (54.3\%) and 136 (44.7\%) respondents take AEDs once and twice per day respectively. Out of the total respondents, 119 (39.1\%) reported side effect of the AED treatment; 104 (34.9\%) of them reported complications related to epilepsy. 63 (20.7\%) and 56 (18.4\%) clients has current comorbidities (other than depression and anxiety) and previous history of hospital admission respectively (Table \hyperref[tab_0]{1}).  
\section[{Factors associated with socio-demographic, personal characteristic and clinical factors with the seven domains of QOL}]{Factors associated with socio-demographic, personal characteristic and clinical factors with the seven domains of QOL}\par
On bivariate analysis the factors found to fulfill the minimum requirement (p-value<0.2 in this study) were entered in to linear regression for further analysis in order to control confounding effects.\par
The results of linear regression analysis showed Sex, Residence of the client (urban or rural), occupational status, performing regular exercise, Doing daily activities independently, Sleep pattern, Frequency of AEDs taking/day, Side effect of the treatment, age of the patient when AEDs started, current co-morbidities and Level of anxiety and depression was significantly associated with at least one of the seven domains of QOL score (table 4-8). 
\section[{Overall quality of life domain:}]{Overall quality of life domain:}\par
was significantly associated with level of depression (P= 0.006) (Table \hyperref[tab_5]{6}). Seizure worry domain: of quality of life was significantly associated with occupational status, performing regular exercise, Perceived stigma because of the illness, current co-morbidities, Level of anxiety and level of depression(P<0.05) (Table \hyperref[tab_3]{4}). Emotional wellbeing domain: was significantly associated with Sex, Perceived stigma because of the illness, Level of anxiety and depression (P<0.05) (Table \hyperref[tab_5]{6}). Energy/Fatigue domain: was significantly associated with Level of anxiety and depression (P<0.05) (Table \hyperref[tab_5]{6}).\par
Cognitive Function domain: was significantly associated with Residence of the client (urban or rural), frequency of AEDs taking per day, Side effect of the treatment, current comorbidity, Having enough and regular sleep, and Level of anxiety and depression(P<0.05) (Table \hyperref[tab_6]{7}). Medication effect domain: was significantly associated with level of anxiety and depression, Doing daily activities independently, Perceived stigma because of the illness and age of the patient when AEDs started (P<0.05) (Table \hyperref[tab_7]{8}). Social functioning domain: was significantly associated with level of anxiety and depression, frequency of AEDs taking per day and current co-morbidity (P<0.05) (Table \hyperref[tab_4]{5}).     V. 
\section[{Discussion}]{Discussion}\par
Epilepsy has a great influence on the three levels of quality of life (physical, mental and social health), where the social functioning has a significant role in obtaining a good QOL.\par
In the current study, sex is associated with emotional well-being function. It was found that among the Male patients emotional well-being domain of QOL score were higher than female a counterpart which is similar with the Indian studies \hyperref[b8]{[11,}\hyperref[b9]{12]}. These women came from both urban and rural areas in economic transition. This may indicate that biological and psychological factors (family issues, personal life, and motherhood) may play a more important role. Therefore, future studies need to find the reason for this lower quality of life in women with epilepsy.\par
In this study, residence of patient was associated with cognitive aspect quality of life. Those clients living in rural area has lower quality of life. This may be related to information difference about the disease and treatment, higher cost and distance to reach health institution among the rural residents and also may be higher social isolation in the rural area. This result is similar with previous studies done in Kenya and India \hyperref[b10]{[13,}\hyperref[b11]{14]}.\par
Seizure worry domain of quality of life is associated with occupation of the patient. According to study quality of life is decreased among housewife and students. The groups are dependent to other family members for economic dependence. This study is similar with previous studies \hyperref[b10]{[13,}\hyperref[b12]{15,}\hyperref[b13]{16,}\hyperref[b22]{25]}.\par
Regarding clinical factors, frequency of AEDs taking per day was a factor associated with cognitive function and social function domains. Quality of life is higher among patients who were taking AEDs once a day (QD) than two or greater times per day. Similarly different literatures \hyperref[b7]{[10,}\hyperref[b12]{[15]}\hyperref[b13]{[16]}\hyperref[b14]{[17]}\hyperref[b15]{[18]} suggested that polytherapy receiving patients had lower mean QOL score as compared to their counterpart.\par
In this study cognitive aspect of quality of life was associated with Side effect of the treatment. Those patients who reports side effect of current AEDs has lower quality of life. This finding is concurrent with previous study done including Uganda and South Korea with the same instrument [3, \hyperref[b7]{10,}\hyperref[b16]{19]}.\par
In current study medication effect and social function domain of quality of life has association with patient's age when AEDs started. Quality of life decreased as among clients who started AEDs at older age which is similar with study finding from South Korea \hyperref[b12]{[15]} According to this study, overall HRQOL score and all domains of quality of life score is decreased among patients experiencing current comorbidity. Having current anxiety and depression decreased overall HRQOL score than those without anxiety and depression. This was consistent with the result of most studies which assessed comorbidities as well as level of anxiety and depression \hyperref[b14]{[17,}\hyperref[b16]{[19]}\hyperref[b17]{[20]}\hyperref[b18]{[21]}\hyperref[b19]{[22]}\hyperref[b20]{[23]}.\par
Concerning personal factors of the patients, current experience of having enough and regular sleep associated with higher cognitive function domain of QOL. Also Emotional wellbeing, medication effect and social function domain of quality of life score was lower among patients who experienced perceived stigma because of the illness which is in line with previous studies \hyperref[b7]{[10,}\hyperref[b12]{15,}\hyperref[b14]{17]}. Another finding of this study was performing regular exercise was associated with better score of seizure worry domain of quality of life scale. Also Medication effect domain was associated with doing daily activities independently. 
\section[{VI. Conclusions And Recommendations}]{VI. Conclusions And Recommendations}\par
Being female, Rural residence, Taking AEDs several times per day, becoming older age, side effect of treatment, current comorbidity with anxiety and depression and other disease, and also those with perceived stigma were associated with lower quality of life. On the other hand performing regular exercise, performing daily activities and enough and regular pattern of sleep were related to better QOL.\par
It is evident that current management of epilepsy that focuses on only seizure control does not improve HRQOL of the patients receiving AEDs. In addition to controlling seizure and antiepileptic drugs side effects, the treatment of epilepsy should include clinical counseling and other interventions to address the physical, mental, psychological, social and emotional aspects for health wellbeing is likely to achieve better health outcomes for epileptic patients. Also recognition of co morbid psychiatric illness like depression and anxiety in people with epilepsy should be of great concern for health care providers. 
\section[{a) Consent for publication}]{a) Consent for publication}\par
All authors are agreed to disseminate and publish the current research result 
\section[{b) Availability of data and materials}]{b) Availability of data and materials}\par
All the data sets used and/or analyzed during this study are included in the article. 
\section[{c) Author's contribution}]{c) Author's contribution}\par
This work was carried out in collaboration between all authors. Author DS designed the study, performed the statistical analysis, wrote the protocol, and wrote the first draft of the manuscript. Author EH managed the analyses of the study. Author DS managed the literature searches. Both authors read and approved the final manuscript. \begin{figure}[htbp]
\noindent\textbf{1} \par 
\begin{longtable}{P{0.3169491525423729\textwidth}P{0.24203389830508473\textwidth}P{0.1152542372881356\textwidth}P{0.17576271186440676\textwidth}}
Variable\tabcellsep Categories\tabcellsep Frequency\tabcellsep Percentage \%\\
Seizure type\tabcellsep \tabcellsep 271\tabcellsep 89.1\\
\tabcellsep \tabcellsep 33\tabcellsep 10.9\\
Seizure frequency\tabcellsep ?1 seizure per year\tabcellsep 260\tabcellsep 85.5\\
\tabcellsep Seizure free for a year\tabcellsep 44\tabcellsep 14.5\\
\tabcellsep One\tabcellsep 191\tabcellsep 62.8\\
Number of AEDs\tabcellsep Two Three\tabcellsep 91 20\tabcellsep 29.9 6.6\\
\tabcellsep Four\tabcellsep 2\tabcellsep 0.7\\
Frequency of AEDs taken\tabcellsep One\tabcellsep 165\tabcellsep 54.3\\
per day\tabcellsep Two\tabcellsep 136\tabcellsep 44.7\\
\tabcellsep Three\tabcellsep 3\tabcellsep 1\\
History of current\tabcellsep Yes\tabcellsep 63\tabcellsep 20.7\\
comorbidity\tabcellsep No\tabcellsep 241\tabcellsep 79.3\end{longtable} \par
 
\caption{\label{tab_0}Table 1 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{2} \par 
\begin{longtable}{P{0.40946843853820597\textwidth}P{0.1270764119601329\textwidth}P{0.12990033222591363\textwidth}P{0.1835548172757475\textwidth}}
Variable\tabcellsep Categories\tabcellsep Frequency\tabcellsep Percentage \%\\
Perceived self esteem\tabcellsep Yes\tabcellsep 234\tabcellsep 77\\
\tabcellsep No\tabcellsep 70\tabcellsep 23\\
Perceived Stigma\tabcellsep Yes\tabcellsep 100\tabcellsep 32.9\\
\tabcellsep No\tabcellsep 204\tabcellsep 67.1\\
Compliance to Self-care\tabcellsep Yes\tabcellsep 266\tabcellsep 87.5\\
\tabcellsep No\tabcellsep 38\tabcellsep 12.5\\
Family support\tabcellsep Yes\tabcellsep 227\tabcellsep 74.7\\
\tabcellsep No\tabcellsep 77\tabcellsep 25.3\\
Regular Exercise\tabcellsep Yes\tabcellsep 52\tabcellsep 17.1\\
\tabcellsep No\tabcellsep 252\tabcellsep 82.9\\
Recreational activities\tabcellsep Yes\tabcellsep 132\tabcellsep 43.4\\
\tabcellsep No\tabcellsep 172\tabcellsep 56.6\\
Enough and regular sleep\tabcellsep Yes\tabcellsep 237\tabcellsep 78.0\\
\tabcellsep No\tabcellsep 67\tabcellsep 22.0\end{longtable} \par
 
\caption{\label{tab_1}Table 2 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{3} \par 
\begin{longtable}{P{0.6101659751037344\textwidth}P{0.058782849239280774\textwidth}P{0.005878284923928077\textwidth}P{0.0035269709543568465\textwidth}P{0.09522821576763485\textwidth}P{0.002351313969571231\textwidth}P{0.028215767634854772\textwidth}P{0.04585062240663901\textwidth}}
\tabcellsep \multicolumn{2}{l}{Variable}\tabcellsep \tabcellsep \multicolumn{2}{l}{Categories}\tabcellsep Frequency\tabcellsep Percentage (\%)\\
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{Normal}\tabcellsep 74\tabcellsep 24.3\\
\tabcellsep \multicolumn{2}{l}{Level of anxiety}\tabcellsep \tabcellsep \multicolumn{2}{l}{Borderline abnormal}\tabcellsep 124\tabcellsep 40.8\\
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{Abnormal}\tabcellsep 106\tabcellsep 34.9\\
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{Normal}\tabcellsep 92\tabcellsep 30.3\\
\tabcellsep \multicolumn{2}{l}{Level of depression}\tabcellsep \tabcellsep \multicolumn{2}{l}{Borderline abnormal}\tabcellsep 124\tabcellsep 40.8\\
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{Abnormal}\tabcellsep 88\tabcellsep 28.9\\
\multicolumn{6}{l}{Mean scores of QOL domains of QOLIE-}\\
\multicolumn{6}{l}{31among epileptic patients at JUMC, Jimma, Ethiopia,}\\
2015. (n= 304)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
The\tabcellsep average\tabcellsep total\tabcellsep QOL\tabcellsep score\tabcellsep of\\
\multicolumn{6}{l}{domains/subscales was as follows: Seizure worry}\\
\multicolumn{6}{l}{(50.8±19.9); Overall QOL (59.8±20.0); Emotional}\\
\multicolumn{6}{l}{wellbeing (59.1 ±14.8), Energy/fatigue (59.9 ±13.6),}\\
\multicolumn{6}{l}{Cognitive function (56.0 ±15.5), Medication effects}\\
\multicolumn{6}{l}{(61.5±19.4), Social functioning (63.6 ± 17.7) and total}\\
\multicolumn{6}{l}{(Overall) quality of life (58.8±10.6). 153 (50.3\%) have}\\
\multicolumn{6}{l}{Overall HRQOL score of Greater than the mean and}\\
\multicolumn{6}{l}{151(49.7\%) have Overall HRQOL score of less than the}\\
mean.\tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \end{longtable} \par
 
\caption{\label{tab_2}Table 3 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{4} \par 
\begin{longtable}{P{0.42339622641509433\textwidth}P{0.1977987421383648\textwidth}P{0.0620125786163522\textwidth}P{0.03742138364779874\textwidth}P{0.07377358490566037\textwidth}P{0.05559748427672956\textwidth}}
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{95\% CI for B}\\
QOLIE-31 domains\tabcellsep Variables\tabcellsep Unstandardized B\tabcellsep P\tabcellsep Lower Bound\tabcellsep Upper Bound\\
\tabcellsep Constant\tabcellsep 48.568\tabcellsep .000\tabcellsep 32.502\tabcellsep 64.635\\
\tabcellsep Current\tabcellsep -9.889\tabcellsep .001*\tabcellsep -15.548\tabcellsep -4.229\\
\tabcellsep co-morbidities\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Yes\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep No\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Performing regular physical\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep exercise\tabcellsep 6.409\tabcellsep .040*\tabcellsep .305\tabcellsep 12.513\\
\tabcellsep Yes\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
Seizure worry\tabcellsep No\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Housewife\tabcellsep -18.154\tabcellsep .001*\tabcellsep -29.010\tabcellsep -7.298\\
\tabcellsep Non housewife (ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Student\tabcellsep -8.753\tabcellsep .028*\tabcellsep -16.536\tabcellsep -.970\\
\tabcellsep Non student (ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Anxiety\tabcellsep -7.653\tabcellsep .012*\tabcellsep -13.606\tabcellsep -1.700\\
\tabcellsep No anxiety(ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Depression\tabcellsep -8.598\tabcellsep .005*\tabcellsep -14.591\tabcellsep -2.605\\
\tabcellsep No depression(ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{2}{l}{Dependent variable: Seizure worry domain}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{6}{l}{Non housewifes: Those without occupation, Merchants, Farmers, Daily laborers, Governmental employees and Students}\\
\multicolumn{6}{l}{Non students: Those without occupation, Merchants, Farmers, Daily laborers, Governmental employees and Housewifes}\\
\multicolumn{5}{l}{Note: *represents variables having statistically significant association. ref: Represents "reference"}\tabcellsep \end{longtable} \par
 
\caption{\label{tab_3}Table 4 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{5} \par 
\begin{longtable}{P{0.32004048582995953\textwidth}P{0.244331983805668\textwidth}P{0.07742914979757085\textwidth}P{0.0430161943319838\textwidth}P{0.09635627530364373\textwidth}P{0.06882591093117409\textwidth}}
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{95\% CI for B}\\
QOLIE-31 domains\tabcellsep Variables\tabcellsep Unstandardized B\tabcellsep P\tabcellsep Lower Bound\tabcellsep Upper Bound\\
\tabcellsep Constant\tabcellsep 78.122\tabcellsep .000\tabcellsep 71.392\tabcellsep 84.851\\
\tabcellsep Frequency of AED taking\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep /day\tabcellsep 5.581\tabcellsep .004*\tabcellsep 1.769\tabcellsep 9.393\\
\tabcellsep Once/day\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep ?2 times/day\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
Domain Social functioning\tabcellsep No Yes Current comorbidities\tabcellsep -6.060\tabcellsep .011*\tabcellsep -10.731\tabcellsep -1.389\\
\tabcellsep Anxiety\tabcellsep -8.365\tabcellsep .002*\tabcellsep -13.602\tabcellsep -3.128\\
\tabcellsep No Anxiety(ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Depression\tabcellsep -6.485\tabcellsep .017*\tabcellsep -11.809\tabcellsep -1.160\\
\tabcellsep No depression(ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{2}{l}{Dependent variable: social functioning domain}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{3}{l}{Note: *represents variables having statistically significant association.}\tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{2}{l}{ref: Represents "reference"}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \end{longtable} \par
 
\caption{\label{tab_4}Table 5 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{6} \par 
\begin{longtable}{P{0.08287981859410432\textwidth}P{0.26116780045351473\textwidth}P{0.20719954648526076\textwidth}P{0.0790249433106576\textwidth}P{0.053004535147392284\textwidth}P{0.11564625850340136\textwidth}P{0.05107709750566893\textwidth}}
Year 2018\tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
12\tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
Volume XVIII Issue III Version I\tabcellsep QOLIE-31 domains\tabcellsep Variables Constant Sex\tabcellsep Unstandardized B 60.594 4.368\tabcellsep P .000 .007*\tabcellsep \multicolumn{2}{l}{95\% CI for B Lower Bound Upper Bound 50.876 70.312 1.228 7.507}\\
D D D D )\tabcellsep \tabcellsep Male Female(ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
(\tabcellsep Emotional\tabcellsep Perceived stigma\tabcellsep -6.406\tabcellsep .000*\tabcellsep -9.733\tabcellsep -3.079\\
Medical Research\tabcellsep wellbeing domain\tabcellsep Yes No Anxiety No anxiety(ref) Depression No depression(ref) Constant\tabcellsep -8.528 -9.481 67.487\tabcellsep .000* .000* .000\tabcellsep -12.705 -13.739 64.024\tabcellsep -4.351 -5.224 70.951\\
Global Journal of\tabcellsep Energy/ Fatigue domain Overall QOL domain\tabcellsep Anxiety No Anxiety(ref) Depression No depression(ref) Constant Depression No depression(ref)\tabcellsep -5.136 -8.112 48.954 -6.899\tabcellsep .014* .000* .000 .006*\tabcellsep -9.212 -12.356 37.354 -11.807\tabcellsep -1.060 -3.867 60.554 -1.991\\
\tabcellsep \multicolumn{5}{l}{Dependent variable: Emotional wellbeing domain, Energy/Fatigue domain, Overall QOL domain}\tabcellsep \\
\tabcellsep \multicolumn{3}{l}{Note: *represents variables having statistically significant association.}\tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep \multicolumn{2}{l}{ref: Represents "reference"}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \end{longtable} \par
 
\caption{\label{tab_5}Table 6 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{7} \par 
\begin{longtable}{P{0.24473684210526314\textwidth}P{0.30394736842105263\textwidth}P{0.08289473684210526\textwidth}P{0.05263157894736842\textwidth}P{0.09210526315789473\textwidth}P{0.07368421052631578\textwidth}}
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{95\% CI for B}\\
QOLIE-31 domains\tabcellsep Variables\tabcellsep Unstandardized B\tabcellsep P\tabcellsep Lower Bound\tabcellsep Upper Bound\\
\tabcellsep Constant\tabcellsep 85.745\tabcellsep .000\tabcellsep 72.511\tabcellsep 98.979\\
\tabcellsep Residence\tabcellsep -5.255\tabcellsep .003*\tabcellsep -8.722\tabcellsep -1.788\\
\tabcellsep Rural\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Urban (ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Frequency of AEDs taking/day\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Once/day\tabcellsep 4.122\tabcellsep .011*\tabcellsep .941\tabcellsep 7.302\\
\tabcellsep ?2 times /day (ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Side effects of AEDs\tabcellsep -3.568\tabcellsep .029*\tabcellsep -6.766\tabcellsep -.370\\
Cognitive function domain\tabcellsep Yes No Current comorbidities\tabcellsep -4.997\tabcellsep .014*\tabcellsep -8.987\tabcellsep -1.008\\
\tabcellsep Yes\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep No\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Enough and regular sleep\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Yes\tabcellsep 3.866\tabcellsep .046*\tabcellsep .062\tabcellsep 7.669\\
\tabcellsep No\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Anxiety\tabcellsep -6.792\tabcellsep .002*\tabcellsep -11.126\tabcellsep -2.457\\
\tabcellsep No anxiety (ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Depression\tabcellsep -11.902\tabcellsep .000*\tabcellsep -16.278\tabcellsep -7.526\\
\tabcellsep No depression (ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{2}{l}{Dependent variable: Cognitive function domain}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{3}{l}{Note: *represents variables having statistically significant association.}\tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{2}{l}{ref: Represents "reference"}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \end{longtable} \par
 
\caption{\label{tab_6}Table 7 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{8} \par 
\begin{longtable}{P{0.38273921200750466\textwidth}P{0.16904315196998124\textwidth}P{0.08133208255159476\textwidth}P{0.04784240150093808\textwidth}P{0.0972795497185741\textwidth}P{0.07176360225140713\textwidth}}
\tabcellsep \tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{95\% CI for B}\\
QOLIE-31 domains\tabcellsep Variables\tabcellsep Unstandardized B\tabcellsep P\tabcellsep Lower Bound\tabcellsep Upper Bound\\
\tabcellsep Constant\tabcellsep 77.888\tabcellsep .000\tabcellsep 69.932\tabcellsep 85.844\\
\multicolumn{2}{l}{Doing daily activities}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Independently\tabcellsep 7.496\tabcellsep .012*\tabcellsep 1.678\tabcellsep 13.314\\
\tabcellsep Yes\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep No\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Perceived stigma\tabcellsep -5.372\tabcellsep .019*\tabcellsep -9.838\tabcellsep -.906\\
Medication\tabcellsep Yes\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
effect domain\tabcellsep No\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Age of the patient\tabcellsep -.723\tabcellsep .020*\tabcellsep -1.329\tabcellsep -.116\\
\multicolumn{2}{l}{when AEDs started}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Anxiety\tabcellsep -11.375\tabcellsep .000*\tabcellsep -17.249\tabcellsep -5.501\\
\tabcellsep No Anxiety(ref)\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\tabcellsep Depression\tabcellsep -7.926\tabcellsep .006*\tabcellsep -13.567\tabcellsep -2.286\\
\multicolumn{2}{l}{No depression (ref)}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{2}{l}{Dependent variable: Medication effect domain}\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\
\multicolumn{3}{l}{Note: *represents variables having statistically significant association}\tabcellsep \tabcellsep \tabcellsep \\
ref: Represents "reference"\tabcellsep \tabcellsep \tabcellsep \tabcellsep \tabcellsep \end{longtable} \par
 
\caption{\label{tab_7}Table 8 :}\end{figure}
 			\footnote{© 2018 Global Journals} 		 		\backmatter   			 
\subsection[{Acknowledgments}]{Acknowledgments}\par
We would like to acknowledge Jimma University for financial support and also our extended gratitude goes to those who participated in this study. 			  			  				\begin{bibitemlist}{1}
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\end{bibitemlist}
 			 		 	 
\end{document}
