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\def\makelabel##1{\upshape ##1}}% } {\end{list}\end{raggedright}} \newenvironment{specHead}[2]% {\vspace{20pt}\hrule\vspace{10pt}% \phantomsection\label{#1}\markright{#2}% \pdfbookmark[2]{#2}{#1}% \hspace{-0.75in}{\bfseries\fontsize{16pt}{18pt}\selectfont#2}% }{} \def\TheFullDate{2018 2018-01-15 (revised: 11 Year 2018 15 January 2018)} \def\TheID{\makeatother } \def\TheDate{2018 2018-01-15} \title{A Clinico-Pathological Presentation of Solitary Thyroid Nodule} \author{}\makeatletter \makeatletter \newcommand*{\cleartoleftpage}{% \clearpage \if@twoside \ifodd\c@page \hbox{}\newpage \if@twocolumn \hbox{}\newpage \fi \fi \fi } \makeatother \makeatletter \thispagestyle{empty} \markright{\@title}\markboth{\@title}{\@author} \renewcommand\small{\@setfontsize\small{9pt}{11pt}\abovedisplayskip 8.5\p@ plus3\p@ minus4\p@ \belowdisplayskip \abovedisplayskip \abovedisplayshortskip \z@ plus2\p@ \belowdisplayshortskip 4\p@ plus2\p@ minus2\p@ \def\@listi{\leftmargin\leftmargini \topsep 2\p@ plus1\p@ minus1\p@ \parsep 2\p@ plus\p@ minus\p@ \itemsep 1pt} } \makeatother \fvset{frame=single,numberblanklines=false,xleftmargin=5mm,xrightmargin=5mm} \fancyhf{} \setlength{\headheight}{14pt} \fancyhead[LE]{\bfseries\leftmark} \fancyhead[RO]{\bfseries\rightmark} \fancyfoot[RO]{} \fancyfoot[CO]{\thepage} \fancyfoot[LO]{\TheID} \fancyfoot[LE]{} \fancyfoot[CE]{\thepage} \fancyfoot[RE]{\TheID} \hypersetup{citebordercolor=0.75 0.75 0.75,linkbordercolor=0.75 0.75 0.75,urlbordercolor=0.75 0.75 0.75,bookmarksnumbered=true} \fancypagestyle{plain}{\fancyhead{}\renewcommand{\headrulewidth}{0pt}} \date{} \usepackage{authblk} \providecommand{\keywords}[1] { \footnotesize \textbf{\textit{Index terms---}} #1 } \usepackage{graphicx,xcolor} \definecolor{GJBlue}{HTML}{273B81} \definecolor{GJLightBlue}{HTML}{0A9DD9} \definecolor{GJMediumGrey}{HTML}{6D6E70} \definecolor{GJLightGrey}{HTML}{929497} \renewenvironment{abstract}{% \setlength{\parindent}{0pt}\raggedright \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt \textcolor{GJBlue}{\large\bfseries\abstractname\space} }{% \vskip8pt \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt } \usepackage[absolute,overlay]{textpos} \makeatother \usepackage{lineno} \linenumbers \begin{document} \author[1]{Dr. Nicola C Lyngdoh} \author[2]{Dr. Ishank Jaiswal} \author[3]{Vidhiya Veeran} \affil[1]{ Regional Institute of Medical Sciences} \renewcommand\Authands{ and } \date{\small \em Received: 14 December 2017 Accepted: 1 January 2018 Published: 15 January 2018} \maketitle \begin{abstract} Background: Thyroid nodules represent a difficult diagnostic problem. They are quite common in the population, while clinically apparent thyroid cancer the principal concern of both patient and physician is comparatively rare. Materials and method: We prospectively evaluated the clinical and pathological profile of 50 consecutive patients presenting with solitary thyroid nodule. Results: Most common age group was 30-39 years (4th decade) with a female: male ratio=6:1. Overall malignancy rate was 32%. The diagnostic assessment by Fine needle aspiration cytology in this study produces sensitivity of 92.71%, specificity of 78.26%, positive predictive value of 83.33% and negative predictive value of 90% thereby having an overall accuracy of 86%. Histopathological examination remains the gold standard for final accurate diagnosis. Materials and method:We prospectively evaluated the clinical and pathological profile of 50 consecutive patients presenting with solitary thyroid nodule.Results: Most common age group was 30-39 years (4th decade) with a female: male ratio=6:1. Overall malignancy rate was 32%. The diagnostic assessment by Fine needle aspiration cytology \end{abstract} \keywords{solitary thyroid nodule, fine needle aspiration cytology (FNAC), histopathological examination (HPE).} \begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) \textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark} \end{textblock*} \begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) \textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}} \end{textblock*} \let\tabcellsep& \section[{I. Introduction}]{I. Introduction}\par solitary thyroid nodule is a palpable discrete swelling within an otherwise apparently normal thyroid gland. Though it is a common disorder of the thyroid gland, it is less prevalent among children. Childhood thyroid nodules need special attention due to higher incidence of malignancy as compared to adults. Differential diagnosis of a thyroid nodule is crucial as malignancy necessitates surgery; while strict follow up is necessary in benign cases. \hyperref[b0]{1} Fine needle aspiration cytology (FNAC) is a cost effective procedure that provides specific diagnosis rapidly with minimal complications. Our objectives were to study the demographic descriptions, clinical, cytological, histopathological profile and correlation of cytological finding with that of histological, of patients with solitary thyroid nodule attending our tertiary referral centre. \section[{II. Materials and Methods}]{II. Materials and Methods}\par Fifty consecutive patients irrespective of age, sex, religion and socio-economic status with solitary thyroid nodule admitted in the department of Otorhinolaryngology, Regional Institute of Medical Sciences, Imphal between August 2015 to September 2017 were prospectively studied.\par Every patient was meticulously worked up with a thorough history taking and clinical examination followed by routine laboratory investigations and investigations specific to thyroid like thyroid hormone assay, Fine needle aspiration cytology (FNAC) and Ultrasonography (USG) of the thyroid. Post operatively the thyroidectomy specimens were sent for Histopathological Examination (HPE). \section[{III. Results and Observation}]{III. Results and Observation}\par The age of the patients ranged from 15 to 70 years. The youngest patient was a 15 year old male while the oldest was a 70 year male. The female to male ratio was 6.1:1.25; (50\%) cases presented with swelling with duration of less than 1 year while 3(6\%) cases had duration of 9-10 year. The shortest duration of swelling was 2 months which was diagnosed as follicular adenoma, while the longest was for 10 years which was diagnosed as colloid goiter.\par All the 50 patients came with chief complaint of swelling in front of the neck of whom 46(92\%) had a gradual increase in size while in 4(8\%) cases there was rapid increase in size. There was Dysphagia in 2(4\%) cases. Associated pain, difficulty in breathing, hoarseness, decreased appetite, weight loss and cervical lymphadenopathy were seen in a 70 year old male patient who was diagnosed as papillary carcinoma. Firm consistency was observed in 38(78\%) cases of which maximum were of colloid goiter while other varieties of consistency (soft/cystic) in follicular adenoma, papillary carcinoma, hashimoto's thyroiditis and Hurthle's neoplasm were also seen. One case had hard consistency with metastatic lymphadenopathy.\par In FNAC 30 (60\%) cases were found to be colloid goiter while papillary carcinoma was seen in 9 (18\%) cases. There were 7 (14\%) cases with follicular neoplasm, 2 (4\%) cases of Hurthle's neoplasm and 1 (2\%) each of Hashimoto's and Lymphocytic thyroiditis. On Ultrasonography 30 (60\%) cases were of cystic nature while 12 (24\%) were solid and 8 (16\%) cases were of suspicious malignancy. On Histopathological examination of the operated tissues 27 (54\%) cases were colloid in nature, 11 (22\%) cases were papillary carcinoma while 3 (6\%) cases were of papillary-follicular variant. There was also a case of squamous carcinoma in a female patient of 26 years who was diagnosed as colloid nodule on FNAC. Most of the solid findings and suspicious cases of malignancy on ultrasonography were found to be papillary carcinoma and follicular adenoma on HPE. Majority of cystic findings on Ultrasonography were colloid goiter in nature. Out of 30 patients of colloid nodule on FNAC, 27 cases were found to be colloid goiter on HPE. The remaining turned out to be papillary carcinoma and squamous cell carcinoma in 1 case. All cases of papillary carcinoma on FNAC were diagnosed to be the same on HPE.\par Hashimoto's and Hurthle's cases were almost same in both examinations. All except one case of follicular neoplasm on FNAC turned out to be follicular adenoma on HPE. There was significantly more occurrence of malignancy at both the extremes of age, a rate of 42.85\% below 20 years and 33.33\% above 60 years. The youngest patient was a 15 year old male and the oldest 70 year old patient and both were diagnosed as papillary carcinoma. \section[{IV. Discussion}]{IV. Discussion}\par In the present study, the maximum number of cases occur in the age group of 30-39 years, i.e. 4 th decade of life. Other studies also reported a higher incidence in the 3 rd and 4 th decade age group. \hyperref[b1]{2,}\hyperref[b2]{3,}\hyperref[b3]{4} Several studies have highlighted the greater risk of malignancy in thyroid nodules in younger age group and older age-group people. \hyperref[b4]{5,}\hyperref[b5]{6} Several studies have highlighted the greater risk of malignancy in thyroid nodules in younger age group and older age-group people. Similar findings noted in our study. Female: Male ratio was 6.1:1, comparable to other literature. \hyperref[b1]{2,}\hyperref[b2]{3,}\hyperref[b6]{7} The overall malignancy rate was 32\%, similar to older literature. \hyperref[b7]{8,}\hyperref[b8]{9} The diagnostic assessment by FNAC in this study produces a sensitivity of 92.71\%, specificity of 78.26\%, a positive predictive value of 83.33\% and negative predictive value of 90\%.The accuracy of FNAC found to be 86\%. This finding was comparable to other studies. \hyperref[b5]{6,}\hyperref[b11]{12} Histopathological examination (HPE) revealed a colloid occurrence in 54\%, papillary carcinoma in 28\%, follicular adenoma in 12\%, 2\% each in Hashimoto's and Hurthle's. These findings tally with that of other studies. The percentage of malignancy in our study was 29\% whereas other series reported 8-37\%. \hyperref[b11]{12,}\hyperref[b12]{13} The most common finding in FNAC in our study is colloid goiter which accounts for almost 60\%, which is consistent with the other studies. {\ref 14} Out of total 14 cases of papillary carcinoma cases diagnosed from HPE, almost 9(64.3\%) cases were identified in FNAC also. This shows there is a chance of false negativity for papillary carcinoma, should always be kept in mind. It is consistent with the \section[{V. Conclusion}]{V. Conclusion}\par The incidence is highest in the 4 th decade of life. The rates of malignancy in extremes of age group are significantly higher than other general population. The incidence of a solitary thyroid nodule is much higher in female (F: M-6.1:1).\par The most common mode of presentation is swelling in the neck with a majority of (92\%) patients giving a history of gradual progression of size. Location of the nodule was slightly more on the right (44\%) as compared to the left lobe and isthmus and most nodules presented with a firm consistency.\par FNAC was found to be not only an easy and inexpensive mode of diagnosis but, also a highly accurate means of investigation with an accuracy of 86\% in this study. Histopathological examination remains the gold standard for the final correct diagnosis of a solitary thyroid nodule.\begin{figure}[htbp] \noindent\textbf{211}\includegraphics[]{image-2.png} \caption{\label{fig_0}Fig. 2 : 1 JAFig. 1 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{1} \par \begin{longtable}{P{0.36998730964467\textwidth}P{0.2491751269035533\textwidth}P{0.23083756345177664\textwidth}} \tabcellsep Age Distribution\tabcellsep \\ Age in years\tabcellsep No. of cases\tabcellsep Percentages (\%)\\ 0-9\tabcellsep 0\tabcellsep 0\%\\ 10-19\tabcellsep 7\tabcellsep 14\%\\ 20-29\tabcellsep 8\tabcellsep 16\%\\ 30-39\tabcellsep 17\tabcellsep 34\%\\ 40-49\tabcellsep 8\tabcellsep 16\%\\ 50-59\tabcellsep 4\tabcellsep 8\%\\ 60-69\tabcellsep 5\tabcellsep 10\%\\ 70 \& above\tabcellsep 1\tabcellsep 2\%\\ \tabcellsep Sex Distribution\tabcellsep \\ Sex\tabcellsep No. of cases\tabcellsep Percentage (\%)\\ Male\tabcellsep 7\tabcellsep 14\%\\ Female\tabcellsep 43\tabcellsep 86\%\\ \tabcellsep Duration of Swelling\tabcellsep \\ Duration (months)\tabcellsep No. of cases\tabcellsep Percentage (\%)\\ 0-12\tabcellsep 25\tabcellsep 50\%\\ 13-24\tabcellsep 10\tabcellsep 20\%\\ 25-36\tabcellsep 6\tabcellsep 12\%\\ 37-48\tabcellsep 4\tabcellsep 8\%\\ 49-60\tabcellsep 1\tabcellsep 2\%\\ 61-72\tabcellsep 1\tabcellsep 2\%\\ 73-108\tabcellsep 0\tabcellsep 0\%\\ 109-120\tabcellsep 3\tabcellsep 6\%\\ \tabcellsep Symptoms of Patient\tabcellsep \\ Symptoms\tabcellsep No. of cases\tabcellsep Percentage (\%)\\ Swelling\tabcellsep 50\tabcellsep 100\%\\ Gradual progression\tabcellsep 46\tabcellsep 92\%\\ Rapid progression\tabcellsep 4\tabcellsep 8\%\\ Associated pain\tabcellsep 1\tabcellsep 2\%\\ Dysphagia\tabcellsep 2\tabcellsep 4\%\\ Difficulty in breathing\tabcellsep 1\tabcellsep 2\%\\ Hoarseness\tabcellsep 1\tabcellsep 2\%\\ Decrease appetite\tabcellsep 1\tabcellsep 2\%\\ Weight loss\tabcellsep 1\tabcellsep 2\%\\ Lymphadenopathy\tabcellsep 1\tabcellsep 2\%\\ \tabcellsep Location of Swelling\tabcellsep \\ Location\tabcellsep No. of cases\tabcellsep Percentage (\%)\\ Right lobe\tabcellsep 22\tabcellsep 44\%\\ Left lobe\tabcellsep 18\tabcellsep 36\%\\ Isthmus\tabcellsep 10\tabcellsep 20\%\\ \tabcellsep Consistency of Swelling\tabcellsep \\ Consistency\tabcellsep No. of cases\tabcellsep Percentage (\%)\\ Cystic\tabcellsep 3\tabcellsep 6\%\\ Soft\tabcellsep 8\tabcellsep 16\%\\ Firm\tabcellsep 38\tabcellsep 76\%\\ Hard\tabcellsep 1\tabcellsep 2\%\end{longtable} \par \caption{\label{tab_0}Table 1 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{2} \par \begin{longtable}{P{0.5914448669201521\textwidth}P{0.16967680608365018\textwidth}P{0.08887832699619772\textwidth}} \multicolumn{2}{l}{FNAC Results}\tabcellsep \\ Cytology\tabcellsep \multicolumn{2}{l}{No. of cases Percentage (\%)}\\ Colloid Goiter\tabcellsep 30\tabcellsep 60\%\\ Papillary Carcinoma\tabcellsep 9\tabcellsep 18\%\\ Follicular Carcinoma\tabcellsep 7\tabcellsep 14\%\\ Hashimoto's Thyroiditis\tabcellsep 1\tabcellsep 2\%\\ Hurthle's Neoplasm\tabcellsep 2\tabcellsep 4\%\\ Lymphocytic Thyroiditis\tabcellsep 1\tabcellsep 2\%\\ \multicolumn{2}{l}{Ultrasound Results}\tabcellsep \\ Ultrasound\tabcellsep \multicolumn{2}{l}{No. of cases Percentage (\%)}\\ Cystic\tabcellsep 30\tabcellsep 60\%\\ Solid\tabcellsep 12\tabcellsep 24\%\\ Suspected Malignancy\tabcellsep 8\tabcellsep 16\%\\ \multicolumn{2}{l}{Histopathological Results (HPE)}\tabcellsep \\ HPE\tabcellsep \multicolumn{2}{l}{No. of cases Percentage (\%)}\\ Colloid Goitre\tabcellsep 27\tabcellsep 54\%\\ Papillary Carcinoma\tabcellsep 14\tabcellsep 28\%\\ Follicular Adenoma\tabcellsep 6\tabcellsep 12\%\\ Follicular Carcinoma\tabcellsep 0\tabcellsep 0\\ Hashimoto's Thyroiditis\tabcellsep 1\tabcellsep 2\%\\ Hurthle's Carcinoma\tabcellsep 1\tabcellsep 2\%\\ Squamous Cell Carcinoma\tabcellsep 1\tabcellsep 2\%\end{longtable} \par \caption{\label{tab_1}Table 2 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{3} \par \begin{longtable}{P{0.39628378378378376\textwidth}P{0.15793918918918917\textwidth}P{0.19527027027027027\textwidth}P{0.03445945945945946\textwidth}P{0.06604729729729729\textwidth}} Type\tabcellsep FNAC (\%)\tabcellsep Subdivision\tabcellsep HPE\tabcellsep \%\\ Colloid Goitre\tabcellsep 30 (60\%)\tabcellsep \tabcellsep 27\tabcellsep 54\%\\ Papillary Carcinoma\tabcellsep 9 (18\%)\tabcellsep \tabcellsep 14\tabcellsep 28\%\\ Follicular Neoplasm\tabcellsep 7 (14\%)\tabcellsep Follicular Adenoma\tabcellsep 6\tabcellsep 12\%\\ \tabcellsep \tabcellsep Follicular Carcinoma\tabcellsep 0\tabcellsep \\ Hashimoto's Thyroiditis\tabcellsep 1 (2\%)\tabcellsep \tabcellsep 1\tabcellsep 2\%\\ Hurthle's Neoplasm\tabcellsep 2 (4\%)\tabcellsep Hurthle's Carcinoma\tabcellsep 1\tabcellsep 2\%\\ Lymphocytic Thyroiditis\tabcellsep 1 (2\%)\tabcellsep \tabcellsep \tabcellsep \\ Squamous Carcinoma\tabcellsep \tabcellsep \tabcellsep 1\tabcellsep 2\%\end{longtable} \par \caption{\label{tab_2}Table 3 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{4} \par \begin{longtable}{P{0.2328767123287671\textwidth}P{0.06210045662100456\textwidth}P{0.1552511415525114\textwidth}P{0.11255707762557077\textwidth}P{0.12031963470319634\textwidth}P{0.16689497716894977\textwidth}} Female\tabcellsep No. of cases\tabcellsep Percentage \%\tabcellsep Male\tabcellsep \multicolumn{2}{l}{No. of cases Percentage \%}\\ Malignant\tabcellsep 13\tabcellsep 30.2\%\tabcellsep Malignant\tabcellsep 3\tabcellsep 42.8\%\\ Benign\tabcellsep 30\tabcellsep 69.8\%\tabcellsep Benign\tabcellsep 4\tabcellsep 57.2\%\\ \multicolumn{2}{l}{Age group}\tabcellsep Total cases\tabcellsep \multicolumn{2}{l}{Malignancy}\tabcellsep Percentage\\ < 20 years\tabcellsep \tabcellsep 7\tabcellsep \tabcellsep 3\tabcellsep 42.85\%\\ >60 years\tabcellsep \tabcellsep 6\tabcellsep \tabcellsep 2\tabcellsep 33.33\%\\ 20-60 years\tabcellsep \tabcellsep 37\tabcellsep \tabcellsep 6\tabcellsep 16.21\%\end{longtable} \par \caption{\label{tab_3}Table 4 :}\end{figure} \footnote{© 2018 Global Journals} \footnote{( )J} \backmatter \begin{bibitemlist}{1} \bibitem[Kamaljit et al. ()]{b8}\label{b8} ‘A comparative study of FNAC, USG and Radio nucleotide scan in the management of solitary thyroid nodule: A prospective analysis of 50 cases’. K Kamaljit , S Nishi , A S Bapna , M Pradeep . \textit{Indian JOtolaryngolHead Neck Surg} 2002. 54 (2) p. 96. \bibitem[Associated pain with hoarseness, weight loss, difficulty in breathing, decreased appetite, and cervical lymphadenopathy was seen in 70 -year -old patient with papillary carcinoma. All these clinical indicators suggestive of malignancy reported in other studies. 8,11 The presence of nodule on the right lobe was in 22 (44%) cases, 18 (36%) in the left lobe and 10 (20%) in the isthmus. Similar findings reported by another author. 10 Firm consistency felt in 38 (76%) cases The most common presenting feature was swelling in the neck seen in all 50 cases (100%)]{b13}\label{b13} ‘Associated pain with hoarseness, weight loss, difficulty in breathing, decreased appetite, and cervical lymphadenopathy was seen in 70 -year -old patient with papillary carcinoma. All these clinical indicators suggestive of malignancy reported in other studies. 8,11 The presence of nodule on the right lobe was in 22 (44\%) cases, 18 (36\%) in the left lobe and 10 (20\%) in the isthmus. Similar findings reported by another author. 10 Firm consistency felt in 38 (76\%) cases’. \textit{The most common presenting feature was swelling in the neck seen in all 50 cases (100\%)}, (This correlates with the observance made by other authors. 4,7,10 There was a gradual increase in size of the solitary thyroid nodule in 46 (92\%) cases, while 4 (8\%) cases had rapid progression. Dysphagia noted in 2 cases of papillary carcinoma and follicular adenoma. cystic in 3 (6\%) cases and soft in 8 (16\%) cases. An elderly) \bibitem[Ashok ()]{b7}\label{b7} ‘Controversies in management of thyroid nodule’. R S Ashok . \textit{Laryngoscope} 2000. 110 p. . \bibitem[George and Victor (ed.) ()]{b4}\label{b4} \textit{Endocrinology, Surgery, Nuclear medicine and Radiotherapy. Philadelphia: Lippincott Raven publishers}, Laf George , G L Victor . Stephen A, Falk editor (ed.) 1997. p. . (Thyroid disease) \bibitem[Sukumaran et al. ()]{b14}\label{b14} ‘Fine Needle Aspiration Cytology of Thyroid Lesions and its Correlation with histopathology in a series of 248 patients’. R Sukumaran , J Kattor , K R Pillai , P T Ramadas , N Nayak , T Somanathan , N A George , P Sebastian . \textit{Indian J SurgOncol} 2014. 5 (3) p. . \bibitem[Kumar et al. 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