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\def\makelabel##1{\upshape ##1}}% } {\end{list}\end{raggedright}} \newenvironment{specHead}[2]% {\vspace{20pt}\hrule\vspace{10pt}% \phantomsection\label{#1}\markright{#2}% \pdfbookmark[2]{#2}{#1}% \hspace{-0.75in}{\bfseries\fontsize{16pt}{18pt}\selectfont#2}% }{} \def\TheFullDate{2020-01-15 (revised: 15 January 2020)} \def\TheID{\makeatother } \def\TheDate{2020-01-15} \title{Cow's Milk Protein Allergy in Children with in herited Epidermolysis Bullosa} \author{}\makeatletter \makeatletter \newcommand*{\cleartoleftpage}{% \clearpage \if@twoside \ifodd\c@page \hbox{}\newpage \if@twocolumn \hbox{}\newpage \fi \fi \fi } \makeatother \makeatletter \thispagestyle{empty} \markright{\@title}\markboth{\@title}{\@author} \renewcommand\small{\@setfontsize\small{9pt}{11pt}\abovedisplayskip 8.5\p@ plus3\p@ minus4\p@ \belowdisplayskip \abovedisplayskip \abovedisplayshortskip \z@ plus2\p@ \belowdisplayshortskip 4\p@ plus2\p@ minus2\p@ \def\@listi{\leftmargin\leftmargini \topsep 2\p@ plus1\p@ minus1\p@ 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\vskip16pt \textcolor{GJBlue}{\large\bfseries\abstractname\space} }{% \vskip8pt \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt } \usepackage[absolute,overlay]{textpos} \makeatother \usepackage{lineno} \linenumbers \begin{document} \author[1]{Svetlana G. Makarova} \author[2]{Nikolay N. Murashkin} \author[3]{Nikolay N. Murashkin} \author[4]{Nikolay N. Murashkin} \author[5]{Tamara R. Chumbadze} \author[6]{Oksana A. Ereshko} \renewcommand\Authands{ and } \date{\small \em Received: 13 December 2019 Accepted: 2 January 2020 Published: 15 January 2020} \maketitle \begin{abstract} Background: Epidermal barrier dysfunction, which is observed in children with inherited epidermolysis bullosa (EB) from the first days of life, can cause sensitization, including sensitization to food.Objective: Evaluate the features of the IgE response to cow's milk protein (CMPA) in children with EB.Methods: We examined 94 patients with EB -72 children with dystrophic EB and 22 -with EB simplex. Assessment of the total wound burden and disease severity was based on "The Epidermolysis Bullosa Disease Activity and Scarring Index" (EBDASI). Diagnosis of CMPA was based on a generally accepted set of clinical and laboratory methods (natural history of disease, clinical manifestations, elimination diet, provocation tests). \end{abstract} \keywords{inherited epidermolysis bullosa, children, cow's milk protein allergy, IgE} \begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) \textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark} \end{textblock*} \begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) \textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}} \end{textblock*} \let\tabcellsep& \section[{??????-}]{??????-}\par ???????????: ????????? ?????????????? ???????, ??????? ??????????? ? ????? ? ?????????? ????????? ????????????? (???) ? ?????? ???? ?????, ????? ????? ???????? ??????????????, ? ??? ????? ???????. ?????????????? ????????????? \hyperref[b0]{[1]}. ???????? ??????? ?????? ?????????? ???????? ? ?????????????? ?????? ???. ????????? ???????????? ???????????? ???? ????? ??????????? ???????? ?????? ?/??? ?????? ?? ???? ? ????????? ?????????. ???????????? ????????? ???????? ????? ??????????? ? ????????????? ???????? ????? (???? ????????????) ? ???????? \hyperref[b1]{[2]}. ? ?????????-???????? ?????? ???????? ?????????? ???????? ? ????????? ????????????? ???????, ?????? ???????, ?????????????, ?????????? ????????, ??? ?????????????? ????????? ????????, ????????? ???????????????????? ????????, ???????? \hyperref[b2]{[3,}\hyperref[b3]{4]}. \section[{???? ????????????: ??????? ???????????}]{???? ????????????: ??????? ???????????}\par ?????? ????? ? ?????????? ?????????? ????????? ??????? ????????????? ?????????? ??????????? ?????????, ? ??? ????? ?????????? ???????? ? ?????????? ?????????????. ?????? ??????? ??????? ?????????????? ? ??????? ???????? ? ?????? ????????? ????????? ??????? ????????????. ???, ????? ?????????? (Web of Science ? PubMed) ???????? ?????????? ???? ???? ?????? H. Marcelo ? ?????. \hyperref[b4]{[5]}, ? ??????? ??????? ?????? ??????????? ?????? ??????? ? ?????????????? ?????? ??? ? ???????? ????????????? ???????????? ? ????????? ? ?????????? ??????? ?????? IgE. ????? ???????????? ?????????? ??????????? ????????? ? ??????? ? ??? \hyperref[b5]{[6]}. ? ?? ?? ?????, ????????????? ????????? ? ??????? ? ?????????????? ???????, ??????? ? ????? ? ??? ????? ????? ? ?????? ???? ?????, ????? ????? ???????? ?????????????? ? ?????? ??????? ????????? ???????? ????????, ??????? ???????? ????? ????????? ??????, ? ??????????? ????????? ?????????? ???????? ????????. ??? ???? ? ??? ????????? ??????????? ???????????? ? ???????????? ? ?????????????? ????????????????? ??????????? ?? ??????? ??????? ? ?????? ?????????? \hyperref[b0]{[1]}.\par ?????? ????? ??????? ???????? ?? ???????? ? ??????????? ??????? ??????????? ??????????? ?? ????????? «??????? ?????????? ??????????? ?? ? ??????????» (EBDASI).\par Ð?"?????????????? ??????? ??????? ? ???? ?????????? ? ????? ?????????????, ?????? ???????? ????????? ? ???? ???????? ? ??????? ?? ??? ????????, ???????????? ??????? ?????? ?? ????? ???????????? ? ????????, ???????????? ??????? ??????? ???????. Ð?"?? ????? ???????????? ????? ??????????????? ?????? ???????????? ?????????????? ??????????? ????? ?????????????????? ??????????, ???????????????? EAACI ??? ?????? ???????? ??? ?????????? ?? ??????? ???????? \hyperref[b6]{[7]}.\par ??? ??????? ?????????? ???????????? ????????? ??????????? ???????? ????????????, ???????? ?? ???????? Hanifin ? Rajka \hyperref[b7]{[8]}.\par ??? ??????? ??????????? ?????? ?? ???????? ?? ????? ????????? ?????? ????????? ??????????????? ??????????? ?????????????? ????? ?????????????????? 30 ????. ?? ???? ?????? ?? ??????? ????????? ??? ???????? ????????, ????????, ????????, ? ????? ?????? «?????????????» ???????????????? ???????? ??? ??????? ??????????????? ??????????? ?????? \hyperref[b8]{[9]}. ????? 1 ??? ????????? ???????? ?????????????? ????? ??? ??????????????? ???????? ????????? ???????? \hyperref[b8]{[9]} ??? ????????????? ??? ?????????? ????. ??????? ???????????? ????? ? ???? ???????????? ? ???????????? ? ??????????? ???????????? ?????????????? \hyperref[b9]{[10]}.\par ?????? ????????? ???????????? ???????????, ??? ??????? ??????? ?????????????? ? ?????? ????????? ??????, ??? ? ??????? ??????? ?????????? ???????? ???????? ? ????? ? ???. ???? ???? ???????? ? 25\% ????? ? ?????????????? ?????? ???, ? 18,1\% ??????? ??? ?????? IgE-?????????????? ???????? (72,2\% ?? ???? ????? ? ?????????? ???????? ????). ? ????? ? ??????? ?????? ??? ?????????? ???????? ???? ???????? ? 9,1\% ???????. ?????????????? ? ?????? ????????? ??????, ???????, ??????? ????????????? ????????? ??????????????? ????????????? ??????? ???? ? ????? ? ?????????????? ?????? ??? ?? ????????? ? ??????? (p<0,05). ????? ??????? ????????????? ?????????????? ? ?????? ????????? ?????? ? ???? ????? ????? ? ?????? ?????? ???????????, ?? ???? ?????????, ??????? ? ????????? ??????????? ??????????? ?????? ????????, ?? ???????????, ? ????? ?????????? ????????? ???????? ?????????-????????? ??????; ??? ? ???? ??????? ????????????? ?????????? ??????????? ?????????, ? ??? ????? ??????? ??????????, ?, ??? ?????????,???????????? ??????? ?????????????? \hyperref[b14]{[16,}\hyperref[b15]{17]}.\par ????????????????? ???????????? ??????? ????? ??????? ?????? ?????? IgE ? 50\% ????? ? ?????????????? ?????? ???, ??? ??????????? ????????????? ??????? ????, ??? ? ?????? ????? ? ??????? ?????? ???, p<0,05. ??????? ??????????? ????? ??????????? 1000 kUA/l (? 10 ????? -13,8\%) ? ?????? ??????? ??????? (????? 3000 kUA/l ? 6 ?????) ?????? IgE ??????? ??????????? ????????.\par ?????? ??????????? ?????? ???????, ??? ??????? ???????? ?????? ???? ????? ? ??????????? ??????? ??????????? ? ?????? ??????????? ????????????????? ? ??????????? ? ??????????? ??????? ???? ??????? ????????? ???????. ??????? ?????????????? ? ??????? ?????????? ??? ?????????? ??????????? ??????? ??????? ???????? ????? ?????????? ????? ??????????? ? ??????? ? ?????????????? ?????? ??? ? ??? ?????????? ??????? ?? ??????? ?????????? ???????? ????????? ?? ??????? ???????. ????????, ?????????? ?????????????? ??????????????? ?????? ? ???????? ?????????????? ?????? ????, ???? ??? ?????????? ?????????????? ? ???????? ??????, ?????? ???????????? ? ???????????? ? ??????????? ???????? ??? ??-IgE-?????????????? ????? ??????? ???????? \hyperref[b8]{[9,}\hyperref[b9]{10]}.\par ??????? ????????, ??? ??????? ??????? ?????????????? ? ??????? ???????? ? ?????? ????????? ??????? ?? ???????. ?????????? ???? ?????? ??????? ? ???, ??? ??????? ??????? ???????? ??????? ??????? ???????? ? ????????? ??? ??????????? ??????? ? ????????????? ??????????? ????????? ???? ??????? ???????.\par ???????????? ???????????? ???????? ? ?????? ??????? ????????? ?????? ?????????, ? ??? ??????????? ???, ??? ??? ????????? ? ?????? ????????????. ??? ????? ???????????? ???????? ??, ??? ? ????????? ?????? ???????????????? ??????????? ? ???????????????? ????? ?????? ?? ???? ??????? ?????????????? ??????, ??? ???????? ???????? ???????? ????????. ??????????? ??????? ?? ?????? ????????, ? ????? ?? ???????? ?????????? ????? ??????? ??????????? ????????.\par ???????????? ?????? ???????? ??????????? ??????, ??????????????? ???????? ?????????????? ? ???????????? ??????? ???????? ? ??????? ? ?????????????? ?????? ??????????? ?????????? ????????????.\par Ð?"????????????? \begin{figure}[htbp] \noindent\textbf{}\includegraphics[]{image-2.png} \caption{\label{fig_0}}\end{figure} \begin{figure}[htbp] \noindent\textbf{123}\includegraphics[]{image-3.png} \caption{\label{fig_1}F??????? 1 , 2 , 3 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{s}\includegraphics[]{image-4.png} \caption{\label{fig_2}Cow' s}\end{figure} \begin{figure}[htbp] \noindent\textbf{}\includegraphics[]{image-5.png} \caption{\label{figure5}}\end{figure} \begin{figure}[htbp] \noindent\textbf{}\includegraphics[]{image-6.png} \caption{\label{figure6}}\end{figure} \begin{figure}[htbp] \noindent\textbf{} \par \begin{longtable}{P{0.007981220657276996\textwidth}P{0.7442931664058424\textwidth}P{0.09001043296817945\textwidth}P{0.007715179968701095\textwidth}} \tabcellsep ???????????? -??? ??????? ??????? ? ?????: KRT5, KRT14, TGM5, DSP, PLEC, COL17A1. ?????? ???????????????? ? ?????? ????? ? ??????? ??????? ???????????? ? ?????? ??????? ?????, ?????????????? ?????? ??? ? ???? ??????, ??? ???????????? ??????? ???????? ???????\tabcellsep ????????? ??? ?????? ?????? ?????????????? ?????? ??????????? ??????? ?????? ??????????, ???????? SPSS 20 («IBM», ???). ?????????? ??????????????? ????????? ??????????? ????????????\\ \tabcellsep ???????????????? ???? ? 6 ????? ?????? ??????????? ???????? ??????? ? ????????????????? ?????????????? ? ?????? ????????? ?????? ?\tabcellsep ?????????????? ?????? ??????????? ?? ???????????? ????????? (5,5\%). ?????????? ???????????? ?????????\\ \tabcellsep ?????? ???????????? ???????? ? ???? ??????????? ? ?? ????????????? ????????????. ???????????? ??????????? ?????????? ???????? ??\tabcellsep ??????????? ????????????? ? ??????? ???????? ???????????? ??? ??????????? ?????????????? ?????\\ \tabcellsep ????????? ????? ?????????? ?????? IgE, ?????? ???????? ??????????? ??????????? ??????? ???????? ????? ? ????? ? ???. ???????? ?? ?????\tabcellsep ??????-?????. Ð?"?? ???????, ?? ????????????? ?????????? ?? ??????? ??????? ????????-?????????\\ \tabcellsep ????????????? IgE (sIgE) ? ?????? ????????? ?????? ? ?????????? ????????????, ????????????? ? ????????? ????????? ?????? ????? ?????? ??????????? ????????,\tabcellsep ??????????? ?????????????, ?????????? ???????, ? ????????.\\ \tabcellsep ??? ???????? (???????, ?-??????????????, ??????? ??? ??????? ???????, ??? ? ????????? ???????? ??????? ???????? ? ?????? ??????? ????????, ????? ??\tabcellsep ????? 25 ? 75 ??????????. ??? ?????? ???????? ??? Ð?"??????????????????? ?????????? ???? -\\ \tabcellsep ????????????? ?????????) ? ??????? ?????? ??????? ? ?????????, ??????????? ???????? ??????? ??????????? ??????? ????? ? ???????????? ???????\tabcellsep ?????????, ????????????? ??????? ??????? ?? ??????????, ???????????, ?????????????? ????, ????\\ \tabcellsep ???????? ??????????????????? ?? ?????????????? ???????? ? ?????? ????????? ????????? ?????? ??????? ????? ????? ???????.\tabcellsep ???????????, ???????????? ???????? ?????-?????. ?? ??????, ?? ???? ?????? ???????? ?????????\\ \tabcellsep ??????????? ImmunoCAP250 (UniCAP System, Thermo ??????????????. ??? ?? ????? ??? ?????????? ?????\tabcellsep ??????? ???????? ??????? ????????? ??? ? < 0,05. ?????????? ??? ?????????????? ????? ??? 16,6\%\\ \tabcellsep Fisher Scientific, ????? Phadia ??). ??????????? ??????????? ???????? ??? ????????????? IgE-??????? ????????, ? ????? ????????? ?????? ????????-???????????? ????? ????????? ????????? ? ???????\tabcellsep III. ?????. ????? ????? ????????, ??? ????? ?????????? ?????????? ??????????? ????? ? 4 ????? ? ???? ?????? ??????,\\ 32 Year 2020 Volume XX Issue II Version I Global Journal of Medical Research ( D D D D ) F\tabcellsep \multicolumn{2}{l}{????? ?? ??????? (????????????, ????????????????) ???????????? ? ???????? ???????, ??? ?????? ????? ??? ????????????? ????????? ????? ????????????, ??? ?????????????? ???????????. ? ????? ??????????? ???????? ??? ???????????? ????? ?????????? ????????????? ??????????????. ? ?????? ???? ???????? 24 ????, ??????? ? ??????? ???????? ???????????????? ?????????? ????????????. ????? ???????????? ??????????????????? ????? ?????????? ? ????????????????? ???? ?????? NCBI (National Center forBiotechnological Information, USA). Ð?"?? ?????? ?????????????? ???????? ???????????? ????????? BLAST [11]. ?????????????????? ???????????????? ??????????? ? ??????? ????????? Beacon Designer 8.10. ???????? ????????????? ??? ????????? ??????????? ? ??????? ????????? Primer-BLAST [12]. Ð?"?????? ??????????????? ?????????? ???????????? ?????????????? ??? ??????? ????????? ??????? ? ???? ????????? 7 ???? (COL7A1), ??????? ????? ?????????? ??????? ??????????????? ?? ????? ??? ?????????? ????????? ???????????. ? ?????? ????? ? ?????????????? ?????? ??????????? ?????? ???? ?????????? ????? ???????? ?? ????? (n = 5), ?????? ? ????? (n = 5), ???? (n = 3). ????? ????? ? ??????? ?????? ??? ??????????? ??????? ?? ???????? ???????? ???? a) ??????? 1: ?????????????? ???????? ?????????? ????????????? ????-???????: 0,35-0,7 kUA/l -I (??????) ????? ??????????????, 0,7-3,5 kUA/l II (???????) ????? ??????????????, 3,5-17,5 kUA/l, III (???????? ???????) ????? ??????????????,17,5-50 kUA/l -IV(???????) ????? ??????????????, 50-100 kUA/l -V (????? ???????) ????? ??????????????, ???? 100 kUA/l -VI (????????? ???????) ????? ??????????????. ?????? ??????? ?????????????? ?? ????????????. ????????? ?????????? ?????? ???? ??? ????? ?????????? ????????-????????? ???????? ??????? ???????? ?????? ????????????? ??????? ??????. ??????????? ????????? ????????? ????????? ?? ???????? ???? ??? ?????? ???????????? ????????? ??? ????????? ?????, ?? ??????????? ??? ????????? ???????????, ?????????. ?????? ?????????????? ?????????? ?????? ?????????? ??????? ????? ??? (n=22) Ð?"????????????? ????? ??? (n=72) ???????, ???? 5,6 (2,11; 7,3) 8,9 (3,6; 13,9) ?????? EBDASI 12,3 (7,1; 16,4) 109,7 (78,2; 143,9) b) ??????????? IgE-?????? ? ?????????? ????? ? ??? ? ??????????? ?? ????? ??????????? 1), ? 6 -???? 3000 kUA/l. Ð?"?? ??????????? ????? ? ?????????????? ?????? ??? ? ?????????? ??????? ??????????????? ?????????????? ????? ? ???????? ?????????????? ?????. ? ?????????? ??????? ???????? ???? ??????????????? ? 2 (9,1\%) ????? ? ??????? ?????? ? ? 18 (25\%) ????? ? ?????????????? ?????? ???. ? ?????? ????? ? ?????????????? ?????? ??? IgE-?????????????? ???? ???? ??????????????? ? 13 ???????????, ??? ????????? 18,1\%. ?????????? ???? ?????????? ? ???? ?????? ? ???????????????????? ?????????. ???????? ???? ????? ???????????? ???? ??? ????? ????????? ????????, ????????? ????????-?????????? ???? ??? ?????????????? ??? ???????? ? ???? ?????????. ? ????? ????? ???????? ????? ??? ???????????? ????????-???????? ??????????. ???????? ???? ?????? ????????????? ????????, ???????????? ??????????? ????????-????????? ????????. sIgE ? ????????? ????? ? ??? ???????? ?????????? ?? ???????, ??????????????? ?????? ?????????????? ?? ??????? ?? ???????? ???????? (????. 3). ? ???? ??????? ???????? ?????????? ? ??????? ??-IgE-?????????????? ???????? ?? ???????? ?????. ?????????? ? 18,1\%. ? 4 ????? ? ?????????????? ?????????? ?????? IgE ? ?????? ????? ? ??????? ?????? ??? ?? ??????????????? ?????????? ????? ? 3 ?????, ??? ???? ?? ????????? 1000 kUA/l. ? ?????? ?? ????? ? ?????????? ??????? IgE ???? ??????????????? ??????? ????????, ? ??????? -??????? ??????????????. ? ?????? ????????? ? ?????????????? ?????? ??? ??????? ?????? IgE ???????? ?????????? ?????????? ? 36 (50\%) ???????????, ??? ???? ? 10 ??????? 2: ??????? ????????? ?????????????? ? ????? ? ??????? ? ?????????????? ?????? ??? ???????? ??????? ????? ??? (n=22) Ð?"????????????? ????? ??? (n=72) p* sIgE, ?? (25; 75) ??????? ?????????????? sIgE, ?? (25; 75) ??????? ?????????????? ?????? 0,04 (0,02; 0,11) 1 (4,5\%) 0,09 (0,05; 0,27) 12 (16,6\%) 0,013 ?-???????????? 0,015 (0,01; 0,02) 1 (4,5\%) 0,04 (0,02; 0,1) 11 (15,3\%) 0,009 ?-????????????? 0,02 (0,01; 0,06) 0 0,04 (0,02; 0,07) 11 (15,3\%) 0,21 ?????? 0,02 (0,01; 0,04) 0 0,04 (0,02; 0,1) 6 (8,3\%) 0,009 ??????????. * -????????????? ???????? ???????? ????? ???????????? ?????????? sIgE, ??????????? ? ??????? ???????? ????? -?????. ????????? ?????????? ??????? sIgE ? ??????? ?????? ??? ?????????? ????? ??????????? ??????? ???? ????????????? ??? ??????????????. ??????? ??????????? ??????????????? ??????????? ????? ? ??????????? ??????????????? ????????? ????????? ???????? (???????? ?????????????? ?????), ?? ????????? ???? ??? ??????????????, ??? ??????????? ?????????? ???????? ????. (IL1?, IL6, IL33) ? ???????? ??????????? ??????????? ???????? ?????? ?? «??????? ?????????» ??????????, ? ???????? ? ????? ? ?????????? ??????? ???. ??????????? ? ???????? ????????????????? ???????? ????????? ???????? ????? ???????? ????? ?? ?????? ??????????? ?????????? ??????? IV. ?????????? Ð?"????????????? ????? ?????????? ???????????? ??????????????? ???????????? ???????????? ?????? ???????? ? ? ???????????? ????? ??????? -????? ? ????????? ???????? ???. ??? ???????? ???????????? ? ????????? ????????? ???????? ???????. ? ?????? ????????????? ????????? ????? ???????????? ??????????, ??????? ????? ? ????? ?????? [15]. ????????????? ?????? ? ??? ??????????? ?? B-?????????? ? IgE-????????????? ?????????????? ????????? IL13), ????????????? ?????????? ? ??????????????? ?????????? ??? ????????????????????? ????????? (IL4, IL5, IL10, ?????????????? ?????? ? ???????? ? ???? ????????? [14]. Th2-?????????, ? ???? ???????, ????????????? ?????????????. ???????? ???????? ????????????? ??????? ????????? ?????? ?????????????? -OX40L ????????? ?????????, ? ??? ????? ? ???????? ??????????????? TSLP ??????????? ???????? ??????????? ??????????? ?? ?????????? ????? CXCR4-????????? ????) ? ????????? ??????? ???? ? ??? ? ??????? ??????? ??? (TSLP), ??????? ?????????? ?????????? ???????? ?????, ??????????? ???????? ?????????? ?????????? ?????? ? ?????????? ??????????????? ??????? ?-?????? ??????????????? ? ?????? Th2-???? [13]. ????? ???????? ?????? ???? TSLP, ????????????? ????? ?? ??????? ?? ???????? ?????????? ?????? ? ???? (???????? ??????????? ?????????? CCR7 ? CXC ????? (13,8\%) ????? ??????? IgE ??? ? ???? 1000 kUA/l (???. IgE ???? ?????????? ????? ??????? ???????? ??????? ????????? ????, ??????? ?????????????? ???????? ????. c) ???????? ?????????????? ? ???????? ?????? ? ????? ? ?????????? ??????? ??? ??????? ????????? ?????????? ??????? ????????????? IgE ? ????? ? ??????? ? ?????????????? ?????? ??? ???????????? ? ????. 2. ????? ?????????????? 0 I II III IV V VI ?????? 4 1 3 2 2 1 0 ?-???????????? 3 3 2 1 2 0 0 ?-????????????? 5 1 2 2 1 1 0 ?????? 5 1 3 0 2 0 0 ??????? 3: ????????}\tabcellsep Year 2020 Volume XX Issue II Version I Global Journal of Medical Research ( D D D D ) F\end{longtable} \par \caption{\label{tab_1}}\end{figure} \begin{figure}[htbp] \noindent\textbf{} \par \begin{longtable}{P{0.5204819277108433\textwidth}P{0.18554216867469878\textwidth}P{0.09457831325301205\textwidth}P{0.04939759036144578\textwidth}} ?????????? ???? ? ???????????? ??????????????\tabcellsep \multicolumn{2}{l}{?????????????? ? ???? ? ?????????? ??????????}\\ ?????????? ?????????.\tabcellsep \multicolumn{2}{l}{(??????? 4), ???????? ?? ?????????? ??????????????}\\ ????????? ??????????? ??????? ??????????\tabcellsep ????? (???. 4, 5).\tabcellsep \\ ???????????? ?????????. ??????, ??????? ???????\tabcellsep \tabcellsep \\ \multicolumn{2}{l}{??????? 4: ImmunoCAP (????????) ??????? ????? (??????, ????????, ??????? ?????, ?????, ??????) VI. ????????? ???????????????}\tabcellsep Results Positive\\ \multicolumn{2}{l}{????? ????????? ?????????? mx2 (Penicilium notatum, Cladosporium herbarum, ?????? ???????? ??????????????? ?????????}\tabcellsep Positive\\ \multicolumn{2}{l}{Aspergillus fumigatus, candida albicans, Altermaria alternata, Helm.hal.) ????? ???????? ???? hx2 (hollister-stier labs,dermatophagoides pteronyssinus, ??? ????? ?????????? ?????????-????????? ?? ????????? ????????????, ? ????? ????? «Ð?"???-dermatophagoides farinae, blatella germanica) ??????? ?????? ???????» ?? ?????????? ??????????? ???????????? ? ??????? Ð?"??????? ???? ??????? ???? ??????? ??????? ????? ? ?????????? ????????? ?????????????.}\tabcellsep Positive 53,2 kUA/l (V) 2,27 kUA/l (ll) 21,8 kUA/l (lV) 4,48 kUA/l (lll) 52,7 kUA/l (V)\tabcellsep Year 2020\\ ?????? Ð?"?????\tabcellsep \tabcellsep 0,86 kUA/l (ll) 0,86 kUA/l (ll)\tabcellsep 35\\ ???????\tabcellsep \tabcellsep >100 kUA/l (VI)\tabcellsep Volume XX Issue II Version I\\ \tabcellsep \tabcellsep \tabcellsep D D D D )\\ \tabcellsep \tabcellsep \tabcellsep (\\ \tabcellsep \multicolumn{2}{l}{???????? ????????? ?.?. ???????? -????????? ????????????????? ??????? ?? ???????????????? ???????? Jansen, Eli Lilly, Novartis. ????????? ????????? ?? ???????}\tabcellsep Medical Research\\ \tabcellsep ???????????????? ?? ???????? Conflict\tabcellsep \tabcellsep Global Journal of\end{longtable} \par {\small\itshape [Note: ?????? 51,7 kUA/l (V) ????? 15,1 kUA/l (lll) Ð?"???? 15,1 kUA/l (lll) ??????? 4, 5: ?? ?? ????????? ?????? 5 ???. ?????? ?????????????? ??????? ????????????????, ????????????, ??????????? ???????????? ????? ????? ?????????????? ??????? ???????????? ????? ? ??????? ?????????, ?????????? ?? ???? ???????? ? ???????????. ?????????? ????????? ????????????? ? ??????? ?????? ??????? ??????????? V. ?????????? ??-????????, ??-?? ???????? ??????????? ? ?????????? ?????????? ????????? ? ?????????????? ?????? ???, ?????? ?? ????????????? ??????? ???????? ? ??? ?? ????????????? ? ?? ???????????? ? ??????? ?????????? (Web of Science ? PubMed).????????????]} \caption{\label{tab_3}}\end{figure} \footnote{© 2020 Global Journals} \footnote{Cow's Milk Protein Allergy in Children with in herited Epidermolysis Bullosa} \backmatter \par Leofarma, Pfizer, AbbVie, Amryt Pharma, Zeldis Pharma LLC companies.\par Alexander I. Materikin, Roman V. Epishev -scientific consultant of Eli Lilly, Novartis, AbbVie, Amryt Pharma companies. Eduard T. Ambarchyan -scientific consultant of Eli Lilly, Novartis, AbbVie, Amryt Pharma, Jansen companies.\par The other contributors confirmed the absence of a reportable conflict of interests. \begin{bibitemlist}{1} \bibitem[??????????? and ?????? (2018)]{b9}\label{b9} ‘??????? ???????? ? ?????’. ??????????? , ?????? . \url{http://blast.ncbi.nlm.nih.gov/Blast.cgi} \textit{BLAST: Basic Local Alignment Search Tool -Available} August 2018. p. 11. \bibitem[Ð?"? and ??????? ()]{b1}\label{b1} \textit{????????? ???????????. ??????: ????????}, ???? Ð?"? , .-Ð?" ??????? , ? . 2014. 357?. \bibitem[???????? et al. ()]{b8}\label{b8} \textit{?????????? ??????? ??????????? ??????? ???????? ? ?????????????? ????????. ??????? ?????????? ???????? ??????????? ????}, ? Ð?" ???????? , ? ? ????????-???????? , ? ? ??????? , ? ? Ð?"??????? , ? ? ????????? , ? ? ?????????? . \xref{http://dx.doi.org/10.15690/vramn.v70i1.1230}{10.15690/vramn.v70i1.1230}. \url{doi.org/10.15690/vramn.v70i1.1230} 2015. 70 p. . \bibitem[Roduit et al. ()]{b14}\label{b14} ‘Development of atopic dermatitis according to age of onset and association with early-life exposures’. C Roduit , R Frei , G Loss , G Buchele , J Weber , M Depner . \xref{http://dx.doi.org/10.1016/j.jaci.2012.02.043}{10.1016/j.jaci.2012.02.043}. \textit{J Allergy Clin Immunol} 2012. 130 (1) p. . \bibitem[Grunwald et al. ()]{b4}\label{b4} \textit{Dystrophic Epidermolysis Bullosa Associated with Eosinophilic Infiltrate and Elevated Serum IgE Pediatric Dermatology}, Marcelo H Grunwald , M D Boaz Amichai , MD , Ilana Avinoach , M D Tamar Kedar Ph , .D , Reuven Bergman , M . \xref{http://dx.doi.org/16-18.10.1046/j.1525-1470.1999.99004.x}{16-18.10.1046/j.1525-1470.1999.99004.x}. 1999. 16. \bibitem[Muraro et al.]{b6}\label{b6} \textit{EAACI Food Allergy and Anaphylaxis Guidelines. Diagnosis and management of food allergy}, A Muraro , T Werfel , K Hoffmann-Sommergruber , G Roberts , K Beyer , C Bindslev-Jensen . \xref{http://dx.doi.org/10.1111/all.12429}{10.1111/all.12429}. 69 p. . \bibitem[Woodcock et al. ()]{b15}\label{b15} ‘Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years’. A Woodcock , L A Lowe , C S Murray , B M Simpson , S D Pipis , P Kissen . \textit{Am. J. Respir. Crit. Care Med} 2004. 170 p. . \bibitem[Müller and Kiritsi (2017)]{b5}\label{b5} ‘Epidermolysis bullosa simplex complicated by allergic contact dermatitis caused by a hydrocolloid dressing’. S Müller , D Kiritsi . \xref{http://dx.doi.org/10.1111/cod.12672}{10.1111/cod.12672}. \textit{Contact Dermatitis} 2017 Mar. 76 (3) p. . \bibitem[Fine and Mellerio ()]{b2}\label{b2} ‘Extracutaneous manifestations and complications of inherited epidermolysis bullosa: part I. Epithelial associated tissues’. J D Fine , J E Mellerio . \xref{http://dx.doi.org/10.1016/j.jaad.2009.03.052}{10.1016/j.jaad.2009.03.052}. \textit{J Am Acad Dermatol} 2009. 61 (3) p. . \bibitem[Fine and Mellerio ()]{b3}\label{b3} ‘Extracutaneous manifestations and complications of inherited epidermolysis bullosa: part II. Other organs’. J D Fine , J E Mellerio . \xref{http://dx.doi.org/10.1016/j.jaad.2009.03.053}{10.1016/j.jaad.2009.03.053}. \textit{J Am Acad Dermatol} 2009. 61 (3) p. . \bibitem[Fine et al. ()]{b0}\label{b0} ‘Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification’. J D Fine , L Bruckner-Tuderman , R A Eady , E A Bauer , J W Bauer , C Has . \xref{http://dx.doi.org/10.1016/j.jaad.2014.01.903}{10.1016/j.jaad.2014.01.903}. \textit{J Am Acad Dermatol} 2014. 70 (6) p. . \bibitem[Library of Congress Cataloging in Publication Data Rajka, Georg. Essential aspects of atopic dermatitis / Georg Rajka]{b7}\label{b7} \textit{Library of Congress Cataloging in Publication Data Rajka, Georg. Essential aspects of atopic dermatitis / Georg Rajka}, \xref{http://dx.doi.org/10.1007/978-3-642-74766-3}{10.1007/978-3-642-74766-3}. \bibitem[Primer-BLAST (A tool for finding specific primers (2018)]{b10}\label{b10} \textit{Primer-BLAST (A tool for finding specific primers}, \url{http://www.ncbi.nlm.nih.gov/tools/primer-blast} August 2018. \bibitem[Stutte et al. ()]{b12}\label{b12} ‘Requirement of CCL17 for CCR7-and CXCR4-dependent migration of cutaneous dendritic cells’. S Stutte , T Quast , N Gerbitzki , T Savinko , N Novak , J Reifenberger , I Forster . \textit{Proceedings of the National Academy of Sciences} 2010. 107 (19) p. . \bibitem[Berin and Shreffler ()]{b13}\label{b13} ‘T(h)2 adjuvants: implications for food allergy’. M C Berin , W G Shreffler . \xref{http://dx.doi.org/10.1016/j.jaci.2008.04.023}{10.1016/j.jaci.2008.04.023}. \textit{J Allergy Clin Immunol} 2008. 121 (6) p. . \bibitem[Izadi et al. ()]{b11}\label{b11} ‘The Role of Skin Barrier in the Pathogenesis of Food Allergy’. N Izadi , M Luu , P Ong , J Tam . \textit{Children} 2015. 2 (3) p. . \end{bibitemlist} \end{document}