\documentclass[11pt,twoside]{article}\makeatletter

\IfFileExists{xcolor.sty}%
  {\RequirePackage{xcolor}}%
  {\RequirePackage{color}}
\usepackage{colortbl}
\usepackage{wrapfig}
\usepackage{ifxetex}
\ifxetex
  \usepackage{fontspec}
  \usepackage{xunicode}
  \catcode`⃥=\active \def⃥{\textbackslash}
  \catcode`❴=\active \def❴{\{}
  \catcode`❵=\active \def❵{\}}
  \def\textJapanese{\fontspec{Noto Sans CJK JP}}
  \def\textChinese{\fontspec{Noto Sans CJK SC}}
  \def\textKorean{\fontspec{Noto Sans CJK KR}}
  \setmonofont{DejaVu Sans Mono}
  
\else
  \IfFileExists{utf8x.def}%
   {\usepackage[utf8x]{inputenc}
      \PrerenderUnicode{–}
    }%
   {\usepackage[utf8]{inputenc}}
  \usepackage[english]{babel}
  \usepackage[T1]{fontenc}
  \usepackage{float}
  \usepackage[]{ucs}
  \uc@dclc{8421}{default}{\textbackslash }
  \uc@dclc{10100}{default}{\{}
  \uc@dclc{10101}{default}{\}}
  \uc@dclc{8491}{default}{\AA{}}
  \uc@dclc{8239}{default}{\,}
  \uc@dclc{20154}{default}{ }
  \uc@dclc{10148}{default}{>}
  \def\textschwa{\rotatebox{-90}{e}}
  \def\textJapanese{}
  \def\textChinese{}
  \IfFileExists{tipa.sty}{\usepackage{tipa}}{}
\fi
\def\exampleFont{\ttfamily\small}
\DeclareTextSymbol{\textpi}{OML}{25}
\usepackage{relsize}
\RequirePackage{array}
\def\@testpach{\@chclass
 \ifnum \@lastchclass=6 \@ne \@chnum \@ne \else
  \ifnum \@lastchclass=7 5 \else
   \ifnum \@lastchclass=8 \tw@ \else
    \ifnum \@lastchclass=9 \thr@@
   \else \z@
   \ifnum \@lastchclass = 10 \else
   \edef\@nextchar{\expandafter\string\@nextchar}%
   \@chnum
   \if \@nextchar c\z@ \else
    \if \@nextchar l\@ne \else
     \if \@nextchar r\tw@ \else
   \z@ \@chclass
   \if\@nextchar |\@ne \else
    \if \@nextchar !6 \else
     \if \@nextchar @7 \else
      \if \@nextchar (8 \else
       \if \@nextchar )9 \else
  10
  \@chnum
  \if \@nextchar m\thr@@\else
   \if \@nextchar p4 \else
    \if \@nextchar b5 \else
   \z@ \@chclass \z@ \@preamerr \z@ \fi \fi \fi \fi
   \fi \fi  \fi  \fi  \fi  \fi  \fi \fi \fi \fi \fi \fi}
\gdef\arraybackslash{\let\\=\@arraycr}
\def\@textsubscript#1{{\m@th\ensuremath{_{\mbox{\fontsize\sf@size\z@#1}}}}}
\def\Panel#1#2#3#4{\multicolumn{#3}{){\columncolor{#2}}#4}{#1}}
\def\abbr{}
\def\corr{}
\def\expan{}
\def\gap{}
\def\orig{}
\def\reg{}
\def\ref{}
\def\sic{}
\def\persName{}\def\name{}
\def\placeName{}
\def\orgName{}
\def\textcal#1{{\fontspec{Lucida Calligraphy}#1}}
\def\textgothic#1{{\fontspec{Lucida Blackletter}#1}}
\def\textlarge#1{{\large #1}}
\def\textoverbar#1{\ensuremath{\overline{#1}}}
\def\textquoted#1{‘#1’}
\def\textsmall#1{{\small #1}}
\def\textsubscript#1{\@textsubscript{\selectfont#1}}
\def\textxi{\ensuremath{\xi}}
\def\titlem{\itshape}
\newenvironment{biblfree}{}{\ifvmode\par\fi }
\newenvironment{bibl}{}{}
\newenvironment{byline}{\vskip6pt\itshape\fontsize{16pt}{18pt}\selectfont}{\par }
\newenvironment{citbibl}{}{\ifvmode\par\fi }
\newenvironment{docAuthor}{\ifvmode\vskip4pt\fontsize{16pt}{18pt}\selectfont\fi\itshape}{\ifvmode\par\fi }
\newenvironment{docDate}{}{\ifvmode\par\fi }
\newenvironment{docImprint}{\vskip 6pt}{\ifvmode\par\fi }
\newenvironment{docTitle}{\vskip6pt\bfseries\fontsize{22pt}{25pt}\selectfont}{\par }
\newenvironment{msHead}{\vskip 6pt}{\par}
\newenvironment{msItem}{\vskip 6pt}{\par}
\newenvironment{rubric}{}{}
\newenvironment{titlePart}{}{\par }

\newcolumntype{L}[1]{){\raggedright\arraybackslash}p{#1}}
\newcolumntype{C}[1]{){\centering\arraybackslash}p{#1}}
\newcolumntype{R}[1]{){\raggedleft\arraybackslash}p{#1}}
\newcolumntype{P}[1]{){\arraybackslash}p{#1}}
\newcolumntype{B}[1]{){\arraybackslash}b{#1}}
\newcolumntype{M}[1]{){\arraybackslash}m{#1}}
\definecolor{label}{gray}{0.75}
\def\unusedattribute#1{\sout{\textcolor{label}{#1}}}
\DeclareRobustCommand*{\xref}{\hyper@normalise\xref@}
\def\xref@#1#2{\hyper@linkurl{#2}{#1}}
\begingroup
\catcode`\_=\active
\gdef_#1{\ensuremath{\sb{\mathrm{#1}}}}
\endgroup
\mathcode`\_=\string"8000
\catcode`\_=12\relax

\usepackage[a4paper,twoside,lmargin=1in,rmargin=1in,tmargin=1in,bmargin=1in,marginparwidth=0.75in]{geometry}
\usepackage{framed}

\definecolor{shadecolor}{gray}{0.95}
\usepackage{longtable}
\usepackage[normalem]{ulem}
\usepackage{fancyvrb}
\usepackage{fancyhdr}
\usepackage{graphicx}
\usepackage{marginnote}

\renewcommand{\@cite}[1]{#1}


\renewcommand*{\marginfont}{\itshape\footnotesize}

\def\Gin@extensions{.pdf,.png,.jpg,.mps,.tif}

  \pagestyle{fancy}

\usepackage[pdftitle={Leading Role of the Principles of Interaction between the Natural Physical Factors and Integral Organism in Medicine of the Future},
 pdfauthor={}]{hyperref}
\hyperbaseurl{}

	 \paperwidth210mm
	 \paperheight297mm
              
\def\@pnumwidth{1.55em}
\def\@tocrmarg {2.55em}
\def\@dotsep{4.5}
\setcounter{tocdepth}{3}
\clubpenalty=8000
\emergencystretch 3em
\hbadness=4000
\hyphenpenalty=400
\pretolerance=750
\tolerance=2000
\vbadness=4000
\widowpenalty=10000

\renewcommand\section{\@startsection {section}{1}{\z@}%
     {-1.75ex \@plus -0.5ex \@minus -.2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\Large\bfseries}}
\renewcommand\subsection{\@startsection{subsection}{2}{\z@}%
     {-1.75ex\@plus -0.5ex \@minus- .2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\Large}}
\renewcommand\subsubsection{\@startsection{subsubsection}{3}{\z@}%
     {-1.5ex\@plus -0.35ex \@minus -.2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\large}}
\renewcommand\paragraph{\@startsection{paragraph}{4}{\z@}%
     {-1ex \@plus-0.35ex \@minus -0.2ex}%
     {0.5ex \@plus .2ex}%
     {\reset@font\normalsize}}
\renewcommand\subparagraph{\@startsection{subparagraph}{5}{\parindent}%
     {1.5ex \@plus1ex \@minus .2ex}%
     {-1em}%
     {\reset@font\normalsize\bfseries}}


\def\l@section#1#2{\addpenalty{\@secpenalty} \addvspace{1.0em plus 1pt}
 \@tempdima 1.5em \begingroup
 \parindent \z@ \rightskip \@pnumwidth 
 \parfillskip -\@pnumwidth 
 \bfseries \leavevmode #1\hfil \hbox to\@pnumwidth{\hss #2}\par
 \endgroup}
\def\l@subsection{\@dottedtocline{2}{1.5em}{2.3em}}
\def\l@subsubsection{\@dottedtocline{3}{3.8em}{3.2em}}
\def\l@paragraph{\@dottedtocline{4}{7.0em}{4.1em}}
\def\l@subparagraph{\@dottedtocline{5}{10em}{5em}}
\@ifundefined{c@section}{\newcounter{section}}{}
\@ifundefined{c@chapter}{\newcounter{chapter}}{}
\newif\if@mainmatter 
\@mainmattertrue
\def\chaptername{Chapter}
\def\frontmatter{%
  \pagenumbering{roman}
  \def\thechapter{\@roman\c@chapter}
  \def\theHchapter{\roman{chapter}}
  \def\thesection{\@roman\c@section}
  \def\theHsection{\roman{section}}
  \def\@chapapp{}%
}
\def\mainmatter{%
  \cleardoublepage
  \def\thechapter{\@arabic\c@chapter}
  \setcounter{chapter}{0}
  \setcounter{section}{0}
  \pagenumbering{arabic}
  \setcounter{secnumdepth}{6}
  \def\@chapapp{\chaptername}%
  \def\theHchapter{\arabic{chapter}}
  \def\thesection{\@arabic\c@section}
  \def\theHsection{\arabic{section}}
}
\def\backmatter{%
  \cleardoublepage
  \setcounter{chapter}{0}
  \setcounter{section}{0}
  \setcounter{secnumdepth}{2}
  \def\@chapapp{\appendixname}%
  \def\thechapter{\@Alph\c@chapter}
  \def\theHchapter{\Alph{chapter}}
  \appendix
}
\newenvironment{bibitemlist}[1]{%
   \list{\@biblabel{\@arabic\c@enumiv}}%
       {\settowidth\labelwidth{\@biblabel{#1}}%
        \leftmargin\labelwidth
        \advance\leftmargin\labelsep
        \@openbib@code
        \usecounter{enumiv}%
        \let\p@enumiv\@empty
        \renewcommand\theenumiv{\@arabic\c@enumiv}%
	}%
  \sloppy
  \clubpenalty4000
  \@clubpenalty \clubpenalty
  \widowpenalty4000%
  \sfcode`\.\@m}%
  {\def\@noitemerr
    {\@latex@warning{Empty `bibitemlist' environment}}%
    \endlist}

\def\tableofcontents{\section*{\contentsname}\@starttoc{toc}}
\parskip0pt
\parindent1em
\def\Panel#1#2#3#4{\multicolumn{#3}{){\columncolor{#2}}#4}{#1}}
\newenvironment{reflist}{%
  \begin{raggedright}\begin{list}{}
  {%
   \setlength{\topsep}{0pt}%
   \setlength{\rightmargin}{0.25in}%
   \setlength{\itemsep}{0pt}%
   \setlength{\itemindent}{0pt}%
   \setlength{\parskip}{0pt}%
   \setlength{\parsep}{2pt}%
   \def\makelabel##1{\itshape ##1}}%
  }
  {\end{list}\end{raggedright}}
\newenvironment{sansreflist}{%
  \begin{raggedright}\begin{list}{}
  {%
   \setlength{\topsep}{0pt}%
   \setlength{\rightmargin}{0.25in}%
   \setlength{\itemindent}{0pt}%
   \setlength{\parskip}{0pt}%
   \setlength{\itemsep}{0pt}%
   \setlength{\parsep}{2pt}%
   \def\makelabel##1{\upshape ##1}}%
  }
  {\end{list}\end{raggedright}}
\newenvironment{specHead}[2]%
 {\vspace{20pt}\hrule\vspace{10pt}%
  \phantomsection\label{#1}\markright{#2}%

  \pdfbookmark[2]{#2}{#1}%
  \hspace{-0.75in}{\bfseries\fontsize{16pt}{18pt}\selectfont#2}%
  }{}
      \def\TheFullDate{2021 2021-07-15 (revised: 69 Year 2021 15 July 2021)}
\def\TheID{\makeatother }
\def\TheDate{2021 2021-07-15}
\title{Leading Role of the Principles of Interaction between the Natural Physical Factors and Integral Organism in Medicine of the Future}
\author{}\makeatletter 
\makeatletter
\newcommand*{\cleartoleftpage}{%
  \clearpage
    \if@twoside
    \ifodd\c@page
      \hbox{}\newpage
      \if@twocolumn
        \hbox{}\newpage
      \fi
    \fi
  \fi
}
\makeatother
\makeatletter
\thispagestyle{empty}
\markright{\@title}\markboth{\@title}{\@author}
\renewcommand\small{\@setfontsize\small{9pt}{11pt}\abovedisplayskip 8.5\p@ plus3\p@ minus4\p@
\belowdisplayskip \abovedisplayskip
\abovedisplayshortskip \z@ plus2\p@
\belowdisplayshortskip 4\p@ plus2\p@ minus2\p@
\def\@listi{\leftmargin\leftmargini
               \topsep 2\p@ plus1\p@ minus1\p@
               \parsep 2\p@ plus\p@ minus\p@
               \itemsep 1pt}
}
\makeatother
\fvset{frame=single,numberblanklines=false,xleftmargin=5mm,xrightmargin=5mm}
\fancyhf{} 
\setlength{\headheight}{14pt}
\fancyhead[LE]{\bfseries\leftmark} 
\fancyhead[RO]{\bfseries\rightmark} 
\fancyfoot[RO]{}
\fancyfoot[CO]{\thepage}
\fancyfoot[LO]{\TheID}
\fancyfoot[LE]{}
\fancyfoot[CE]{\thepage}
\fancyfoot[RE]{\TheID}
\hypersetup{citebordercolor=0.75 0.75 0.75,linkbordercolor=0.75 0.75 0.75,urlbordercolor=0.75 0.75 0.75,bookmarksnumbered=true}
\fancypagestyle{plain}{\fancyhead{}\renewcommand{\headrulewidth}{0pt}}

\date{}
\usepackage{authblk}

\providecommand{\keywords}[1]
{
\footnotesize
  \textbf{\textit{Index terms---}} #1
}

\usepackage{graphicx,xcolor}
\definecolor{GJBlue}{HTML}{273B81}
\definecolor{GJLightBlue}{HTML}{0A9DD9}
\definecolor{GJMediumGrey}{HTML}{6D6E70}
\definecolor{GJLightGrey}{HTML}{929497} 

\renewenvironment{abstract}{%
   \setlength{\parindent}{0pt}\raggedright
   \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}}
   \vskip16pt
   \textcolor{GJBlue}{\large\bfseries\abstractname\space}
}{%   
   \vskip8pt
   \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}}
   \vskip16pt
}

\usepackage[absolute,overlay]{textpos}

\makeatother 
      \usepackage{lineno}
      \linenumbers
      
\begin{document}

             \author[1]{Vladimir Dodtievich  Bitsoev}

\renewcommand\Authands{ and }

\date{\small \em Received: 9 June 2021 Accepted: 1 July 2021 Published: 15 July 2021}

\maketitle


\begin{abstract}
        


The paper discusses the search of evidences of advantage of the physiotherapy over the drug therapy by the parameters and treatment methods according to clinical stage of a disease development, based on the results of labor medical examination and improvement of the quality of life.The above indicators were confirmed with a high statistical accuracy by example of a new rehabilitation technology: "Underwater horizontal spine traction with underwater phototherapy to solve an essential medical and social problem: treatment of patients with degenerative and dystrophic lesions of the lumbosacral spine with herniated protrusions of intervertebral discs, being one of the most common neurological pathologies worldwide.

\end{abstract}


\keywords{physiodynamics, physiokinetics, supramolecular structures, blood spectrum biopsy.}

\begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) 
\textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark}
\end{textblock*}

\begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) 
\textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}}
\end{textblock*}


\let\tabcellsep& 	 	 		 
\section[{Introduction}]{Introduction}\par
ny pharmacological preparation, from the moment of its introduction into organism and during the whole way of movement is exposed to complex physical and chemical changes with formation of reversible and irreversible compounds (intermediate formations) with obligatory release of a certain energy for continuation of cyclic process of transition from one state to the next one up to exit from the integral organism.\par
It is known that "the interaction of a medicinal product with the organism is studied in two aspects: how it affects the body  {\ref (pharmacodynamics)} and what happens to it in the body (pharmacokinetics). Pharmacodynamics studies localization, mechanism of action and pharmacological effects of the medicinal substances.\par
Pharmacokinetics studies the common factors of absorption, distribution and elimination of the medicinal substances in a human or animal organism. \hyperref[b2]{[1]} Compliance with this concept contributes to ensuring high therapeutic effect, primary and secondary prevention of diseases, prevention of complications and side effects on the body. This is not observed in global healthcare and pharmaceutical practice due to the lack of methods of research of pharmacological preparations at the supramolecular level.\par
From the organism's viewpoint, any substance coming from outside is regarded as a foreign body, thereby initiating a system of quick escape of the same. Even an own blood outside the vascular bed is treated as a foreign body by the organism. Therefore, an immediate shift of work of all organs and systems of the body into extraordinary mode takes place.\par
It should be noted, given the present state of development of the medicine, that there are no methods to determine the cycle temporal level of each system at the moment of effect of the medicinal substance on organism, in its transitional states at the supramolecular level and when all systems return to normal mode of life.\par
In this regard, it is difficult to imagine the advantage of a particular medicinal substance in general and, in particular, for a specific patient. The lack of data in the chronological sequence of the medicinal substance in its path to achieving the goal calls into question the prevalence of the drug therapy over physiotherapy.\par
It is known that the final characteristic of any medicinal substance at the supramolecular level is an "energy", which is difficult to dose and regulate for therapeutic purposes -this is the reason for the lack of these characteristics in the global medical and pharmaceutical literature.\par
The impact of energy of any physical factor is dosed and regulated (physiodynamics) with the help of nanotechnologies and its path to each molecule of the integral organism (physiokinetics) is easily traced without disturbing supramolecular structures and any negative consequences.\par
The modern global pharmaceutical science does not have such a high level of control over the path of a medicinal substance in the body.\par
According to A.L. Chizhevsky "an obligatory condition for the life of a living organism is an exchange of the "electrical" component being the foundation of metabolism process, and the total energy content in the cellular structures of the body has a strictly defined meaning". \hyperref[b3]{[2]} Bioelectric potential for each human being is strictly individual both in norm and pathology. In this regard, any nosology causes in each individual a deviation of his or her bioelectric potential in accordance with the stage of disease development, i.e. development of intermediate states of the body with certain disorders of its supramolecular structures.\par
This, in turn, determines the clinical findings at the time of examination of the patient and constitutes the leading condition for selecting the right treatment strategy for any specialist physician, so that the regression of the disease is accompanied by the restoration of destroyed supramolecular structures, avoiding new gross disturbances at any level of the integral organism.\par
This concept is not the main principle for drug therapy due to the lack of highly informative research methods: frequency, dose, mechanism of action of pharmacological preparations at the supramolecular level. 
\section[{II. Research Materials \& Methods a) Experimental studies}]{II. Research Materials \& Methods a) Experimental studies}\par
Methods of experimental study of the action of PVIP light device "BIOPTRON" via fiber optic cable to water, blood plasma and integral organism: IR spectroscopy in the region 4000-400 cm -1 on a Fourier spectrometer Perkin-Elmer 2000 between the plates KRS-5, conducted at the Establishment of the Academy of Science A.A. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Science ( IPCE of RAS), Moscow; Experimental measurements of the spectra of Raman scattering (Raman effect) of various water samples on the automated fiber optic spectrometers at the Institute of Spectroscopy of the Russian Academy of Sciences RAS (ISAS), town Troitsk, Moscow region and the Research Center of fiber optics of the Russian Academy of Sciences, Moscow; Evanescent infrared spectroscopy of the skin in vivo by fiber optic sensor, at the Scientific center of Fiber Optics of the Russian Academy of Sciences, Moscow. 
\section[{b) Clinical trials}]{b) Clinical trials}\par
This paper is based on analysis of the treatment outcomes of 745 individuals (454 males and 291 females) aged 17 to 60 years with degenerative and dystrophic processes of intervebral discs of lumbosacral spine, with hernial protrusions into the spinal canal of up to 13 mm.\par
In accordance with the purpose and tasks of the trial, all patients were examined and splitted up into groups according to following indices: four age subgroups: 1) aged 17 to 30 years; 2) 31 to 40 years; 3) 41 to 50 years; 4) 51 to 60 years) and by gender (males and females); by duration of the disease (n=745): 1) 1 to 5 years; 2) 6 to 10 years; 3) more than 10 years; by incidence of various clinical evidences of degenerative and dystrophic processes in lumbosacral spine (n=745); by quantitative characteristic of radiodiagnostic data: computer tomography (CT) -244, magnetic resonance imaging (MRI) -269, X-ray radiography -745; by MRI results and age groups of randomized trial population n=269 with hernial protrusion into the spinal canal L4-S1 of up to 5 mm and from 5 to 13 mm; All of the patients were splitted up into 5 groups by treatment methods and into 4 groups by age.\par
1st control group -175 patients: 24 patients aged 17 to 30 years, 37 patients aged 31 to 40 years, 65 patients aged 41 to 50 years, 49 patients aged 51 to 60 years, were administered the drug therapy according to Moscow standard. Agerage therapy regimen was 20 days.\par
2nd control group -157 patients: 26 patients aged 17 to 30 years, 39 patients aged 31 to 40 years, 62 patients aged 41 to 50 years, 30 patients aged 51 to 60 years were administered the physiotherapy (magnetotherapy, amplipulse therapy, laser therapy, acupuncture, ultrasonic therapy, therapeutic physical training in various combinations) with drug therapy.\par
Average therapy regimen was 17 days. Information for each patient was collected according to medical documents (outpatient records, medical and physiotherapeutic treatment procedural records), registers of primary and recurrent patients, registers of specialists), as well as by interviews and questionnaires according to the "map of examination for detection of musculoskeletal pathology" (Appendix 1) developed by us, which represents a slightly modified standard WHO questionnaire.\par
The rest of 413 patients under attendance were distributed into three groups by the adopted treatment methods and into four age groups, the same as two control groups:  
\section[{c) Results of the trial and discussion}]{c) Results of the trial and discussion}\par
Clinical physiotherapy is closely connected with the other fields of the medicine, physics and biology.\par
Thus, the investigation of etiology and pathogenesis of many diseases allows not only the application of the necessary physical factor, but the development of a rational method, its application, combination with other physical factors as well \hyperref[b4]{[3,} {\ref 4,}\hyperref[b5]{5,}\hyperref[b6]{6]}.\par
The achievements in physics and development of highly sensitive equipment made possible determination of the mechanism of action of low-energy physical factors on cellular and subcellular levels of the organism \hyperref[b7]{[7,}\hyperref[b8]{8,}\hyperref[b9]{9]}.\par
It is established that when any electromagnetic wave passes through the fiber, evanescent waves are always formed around the fiber perpendicular to the outer surface of the latter and they attenuate at a distance from it.\par
These previously unknown light properties were recently discovered by scientists from Japan, USA, Ukraine and Korea \hyperref[b10]{[10]}.\par
In this regard, we have conducted a number of experimental studies (recording of standing evanescent wave photons on the skin surface after exposure to PVIP (Polychromatic Visible and Infrared Polarized) light of 480-3400 nm).   It was established that the evanescent infrared spectra of the skin after exposure to water activated by light through the fiber optic cable from Bioptron device demonstrate an increase in the absorption area within the wavelength ranges from 3200 to 3500 cm -1 and within the range up to 800 cm -1 , i.e. there is an increase in hydration \hyperref[b11]{[11,}\hyperref[b12]{12,}\hyperref[b13]{13,}\hyperref[b14]{14]}.\par
In this regard, there is a substantiation to use phototherapy with Bioptron device through fiber optic cable both under direct exposure and indirectly, i.e. 
\section[{( B )}]{( B )}\par
through water, for treatment of various diseases of the musculoskeletal system, skin and other organs and systems.\par
Based on the above experiments, it is possible to conclude that the photo excitation of water by Bioptron source indeed results in changes of water structure. This was made possible by absorbing the radiation from the source in the water, stimulating the growth of water nanoclusters linked by hydrogen bond, which, in its turn, was made possible by discovering the unusual properties of light by the abovementioned scientists (emergence of evanescent waves) and creation of "scanning tunneling microscope". (Dr.\par
Stephen Mendak and his colleagues from Germany created a working tool able to reconstruct twodimensional images of three-dimensional nanoscale objects using the light of visible frequency and the near infrared spectrum. The device was developed on the basis of the "super lenses" made of thin silver strips in the form of a tube with center opening of about 2 µm. The evanescent waves pass from its inner surface perpendicularly to the circumference and during such movement there is a primary image magnification, i.e. the "scanning tunneling microscope") \hyperref[b10]{[10]} Russian scientist, winner of the Lenin Prize in physics Gurgen Ashotovich Askarian in 1982 experimentally proved: "increasing in the passage of laser and other radiation through soft turbid physical and biological environments" \hyperref[b15]{[15]}.\par
It is known that one of the interesting applications of laser is based on its stimulating effect on regenerative, anti-inflammatory and immune processes in cells and tissues of the body, especially in view of the resonant nature of absorption and stimulation (one of the absorption fields is close to the generation line of a He-Ne-laser with a wavelength of 0.63 µm).\par
It is precisely these processes that link the use of such lasers with the treatment of purulent processes of the maxillary sinuses, trophic ulcers, non-healing wounds, stomatitis, polyneuritis and other pathological processes.\par
In this regard, we widely used low-energy lasers in the comprehensive therapy of trophic long-term nonhealing wounds, on an annual basis, for 150-170 patients in average, according to the following method:\par
Magneto therapy of a limb during 5-7 minutes up to 30 mt, transversely to the wound area during 5-7 minutes up to 30 mt (Polyus-1 device); ultratone therapy\par
The treatment regimen consisted of 17 procedures.\par
There was always a persistent remission and complete healing of the wound.\par
Over the past five years, an average of 180 patients with the diagnosis of "bilateral purulent process of the maxillary sinuses" were treated annually by physiotherapy according to the following profile: UHF, maxillary sinus area 40 W, 10 minutes, treatment regimen of 10 days; irradiation of nasal passages with short-wave ultraviolet rays for 40 seconds, 10 days; laser therapy, area of the maxillary sinuses with moderate pressure of the device Uzor-A-2K emitters of soft tissues over the areas of the nasal sinuses, 5 Hz, for 5 minutes, treatment regimen of 10 days.\par
There was always a clinical recovery under the X-ray radiography monitoring of the paranasal sinuses and patients did not need surgical treatment.\par
G. A. Askaryan used in his first experiment a layer of polyurethane foam simulating a highly scattering medium. He used as an experiment a continuously operating He-Ne laser LG-75 with a power of 15-20 mW. Its beam was aimed at the test layer contained by a cylinder or tube. A spot of the scattered light was recorded by the camera at the exit from the scattering layer. The spot of scattering light at the exit depended on thickness of the compressed layer. The lower the thickness of the compressed layer was, the larger was the spot of the scattered light at the exit \hyperref[b15]{[15]}.\par
(supersonic frequency currents) on the wound area, average power, during 10 minutes; laser therapy: 4 areas around the wound perimeter, stably for 4 minutes each, 1500 Hz and in the fifth area in the wound center, stably for 4 minutes, 80 Hz. 
\section[{( B )}]{( B )}\par
Fig.  {\ref 6}: Increased light penetration when pressing on the foam layer In his second experiment, G. A. Askarian investigated the change in the light penetration through tissues of the human body. He used a palm as a scattering layer, the center of which was hit by a heliumneon laser beam. The thickness of the palm in its central part was 2.7 cm and 2 cm with slight pain compression.\par
When the beam hit the back of the right palm and when the glass stick pressed on the flesh of the palm from the opposite side, a sharp increase in the light passage was observed. When pressing the left palm on the plexiglass cylinder through which the light passed, the increased light passage observed from the opposite side. Such increase was observed already when compressing from 2.7 to 2 cm, i.e. the translucence effect is much more intense when pressing the palm than when using the foam \hyperref[b15]{[15]}. The author attributes this to the lateral displacement of blood and tissue. However, it should be noted in his experiment that even the thicker parts of the palm, i.e. the flesh with blood and area at the phalanges of fingers are more permeable to light and more susceptible to translucence by compression than its central part. It is interesting to note the relaxation of translucence: when the pressure is released, the translucence does not disappear immediately -the trace of pressure passes the light for another 1 to 3 seconds. This is confirmed in papers \hyperref[b11]{[11,}\hyperref[b12]{12]} -irradiation after effect.\par
The works \hyperref[b12]{[12,}\hyperref[b13]{13,}\hyperref[b14]{14,}\hyperref[b16]{16]} established that the cardiovascular, nervous and lymphatic systems can be the light guides and evanescent (attenuating) waves also form around them, perpendicular to the outer surface of vessels, capillaries, and nerve roots, when they are exposed to electromagnetic waves in any areas of the skin surface.\par
In this regard, we have developed a sensormininano microscope, through which a direct and back communication of internal organs and systems of the integral organism is carried out. 3. Optical fiber cable. 4. Device of information exchange between the integral organism and biosphere.  7. The mirror-lens accessory for connection of "Device of information exchange between the integral organism and biosphere" to Fourier-transform spectrometer "Vector 22". 8. Computer. 9. Contact switch. 10. Terminals from the shell-less fiber AgClBr. 11. Sensor-mininanomicroscope. 12. Skin surface of the integral organism. The mininano microscope sensor is made of two glass plates, placed one above each other with displacement of 5 mm, as to provide space between the skin epidermis and upper glass plate, as well as of 7 µm space between the glass plates for information reciprocal exchange between the integral organism and biosphere through the perspiration system and optical fiber cable.\par
Therefore, evanescent IR spectroscopy of the attenuated total reflection when touching the IR fiber us an unique, non-damaging, not requiring special preparation of the skin method -"Blood Spectrum Biopsy", which reflects the entire information picture of the body at the supramolecular (atomic) level (Fig.  {\ref 2}    Based on the results of experiments, we can assert that the experiments of G. A. Askarian of "increase in the passage of laser and other radiation through turbid physical and biological mediums" support our concept that an integral organism reacts to any external influence on the principle of "biological scanning tunneling microscope", i.e. the light passage through the entire thickness of palm is not due to the lateral displacement of blood and tissue, as stated by the author of the experiment, but to a layer-by-layer formation of evanescent waves deep in the palm with their subsequent increase at the exit of the opposite side of the palm. Also in favor of our concept, the conclusion of the author of the experiment is that the effect of illumination when pressing the palm is much stronger than when using polyurethane foam, and even the thicker parts of the palm -the flesh with blood, the area at the phalanges of the fingers is more permeable to light and more susceptible to illumination by compression than its central part. 
\section[{Palmar surface Back surface}]{Palmar surface Back surface}\par
Our concept of the tunnel effect of the integral organism emerging at exposure to low-energy Back surface after removal of two layers of skin with the adhesive tape Back surface of the hand irradiated during 10 minutes. 
\section[{( B )}]{( B )}\par
electromagnetic waves is supported by the works of Russian and foreign scientists. They discovered the causes of emergence of the evanescent waves: Doctor of Physics and Mathematics, Professor German Nikolaevich Zhizhin, Doctor of Physics and Mathematics, Professor Vinogradov , V. N. Galynsky, A. I. Furs, L. M. Barkovsky, and some others. They believe that the interaction between photons and elementary excitations of the medium produces polaritons. The interaction between electromagnetic waves and excitations of the medium (phonons) leading them to bond becomes especially strong when their frequencies and wave-number vectors coincide (resonance). The bound waves are formed in this region, i.e. polaritons at the border of two media, and attenuate exponentially with the distance from the interface (near field). Phonon is a quasi particle introduced by the Russian scientist Igor Tamm representing a quantum of vibrational motion of crystal atoms.\par
Scientists discovered pseudo-particles traveling on the surface of light-sensitive materials.\par
Researchers from the Karlsruhe Institute of Technology, working together with scientists from the Fritz Haber Institute, Berlin, Germany, and Aalto University, Helsinki, Finland made a significant step towards implementing technologies for converting light into energy that can be used for the benefit of people \hyperref[b3]{[2,}\hyperref[b7]{7]}.\par
Processes that convert light energy into energy of other types can and are gradually becoming the basis of technologies that will supply humanity with energy in the near future.\par
"The conversion of the energy of photons, particles of light, into electrical energy takes place in several stages," explains Professor Christoph Well, Head of the IFG Institute. First, light is absorbed on the surface of the light-sensitive material. The electrons leave their places as influenced by the energy of photons of light, leaving electron holes in their place, with which they immediately form quasi particles called polaritons. These polaritons exist only for a very short time, moving to the boundaries of the material, where they disintegrate into electrons and holes, which continue to move independently further on. The afterlife of these charge carriers already depends on the nature of the light-sensitive material used"  {\ref [18]} It is known that the English physicist B. Josephson predicted in 1962 the D? and AC effects in the superconductor-dielectric contact on the basis of the Bardeen-Cooper-Schrieffer superconductivity theory.\par
Two superconducting layers separated by a negligibly thin insulator layer with thickness of a few atoms only will behave as a single system.\par
When a current is passed through the contact that does not exceed the critical value, there is no voltage drop on the contact (despite the presence of a dielectric layer).\par
This effect is caused by the fact that the conduction electrons pass through the dielectric without resistance due to the tunnel effect. Electrons can pass the barrier even if there is no voltage applied to them (Cooper pair tunneling). The effect is called the DC Josephson effect \hyperref[b18]{[19]}.\par
If a constant voltage is applied on both sides of the passage, quantum mechanics predicts that Cooper pairs of electrons will move through the barrier first in one direction and then in the opposite direction, resulting in an alternating current, which frequency increases as the voltage grows. This effect is called the AC Josephson effect"  {\ref [18,}\hyperref[b18]{19]}.\par
According to the laws of physics, when an integral organism is exposed to electromagnetic waves, evanescent waves are formed from the outside of all capillaries, vessels, nerve trunks and roots, this is a set of "scanning tunneling biomicroscopes", and the effect of PVIP light on the organism is recorded using a "scanning tunneling photon microscope". Therefore, it should be considered that the animal organism is a single superconducting system working on the principle of the Josephson effect in superconductors.\par
In this regard, there is reason to assert that we have identified new, previously unknown mechanisms of action of weak electromagnetic waves on the integral organism and ways to record the organism's responses. In other words, the integral organism functions on the principle of a "scanning tunneling near-field biomicroscope", as it corresponds to the description of the device by Stephen Mendek from Germany. 
\section[{( B )}]{( B )}\par
Structure of the vessel wall. The cardiovascular, nervous and lymphatic systems can be light guides and evanescent (attenuated) waves are also formed around them perpendicular to the outer surface of vessels, capillaries, and nerve roots when they are exposed to electromagnetic waves on any part of the skin surface, i.e. the integral organism enters the operation mode of the "scanning tunneling microscope", so evanescent IR spectroscopy of disturbed full reflection when touching the IR fiber is unique, not-damaging, not requiring special skin preparation -"blood spectrum biopsy", which reflects the entire information picture of the body at the atomic level. (A new advanced trend in Medicine). \hyperref[b12]{[12,}\hyperref[b13]{13,}\hyperref[b14]{14]} An international team of biologists discovered a natural compound that slowed ageing in healthy mice. The study was published in the Cell Metabolism Journal and EurekAlert issue (28.10.2016). Scientists believe that the deficiency of NAD (nicotinamide adenine dinucleotide) in the body is manifested with age. Thanks to NMN (nicotinamide mononucleotide), researchers were able to significantly slow down the physiological decline in ageing mice, as the level of metabolism in these animals was almost equal to that peculiar for young population \hyperref[b19]{[20,}\hyperref[b20]{21]}.\par
Scientists believe that such impressive results are relevant for human beings as well.\par
Testing NMN containing drugs in humans has already begun in Japan. Scientists were able to use the NMN nucleotide, which is involved in the energy exchange of cells for the synthesis of the coenzyme NAD in animals' organisms. It is not possible to directly inject NAD into animals. NAD synthesis in the body slows down with age due to DNA damage. Experiments on mice showed that water-soluble NMN is absorbed into the blood within three minutes and later converted into NAD in tissues. Experts note that taking NMN by young mice has no effect. This compound (NMN), as scientists note, is found in a number of foods, in particular, broccoli, cabbage, cucumbers and avocado. The coenzymes NAD and NADP regulate the metabolism \hyperref[b19]{[20,}\hyperref[b20]{21,}\hyperref[b21]{22]}.\par
NADP is the reduced form of NAD and takes on the hydrogen and electrons of the oxidized compound and transfers them to other substances. 
\section[{( B )}]{( B )}\par
Research conducted by scientists from the University of Washington showed that the substance NMN activates genes responsible for the production of certain proteins and sirtuins. The presence of these proteins in an increased concentration in the bodies of experimental rodents caused a significant slowdown in the age-related degradation of vision and metabolic processes in their bodies \hyperref[b20]{[21,}\hyperref[b21]{22,}\hyperref[b22]{23]}.\par
It is also worth noting that modern ideas about the regulation of cellular processes allow us to highlight a nitrogen oxide, which has a multifunctional physiological effect. This free radical can have both activating and inhibiting effects on various metabolic processes occurring in organisms of mammals and humans \hyperref[b19]{[20,}\hyperref[b20]{21]}.\par
Intensive study of the biological effect of NO began in the 80's, When R. Furshgott and J. Zawadzki showed that the expansion of blood vessels under the influence of acetylcholine occurs only in the presence of endothelium -epithelial cells lining the inner surface of all vessels.\par
The substance released by endothelial cells in response not only to acetylcholine, but also to many other external influences resulting in vasodilation (as in the research of Professor K. A. Samoylova) was called "vasodilating endothelial factor". \hyperref[b19]{[20,}\hyperref[b20]{21,}\hyperref[b23]{24]} Soon later, it was proved that this substance is a NO gas and there are special enzyme systems in cells that are able to synthesize it.\par
In humans and mammals, nitrogen oxide is mainly formed as a result of the oxidation of the guanidine group of L-arginine amino acid with the simultaneous synthesis of another amino acid -citruline -under the influence of NO-synthase enzyme. The enzyme was called a synthase, not a synthetase, because it does not require ATP energy to work. \hyperref[b2]{[1,}\hyperref[b19]{20,}\hyperref[b20]{21,}\hyperref[b22]{23]} Currently, there are three cell populations that are most studied with respect to synthesis and formation of NO: endothelium of blood vessels, nerve tissue cells (neurons) and macrophages -connective tissue cells with high phagocytic activity. In this regard, there are traditionally three main isoforms of NOsynthases (NOS): neuronal, macrophage, and endothelial (designated respectively as NO-synthase I, II, and III). Neuronal and endothelial isoforms of the enzyme are constantly present in cells and called constitutive, and the second isoform (macrophage) is inducible -the enzyme is synthesized in response to a certain external influence on the cell. \hyperref[b19]{[20,}\hyperref[b21]{22,}\hyperref[b22]{23]} Based on above, it should be emphasized that the second macrophage isoform (NOS) is synthesized under the influence on the integral organism of PVIP light at a wavelength of 480-3400 nm, according to the research of Professor K. A. Samoilova, there is also a basis to conduct fundamental research on discovering the increase in isoforms I and III under the action of PVIP light, due to the fact that according to our research, there is an instant impact of PVIP light on cardiovascular system and full coverage by the light exposure of the integral organism. \hyperref[b12]{[12,}\hyperref[b13]{13,}\hyperref[b14]{14,}\hyperref[b16]{16]} Professor K. A. Samoilova claims in her research that the most important role in the stimulating effect of optical radiation on cells and tissues is assigned to two light -absorbing enzyme complexes that have the properties of oxidants-nicotine-adeninedinucletide-phosphate oxidase (NADP-oxidase) and nucleotide-containing bioptero flavoprotei -NOsynthase. Exposed to action of visible and IR light, these enzymes localized in the cell membrane are activated and, using the ambient oxygen, produce its active forms (ROI) -superoxidanion, hydrogen peroxide, hydroxyl radical and nitrogen oxide (NO). These highly reactive molecules conduct a light signal from the surface of the irradiated cell to its nucleus, affecting specialized intracellular mechanisms for conducting the activation signal.\par
It has already been established that the formation of nitrogen oxide -NO-in the systemic circulation is the most important mechanism for such effects of visible and IR light as dilation of blood vessels and platelet disaggregation, failing which phototherapy could hardly be highly effective. \hyperref[b2]{[1]} Before proceeding to considering specific examples of the biological activity of NO in humans and animals, we should once again point out the multifunctional nature of its action, which can not be reduced only to "positive" or only to "negative" effects. \hyperref[b19]{[20,}\hyperref[b20]{21,}\hyperref[b21]{22]} The biological response to NO is largely determined by the conditions of its generation -where, when, and in what quantity this compound is produced. \hyperref[b18]{[19,}\hyperref[b22]{23]} It is worth noting that to date, the localization, distribution of NO-synthase, non-enzymatic formation of nitrogen oxide, participation of NO in the regulation of the nervous system, in protective immunological reactions, participation of NO in the Central Nervous System (CNS), the role of nitrogen oxide as a regulator of cellular processes in the formation of multiple organ failure are underexplored.\par
Based on the above, it should be argued that there is a need to expand basic research on the basis of an academic research Institute with the involvement of specialists in physics, chemistry, ?ytology, physiology, biology and optical physics to create a methodology with the subsequent development of the subject and program on slowing down the natural ageing of a living organism.\par
In this regard, it should be considered that the results of the research of Professor K. A. Samoilova, published in the Materials of the scientific and practical 
\section[{( B )}]{( B )}\par
conference "New trends in use of light therapy "Bioptron", Moscow, Yekaterinburg, April 2003, are the first data in the World on this problem.\par
The above concepts were confirmed with a high statistical accuracy by example of a new rehabilitation technology: "Underwater horizontal traction of the spine with underwater phototherapy" to solve an essential medical and social problem: treatment of patients with degenerative and dystrophic lesions of the lumbosacral spine with herniated protrusions of intervertebral discs, being one of the most common neurological pathologies worldwide. At the present stage of development of rehabilitation medicine, a wide inventory of medicinal and non-medicinal methods (physiotherapy, traction and manual therapy, reflexology, therapeutic physical training), as well as surgical (operative) treatment is used for the treatment of this category of patients. However, it is not possible to achieve the desired therapeutic effect from the applied methods, due to the ineffectiveness of their combined use \hyperref[b4]{[3,} {\ref 4,}\hyperref[b5]{5,}\hyperref[b6]{6]}.\par
The least effect was received by the patients treated with the first method (control group) of drug therapy: improvement (no pain syndrome with the onset of persistent remission) was observed at 45.7\% of patients, no changes (no clinical dynamics) -at 34.3\% and deterioration (negative clinical dynamics) at 20\%.\par
The results of therapy of patients of the second control group treated with the second method: combination of drugs with physical therapy is slightly higher than in patients of the first control group, namely: improvement (no pain syndrome with the onset of persistent remission) was 54.1\%, no changes (no clinical dynamics) -30.6\% and deterioration (negative clinical dynamics) -15.3\%\par
It should be noted that the efficacy of treatment methods 3, 4 and 5, where one of the components of treatment is underwater spinal traction or underwater phototherapy, is significantly higher than in the first and second control groups, by 25-34\%, 33-41\% and 43-51\% respectively.\par
It should also be noted that in the fifth group (n=128), improvement (no pain syndrome with the onset of stable remission) was observed in the first age group of patients aged 17 to 30 yerars, the fourth age group of patients aged 51 to 60y years, with the protrusion of HNP Z4-S1 into the spinal canal in cases of up to 5 mm and from 5 mm to 13 mm, 100\% improvement was observed in patients of the second age group aged 31 to 40 years with the protrusion of HNP Z4-S1 into the spinal canal from 5 mm to 13 mm -92.3\%.\par
In three groups (3, 4 and 5), the largest share of patients without changes (no clinical dynamics) was found in the third group -20.3\%, and among the age groups, the largest share was found in patients of the third age group 41 to 50 -7.8\%.\par
The smallest share of patients without changes (no clinical dynamics) was represented by the patients of the fifth group (n=128) -2.4\%, and among the age groups, the largest share was also found in patients of the third age group aged 41 to 50 years -1.6\%.\par
As a result of comparisons of two control groups (I -n=175 and II-t=157) by age groups, it was found that the deterioration (negative clinical dynamics) was detected in the fourth age group of patients aged 51 to 60 years of the first control group n=175 -6.8\%, and the smallest share was represented by patients of the first age group of patients aged 17 to 30 years -2.3\% of the second control group n=157.\par
The analysis of long-term results of treatment of patients with dorsopathy, osteochondrosis of the lumbosacral spine with protrusion into the spinal canal of HNP L4-S1 up to 5 mm and from 5 mm to 13 mm for three years is presented in table \hyperref[b24]{25}.\par
It follows that the lowest incidence of relapse of severe pain syndrome was observed in groups 3, 4 and 5 -20\% in comparison with control groups 1 and 2 -80\%. 
\section[{( B )}]{( B )}\par
It is worth noting that the inclusion of underwater traction of the lumbosacral spine and underwater phototherapy into the treatment regimen results in a lower incidence of pain relapse compared to the control groups treated with drugs only (first control group n=175) and a combination of drugs and physiotherapy (second control group n=157).\par
In other words, "the joint use of underwater horizontal spine traction with underwater phototherapy via fiber optic cable" contributes to restoration of impaired functions in 96-98\% of patients with degenerative-dystrophic lesions of the spine, due to the regression of herniated protrusion of intervertebral discs by 30-50\% and anti-inflammatory antioxidant effect of underwater phototherapy, but to date, such a regimen has not been used anywhere in the world for this pathology.\par
At the same time, repeated treatment during 5-7 years was undergone only by 0.5\% of patients, and the pain passed in all patients after the first procedure. This is due to the unique combination of underwater horizontal spine traction with underwater phototherapy (yellow light with infrared light at wavelength of 480-3400 nm) via a fiber optic cable \hyperref[b11]{[11]}.\par
A high percentage of positive treatment outcomes, both immediately after the course of therapy and in the long term, indicates the high efficacy of the developed complex of rehabilitation medicine of underwater lumbosacral spine traction with underwater phototherapy.\par
The reliability of treatment outcomes is supported by the use of modern highly sensitive informative methods for assessing the condition of intervertebral discs (MRI and CT) and pathological morphological processes using blood plasma spectroscopy, blood spectrum biopsy from the skin surface for the first time in world healthcare practice. \hyperref[b2]{[1,}\hyperref[b14]{14]} It should be noted that the presented rehabilitative technology surpasses all existing pharmaceutical products, non-drug treatment methods and occupies a well-deserved leading place in the primary prevention of degenerative and dystrophic spinal lesions in adolescents, sportsmen, drivers of road, railway and other vehicles with a driving time of more than 60 minutes per day.\par
The high efficacy of anti-inflammatory immunomodulatory, antiviral and antitumor effects of Medinica, Institute of Dermatovenerology of the Clinical Center, University of Belgrade, Yugoslavia. \hyperref[b11]{[11,}\hyperref[b16]{16]} A peculiarity of phototherapy performed using PVIP light is a very rapid "disappearance" of proinflammatory cytokines -tumor necrosis factor (TNF-?), interleukins-IL-6, IL-2 and IL-12 from the circulating blood, which is recorded just within 30 minutes after the first irradiation. So, at the initial increased content of TNF-?, it drops by 30 times, IL-8 -by 4-6 times, IL-2by 4-10 times and IL-12 -by 12 times (by the end of the treatment course). At the same time, the levels in plasma of anti-inflammatory cytokines -IL-10 and transforming growth factor -TGF-?1 increase, as well as a rapid six-fold increase in the blood of the most important immunomodulator -interferon-? (IFN-?) even at its initial normal levels. The most important function of this cytokine is to activate cellular immunity (functional state of monocytes, macrophages, natural killers, and cytotoxic T-lymphocytes), which primarily increases the body's antiviral and antitumor resistance \hyperref[b23]{[24]}.\par
Experience with PVIP irradiation of blood in vitro gives reason to associate all the described effects with the direct action of light on the blood. In experiments of all designs, light not just stimulates, but regulates the cytokines levels.\par
Also, there is also direct contact in vivo with the cardiovascular system (blood) through perspiration.\par
This is an instantaneous effect on the cellular, supramolecular (atomic) level \hyperref[b13]{[13,}\hyperref[b14]{14,}\hyperref[b16]{16]}.\par
In this regard, there is reason to assert that the system of underwater horizontal spine traction with underwater phototherapy, for the primary disease prevention in adolescents, sportsmen and improving the quality of life of patients with degenerative and dystrophic lesions of the spine, deserves to be promptly introduced into the practice of rehabilitation centers, medical and sports dispensaries, health resorts, departments of therapeutic physical training of healthcare institutions and boarding houses.\par
A human being is a particle of Nature, and all biological processes proceed in him or her in accordance with a strict "program", in the strictest hierarchy from elementary particles to complex structures \hyperref[b12]{[12,}\hyperref[b13]{13]}.\par
There are no two identical elementary particles in nature, hence the supramolecular formations consisting of them up to the Cosmos itself. As exemplified by a living organism in any system (muscular, circulatory, nervous, cardiovascular, etc.), there are no two identical cells either in content or in form, because there would be no muscle contraction, impulse transmission, intracellular and intercellular movement, i.e. the complete absence of visible life activity, i.e. movement with super-low speeds at the supramolecular level, but our cognition of the same is limited by the range of human knowledge \hyperref[b13]{[13,}\hyperref[b14]{14]}. 
\section[{( B )}]{( B )}\par
The intracellular structure of any system is unique, so the intracellular energy is. Therefore a difference of intercellular energy exists as a source of constant endless movement with the huge endless range of speeds, which creates a cyclical nature of processes of "matter-energy" transition from one state to the next ones. This should be considered by a specialist physician, when prescribing drug therapy to patients, otherwise it may result in various complications and addiction to drugs (disorders of organs and systems functions, development of drug addiction, allergies to drugs) \hyperref[b13]{[13,}\hyperref[b14]{14,}\hyperref[b24]{25]}.\par
It is known that "the concept of radiation hormesis was introduced to biology in the 80's and, as homeopathy postulated, while large doses of radiation have adverse effects on living organisms -inhibit cell division, growth and development, then small doses stimulate almost all physiological processes." The effects associated with the manifestation of the stimulating effect of low doses of radiation were called radiation hormesis. \hyperref[b25]{[26]} In this regard, there is a reason to believe that any physical factor affects the body through liquid perspiration from the skin surface. The cardiovascular system instantly connects the physical factor to all organs and systems at the supramolecular level. The same instantaneous connection is carried out by the "tunnel effect", but the current level of technological development does not allow to differentiate them.\par
According to Einstein's famous formula stating the "mass-energy equivalence" and thus justifying the process of mutual transformation of mass and energy (E=m ?? 2 ), the real primary quantum touch of pathological cells with the physical factor selected for treatment is completed.\par
Weak physical effects are more selective and require a very fine adjustment of parameters of the same, in order to implement an interaction contributing to restoration of the disturbed specific biological process \hyperref[b13]{[13,}\hyperref[b14]{14]}.\par
A selective, correct method of a therapeutic physical factor application for a specific intermediate state of the integral organism in the course of its cyclic development at pathology provides for the rejection of use of high-energy parameters of the selected physical factor. This is necessary to prevent the simultaneous destruction of intermediate cyclic states of weakened morphological supramolecular formations of the body and strong pathological supramolecular formations, which is a gross interference with the biological cyclic processes of the body.\par
This can lead to complete or partial irreversible states of organs and systems of the integral organism. In this regard, it should be argued that the application of "established medicamentous standards for diseases" for all patients with the same diagnosis is anti-scientific and extremely dangerous.\par
Due to the fact that any disease is unique for each patient: etiology, pathogenesis, clinical findings, disease outcome, consequences for the integral organism in the future, because even two identical pathogens of any disease do not exist in Nature. 
\section[{III.}]{III.} 
\section[{Conclusion}]{Conclusion}\par
Development of a system of rehabilitation treatment of patients with degenerative and dystrophic lesions of the lumbosacral spine with herniated protrusions of intervertebral discs is an challenging medical and social problem (this pathology is one of the most common neurological diseases in the world and, especially, in Russia).\par
The combined use of underwater horizontal spine traction with underwater phototherapy can contribute to restoration of impaired functions in patients with degenerative and dystrophic lesions of the spine, but to date, such a complex has not been used for treatment of this pathology.\par
From the point of view of rehabilitation medicine, this work implements a comprehensive therapy of herniated protrusions of the intervertebral discs of the lumbosacral spine through a new system of rehabilitation treatment by underwater horizontal spine traction and underwater phototherapy.\par
The therapeutic effect on the body of polychromatic visible and infrared polarized light through the water environment, which may be determined by its activating effect on water, was proved for the first time under experimental conditions. The author a) showed a remarkable regression of herniated protrusion of the intervertebral disc of the lumbosacral spine, when using the developed system of rehabilitation treatment. b) substantiated the expediency of using and a) proved a high clinical efficacy of the combined use of underwater horizontal spine traction and underwater phototherapy for treatment of degenerative and dystrophic spine lesions.\par
In a comparative perspective, a high efficacy of rehabilitation technology applied according to the author's method was established in comparison both with drug therapy and combination with other known methods of physiotherapy and drug treatment.\par
The results of experimental and clinical data confirm the clear advantage of the physical factors use over drug therapy in case of pathology of the musculoskeletal system. Therefore, "Physiotherapy science" should take its rightful place among the leading scientific disciplines of the world medical science. 
\section[{Conclusions}]{Conclusions}\par
1. It was established that the impact of energy of any physical factor is dosed and regulated (physiodynamics) with the help of nanotechnologies and its path to each molecule of the integral organism (physiokinetics) is easily traced without disturbing supramolecular structures and any negative consequences. Modern world pharmaceutical science does not have such a high level of pharmacodynamics and pharmacokinetics. 2. We discovered that the bioelectric potential for each human being is strictly individual both in norm and pathology. In this regard, any nosology causes in each individual a deviation of his or her bioelectric potential in accordance with the stage of disease development, i.e. development of intermediate states of the body with certain disorders of its supramolecular structures. 3. We believe that there is a need to expand basic research on the basis of an research institute with the involvement of specialists in physics, chemistry, ?ytology, physiology, biology and optical physics to create a methodology with the subsequent development of the subject and program on slowing down the natural ageing of a living organism. 4. It is established that the created new system of rehabilitation technology of underwater horizontal spine traction with underwater phototherapy through fiber optic cable exceeds all existing pharmacological means, other non-medicinal methods of treatment and occupies a well-deserved leading place in the primary and secondary prevention of degenerative and dystrophic spine lesions in adolescents, sportsmen, drivers of all types of vehicles. There are no analogues in the world healthcare practice. 5. It was established, that the system of underwater horizontal spine traction with underwater phototherapy, for the primary disease prevention in adolescents, sportsmen and improving the quality of life of patients with degenerative and dystrophic lesions of the spine, deserves to be promptly introduced into the practice of rehabilitation centers, medical and sports dispensaries, health resorts, departments of therapeutic physical training of healthcare institutions and boarding houses. 
\section[{Soul covenants of my dearest mother:}]{Soul covenants of my dearest mother:}\par
"Ask God in your prayer to heal the people that begraced you, always be warm-hearted and kind in praise of the Heavenly King" "Look into the eyes and face of the servant of God, where you can see his distress, do not look onto his hands -you will drown in unholy temptations and will not be able to cure neither his soul, nor his body".\par
"Keep the secrets of the people who shared them with you and do not use them for your Glory". "Do not chase the "Glory", it can be neither overtaken nor embraced, it finds the ones worth? of it".\par
"Be happy with the happiness of the others, feel the people's distress and provide them with diligent help without waiting for request".\par
"Your way must always be lit up and shown by your heart and mind". \begin{figure}[htbp]
\noindent\textbf{}\includegraphics[]{image-2.png}
\caption{\label{fig_0}}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{12}\includegraphics[]{image-3.png}
\caption{\label{fig_1}Fig. 1 :Fig. 2 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{34}\includegraphics[]{image-4.png}
\caption{\label{fig_2}Fig. 3 :Fig. 4 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{5}\includegraphics[]{image-5.png}
\caption{\label{fig_3}Fig. 5 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{7}\includegraphics[]{image-6.png}
\caption{\label{fig_4}Fig. 7 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{8}\includegraphics[]{image-7.png}
\caption{\label{fig_5}Fig. 8 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{8}\includegraphics[]{image-8.png}
\caption{\label{fig_6}Fig. 8}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{8}\includegraphics[]{image-9.png}
\caption{\label{fig_7}Fig. 8}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{9}\includegraphics[]{image-10.png}
\caption{\label{fig_8}Fig. 9 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{11}\includegraphics[]{image-11.png}
\caption{\label{fig_9}Fig. 11 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{1012}\includegraphics[]{image-12.png}
\caption{\label{fig_10}Fig. 10 :Fig. 12 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{13}\includegraphics[]{image-13.png}
\caption{\label{fig_11}Fig. 13 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{15}\includegraphics[]{image-14.png}
\caption{\label{fig_12}Fig. 15 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{16}\includegraphics[]{image-15.png}
\caption{\label{fig_13}Fig. 16 :}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{}\includegraphics[]{image-16.png}
\caption{\label{fig_14}}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{}\includegraphics[]{image-17.png}
\caption{\label{figure17}}\end{figure}
 \begin{figure}[htbp]
\noindent\textbf{} \par 
\begin{longtable}{P{0.7129032258064516\textwidth}P{0.060322580645161286\textwidth}P{0.01096774193548387\textwidth}P{0.06580645161290323\textwidth}}
Therefore,\tabcellsep application\tabcellsep of\tabcellsep "established\\
\multicolumn{4}{l}{medicamentous standards for diseases" for all}\\
\multicolumn{4}{l}{patients with the same diagnosis is anti-scientific}\\
\multicolumn{2}{l}{and extremely dangerous.}\tabcellsep \tabcellsep \end{longtable} \par
 
\caption{\label{tab_1}}\end{figure}
 			\footnote{© 2021 Global Journals} 		 		\backmatter  			  				\begin{bibitemlist}{1}
\bibitem[Klyachkin and Vinogradova]{b5}\label{b5} 	 		\textit{},  		 			L M Klyachkin 		,  		 			M N Vinogradova 		.  	 	 		\textit{Physiotherapy. M.: Meditsina}  		p. .  	 
\bibitem[Bitsoev]{b16}\label{b16} 	 		\textit{},  		 			V D Bitsoev 		.  		 ?7 -2016.  	 	 		\textit{Blood Spectrum Biopsy as Screening Diagnostics of Health. -American Scientific Journal}  		 	 
\bibitem[Brandt and Superconductivity ()]{b18}\label{b18} 	 		\textit{},  		 			N B Brandt 		,  		 			Superconductivity 		.  	 	 		\textit{/ Sorovsky Educational Journal}  		1996.  (1)  p. .  	 
\bibitem[Lehn ()]{b9}\label{b9} 	 		\textit{},  		 			Jean-Marie Lehn 		.  	 	 		\textit{Supramolecular Chemistry}  		1998.  	 
\bibitem[Batanov et al. ()]{b15}\label{b15} 	 		\textit{},  		 			G M Batanov 		,  		 			B M Bolotovsky 		,  		 			S S Grigoryan 		,  		 			I A Kossyi 		,  		 			I Sokolov 		.  		1998. Moscow: Znak. 376.  	 
\bibitem[Ulaschik ()]{b6}\label{b6} 	 		\textit{Analytical reviews of general physiotherapy. Minsk. Nauka i tekhnika Publ},  		 			V S Ulaschik 		.  		1994. 198.  	 
\bibitem[Einstein ()]{b24}\label{b24} 	 		\textit{Collection of research works IV Articles, reviews, letters. Evolution of physics. -Nauka publishing house},  		 			A Einstein 		.  		1967. Moscow.  	 
\bibitem[Volkov et al.]{b3}\label{b3} 	 		\textit{Electricity at service of health. K.: Zdorovye},  		 			E S Volkov 		,  		 			V I Vlyalko 		,  		 			E S Volkov 		,  		 			V I Vlyalko 		.  		p. .  	 
\bibitem[Orekhova et al.]{b1}\label{b1} 	 		\textit{I remember my Great teachers with deep gratitude: Professor E. P. Semenov, Professor V. S. Ulashchik and Academician Jaromir Hrbek. May the memory of them live forever},  		 			M Orekhova 		,  		 			A I Shchukin 		,  		 			N B Korchazhkina 		,  		 			T V Konchugova 		,  		 			M Yu 		,  		 			Gerasimenko 		,  		 			V G Academician 		,  		 			Zilov 		.  		 	 	 (References Références Referencias) 
\bibitem[Samoylova (2003)]{b23}\label{b23} 	 		‘Mechanism of anti-inflammatory, immunomodulating, wound healing and normalizing the metabolism light of the device "BIOPTRON’.  		 			K A Samoylova 		.  	 	 		\textit{Materials of Scientific and Practical Conference},  				 (Moscow, Yekaterinburg)  		April 2003.  	 
\bibitem[Aldersons ()]{b7}\label{b7} 	 		\textit{Mechanism of electrodermal reactions},  		 			A A Aldersons 		.  		1985. Riga.  	 
\bibitem[Alberts et al. ()]{b22}\label{b22} 	 		‘Molecular biology of the cell: in 3 vols’.  		 			A Alberts 		,  		 			D Bray 		,  		 			R Lewis 		.  	 	 		\textit{Translation from English 2nd},  				1994. Mir.  	 
\bibitem[Bitsoev (2016)]{b14}\label{b14} 	 		\textit{New approach in investigating the role of interaction between AN ORGANISM and physical factors in complex patient therapy. -Open Access Library Journal},  		 			V D Bitsoev 		.  		 \url{http://www.oalib.com/articles/526387}  		March 2016.  	 
\bibitem[Bitsoev ()]{b12}\label{b12} 	 		\textit{New line in research of a role of interaction between the organism and physical factors in comprehensive therapy of patients},  		 			V D Bitsoev 		.  		2015. Moscow.  	 
\bibitem[Sosunov ()]{b20}\label{b20} 	 		\textit{Nitrogen oxide as an intercellular mediator},  		 			A A Sosunov 		.  		2000. Saransk.  		 			Ogarev Mordovian State University 		 	 
\bibitem[Bertram et al. ()]{b2}\label{b2} 	 		‘PhD Translation from English edited by Doctor of Medicine’.  		 			G Bertram 		,  		 			Katzung 		,  		 			Md 		.  	 	 		\textit{Prof. Zvartau E. E. Basic and clinical pharmacology}  		1998. Binom. 1  (2) .  	 
\bibitem[Michael ()]{b17}\label{b17} 	 		‘Photon Upconversion at Crystalline Organic-Organic Heterojunctions’.  		 			Oldenburg Michael 		.  	 	 		\textit{Advanced Materials},  				 (Moscow)  		August 2016 -95p. 18. 2000. 6 p. .  	 	 (Josephson effects in superconductors) 
\bibitem[Andryushin and Andryushin ()]{b10}\label{b10} 	 		‘Power of nanotechnologies: science \& business/Andryushin E.A’.  		 			E A Andryushin 		,  		 			E A Andryushin 		.  	 	 		\textit{Successes of Physics},  				2007. p. .  	 
\bibitem[Bogolyubov and Ponomarenko ()]{b4}\label{b4} 	 		‘Saint Petersburg: SPP, 1997-480 p’.  		 			V M Bogolyubov 		,  		 			G N Ponomarenko 		.  	 	 		\textit{Clinical Physiotherapy}  		Orzheshkovskiy V. V., K.: Zdorovye (ed.)  		1985.  	 	 (General Physiotherapy. 446 p) 
\bibitem[Bitsoev]{b11}\label{b11} 	 		\textit{System of rehabilitation treatment of degenerative and dystrophic lesions of spinal cord: Abstract of thesis of Doctor of Medicine},  		 			V D Bitsoev 		.  		Moscow. p. .  	 
\bibitem[Bitsoev (2015)]{b13}\label{b13} 	 		‘The Application of Corrective Underwater Spinal Traction with Underwater Phototherapy to the Spine Pathology’.  		 			V D Bitsoev 		.  		 \xref{http://dx.doi.org/10.11648/j.cmr.20150406.17}{10.11648/j.cmr.20150406.17}.  		 \url{http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=151\&doi=10.11648/j.cmr.20150406.17}  	 	 		\textit{Clinical Medicine Research}  		November 2015. Nov. 26. 2015. 2015. Dec/ 22, 2015. 4  (6)  p. .  	 	 (Accepted: Dec.6. Published) 
\bibitem[Malkoch et al.]{b21}\label{b21} 	 		\textit{The physiological role of nitrogen oxide in organism},  		 			A V Malkoch 		,  		 			V G Maydannik 		,  		 			E Kurbanova 		.  		 \url{http://www.dialvsis.ru/magazin/1\textunderscore 2\textunderscore 2000/no1.htm}  		 	 	 (Part 1) 
\bibitem[Ryabov and Yu]{b19}\label{b19} 	 		\textit{The role of nitrogen oxide as a regulator of cellular processes in the formation of multiple organ failure},  		 			G A Ryabov 		,  		 			Azizov Yu 		.  		Moscow.  	 	 (Research Center of the Medical Center at Administration of the President of the Russian Federation) 
\bibitem[Ryabov and Yu]{b25}\label{b25} 	 		\textit{The role of nitrogen oxide as a regulator of cellular processes in the formation of multiple organ failure},  		 			G A Ryabov 		,  		 			Azizov Yu 		.  		Moscow.  	 	 (Research Center of the Medical Center at Administration of the President of the Russian Federation) 
\bibitem[Garyaev ()]{b8}\label{b8} 	 		\textit{Wave genetic code},  		 			P Garyaev 		.  		1997. Moscow.  	 
\bibitem[The Great Alania and Gabolaevna Kulova-Bitsoeva (ed.)]{b0}\label{b0} 	 		\textit{With undying love, son Vladimir. I express deep gratitude to my family, especially to my dear granddaughter Dzerassa Margieva. As well as to Professors},  		 			Averi The Great Alania 		,  		 			Gabolaevna Kulova-Bitsoeva 		.  		A. A. Hadartsev, V. M. Byakov, A. N. Sheina, E (ed.)  		 	 
\end{bibitemlist}
 			 		 	 
\end{document}
