# Introduction ne of the achievements of modern medicine is the development of principles for prescribing immunotherapy to patients, consisting of assessing the immune status, verifying the diagnosis of the underlying disease, comparing the signaling mechanisms of pathology and targets of the modulator, and testing the correction option in practice. Considering the certain complexity of the implementation of the above technologies, permission was given to develop a simplified algorithm for identifying the main immunopathological syndromes by the questionnaire method, to carry out auxiliary corrective therapy with traditional drugs, and to simplify the appointment of targeted immunotherapy to patients based on a set of programs for the Electronic Computing Machine, taking into account the laboratory examination of patients. 1,2,3,4 II. # Pre-Laboratory Analysis a) Identification of immunocompromised persons by the method of pre-laboratory analysis Table 1 shows questionnaires for identifying 11 immunopathological syndromes, which include a predisposition to immune disorders, secondary immunodeficiency, infectious bacterial, viral, allergic, pseudo-allergic, metabolic, autoimmune and immunocomplex, lymphoproliferative, other syndromes, and concomitant chronic and combined diseases and conditions. 5 Table 1: Immunopathological syndromes I. Immune Disorder Predisposition Syndrome 1. Professional harm. 2. Bad habits: smoking, alcohol, drug addiction, substance abuse, etc. 3. Frequent cooling, overheating, change of climatic zones. 4. Metabolic disorders, obesity. 5. Transfer in the last 3-6 months of great stress, burns, poisoning, physical exertion, radiation. 6. Risk groups -childhood, pregnancy, childbirth, menopause, old age. 7. Long-term stay in isolated spaces (prisons, submarines, spaceships). 8. Transplantation of foreign organs, tissues, implants. II. Secondary Immunodeficiency Syndromes 1. Syndrome of immune deficiency in children 1 year of life, is manifested by frequent, chronic infectious lesions of opportunistic pathogens, low virulent flora, viruses, chlamydia. 2. The syndrome of immunodeficiency in the elderly is manifested by frequent viral, bacterial, fungal infections of the bronchopulmonary, digestive, and genitourinary systems. 3. Syndrome of general variable immunodeficiency, which implies protracted recurrent bacterial infections of the respiratory, intestinal tracts, paranasal sinuses. 4. Post-tonsillectomy syndrome, which is characterized by recurrent infections of the nasopharynx, upper respiratory tract, hyperplasia of the lymphoid tissue of the nasopharynx. 5. Post-splenectomy syndrome with increased sensitivity to a wide range of infections. 6. Post-appendicectomy syndrome, manifested by chronic infections of the intestinal tube, dysbiosis. 7. Medical factors, which include surgery, anesthesia, antibiotics, nitrofurans, alkylating derivatives, corticosteroids, antimetabolites, drugs. III. Infectious Bacterial Syndrome 1. The frequency of infectious diseases is more than 3-4 times a year in adults, more than 6 times in children. 2. Atypical temperature reaction in case of an infectious disease. 3. Chronic pustular diseases of the skin, subcutaneous fatty tissue, soft tissues (furunculosis, sycosis, abscesses, lymphadenitis, phlegmons, proctitis, paraproctitis). 4. Gastrointestinal infections (gastroenteropathy, chronic diarrhea, dysbiosis, cholecystitis, pancreatitis). 5. Chronic lesions of the urogenital tract (pyelonephritis, cystitis, chlamydia, gardnerellas, mycoplasmosis, Reiter's syndrome). 6. Chronic infections of ENT organs (sinusitis, frontal sinusitis, gaymority, purulent otitis media). 7. Purulent keratoconjunctivitis. 8. Torpid to treatment recurrent aphthous stomatitis. 9. Specific infections tuberculosis, toxoplasmosis, brucellosis, leprosy, syphilis, malaria. 10. Sepsis, septicopyemia, peritonitis, abscesses of the lungs, and other organs. IV. Infectious Viral Syndrome 1. Frequent relapses of viral infections. 2. Refractoriness, i.e. resistance of viral diseases to traditional therapy. 3. Prolonged low-grade fever, unmotivated lymphadenopathy, chronization of infectious processes. 4. Persistent viral infections -cytomegalovirus, herpes, caused by the Epstein-Barr virus, Dengue fever, chronic viral hepatitis (B and C). 5. Persistently recurrent clinical manifestations of papillomatosis and candilomatosis against the background of ongoing standard therapy. 6. Chronic fatigue syndrome, which occurs in young women and men. 7. Risk groups of ARVI. These include newborn babies, early age, with late-onset of reactivity, low body weight, and those born during pathological pregnancy. These are older children with chronic diseases of the heart, lungs, kidneys, etc. V. Other Infectious Syndromes 1. Mycoses (superficial, subcutaneous, systemic, opportunistic). 2. Lesions with protozoa (trypanosomes, leishmania, lamblia, trichomonad, malaria plasmodium, toxoplasma, intestinal balantidia). 3. Defeats by intracellular parasites (chlamydia, gardnerella, mycoplasma, ureaplasma). # b) Interpretation of the results of the analysis of the prelaboratory examination of patients It concerns the syndrome of susceptibility to immune disorders, displayed when there are three positive answers to any question in the questionnaire. This also includes immunodeficiency, infectious, pseudo-allergic syndromes, and a syndrome of combined and accompanying diseases, presented with a positive answer to two questions of the questionnaire. And, finally, autoimmune, lymphoproliferative, allergic, and metabolic syndromes, which are displayed with a positive answer to one question of the corresponding questionnaires. # c) Options for the conclusion based on the results of the survey According to these results, the patient belongs to a risk group for predisposition or immunodeficiency syndromes and a high-risk group for allergic, autoimmune, lymphoproliferative, or the same, with a combination of several immunopathological syndromes. # III. Syndromic Appointment of Auxiliary Immunotherapy Auxiliary immunotherapy involves the use of traditional medicines with an immunotropic effect in the treatment of patients. When choosing antibacterial drugs, in addition to their antibiotic sensitivity to pathognomonic microflora, it is recommended to take into account their immunosuppressive effect, for example, in Abactal, Ampicillin, Isoniazid, Kanamycin, Chloramphenicol, Monomycin, PASK, Pyrazinamide, Rifampicin, Streptomycin, Tetracycline, Furacillin, Furagin, and immunostimulating activity, as in the case of Erythromycin, Miramistin, Nizoral, Nystatin, Levin, Roxithromycin, Amphotericin, Metacyclin, Bactrim, Macropen, Isoniazid, and Clindamycin. 8.9 # e) Metabolic syndrome g) Elimination of metabolic disorders It is carried out by energizers Riboflavin and Nicotinamide, glycolysis activators Thiamine and Riboxin, and the tricarboxylic acid cycle Biotin Lipoat. bronchial asthma + chronic pneumonia), or different genesis (autoimmune thyroiditis + obstructive pulmonary disease). Patients from this group, in addition to the basic treatment, receive "small" immune correctors. These include adaptogens (Manchurian aralia, Roseola Rosea, extracts from ginseng, Pantocrine, Eleutherococcus, Esberitox, tincture of Chinese magnolia vine) and metabolites, antioxidants, and vitamins (Riboxin, Potassium orotate, Hypoxenes, Reamberin, Tramelan, Pentoxyl, Methyluracil, Mildronate, Pantholex, vitamins of group B, C, A, E, Quercetin, Pangamic acid, Lipoic acid, Asparkam, brewer's yeast, Sodium nucleinate). The group of other drugs includes Piracetam, Polistim, Bendazole, Glutamic acid, Curantil, Apilac, Splenin, Leucogen, interferon, Cinnarizine, Zaditen. Finally, the eubiotics group consists of Acipol, Acylact, Bactisubtil, Bactobacterin, Bifacid, Bifibin, Bifilong, Bifidumbacterin, Bificol, Colibacterin, Biphilis, Lactobacterin, Vitanar, Linex, Narine, Sporobacterin. # Combinations of immunopathological syndromes (infectious + allergic, immunodeficient + infectious). 4. Medicinal complications (dysbacteriosis, toxicosis, allergization, immune disorders). # Mathematical # b) High-risk group Patients of this group, in addition to traditional therapy, receive a combination of two or three small immunocorrectors or broad-spectrum modulators. The latter include Sodium nucleinate, Isoprinosine, thymus drugs, Myelopid, Levamisole, Hemodez, Reamberin, Splenin, Sanaviron, Leukinferon, Polyelectrolytes, Diucifon, etc. # f) Dysnucleotidosis In this condition, Derinat, Ridostin, Sodium nucleinate, Riboxin, Potassium orotate, Methyluracil, Pentoxil, Asparkam (Panangin), Vitamin B6, Glycerophosphate, Folic acid, Hypoxene, Cygapan, Lemont, and Tikveol are quite effective. # d) Infectious viral syndrome In this case, it is permissible to use a combination of two or three drugs. The list includes Dibazol, Interferon, Kurantil, Quercitin, Leukinferon, Levamisole, Myelopid, Methyluracil, Pentoxil, Prodigiosan, Remantadin, Arbidol, Vitamin A, Diucifon, Acyclovir. For persistent viral hepatitis, respectively, Katergen, Piracetam, Leukinferon, Sodium nucleinate, Lipoic acid, Acyclovir, Ribamidil, Sirepar, Cycloferon, human ?-interferon, or recombinant genetically engineered human interferon Reaferon. # i) Allergic syndrome j) Treatment principles They consist of (1) elimination of the allergen, (2) the use of agents that nonspecifically suppress allergic reactions, (3) nonspecific immunosuppressive therapy, (4) specific immunotherapy, (5) targeted immunomodulation, (6) non-drug immune correction. In practice, one principle of treatment is rarely used, mainly combinations of them are used. The tactics of treating patients significantly depend on the stage of the disease. So, in the period of exacerbation, therapy is aimed at eliminating acute clinical manifestations of an allergic reaction, and in the period of remission at preventing its progression. # k) Pseudoallergic syndrome A variety of medications are used to relieve this condition. # i. Antihistamines There are six groups of antihistamine compounds. These include (1) ethylenediamine, Suprastin, (2) ethanolamines, Diphenhydramine, (3) alkylamines, Dimethindene, (4) phenothiazine derivatives, Pipolfen, (5) piperazine derivatives, Cinnarizine, (6) antihistamines of various origins Tavegil, Fenkarol, Bicarfen, Peritol, Pernovin, Diazolin, Ketotyphene. # l) H1 -2 nd generation antihistamines These include Teldan, Claritin, Gismanal, Zirtek, Semprex, Avastin, Terfenadine, Astemizole, Cimetidine, etc. # n) Choleretic drugs Which are Alcohol, Lyobil, Cholenzyme, decoctions of the sandy immortelle flower, immortelle extract, corn silk, Tanacehol, Konvaflavin, Flacumin, Oxyphenamide, and Tsikvalone. # p) Eubiotics Various eubiotics, Acipol, Bactisubtil, Bactobacterin, Bifilong, Bifilis, Bifinormalizer, Bifidumbacterin, have also proved to be effective. q) Autoimmune syndrome i. Correction principles They consist of (1) Elimination of "forbidden" clones of sensitized lymphocytes, (2) Removal of an immunogen or an adjuvant. (3) Plasmapheresis, (4) Immunosuppressive therapy, (5) Blockade of mediators of immune responses with antihistamines, (6) Replacement therapy for pernicious anemia with vitamin B12, for myxedema thyroxine, (7) Prescription of antiinflammatory drugs, nonsteroidal drugs and salicylates, corticosteroids, (8) Prescription of cyclosporin A, (9) Immunotherapy using causative allergens, (10) Immunocorrection of T-suppressor deficiency, (11) Use of gammaglobulins (immunoglobulins) for intravenous administration, (12) Application monoclonal antibodies against proinflammatory cytokines, (13) Autologous hematopoietic stem cell transplantation against the background of high-dose immunosuppression, ( 14) Gene therapy due to suppression of cytokine formation by genes transferred by viral vectors. It is essential to note that the effectiveness of the autoimmune syndrome correction is temporary and is expressed in remission. # r) Lymphoproliferative syndrome i. Correction principles The main types of treatment for lymphoproliferative and malignant neoplasms are surgical, radiation, and drug actions, which have a suppressive effect on the immune system, and this is the basis for the appointment of the thymus, polysaccharide, nucleic acid drugs, interferons, and interferon genes, synthetic polyoxidonium stimulants, Dapsone, Lycopid, Levamisole, vitamins, as well as blood plasma, etc. # IV. Simplified Purpose of Patients with Differentiated Immunotherapy based on the Software a) Unified immunotherapy This type of immunotherapy is implemented, taking into account the nature of the disease. 10,11,12 The choice of options is carried out according to the formulas of disorders of the immune system (FDIS is compiled by selecting the most significantly altered immune parameters from the normal level) 1 for specific diseases. The analysis of the immune status in patients may not be carried out because a verified clinical diagnosis of the disease, the key parameters of the previously defined typical FDIS for a specific isoform, Legend: FDIS is a formula for disorders of the immune system, built on three key parameters that are most different from the level of the norm, with an indication of the direction of the dynamics vector (+ hyperactivation, -deficiency) and the degree of these changes (1-3, where 1-I degree of changes is transient up to 33% of the norm, 2-II degree is reliable from 34 to 66%, 3-III degree highly significant> 66%), L -leukocytes, RN -rod-nuclear neutrophils, IL -interleukins. ESR-erythrocyte sedimentation rate, NBTac- # Legend: (C) cellular, T-dependent, (H) humoral, B-dependent, (N) nonspecific links of immunity, + target of positive action of the drug # Legend: AF -absorption function (phagocytic index and number), MF -metabolic function (NBT-test spontaneous or activated), CIC-circulatory, immune complexes, MWM -medium-weight molecules, Tc-Lph -cytotoxic T-lymphocytes, + the effect of the drug is established # NBT-test activated, NBTsp-NBT-test spontaneous, TNF-tumor necrosis factor, Tc-T-cytotoxic lymphocytes, T-T-lymphocytes, Eeosinophil, Lph-lymphocytes, FI-phagocytic index The algorithm for prescribing differentiated immunotherapy is that the recommended drugs are selected for patients with certain diseases based on the key parameters of FDIS by the tables given. For example, in acute pneumonia with FDIS constituting CD3 2 ¯IgM 2 ¯IgA 2 ¯ (deficiency of T-lymphocytes, IgA, and IgM of the second degree), the recommended drugs for correcting CD3 2 deficiency are autohemotherapy, vitamins, Viferon, etc. Regarding IgM 2 ¯, IgA 2 ¯ shows the same drugs, etc. # b) Generalized immunotherapy It is used without considering the nature of the disease. 6 It is used in the severe clinical condition of patients. It is based on a generalized definition of altered links of immunity (by the presence of indicators with second-third degrees of immunodeficiency) and the choice of modulators based on grouped passport targets of action on individual links of the immune system without taking into account the nature of the diseases (Tables 2, 5). # c) Interpretation of the results of the immune examination of patients If one or more indicators coincide in a particular patient, grouped by immunity links with tabulated ones, a conclusion is made about the deficit of the secondthird degree of the link as a whole (Table 5). Table 5: Reference values of laboratory parameters, grouped by immunity links # Legend: ?U-conventional units; PhI, PN -phagocytic index and number, other designations -see above d) Detailed immunotherapy It is carried out without taking into account the nature of the disease. 13 Specific critically reduced laboratory parameters of the second or third degree are determined in patients according to the table's values. Based on their coincidence with the passport targets of modulators, variants of detailed immunotherapy are selected. # e) Algorithm for prescribing detailed immunotherapy The changed indicator/indicators in a particular patient are determined if its value coincides with the tabular value of the modulator target. According to these data, specialized drugs are selected for a prescription that can act on these indicators. # f) Personalized immunotherapy It is carried out, taking into account the nature of the disease. 14,15,16,17 The algorithm for choosing personalized immunotherapy is implemented according to certain formulas for the targets of immunoprotection (ITF, determined by the three most altered immune parameters from the initial level after performing immunocorrection) 1 in certain diseases (Table 6). The essence of the program is that based on ITF, including the second-third degree of changes in laboratory signal parameters towards a decrease or increase, the key values of diagnostically significant immune parameters are selected, summarized in the tables. By comparing the data of laboratory examination of certain patients with tabular values, marker parameters changed from the normal level are revealed according to the vector and the degree of their changes. When the selected indicators coincide with the three key components of ITF for certain diseases, the optimal options for immunotherapy are selected, which are prescribed against the background of traditional basic treatment of diseases. Legend: DID, DIH-the degree of immune deficiency, the degree of immune hyperfunction, Nph -neutrophil, ESR-erythrocyte sedimentation rate, for other designations, see above. V. # Conclusion A certain problem of the current state of clinical immunology is the insufficient introduction of innovative diagnostic and therapeutic technologies into practice, which is often accompanied by not always full use of the latest immunotherapeutic effects in the treatment of patients and, as a consequence, their often insufficient effectiveness. This also includes the lack of simple and, at the same time, informative methods of immune diagnostics. One solution to the stated problem is the development at the first level of a simplified technology for the clinical detection of marker immunopathological syndromes with the appointment of profile "small" immunocorrectors to patients. At the second level, based on laboratory assessment of the reactivity of patients, created laboratory support and preliminary study of the effectiveness and targets of differentiated immunotherapy of certain diseases in work, mathematically justified unified, generalized, detailed, and personalized methods for choosing options for optimal immunotherapy are presented. ... They are a good help in the daily work of a practical clinical immunologist. 2PreparationsCHNPreparationsCHNAdaptogens+Ozonized sodium chloride+++Anabol+Lysozyme+Autohemotherapy+++Methyluracil++++Myelopid+++Acyclovir+Trace elements+++Bronchomunal+++Leukomax+Vaccines+Likopid+++Vitamin A++Sodium nucleinate+++Vitamins B++Potassium orotate++Vitamin C+Polyoxidonium+++Viusid++Synthetic polynucleotides+++Gammaglobulin+Plasma++?-interferon++Plasmapheresis++Gepon+++Panavir++Hemodez+++Piracetam+Hypoxene+++Plasmapheresis+++Heparin++Polyelectrolytes+++Glutoxim+++Pentoxil+++Dalargin+++Pyrogenal+++Derinat+++Preventan+++Dibazol+++Prodigiosan+++Diuciphon+++Reaferon+Diuciphon+Reopolyglyukin+++Zixorin+Riboxin++Isoprenosine+++Ridostin+++Isoprenosine+Roncoleukin+++Immunomax+++Ruzam++Immunomax+++Splenin+++Indomethacin+Superlimph+++Lysate of bacteria IRS-19+Tamerid+++Katergen+Thymus preparations+++Camedon+TrichopolusCombined immune drug+++Body ultraviolet irradiation+Kipferon+++Ultraviolet blood irradiation++Quercetin++Phenazepam++Bloodletting+++Cycloferon+++Leakadin+++Cinnarizine+Levamisole+++Cimetidine++Leukinferon++Cygapan+++Low-intensity laser radiation+++Erythrocytes+++ 3PreparationCD3+CD4+CD8+CD16+CD19+IgCICMWMCD11?AFMFTc-LphAutohemotherapy++++Vitamins+++++Viferon+++++Hemodez+++++Hypoxene+++++++Gepon++++++++Glutoxim++++Dalargin++++Decaris/levamisole+++++Derinat+++++++Diuciphon++++++Donor ?-globulin++++++Isoprinosine++++++Imudon++++Immunomax++++++Imunofan++++++++Combined immune preparation (CIP)+++++?IPferon++++++++Leakadin+++++++Leukinferon+++++++Likopid++++++Limontar+++++++Therapeutic plasmapheresis++++++Myelopid+++++++Neovir++++Low-intensity laser radiation+++++++Sodium nucleinate++++++++++Ozone+++++++Polystim++++Polyoxidonium+++++++++Polysaccharides+++++++++Ridostin+++++++Sorbents++++++Splenin+++++++Superlimph+++++Tamerid+++++Thymomimetic++++++++++Tikveol++++Ultraviolet blood irradiation+++++Cygapan+++Esberitox++++++ 4DiseasesFDISI. Bronchopulmonary diseasesAcute pneumonia?D3 2 ¯IgM 2 ¯IgA 2 ¯Chronic pneumonia in adults?D3 3 ¯IgA 2 ¯Ig? 2 ¯Chronic pneumonia in children?D3 2 ¯?D19 2 ¯Ig? 2 ¯The mixed form of bronchial asthma in adults?D3 2 ¯?D19 2 ¯IgA 2 ¯Exogenous bronchial asthmaLph 2 + ?D4 2 ¯?D3 2 ¯Endogenous bronchial asthmaRN 2 + ?D3 2 ¯NBTsp 2 +The mixed form of bronchial asthma in children?D3 2 ¯?D4 2 ¯?D8 2 ¯Corticosteroid bronchial asthma in adults?D3 2 ¯?D19 2 ¯IgA 3 ¯The mixed form of bronchial asthma, stage of exacerbationL 2 + ?D4 2 ¯?D3 2 ¯The mixed form of bronchial asthma, stage of remissionRN 3 + ?D19 2 ¯MWM 2+Chronic bronchitis?D3 2 ¯?D19 2 ¯IgA 3 ¯Chronic obstructive pulmonary disease?D4 3 ¯?D8 3 + CIC 3 +Infectious destruction of the lungs?D3 2 ¯?D19 2 ¯IgA 3 ¯Chronic obstructive bronchitis?D3 2 ¯?D19 2 ¯IgA 2 ¯II.Purulent-inflammatory diseasesDeep pyodermaIL8 3 + CIC 3 + NBT?c 3 ¯Purulent soft tissue infection?D8 3 + E 3 + ?D19 2 ¯Acute salpingo-oophoritisL 3 + CIC 3 + ?D4 2 ¯Exacerbation of chronic salpingo-oophoritis?c 3 + IL8 3 + ? 3 +Acute pyelonephritisIgG + 3 MWM + 3 L +2Exacerbation of chronic pyelonephritisESR 3 + IgG 3 + ?D8 3+Exacerbation of chronic calculous pyelonephritis?D4 2 ¯?D3 2 ¯FI 2 ¯Exacerbation of chronic non-calculous pyelonephritis?D8 2 ¯?D19 2 ¯?D3 2 ¯Exacerbation of chronic salpingo-oophoritis + cervicitisE 3 + ?D3 2 ¯?D3 2 +CervicitisHLA-DR-Lph 2 + ?D3 2 ¯?D19 2 ¯IgA 2 ¯Exacerbation of chronic cystitisIgG 3 + NBT?c 3 ¯TNF 3 + 6Year 20219 7Immune phenotypic and functionalImmune System Disorders Formulas (FDIS)characteristics2 DID(-2)3 DID(-3)2 DIH(+2)3 DIH(+3)?-Lph (CD45+CD3+), 10 9 /l0,5-1,0<0,52,0-2,5>2,5?-helpers (CD45+CD3+CD4+), 10 9 /l0,38-0,74<0,381,46-1,82>1,82T-cytotoxic Lph(CD45+CD3+CD8+), 10 9 /l0,14-0,28<0,140,56-0,7>0,7T-activated Lph(?D3+HLA-DR), 10 9 /l0,04-0,08<0,040,16-0,2>0,2T-regulatory Lph(?D3+?D4+?D25+), 10 9 /l0,03-0,07<0,030,15-0,19>0,19NK-cytolytic(?D3-?D16+?D56+), 10 9 /l0,04-0,08<0,040,16-0,2>0,2?-Lph (CD19+), 10 9 /l0,2-0,4<0,20,4-0,6>0,6Ig?, g/l0,6-1,3<0,63,3-4,6>4,6Ig?, g/l0,5-1,1<0,52,1-2,6>2,6IgG, g/l10,8-14,4<10,814,4-18,0>18,0CIC, CU9,1-18,3<9,136,7-45,9>45,9MWM, CU1,9-3,7<1,97,3-9,1>9,1PhI, %24,3-48,4<24,396,6-120,7>120,7PhN, number of bacteria\Nph2,4-4,7<2,49,3-11,6>11,6NBTsp, %2,9-5,7<2,911,3-14,1>14,1NBTac, %7,5-15,0<7,530,0-37,5>37,5IL4, pkg/ml6,6-13,1<6,626,1-32,6>32,6IL6, pkg/ml5,5-10,9<5,521,7-27,1>27,1IL8, pkg/ml4,7-9,4<4,718,8-23,5>23,5TNF, pkg/ml0,06-0,13<0,060,26-0,32>0,32Lymphocytes (CD95+), 10 9 /l0,02-0,05<0,020,11-0,14>0,14L (leucocytes), 10 9 /l1,3-2,7<1,35,5-6,9>6,9Lph (lymphocytes), %13,8-27,5<13,854,9-68,6>68,620,4-40,5<20,480,7-100,8>100,80,64-1,27<0,642,53-3,2>3,24,2-8,5<4,213,0-17,2>17,24,3-8,4<4,316,6-20,7>20,7 * Drug intolerance, vaccination reactions, iatrogenic diseases (serum sickness, D-penicillamine nephropathy, drug thrombocytopenia) * Transfer in anamnesis of anaphylactic shocks, Quincke's edema, Lyell's syndrome, Stephen-Johnson's, drug-disease, and other allergic reactions * Allergic reactions to insect bites contact with plants, odors, dyes, cosmetics, house dust, chemicals, bio-preparations, precious metals * Helminthic invasion * Cold allergy. VII. Pseudo-allergic Syndrome 1. Violations of the diet (citrus fruits, fish, potatoes, cheese, chocolate) * Disorders of intestinal absorption * Dysbacteriosis * Activation of the complement system with accumulation (???, ?2?, ?4?, ?5?) * Reaction to medications -local anesthetics, X-ray contrast agents, carrying out physiotherapy VIII. Metabolic Syndrome * The actual metabolic syndrome (abdominal obesity, type 2 diabetes mellitus or impaired glucose tolerance, arterial hypertension, dyslipidemia) * Dysnucleotidosis * Autoimmune, Immunocomplex Syndrome 1. Diseases with an autoimmune component (hemolytic anemia, systemic lupus erythematosus, pernicious anemia, Sjogren's syndrome, Behcet's disease, Goodpasture's syndrome, systemic vasculitis Disorders of the antioxidant system. IX s granulomatosis * Diseases with the presence of immune complexes (rheumatoid arthritis, ankylosing spondylitis, essential cryoglobulinemia, scleroderma * Renal diseases (acute glomerulonephritis, Berger's disease, renal transplant) * Skin diseases (dermatitis herpetiformis, pemphigus, pemphigoid) * Diseases of the gastrointestinal tract (Crohn's disease, ulcerative colitis, active hepatitis primary biliary cirrhosis * Neurological diseases (subacute sclerosing panencephalitis, amyotrophic lateral sclerosis, multiple sclerosis * Diseases of the endocrine system chronic autoimmune thyroiditis * Syndrome 1. Symptomatic (secondary) lymphoproliferative syndrome XLymphoproliferative * Lymphadenopathy, chronic tonsillitis, hypoplasia of lymph nodes * HyperplasiaThymomegaly or hypoplasia of the thymus in children * Transferring a history of infectious mononucleosis * Lymphogranulomatosis (Hodgkin's disease) * Non-Hodgkin s lymphomas * Burkitt's Lymphoma * Sarcoidosis * Macroglobulinemia * The presence of any malignant neoplasms * Syndrome of Concomitant Chronic, Combined Diseases, and Conditions Xi * Cours of lectures on clinical immunophysiology AMZemskov IEEsaulenko VAChereshnev VMZemskov SVSuchkov VIPopov VAZemskova 2017 Textbook. Voronezh, Publishing House: Ritm 1048 * Electronic software doctor's assistant for the diagnosis and treatment of immunological disorders. ?ertificate of state registration of software for the Electronic Computing Machine AMZemskov VMZemskov MAZemskov VAZemskova 2016619036. 2016 Russia Published on 11.08. * Immunological studies and diagnostic methods of infectious diseases in clinical practice AAKishkun * PublishingMoscow House Medical Information Agency 711 2009 * Manual for physicians of general clinical immunology, allergology, immunogenetics, and immunopharmacology VIPokrovsky Triada-X 2 517 2005 * Selection of options for differentiated auxiliary immunotherapy based on the results prelaboratory examination. ?ertificate of state registration of software the Electronic Computing Machine AMZemskov VMZemskov MAZemskov VAZemskova Etc 2014619643. 2014 Russia Published on 18.09. * The choice of options for differentiated immunotherapy is based on generalized laboratory diagnostics in patients with immune disorders. Certificate of state registration of software for the Electronic Computing Machine AMZemskov VAZemskova Etc 2015612811. 2015 Russia Published on 26.02. * Program choice of options for purulent-inflammatory diseases. Certificate of state registration of software for the Electronic Computing Machine AMZemskov VMZemskov MAZemskov VAZemskova Etc 2014660956. 2014 Russia Published on 20.10. * Problems of clinical immunology in the 21 st Century -II. Natural and drug regulation mechanisms of immunological homeostasis AMZemskov VAChereshnev ARevishvili Sh VMZemskov VIPopov VAZemskova 2018 Moscow, Publishing House: Scientific Book 286 * The choice of treatment options for infections based on the immunosuppressive or immunostimulating effect of antibiotics. Certificate of state registration of software for the Electronic Computing Machine AMZemskov VAZemskova 2015614569. 2015 Russia Published on 21.04. * The choice of differentiated immunotion of software for the Electronic Computing Machine AMZemskov VAZemskova Etc 2015614977. 2015 Russia Published 05.05. * Laboratory markers in the diagnosis of purulent-inflammatory Computing Machine AMZemskov VAZemskova TABerezhnova YAKulintsova 2017662910. 2017 Russia Published on 21.11. * An additional method for diagnosing the pathogenesis of pyo-inflammatory diseases. Certificate of state registration of software for the Electronic Computing Machine AMZemskov TABerezhnova YaVKulintsova VAZemskova 2018616529. 2018 Russia Published on 14.09 * The choice of options rendered immunotherapy according to the detailed immunological analysis. Certificate of state registration of software for the Electronic Computing Machine AMZemskov VAZemskova MAZemskov Etc 2014619846. 2014 Russia Published 23.09. * A method for selecting options in the treatment of nonspecific inflammatory lung diseases. Certificate of state registration of software for the Electronic Computing Machine AMZemskov MAZemskov Popov Vi AVLikhachev VIZoloedov 2015619428. 2015 Russia Published on 03.09. * Diseases of the immune system NMKalinina SAKetlinsky SVOkovity SNShulemin Diagnostics and pharmacotherapy Moscow, Publishing House: Eksmo 2008 494 * The national conception of prevention of infections associated with first aid rendering and informational material based on its provisions VIPokrovsky 2012 Nizhny Novgorod, Publishing House: Remedium Privolzhye 84 Russia * A program for calculating a personal formula for immune system disorders in various diseases. Certificate of state registration of software for the Electronic Computing Machine IYLvovich AMZemskov MALutskiy Etc 201861202. 2018 Russia Published 09.02