\documentclass[11pt,twoside]{article}\makeatletter

\IfFileExists{xcolor.sty}%
  {\RequirePackage{xcolor}}%
  {\RequirePackage{color}}
\usepackage{colortbl}
\usepackage{wrapfig}
\usepackage{ifxetex}
\ifxetex
  \usepackage{fontspec}
  \usepackage{xunicode}
  \catcode`⃥=\active \def⃥{\textbackslash}
  \catcode`❴=\active \def❴{\{}
  \catcode`❵=\active \def❵{\}}
  \def\textJapanese{\fontspec{Noto Sans CJK JP}}
  \def\textChinese{\fontspec{Noto Sans CJK SC}}
  \def\textKorean{\fontspec{Noto Sans CJK KR}}
  \setmonofont{DejaVu Sans Mono}
  
\else
  \IfFileExists{utf8x.def}%
   {\usepackage[utf8x]{inputenc}
      \PrerenderUnicode{–}
    }%
   {\usepackage[utf8]{inputenc}}
  \usepackage[english]{babel}
  \usepackage[T1]{fontenc}
  \usepackage{float}
  \usepackage[]{ucs}
  \uc@dclc{8421}{default}{\textbackslash }
  \uc@dclc{10100}{default}{\{}
  \uc@dclc{10101}{default}{\}}
  \uc@dclc{8491}{default}{\AA{}}
  \uc@dclc{8239}{default}{\,}
  \uc@dclc{20154}{default}{ }
  \uc@dclc{10148}{default}{>}
  \def\textschwa{\rotatebox{-90}{e}}
  \def\textJapanese{}
  \def\textChinese{}
  \IfFileExists{tipa.sty}{\usepackage{tipa}}{}
\fi
\def\exampleFont{\ttfamily\small}
\DeclareTextSymbol{\textpi}{OML}{25}
\usepackage{relsize}
\RequirePackage{array}
\def\@testpach{\@chclass
 \ifnum \@lastchclass=6 \@ne \@chnum \@ne \else
  \ifnum \@lastchclass=7 5 \else
   \ifnum \@lastchclass=8 \tw@ \else
    \ifnum \@lastchclass=9 \thr@@
   \else \z@
   \ifnum \@lastchclass = 10 \else
   \edef\@nextchar{\expandafter\string\@nextchar}%
   \@chnum
   \if \@nextchar c\z@ \else
    \if \@nextchar l\@ne \else
     \if \@nextchar r\tw@ \else
   \z@ \@chclass
   \if\@nextchar |\@ne \else
    \if \@nextchar !6 \else
     \if \@nextchar @7 \else
      \if \@nextchar (8 \else
       \if \@nextchar )9 \else
  10
  \@chnum
  \if \@nextchar m\thr@@\else
   \if \@nextchar p4 \else
    \if \@nextchar b5 \else
   \z@ \@chclass \z@ \@preamerr \z@ \fi \fi \fi \fi
   \fi \fi  \fi  \fi  \fi  \fi  \fi \fi \fi \fi \fi \fi}
\gdef\arraybackslash{\let\\=\@arraycr}
\def\@textsubscript#1{{\m@th\ensuremath{_{\mbox{\fontsize\sf@size\z@#1}}}}}
\def\Panel#1#2#3#4{\multicolumn{#3}{){\columncolor{#2}}#4}{#1}}
\def\abbr{}
\def\corr{}
\def\expan{}
\def\gap{}
\def\orig{}
\def\reg{}
\def\ref{}
\def\sic{}
\def\persName{}\def\name{}
\def\placeName{}
\def\orgName{}
\def\textcal#1{{\fontspec{Lucida Calligraphy}#1}}
\def\textgothic#1{{\fontspec{Lucida Blackletter}#1}}
\def\textlarge#1{{\large #1}}
\def\textoverbar#1{\ensuremath{\overline{#1}}}
\def\textquoted#1{‘#1’}
\def\textsmall#1{{\small #1}}
\def\textsubscript#1{\@textsubscript{\selectfont#1}}
\def\textxi{\ensuremath{\xi}}
\def\titlem{\itshape}
\newenvironment{biblfree}{}{\ifvmode\par\fi }
\newenvironment{bibl}{}{}
\newenvironment{byline}{\vskip6pt\itshape\fontsize{16pt}{18pt}\selectfont}{\par }
\newenvironment{citbibl}{}{\ifvmode\par\fi }
\newenvironment{docAuthor}{\ifvmode\vskip4pt\fontsize{16pt}{18pt}\selectfont\fi\itshape}{\ifvmode\par\fi }
\newenvironment{docDate}{}{\ifvmode\par\fi }
\newenvironment{docImprint}{\vskip 6pt}{\ifvmode\par\fi }
\newenvironment{docTitle}{\vskip6pt\bfseries\fontsize{22pt}{25pt}\selectfont}{\par }
\newenvironment{msHead}{\vskip 6pt}{\par}
\newenvironment{msItem}{\vskip 6pt}{\par}
\newenvironment{rubric}{}{}
\newenvironment{titlePart}{}{\par }

\newcolumntype{L}[1]{){\raggedright\arraybackslash}p{#1}}
\newcolumntype{C}[1]{){\centering\arraybackslash}p{#1}}
\newcolumntype{R}[1]{){\raggedleft\arraybackslash}p{#1}}
\newcolumntype{P}[1]{){\arraybackslash}p{#1}}
\newcolumntype{B}[1]{){\arraybackslash}b{#1}}
\newcolumntype{M}[1]{){\arraybackslash}m{#1}}
\definecolor{label}{gray}{0.75}
\def\unusedattribute#1{\sout{\textcolor{label}{#1}}}
\DeclareRobustCommand*{\xref}{\hyper@normalise\xref@}
\def\xref@#1#2{\hyper@linkurl{#2}{#1}}
\begingroup
\catcode`\_=\active
\gdef_#1{\ensuremath{\sb{\mathrm{#1}}}}
\endgroup
\mathcode`\_=\string"8000
\catcode`\_=12\relax

\usepackage[a4paper,twoside,lmargin=1in,rmargin=1in,tmargin=1in,bmargin=1in,marginparwidth=0.75in]{geometry}
\usepackage{framed}

\definecolor{shadecolor}{gray}{0.95}
\usepackage{longtable}
\usepackage[normalem]{ulem}
\usepackage{fancyvrb}
\usepackage{fancyhdr}
\usepackage{graphicx}
\usepackage{marginnote}

\renewcommand{\@cite}[1]{#1}


\renewcommand*{\marginfont}{\itshape\footnotesize}

\def\Gin@extensions{.pdf,.png,.jpg,.mps,.tif}

  \pagestyle{fancy}

\usepackage[pdftitle={Pulmonary Lymphangioleiomyomatosis and Extra-Pulmonary Lymphangioleiomyomas in Postmenopausal Women},
 pdfauthor={}]{hyperref}
\hyperbaseurl{}

	 \paperwidth210mm
	 \paperheight297mm
              
\def\@pnumwidth{1.55em}
\def\@tocrmarg {2.55em}
\def\@dotsep{4.5}
\setcounter{tocdepth}{3}
\clubpenalty=8000
\emergencystretch 3em
\hbadness=4000
\hyphenpenalty=400
\pretolerance=750
\tolerance=2000
\vbadness=4000
\widowpenalty=10000

\renewcommand\section{\@startsection {section}{1}{\z@}%
     {-1.75ex \@plus -0.5ex \@minus -.2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\Large\bfseries}}
\renewcommand\subsection{\@startsection{subsection}{2}{\z@}%
     {-1.75ex\@plus -0.5ex \@minus- .2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\Large}}
\renewcommand\subsubsection{\@startsection{subsubsection}{3}{\z@}%
     {-1.5ex\@plus -0.35ex \@minus -.2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\large}}
\renewcommand\paragraph{\@startsection{paragraph}{4}{\z@}%
     {-1ex \@plus-0.35ex \@minus -0.2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\normalsize}}
\renewcommand\subparagraph{\@startsection{subparagraph}{5}{\parindent}%
     {1.5ex \@plus1ex \@minus .2ex}%
     {-1em}%
     {\reset@font\normalsize\bfseries}}


\def\l@section#1#2{\addpenalty{\@secpenalty} \addvspace{1.0em plus 1pt}
 \@tempdima 1.5em \begingroup
 \parindent \z@ \rightskip \@pnumwidth 
 \parfillskip -\@pnumwidth 
 \bfseries \leavevmode #1\hfil \hbox to\@pnumwidth{\hss #2}\par
 \endgroup}
\def\l@subsection{\@dottedtocline{2}{1.5em}{2.3em}}
\def\l@subsubsection{\@dottedtocline{3}{3.8em}{3.2em}}
\def\l@paragraph{\@dottedtocline{4}{7.0em}{4.1em}}
\def\l@subparagraph{\@dottedtocline{5}{10em}{5em}}
\@ifundefined{c@section}{\newcounter{section}}{}
\@ifundefined{c@chapter}{\newcounter{chapter}}{}
\newif\if@mainmatter 
\@mainmattertrue
\def\chaptername{Chapter}
\def\frontmatter{%
  \pagenumbering{roman}
  \def\thechapter{\@roman\c@chapter}
  \def\theHchapter{\roman{chapter}}
  \def\thesection{\@roman\c@section}
  \def\theHsection{\roman{section}}
  \def\@chapapp{}%
}
\def\mainmatter{%
  \cleardoublepage
  \def\thechapter{\@arabic\c@chapter}
  \setcounter{chapter}{0}
  \setcounter{section}{0}
  \pagenumbering{arabic}
  \setcounter{secnumdepth}{6}
  \def\@chapapp{\chaptername}%
  \def\theHchapter{\arabic{chapter}}
  \def\thesection{\@arabic\c@section}
  \def\theHsection{\arabic{section}}
}
\def\backmatter{%
  \cleardoublepage
  \setcounter{chapter}{0}
  \setcounter{section}{0}
  \setcounter{secnumdepth}{2}
  \def\@chapapp{\appendixname}%
  \def\thechapter{\@Alph\c@chapter}
  \def\theHchapter{\Alph{chapter}}
  \appendix
}
\newenvironment{bibitemlist}[1]{%
   \list{\@biblabel{\@arabic\c@enumiv}}%
       {\settowidth\labelwidth{\@biblabel{#1}}%
        \leftmargin\labelwidth
        \advance\leftmargin\labelsep
        \@openbib@code
        \usecounter{enumiv}%
        \let\p@enumiv\@empty
        \renewcommand\theenumiv{\@arabic\c@enumiv}%
	}%
  \sloppy
  \clubpenalty4000
  \@clubpenalty \clubpenalty
  \widowpenalty4000%
  \sfcode`\.\@m}%
  {\def\@noitemerr
    {\@latex@warning{Empty `bibitemlist' environment}}%
    \endlist}

\def\tableofcontents{\section*{\contentsname}\@starttoc{toc}}
\parskip0pt
\parindent1em
\def\Panel#1#2#3#4{\multicolumn{#3}{){\columncolor{#2}}#4}{#1}}
\newenvironment{reflist}{%
  \begin{raggedright}\begin{list}{}
  {%
   \setlength{\topsep}{0pt}%
   \setlength{\rightmargin}{0.25in}%
   \setlength{\itemsep}{0pt}%
   \setlength{\itemindent}{0pt}%
   \setlength{\parskip}{0pt}%
   \setlength{\parsep}{2pt}%
   \def\makelabel##1{\itshape ##1}}%
  }
  {\end{list}\end{raggedright}}
\newenvironment{sansreflist}{%
  \begin{raggedright}\begin{list}{}
  {%
   \setlength{\topsep}{0pt}%
   \setlength{\rightmargin}{0.25in}%
   \setlength{\itemindent}{0pt}%
   \setlength{\parskip}{0pt}%
   \setlength{\itemsep}{0pt}%
   \setlength{\parsep}{2pt}%
   \def\makelabel##1{\upshape ##1}}%
  }
  {\end{list}\end{raggedright}}
\newenvironment{specHead}[2]%
 {\vspace{20pt}\hrule\vspace{10pt}%
  \phantomsection\label{#1}\markright{#2}%

  \pdfbookmark[2]{#2}{#1}%
  \hspace{-0.75in}{\bfseries\fontsize{16pt}{18pt}\selectfont#2}%
  }{}
      \def\TheFullDate{2020 2020-01-15 (revised: 30 Year 2020 15 January 2020)}
\def\TheID{\makeatother }
\def\TheDate{2020 2020-01-15}
\title{Pulmonary Lymphangioleiomyomatosis and Extra-Pulmonary Lymphangioleiomyomas in Postmenopausal Women}
\author{}\makeatletter 
\makeatletter
\newcommand*{\cleartoleftpage}{%
  \clearpage
    \if@twoside
    \ifodd\c@page
      \hbox{}\newpage
      \if@twocolumn
        \hbox{}\newpage
      \fi
    \fi
  \fi
}
\makeatother
\makeatletter
\thispagestyle{empty}
\markright{\@title}\markboth{\@title}{\@author}
\renewcommand\small{\@setfontsize\small{9pt}{11pt}\abovedisplayskip 8.5\p@ plus3\p@ minus4\p@
\belowdisplayskip \abovedisplayskip
\abovedisplayshortskip \z@ plus2\p@
\belowdisplayshortskip 4\p@ plus2\p@ minus2\p@
\def\@listi{\leftmargin\leftmargini
               \topsep 2\p@ plus1\p@ minus1\p@
               \parsep 2\p@ plus\p@ minus\p@
               \itemsep 1pt}
}
\makeatother
\fvset{frame=single,numberblanklines=false,xleftmargin=5mm,xrightmargin=5mm}
\fancyhf{} 
\setlength{\headheight}{14pt}
\fancyhead[LE]{\bfseries\leftmark} 
\fancyhead[RO]{\bfseries\rightmark} 
\fancyfoot[RO]{}
\fancyfoot[CO]{\thepage}
\fancyfoot[LO]{\TheID}
\fancyfoot[LE]{}
\fancyfoot[CE]{\thepage}
\fancyfoot[RE]{\TheID}
\hypersetup{citebordercolor=0.75 0.75 0.75,linkbordercolor=0.75 0.75 0.75,urlbordercolor=0.75 0.75 0.75,bookmarksnumbered=true}
\fancypagestyle{plain}{\fancyhead{}\renewcommand{\headrulewidth}{0pt}}

\date{}
\usepackage{authblk}

\providecommand{\keywords}[1]
{
\footnotesize
  \textbf{\textit{Index terms---}} #1
}

\usepackage{graphicx,xcolor}
\definecolor{GJBlue}{HTML}{273B81}
\definecolor{GJLightBlue}{HTML}{0A9DD9}
\definecolor{GJMediumGrey}{HTML}{6D6E70}
\definecolor{GJLightGrey}{HTML}{929497} 

\renewenvironment{abstract}{%
   \setlength{\parindent}{0pt}\raggedright
   \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}}
   \vskip16pt
   \textcolor{GJBlue}{\large\bfseries\abstractname\space}
}{%   
   \vskip8pt
   \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}}
   \vskip16pt
}

\usepackage[absolute,overlay]{textpos}

\makeatother 
      \usepackage{lineno}
      \linenumbers
      
\begin{document}

             \author[1]{Orozco  Maira}

             \author[2]{Garay M.  Florencia}

             \author[3]{Mattar  Daniel}

\renewcommand\Authands{ and }

\date{\small \em Received: 13 December 2019 Accepted: 1 January 2020 Published: 15 January 2020}

\maketitle


\begin{abstract}
        


Lymphangioleiomyomatosis (LAM) is a rare disorder of unknown cause characterized by progressive cystic destruction of the lung, lymphatic abnormalities and abdominal tumors. It occurs almost exclusively in women of fertile age due to a hormonal influence, for this reason it is extremely rare in post-menopausal patients. While LAM is a systemic disease, the main manifestations are pulmonary. Lymphangioleiomyomas are larger cystic masses; these most commonly occur in the abdomen, retroperitoneum and pelvis but occasionally in the mediastinum and neck. In the cases of older women the disease presents a similar clinical manifestation than younger?s female, with the exception that the clinical course is benign and longer.

\end{abstract}


\keywords{Lymphangioleimyomatosis, mediastinal lymphangioleiomyomas, postmenopausal women, cystics lungs.}

\begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) 
\textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark}
\end{textblock*}

\begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) 
\textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}}
\end{textblock*}


\let\tabcellsep& 	 	 		 \par
of unknown cause characterized by progressive cystic destruction of the lung, lymphatic abnormalities and abdominal tumors. It occurs almost exclusively in women of fertile age due to a hormonal influence, for this reason it is extremely rare in post-menopausal patients. While LAM is a systemic disease, the main manifestations are pulmonary. Lymphangioleiomyomas are larger cystic masses; these most commonly occur in the abdomen, retroperitoneum and pelvis but occasionally in the mediastinum and neck. In the cases of older women the disease presents a similar clinical manifestation than younger's female, with the exception that the clinical course is benign and longer.\par
Resumen-La linfangioleiomiomatosis es una enfermedad poco común de causa desconocida que se caracteriza por la destrucción quística progresiva del pulmón, anomalías linfáticas y tumores abdominales. Ocurre casi exclusivamente en mujeres en edad fértil debido a influencia hormonal, por esta razón es extremadamente raro en pacientes posmenopáusicas. Si bien la LAM es una enfermedad sistémica, las principales manifestaciones son pulmonares. Los linfangioleiomiomas son masas quísticas grandes; se encuentran con mayor frecuencia en el abdomen, retroperitoneo y pelvis, pero ocasionalmente en el mediastino y el cuello. En los casos de mujeres mayores la enfermedad presenta una manifestación clínica similar a la de las mujeres más jóvenes, con la excepción de que el curso clínico es más benigno y prolongado.\par
Resumo-Linfangioleiomiomatose é uma doença rara de causa desconhecida, caracterizada por destruição cística progressiva do pulmão, anormalidades linfáticas e tumores abdominais. Ocorre quase exclusivamente em mulheres em idade fértil devido a uma influência hormonal, por isso é extremamente raro em pacientes pós-menopáusicas. Embora a LAM seja uma doença sistêmica, as principais manifestações são pulmonares. Linfangioleiomiomas são massas císticas maiores; estes ocorrem mais comumente no abdômen, retroperitônio e pelve, mas ocasionalmente no mediastino e pescoço. Nos casos de mulheres mais velhas, a doença apresenta manifestação clínica semelhante à das mulheres mais jovens, exceto que o curso clínico é benigno e mais longo. 
\section[{Keywords:}]{Keywords:}\par
Lymphangioleimyomatosis, mediastinal lymphangioleiomyomas, postmenopausal women, cystics lungs.    
\section[{Discussion}]{Discussion}\par
Lymphangioleiomyomatosis (LAM) is a rare disorder of unknown cause characterized by peribronchial, perivascular, and perilymphatic proliferation of abnormal smooth muscle cells (1) leading to progressive cystic destruction of the lung, lymphatic abnormalities and abdominal tumors \hyperref[b1]{(2)}.\par
It occurs almost exclusively in women of fertile age due to a hormonal influence, for this reason it is extremely rare in post-menopausal patients. In these cases it is usually associated with hormone replacement therapies. It is known that this disease is strongly associated with other conditions, such as tuberous sclerosis and renal angiomyolipomas (3).\par
In the cases of older women the disease presents a similar clinical manifestation than younger's female, with the exception that the clinical course is benign and longer after menopause (3). 
\section[{a) Physiopathology}]{a) Physiopathology}\par
Pathologically, LAM cells contain proteins related to melanoma, including glycoprotein 100, the HMB-45 and receptors for estrogens and progesterone. These cells have a high proliferation capacity, damaging the airway through the production of metalloproteinases with the obstructing capillaries, lymphatics and the airway. Lymphatic obstruction usually causes chylothorax and airway obstruction conditions an obstructive functional pattern. A 30\% -40\% of cases present pneumothorax, which can be bilateral and recurrent (4). 
\section[{b) Pulmonary Manifestations}]{b) Pulmonary Manifestations}\par
While LAM is a systemic disease, the main manifestations are pulmonary. In lungs, the atypical progressive proliferation is seen around small airways giving rise to cystic pulmonary changes and progressive respiratory failure \hyperref[b4]{(5)}.\par
The pulmonary symptoms tend to dominate the clinical course, with the most common features being pneumothorax, progressive dyspnoea and chylous pleural effusions .Other respiratory symptoms include cough, haemoptysis and chyloptysis. Dyspnea is suffered by the vast majority of patients with LAM and is the result of airflow obstruction and replacement of the lung parenchyma by cysts. Approximately two thirds of patients will have a pneumothorax at some point in their clinical course, which are recurrent in most and a cause of significant morbidity. Chylous pleural effusions are less common, but again can be difficult to treat conservatively and tend to recur after simple aspiration. Haemoptysis and chyloptysis are due to LAM cell obstruction of pulmonary capillaries and lymphatics, respectively, and both occur in a small number of patients \hyperref[b1]{(2)}.\par
The chest radiograph often appears normal in early disease, although it may show pleural effusions or pneumothorax (2) in a 40\% de los pacientes \hyperref[b6]{(7)}.\par
The main pulmonary finding includes cysts these are a thin-walled (usually <3 mm), well-defined and circumscribed, air-or fluid-containing lesion 1 cm or more in diameter, nevertheless, some do not have walls and others have an irregular configuration \hyperref[b6]{(7)}. Cysts are scattered in a bilateral roughly symmetric pattern, without any lobar predominance. These cysts range in size from barely perceptible to several centimeters and in number from a few scattered cysts to near complete replacement of the lung parenchyma (2) with increased lung volume \hyperref[b6]{(7)}. 
\section[{c) Extrapulmonary manifestations}]{c) Extrapulmonary manifestations}\par
Extrapulmonary manifestations of LAM are angiomyolipoma, which occur mostly in the kidneys, chylous ascites, abdominal lymphadenopathy and large cystic lymphatic masses termed lymphangioleiomyomas \hyperref[b1]{(2)}. Lymphangioleiomyomas are larger cystic masses; these most commonly occur in the abdomen, retroperitoneum and pelvis but occasionally in the mediastinum and neck. Symptoms associated with lymphangioleiomyomas are nausea, bloating, abdominal distension, peripheral oedema and urinary symptoms \hyperref[b5]{(6)}.\par
Abdominal findings may be present in more than 70\% of patients with LAM, and the most common abdominal finding is renal angiomyolipoma. These are often small (<1 cm), multiple, bilateral, and asymptomatic \hyperref[b6]{(7)} and can usually be identified by CT because of the presence of fat, which gives lesions a characteristic CT appearance. MRI may be adequate for the diagnosis when iodinated contrast is contraindicated. Diagnostic difficulty may arise in the small number of angiomyolipomas showing little evidence of fat \hyperref[b1]{(2)}.\par
Lymphangioleiomyomas are produced by a proliferation of smooth muscle cells in the lymph vessels with the production of cystic masses consistent with dilatations of the abdominal lymph vessels due to lymphatic obstruction \hyperref[b6]{(7)}. Lymphangioleiomyomas are usually localized in the mediastinum, retroperitoneum, and pelvis along the axial lymphatics and can appear larger in the evening due to accumulation of chyle in the cystic structures \hyperref[b1]{(2)}.\par
Enlarged lymph nodes are described in up to 40\% of cases and Chylous Ascites is an unusual abdominal complication of LAM that can occur in the absence of pleural effusion \hyperref[b6]{(7)}. 
\section[{d) Imaging Diagnosis}]{d) Imaging Diagnosis}\par
High-resolution CT (HRCT) is the recommended imaging technique for LAM. The diagnosis of LAM is probable when a characteristic lung CT is found in a patient with compatible clinical history or when compatible CT features are present in a patient with angiomyolipoma or chylous effusion (2). 
\section[{e) Differential diagnoses}]{e) Differential diagnoses}\par
Within the main differential diagnoses we mention tuberous sclerosis, pulmonary Langerhans cell histiocytosis, emphysema, and pulmonary fibrosis \hyperref[b7]{(8)}. 
\section[{f) Treatment}]{f) Treatment}\par
The treatment of this pathology is based on treating complications. Hormone treatment should be discouraged except in individual cases with rapid progression of the disease in which progesterone may be trialled \hyperref[b1]{(2)}. The first successful lung transplantation for LAM was performed in 1983. However, is unclear whether lung transplantation actually improves longterm survival in patients with LAM compared with continued medical management \hyperref[b7]{(8)}. 
\section[{III.}]{III.} 
\section[{Conclusion}]{Conclusion}\par
LAM is a systemic disease, the main manifestations are pulmonary. The extrapulmonary manifestations are unusual. The clinical course is benign and longer in post-menopausal women.\begin{figure}[htbp]
\noindent\textbf{}\includegraphics[]{image-2.png}
\caption{\label{fig_0}}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{2}\includegraphics[]{image-3.png}
\caption{\label{fig_1}Fig. 2 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{3}\includegraphics[]{image-4.png}
\caption{\label{fig_2}Fig. 3 :}\end{figure}
 		 		\backmatter  			  				\begin{bibitemlist}{1}
\bibitem[Lymphangioleiomyomatosis ()]{b5}\label{b5} 	 		\textit{},  		 			Johnson S Lymphangioleiomyomatosis 		.  	 	 		\textit{European Respiratory Journal}  		2006. 27 p. .  	 
\bibitem[Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P) ()]{b0}\label{b0} 	 		\textit{Groupe d'Etudes et de Recherche sur les Maladies "Orphelines" Pulmonaires (GERM"O"P)},  		1999.  	 
\bibitem[Soler-Ferrer ()]{b2}\label{b2} 	 		‘Lymphangioleiomyomatosis in a Post-Menopausal Women. Archivos de Bronconeumonología’.  		 			C Soler-Ferrer 		.  	 	 		\textit{Núm. 3}  		2010. 46 p. 150.  	 
\bibitem[Lamrani ()]{b4}\label{b4} 	 		‘Lymphangioleiomyomatosis: An unusual age of diagnosis with literature review’.  		 			Y A Lamrani 		.  	 	 		\textit{International Journal of Diagnostic Imaging}  		2014. 1  (1) .  	 
\bibitem[Pallisa]{b6}\label{b6} 	 		‘Lymphangioleiomyomatosis: Pulmonary and Abdominal Findings with Pathologic Correlation’.  		 			E Pallisa 		.  	 	 		\textit{RadioGraphics}  		22  (1) .  	 
\bibitem[Abbott]{b7}\label{b7} 	 		‘Lymphangioleiomyomatosis: Radiologic-Pathologic Correlation’.  		 			G Abbott 		.  	 	 		\textit{RadioGraphicsVol}  		25  (3) .  	 
\bibitem[Harari and Moss (2011)]{b1}\label{b1} 	 		‘Lymphangioleiomyomatosis: what do we know and what are we looking for?’.  		 			S Harari 		,  		 			Torre S Moss 		,  		 			J 		.  	 	 		\textit{Eur Respir Rev}  		2011 March. 20  (119)  p. .  	 
\bibitem[Rafael ()]{b3}\label{b3} 	 		‘Pulmonary lymphangioleiomyomatosis: Report of one case’.  		 			S Rafael 		.  	 	 		\textit{Rev Méd Chile}  		2009. 137 p. .  	 
\end{bibitemlist}
 			 		 	 
\end{document}
