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\def\makelabel##1{\upshape ##1}}% } {\end{list}\end{raggedright}} \newenvironment{specHead}[2]% {\vspace{20pt}\hrule\vspace{10pt}% \phantomsection\label{#1}\markright{#2}% \pdfbookmark[2]{#2}{#1}% \hspace{-0.75in}{\bfseries\fontsize{16pt}{18pt}\selectfont#2}% }{} \def\TheFullDate{2020-01-15 (revised: 15 January 2020)} \def\TheID{\makeatother } \def\TheDate{2020-01-15} \title{Study of Maternal and Fetal Outcome in COVID-19 Pregnancies} \author{}\makeatletter \makeatletter \newcommand*{\cleartoleftpage}{% \clearpage \if@twoside \ifodd\c@page \hbox{}\newpage \if@twocolumn \hbox{}\newpage \fi \fi \fi } \makeatother \makeatletter \thispagestyle{empty} \markright{\@title}\markboth{\@title}{\@author} \renewcommand\small{\@setfontsize\small{9pt}{11pt}\abovedisplayskip 8.5\p@ plus3\p@ minus4\p@ \belowdisplayskip \abovedisplayskip \abovedisplayshortskip \z@ plus2\p@ \belowdisplayshortskip 4\p@ plus2\p@ minus2\p@ \def\@listi{\leftmargin\leftmargini \topsep 2\p@ plus1\p@ minus1\p@ \parsep 2\p@ plus\p@ minus\p@ \itemsep 1pt} } \makeatother \fvset{frame=single,numberblanklines=false,xleftmargin=5mm,xrightmargin=5mm} \fancyhf{} \setlength{\headheight}{14pt} \fancyhead[LE]{\bfseries\leftmark} \fancyhead[RO]{\bfseries\rightmark} \fancyfoot[RO]{} \fancyfoot[CO]{\thepage} \fancyfoot[LO]{\TheID} \fancyfoot[LE]{} \fancyfoot[CE]{\thepage} \fancyfoot[RE]{\TheID} \hypersetup{citebordercolor=0.75 0.75 0.75,linkbordercolor=0.75 0.75 0.75,urlbordercolor=0.75 0.75 0.75,bookmarksnumbered=true} \fancypagestyle{plain}{\fancyhead{}\renewcommand{\headrulewidth}{0pt}} \date{} \usepackage{authblk} \providecommand{\keywords}[1] { \footnotesize \textbf{\textit{Index terms---}} #1 } \usepackage{graphicx,xcolor} \definecolor{GJBlue}{HTML}{273B81} \definecolor{GJLightBlue}{HTML}{0A9DD9} \definecolor{GJMediumGrey}{HTML}{6D6E70} \definecolor{GJLightGrey}{HTML}{929497} \renewenvironment{abstract}{% \setlength{\parindent}{0pt}\raggedright \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt \textcolor{GJBlue}{\large\bfseries\abstractname\space} }{% \vskip8pt \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt } \usepackage[absolute,overlay]{textpos} \makeatother \usepackage{lineno} \linenumbers \begin{document} \author[1]{Dr. Pushpa C} \author[2]{Dr. Tushar T Palve} \renewcommand\Authands{ and } \date{\small \em Received: 13 December 2019 Accepted: 5 January 2020 Published: 15 January 2020} \maketitle \begin{abstract} Background: Coronavirus has created a pandemic and extraordinary global Health crisis. Coronavirus disease 2019 (COVID-19) is an illness caused by a novel coronavirus now called Severe acute respiratory syndrome coronavirus 2(SARS â??" COV-2). The virus can cause mild to severe respiratory diseases. The objective of this study is to summarize the Maternal and Fetal outcome in COVID-19 Pregnancies. Materials and Methods: We conducted an observational study over two months in the Department of Obstetrics, and Gynaecology, at a COVID care Centre, Cama and Albless Hospital, Mumbai. The study enrolled a total of 192 COVID positive pregnant women with inclusion and exclusion criteria. We noted, Antepartum, Intrapartum and Neonatal parameters using preformed proforma. Results: In our study, we observed that most COVID positive pregnant women belonged to the age group of 25-29years.COVID-19 is more prevalent among primigravida (35%). Preeclampsia (37%) is more commonly associated with COVID patients. The Majority of pregnancies (74%) extended till Term. Vaginal Delivery (60%) was the most common mode of Delivery. 10% COVID positive pregnant women admitted to the Intensive Care Unit. Maternal Mortality was 4% among COVID positive pregnancies. 13% of the babies tested COVID positive born to COVID positive mothers. NICU admission was required for 38% of the positive babies. Only one neonatal death occurred among COVID positive babies. Materials and Methods:We conducted an observational study over two months in the Department of Obstetrics, and Gynaecology, at a COVID care Centre, Cama and Albless Hospital, Mumbai. The study enrolled a total of 192 COVID positive pregnant women with inclusion and exclusion criteria. We noted, Antepartum, Intrapartum and Neonatal parameters using preformed proforma.Results: In our study, we observed that most COVID positive pregnant women belonged to the age group of 25-29years.COVID-19 is more prevalent among primigravida (35%). Preeclampsia (37%) is more commonly associated with COVID patients. The Majority of pregnancies (74%) extended till Term. Vaginal Delivery (60%) was the most common mode of Delivery. 10% COVID positive pregnant women admitted to the Intensive Care Unit. Maternal Mortality was 4% among COVID positive pregnancies. 13% of the babies tested COVID positive born to COVID positive mothers. NICU admission was required for 38% of the positive babies. Only one neonatal death occurred among COVID positive babies. \end{abstract} \keywords{COVID positive pregnancies, maternal and fetal outcome.} \begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) \textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark} \end{textblock*} \begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) \textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}} \end{textblock*} \let\tabcellsep& \section[{Introduction}]{Introduction}\par n 31 st Dec 2019, Wuhan Municipal Commission, China, reported a cluster of 27 pneumonia cases of unknown etiology. \hyperref[b10]{[1]} Samples tested positive for novel coronavirus.\par On 30 th January, 2020, WHO declared this outbreak of novel coronavirus as "A Public Health Emergency of International Concern" \hyperref[b0]{[2,}\hyperref[b1]{3]}. A large number of cases have been diagnosed Globally. On 11th March 2020-WHO declared COVID-19 as a Global Pandemic. \hyperref[b2]{[4]} Author ? ?: Department of obstetrics and gynecology, Grant Govt Medical College, Mumbai, India. e-mail: pushpacgowda@gmail.com Despite extensive studies on the epidemiology of COVID-19 infection, studies on pregnant women with COVID-19 diseases remain relatively less. The physiological changes occurring during pregnancy make pregnant women more vulnerable to corona infection.\par The purpose of this study is to summarize the maternal and fetal outcome in COVID-19 pregnancies. \section[{II.}]{II.} \section[{Material and Methods}]{Material and Methods}\par An observational study conducted over two months (June2020-July2020) in the Department of Obstetrics and Gynaecology, at a COVID care center, Cama and Albless Hospital, Mumbai, India. A total of 192 women tested positive for COVID-19 by RT-PCR method either antenatally or postnatally are included in this study. \section[{Inclusion Criteria}]{Inclusion Criteria}\par ? COVID positive women beyond 28 weeks of gestation. ? Women tested positive for the corona virus within five days of delivery.\par Exclusion Criteria ? Women who were less than 37 weeks of gestation. ? COVID negative pregnancies. ? Women tested COVID positive after five days of delivery.\par III. \section[{Results}]{Results}\par The study included a total of 192 women with COVID positive status diagnosed by the RT-PCR method, and we noted the following observations. \section[{Maternal age affected with COVID-19}]{Maternal age affected with COVID-19}\par Majority of the COVID positive pregnant women belonged to the age group of 25-29yrs(32\%), followed by 20-24yrs(30\%), 30-34yrs(25\%), 35-39yrs(9\%), 3\% are less than 20yrs and 1\% are above the age 40years. \section[{Parity of the patient}]{Parity of the patient}\par As per the observation made, COVID-19 is more prevalent in primigravida 35\%, followed by gravida two 27\%, 23\% is gravida three, 7\%, and 8\% are in seen in gravida four and five respectively. \section[{Symptoms of patients}]{Symptoms of patients}\par In our study, fever (65\%) was the most common symptom, followed by shortness of breath(60\%), cough(25\%), cold and anosmia (15\%), loss of taste sensation(10\%) vomiting(10\%), diarrhea(5\%) and generalized weakness(5\%). \section[{Comorbidities}]{Comorbidities}\par In this study, 37\% of COVID positive patients had Preeclampsia, thyroid disorders were found in 28\% women, 21\% were anemic, 9\% of patients had a past history of tuberculosis, 5\% had gestational diabetes. \section[{Period of gestation}]{Period of gestation}\par According to the study done in our hospital, 74\% of pregnancies extended till term, and 26\% delivered before 37 weeks of gestation. \section[{Outcome}]{Outcome}\par In our study, out of 192 patients, 116(60\%) delivered vaginally, 55(29\%) underwent cesarian section, and 21(11\%) patients were discharged with follow-up advice. \section[{Discussion}]{Discussion}\par In our study, the Majority of the COVID positive pregnant women belonged to the age group of 25-29yrs(32\%), followed by 20-24yrs(30\%), 30-34yrs(25\%). While a study conducted by MJ Blist and coworkers \hyperref[b3]{[5]} showed 6(46\%) out of 13 patients were of >35years of age.\par As per the observation, COVID-19 is more prevalent in primigravida 35\%, followed by gravida two 27\%.\par In our study, fever (65\%) was the most common symptom, followed by shortness of breath(60\%), cough(25\%), cold(10\%), vomiting(10\%), diarrhea(5\%) and generalized weakness(5\%).Similarly, in a study done by Paudel SS et al., fever was the most common symptom(17\%). \hyperref[b4]{[6]} In this study, 37\% of COVID positive patients had preeclampsia, 28\% had thyroid disorders, 21\% were anemic, 9\% of patients had a past history of tuberculosis, 5\% had gestational diabetes. Similar results were found in a study conducted by MJ Blist and coworkers, 23\% had pregnancy-induced hypertension, 15\% had a past history of lung disease, 8\% had gestational diabetes. \hyperref[b3]{[5]} According to the study done in our hospital, 74\% of pregnancies extended to term. 26\% delivered before term gestation while in a study conducted by Mullins and colleagues, \hyperref[b5]{[7]} 47\% of the COVID positive women delivered before 37 weeks of gestation.\par In our study, the majority of the patients delivered vaginally (60\%), and the cesarian section rate was 29\%, unlike the research conducted at BMJ where the cesarian section rate was 59\%. \hyperref[b6]{[8]} In our institution, 10\% of the patients required intensive care unit admission, seven patients required mechanical ventilator support, whereas in a study conducted by Vinayak Smith, Densearn Seo et al, 30\% of the patients required ICU admission. \hyperref[b7]{[9]} As per this study, there were 4\%(7 out of 192 patients) maternal death among COVID positive pregnant women at our institution. There was complication in 8 out of 20 ICU admitted patients with pneumonia, and six patients had acute respiratory distress syndrome, and two patients had septicemia. Three among seven patients were pre-eclamptic, and two patients had a previous history of Koch's etiology. Per se only two maternal death has occurred in the patients without having any pre-existing medical conditions, which accounts for 1\% of the maternal death rate.\par While in a study carried out by Forestieri, Migliore, et al., two out of seven (28\%) women died who were tested positive for the Corona virus. In our institution, among 171 babies born to COVID positive women, we noted that a higher percentage (77\%) of babies weighed more than 2500gms. 23\% of babies had weight less than 2500gms.\par According to this study, 38\% of the babies born to COVID mothers required NICU admission for various reasons; fetal respiratory distress being the most common cause. Similarly, in a study conducted by Yan-Ting Wu, et al. Of 30 neonates, 18 (60\%) required NICU admission, 12 of hospitalized neonates presented with features of pneumonia. \hyperref[b9]{[11]} As per the observation made, the majority of the babies born to COVID positive mothers tested negative (87\%), and 13\% tested positive for coronavirus. Similar results were found in a study done by Rui, Wang, and coworkers \hyperref[b11]{[12]}, where only 2\% of babies tested positive among 493 infants tested for SARS-COV-2.\par In our institution, we observed only one (5\%) neonatal death among 21 babies who tested positive for the Corona virus. The cause of death was type 1 respiratory failure with thick meconium aspiration syndrome with persistent pulmonary hypertension with septic shock, 95\% of COVID positive babies recovered successfully.\par V. \section[{Conclusion}]{Conclusion}\par In our study, we observed that the COVID-19 could cause mild-lethal disease in pregnant women and neonates. Most of the women are asymptomatic or have a mild illness, but some of them require intensive care. Pregnancy represents highly adaptive immunity, allowing pregnant women to become tolerant of her fetus yet remain immunocompetent. So per se, pregnancy and childbirth do not increase the risk of acquiring SARS-COV-2 infection. However, pregnancy with high-risk factors like age >35years, pre-eclampsia, preexisting lung pathology, diabetes, obesity increases the inflammatory response (cytokine storm) and may worsen the clinical course of COVID-19. Health care providers should be aware of the epidemiology of Coronavirus disease. The evidence of Vertical transmission appears equivocal. There is no evidence to suggest contraindication to vaginal delivery. Use of proper precautionary measures like regular ANC checkups, use of mask, sanitization, maintaining social distance, educating the community regarding the same, early diagnosis, cater to the required investigations, close follow up, isolation, or in-patient admission if required reduces the maternal and fetal morbidity and mortality.\par Modular infrastructure, facilities offered at Tertiary Care Centre such as well-equipped operation theatre, NICU, ventilator availability, NST monitoring, monitoring of feto-maternal wellbeing, expert obstetrician, neonatologist, anesthesiologist, medicine team plays a critical role in safe delivery and good health of both mother and neonate.\begin{figure}[htbp] \noindent\textbf{7912}\includegraphics[]{image-2.png} \caption{\label{fig_2}7 . 9 . 12 .}\end{figure} \footnote{© 2020 Global Journals} \backmatter \begin{bibitemlist}{1} \bibitem[Mullins et al.]{b5}\label{b5} \textit{}, E Mullins , Evans , Viner . \xref{http://dx.doi.org/10.1002/uog.22014}{10.1002/uog.22014}. \url{http://doi.org/10.1002/uog.22014} \bibitem[Stefano Forestieri (ed.)]{b8}\label{b8} \textit{}, \xref{http://dx.doi.org/10.1080/14767058.2020.1771692}{10.1080/14767058.2020.1771692}. \url{http://doi.org/10.1080/14767058.2020.1771692} Stefano Forestieri (ed.) 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