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\title{Matily Herbal Drink May Reduce Oxidative Stress, Hyperglycemia, and Hyperlipidemia and Increases Immunity-Case Study Reports}
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             \author[1]{John T.  Eapen}

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\date{\small \em Received: 12 December 2019 Accepted: 1 January 2020 Published: 15 January 2020}

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\begin{abstract}
        


Introduction-Oxygen is an element indispensable for all aerobic organisms to sustain life (1). Cells produce energy mainly in the mitochondria through oxidative phosphorylation, a series of electron transfer in the Electron Transport Chain (ETC), where oxygen is the final electron acceptor. During this process, it creates free radicles by the mitochondria. Oxidative stress produces free radicals. A 70 Kgs man may produce nearly 2 Kg of free radicals in his body in a year (2). It is comparatively a huge amount. Examples offree radicals with one or more unpaired electrons are superoxide, hydroxyl, andnitric oxide radicals (1, 3).A molecule like oxygen is stable when it shares its electrons in the paired state, when it loses or gains an extra electron, it becomes unstable. This condition leads them to "steal" or take it from other biomolecules. This process leaves the biomolecules in the oxidative state, which can start pathological conditions. For example, when Low-Density Lipoproteins when becomingoxidized, causes atherosclerosis in the blood vessels and cause plaques inside the arteries (4).

\end{abstract}


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\let\tabcellsep& 	 	 		 
\section[{Introduction}]{Introduction}\par
xygen is an element indispensable for all aerobic organisms to sustain life \hyperref[b0]{(1)}. Cells produce energy mainly in the mitochondria through oxidative phosphorylation, a series of electron transfer in the Electron Transport Chain (ETC), where oxygen is the final electron acceptor. During this process, it creates free radicles by the mitochondria. Oxidative stress produces free radicals. A 70 Kgs man may produce nearly 2 Kg of free radicals in his body in a year \hyperref[b1]{(2)}. It is comparatively a huge amount. Examples offree radicals with one or more unpaired electrons are superoxide, hydroxyl, andnitric oxide radicals \hyperref[b0]{(1,}\hyperref[b2]{3)}.\par
A molecule like oxygen is stable when it shares its electrons in the paired state, when it loses or gains an extra electron, it becomes unstable. This condition leads them to "steal" or take it from other biomolecules. This process leaves the biomolecules in the oxidative state, which can start pathological conditions. For example, when Low-Density Lipoproteins when becomingoxidized, causes atherosclerosis in the blood vessels and cause plaques inside the arteries (4).\par
Oxidative stress and disease remained a chicken and egg puzzle for a long time. Earlier it was believed that disease caused oxidative stress in the human body. Now the consensus among medical fraternity is that oxidative stress leads to various disease conditions.\par
"\par
The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements"(1). Antioxidants provide electrons needed for the stressed molecules and eliminate the free radicals \hyperref[b4]{(5)}.\par
There are many biochemical markers to measure the quantity of free radical status in the body. An excessive free radical produces fatigue in the human body, and we could take this as a general standard for the common man to assess the status of his body. Thus wellness of human health is inversely proportional to the free radicals in the body.\par
In this communication, we want to report a herbal drink (Matily Drink) we designed with natural products and tested in patients as case studies and among some volunteers. The pharmacological means of controlling hyperglycemia and hyperlipidemia are expensive for the poor masses without and income and insurance. Hence we developed a drink with natural ingredients and tested as a case study and on some volunteers. It reduced weight, hypoglycemia, and hyperlipidemia and gave better wellness feeling, even relieving wheezing difficulty in the patient.\par
In another case study, with a person who was a chain smoker and had a frequent cough, found relief for his cough after taking the drink for a month.\par
All the volunteers reported wellness feeling and found that they were energetic after taking this drink.\par
Based on these encouraging results, we were about to commercialize the product. However, now in the corona pandemic season, we bring it to the public domain hoping this drink may help people to boost their immunity and also some clinicians will try it on COVID 19 patients to see whether the severity of lung infection is reduced, as we found some benefit to the lungs in the above case studies. 
\section[{II.}]{II.} 
\section[{Rational behind Designing and Testing of Drink}]{Rational behind Designing and Testing of Drink}\par
In December 2017, an elderly male patient of 62 years with a history of cardiac asthma presented his case to a cardiologist. The cardiologist wanted to rule out ischemic cardiac asthma and suggested to the patient to undergo an angiogram. He prescribed the following medicines for the patient. Glucophage for blood sugar, Starvas to lower cholesterol, Clopilet A for thinning of blood, Losar 50 for blood pressure, Selaken XL as beta-blocker, Imdur 30mg for angina, and Dytor 10mg to remove excess water from the body.\par
The patient was already on Loser 50 for his blood pressure and he continued the same from the prescription list. He did not take other medicines because he was not sure whether he could take the medications regularly because of his poor economic condition. He took Dytor whenever he felt bloated. Proper exercises reduced bloated feeling, and in those days, he avoided Dytor. 
\section[{O}]{O}\par
The patient had diabetics for seven years. In the beginning, he took medication for one month, and he was feeling starving after taking the medicines. So he discontinued medication and started with diet and exercise to control the blood sugar levels. He used to take a small quantity meal four or five times a day. He used to walk at least two kilometers every day.\par
With the above prescription in his hand, the patient was searching for natural products that will help his condition. He developed a herbal drink with the following ingredients, and the reasons for selecting them are in the reference.\par
Okra has antidiabetic and anti-fatigue properties. It also reduces hyperlipidemia \hyperref[b5]{(6,}\hyperref[b6]{7)}. Mint leaves stimulate bile secretion, which uses cholesterol in the blood and may thus reduce cholesterol levels in the blood naturally \hyperref[b8]{(8)}. Curry leaves are good for liver as it has got anti hepatotoxicity effect \hyperref[b9]{(9,}\hyperref[b10]{10)}. Ginger has medicinal properties, and it has blood-thinning capability \hyperref[b11]{(11,}\hyperref[b12]{12)}. Lemon has various properties, and it is rich in Vitamin C \hyperref[b13]{(13,}\hyperref[b14]{14)}. Sometimes, we used lemon with its peels for making the drink. We mention elsewhere the health benefits of lemon peels \hyperref[b15]{(15)}. Sea salt with no anti-caking agent and sugar was added for taste (optional).\par
All ingredients and about 200 ml water was added in a blender. It was ground and blended with water for a few minutes. It was made up to 750 ml, and filtered through a strainer. When the constituents were whipped well, there was no trace of mucilage of okra in the drink. We give a concoction and procedure in note 1. 
\section[{III.}]{III.} 
\section[{Results and Discussion}]{Results and Discussion}\par
Table \hyperref[tab_0]{1} shows different parameters before and after taking the drink. Results are shown in Tables \hyperref[tab_1]{1 and 2} shows that Matily drink had some beneficial benefits to the patient.\par
The weight of the patient reduced from 95 kgs to 86kgs in about six months with no crash dieting or excess exercises. It was a natural way of shedding weight. It remained in that state as long as the patient limited his calorie intake was same and continued his daily walk of two km.\par
The total cholesterol of the patient was always between 220 to 240 mg/ dl in the past. But within three months, it lowered the total cholesterol to 182 mg/ dl. Similarly, HDL cholesterol was always between 35 to 38 in the past. It rose to 44 mg/dl within three months' with Matily Drink. Total cholesterol / HDL Cholesterol ratio was 4.1, and the LDL cholesterol / HDL cholesterol was 2.9, which was within the acceptable range (Table \hyperref[tab_1]{2}).\par
Matily, Drink influenced the blood sugar of the patient. The patient always took a limited amount of free sugar in his tea. He never avoided free sugar. His random blood sugar was 271 mg/dl in the beginning before he started taking Matily Drink. In three months, the fasting sugar was 123.5 mg /dl, and postprandial sugar was 167.5 mg /dl.\par
The patient had some wheezing problems in the beginning before starting the course. However, it reduced with Matily Drink. Before taking the MatilyDrink patient had difficulty climbing steps, especially in the morning when the temperatures were down. However, maybe because of weight reduction, reduction of blockage of blood vessels and, or improved microbiome in the gut, patient stopped having difficulty in climbing steps.\par
The case study presented here shows that certain natural products can control hyperglycemia and hyperlipidemia without depending on pharmacological methods. Cholesterol is essential for the body, and our body produces it in the liver. The patient did not prefer the use of statins to manipulate the synthesis of cholesterol by the liver. Similarly, instead of depending on pharmacological methods to change the blood thinning process, he preferred natural products like ginger. The drink also improved his lung function, and it reduced wheezing problems.\par
In another case study, a 48-year-old male on chain-smoking of, "beedies", a crudely prepared cigar, took Matily drink to boost his immune system during COVID 19 lockdown. He always had frequent cough, and it disappeared after one month.\par
We mention the properties of the ingredients used in the drink and its benefits on human health in the references given.\par
To conclude: In the case-studies given above show the benefits of Matily drink, especially to those who cannot afford pharmacological methods. The wellness feelings reported by volunteers could show the reduction of free radicals in their bodies with the drink. It reduces free radical generation in the human body when hyperglycemia and hyperlipidemia are under control. The body will increase its immunity. Since Matily drink shows a beneficial effect on the functioning of lungs, it is worth checking whether it could reduce the severity of disease in the COVID 19 patients. 
\section[{Note 1. Preparation of Matily Drink}]{Note 1. Preparation of Matily Drink}\par
Okra -one small one Ginger -about 2 cm long Mint -2 or 3 leaves Curry leaves -2 or 3 leaves Lemon -one Sea salt -to taste Sugar -to taste All these were blended in a mixer with about 200ml water, and finally strained. The total volume was made to 750 ml with water and the drink was consumed throughout the day.\par
Disclaimer: Any patients on pharmacological methods to control blood sugar, cholesterol, and blood thinning process should try this drink only under medical supervision.\begin{figure}[htbp]
\noindent\textbf{1} \par 
\begin{longtable}{P{0.37583547557840613\textwidth}P{0.15951156812339332\textwidth}P{0.16169665809768635\textwidth}P{0.15295629820051412\textwidth}}
Parameters measured\tabcellsep Before the drink\tabcellsep \multicolumn{2}{l}{After taking the drink}\\
\tabcellsep 12/12/2017\tabcellsep 24/03/2018\tabcellsep 19/06/2018\\
Blood glucose (mg/dl)\tabcellsep 271\tabcellsep \textunderscore \tabcellsep \\
(random)\tabcellsep \tabcellsep \tabcellsep \\
Blood glucose fasting\tabcellsep \textunderscore \tabcellsep 123.5\tabcellsep 134.7\\
(mg/dl)\tabcellsep \tabcellsep \tabcellsep \\
Blood glucose\tabcellsep \textunderscore \tabcellsep 167.5\tabcellsep 156.9\\
postprandial (mg/dl)\tabcellsep \tabcellsep \tabcellsep \\
Total cholesterol\tabcellsep 220\tabcellsep 182.7\tabcellsep \textunderscore \\
(mg/dl)\tabcellsep \tabcellsep \tabcellsep \\
HDL (mg/dl)\tabcellsep 38.0\tabcellsep 44.0\tabcellsep \textunderscore \\
LDL (mg/dl)\tabcellsep 130\tabcellsep 128.0\tabcellsep \textunderscore \\
Body weight (Kgs)\tabcellsep 95\tabcellsep 89\tabcellsep 86\end{longtable} \par
 
\caption{\label{tab_0}Table 1 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{2} \par 
\begin{longtable}{P{0.40492125984251964\textwidth}P{0.12716535433070866\textwidth}P{0.13385826771653542\textwidth}P{0.18405511811023623\textwidth}}
Test\tabcellsep Value\tabcellsep Units\tabcellsep Ref Range\\
Appearance\tabcellsep Clear\tabcellsep \tabcellsep \\
S. Total\tabcellsep 182.7\tabcellsep Mg/dl\tabcellsep 140 -240\\
cholesterol\tabcellsep \tabcellsep \tabcellsep \\
S.HDL\tabcellsep 44.0\tabcellsep Mg/dl\tabcellsep 30 -65\\
Cholesterol\tabcellsep \tabcellsep \tabcellsep \\
Triglycerides\tabcellsep 94.4\tabcellsep Mg/dl\tabcellsep 25 -160\\
LDL\tabcellsep 128.0\tabcellsep Mg/dl\tabcellsep 0 -130\\
cholesterol\tabcellsep \tabcellsep \tabcellsep \\
S.VLDL\tabcellsep 28.0\tabcellsep Mg/dl\tabcellsep 10 -30\\
Cholesterol\tabcellsep \tabcellsep \tabcellsep \\
TC/HDLC\tabcellsep 4.1\tabcellsep Mg/dl\tabcellsep 3 -5\\
ratio\tabcellsep \tabcellsep \tabcellsep \\
LDLC / HDLC\tabcellsep 2.9\tabcellsep Mg/dl\tabcellsep Up to 3.5\\
ratio\tabcellsep \tabcellsep \tabcellsep \end{longtable} \par
 
\caption{\label{tab_1}Table 2 :}\end{figure}
 		 		\backmatter   			 
\subsection[{Acknowledgments}]{Acknowledgments}\par
The author named the drink as Matily in remembrance of his father, Mr. M.E. Eapen (1926-2018), known among his American friends as "MAT" and who continuously encouraged the author to innovate methods to ease the suffering of the afflicted. 			  			  				\begin{bibitemlist}{1}
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\end{document}
