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\title{The Impress of Low Level Lasers in the Treatment of Patients with in Virus COVID-19 (SARS-Cov-2)}
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\begin{document}

             \author[1]{Ehsan  Kamani}

             \affil[1]{  University of Medical Sciences, Arak}

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\date{\small \em Received: 10 February 2021 Accepted: 3 March 2021 Published: 15 March 2021}

\maketitle


\begin{abstract}
        


Coronavirus disease 2019 (COVID-19) originated in the city of Wuhan, Hubei Province, Central China. COVID-19 is caused by a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, the newly identified SARS-CoV-2 has caused a large number of deaths with Millions person of confirmed cases worldwide, posing a serious threat to public health. However, there are no clinically approved vaccines or specific therapeutic drugs available for COVID-19(1). The evidence shows that blue 450 nm light is antimicrobial against numerous bacteria, and that it accounts for Niels Ryberg Finsen's Nobelwinning treatment of tuberculosis. Further evidence shows that blue light inactivates several viruses, including the common flu coronavirus, and that in experimental animals, red and near infrared light reduce respiratory disorders, similar to those complications associated with coronavirus infection. Moreover, in patients, red light has been shown to alleviate chronic obstructive lung disease and bronchial asthma(2). LLLT can be added to the conventional treatment in COVID-19 at different stages of the disease.

\end{abstract}


\keywords{Low-level laser therapy; Covid19; laser blue; laser red; Virus; SARS-CoV-2, Corona.}

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\let\tabcellsep& 	 	 		 \par
The Impress of Low Level Lasers in the Treatment of Patients with in Virus COVID-19 (SARS-Cov-2)\par
Ehsan Kamani 
\section[{Introduction}]{Introduction}\par
One under laser blood irradiation, antiinflammatory effects were observed that improved the immunologic activity of the blood.\par
A diminishing tendency of aggregation of thrombocytes and an improved deformability of erythrocytes result in an improved oxygen supply and with that to a decrease of partial carbon dioxid pressure, which is particularly relevant to wound healing.\par
Furthermore, the activation of phagocytic activity of macrophages was proved in conjunction with structural modifications. A positive effect on the proliferation of lymphocytes and B-and T-cellsubpopulations could be verified too \hyperref[b6]{[7]}. According to all studies, low-level laser, whether Therapy or intravenous, can cause the following factors for the recovery of patients with Covid 19 virus:  \hyperref[b0]{(1)}. The evidence shows that blue 450 nm light is antimicrobial against numerous bacteria, and that it accounts for Niels Ryberg Finsen's Nobel-winning treatment of tuberculosis. Further evidence shows that blue light inactivates several viruses, including the common flu coronavirus, and that in experimental animals, red and near infrared light reduce respiratory disorders, similar to those complications associated with coronavirus infection. Moreover, in patients, red light has been shown to alleviate chronic obstructive lung disease and bronchial asthma \hyperref[b1]{(2)}. LLLT can be added to the conventional treatment in COVID-19 at different stages of the disease. Because of its anti-inflammatory effect, and ability to shorten recovery times, LLLT can reduce the need of ventilators in the healing process. Clinical trials are necessary to objectively evaluate the effect of LLLT on COVID-19 treatment and recovery \hyperref[b2]{(3)}. Blue laser light of different wavelengths has been reported to have positive effects on our immune system. in covid19 with The goal is to reduce inflammation of the lungs and increase the amount of nitric oxygen that will increase the body's immunity and improve oxygen delivery to the blood and tissues(4.5) The coronavirus has been shown to bind to the cell via the angiotensin-converting enzyme receptor, which is highly expressed in lung and heart cells. if vitamin D levels in the body are balanced, acute cases of coronary heart attack will not occur can balance C vitamin D in the body with yellow laser light, And largely prevented the virus from invading the heart and lungs \hyperref[b5]{(6)}. Effects and mode of operation of intravenous Low-Level-Laser-Therapy of the blood.\par
Keywords: Low-level laser therapy; Covid19; laser blue; laser red; Virus; SARS-CoV-2, Corona.\begin{figure}[htbp]
\noindent\textbf{} \par 
\begin{longtable}{P{0.85\textwidth}}
oronavirus disease 2019 (COVID-19) originated in\\
the city of Wuhan, Hubei Province, Central China.\\
COVID-19 is caused by a novel coronavirus,\\
named severe acute respiratory syndrome coronavirus 2\\
(SARS-\\
1. Reduce inflammation\\
2. Lymphocyte proliferation\\
3. Increase in nitric oxide\\
4. Increase vitamin D.\\
5. Increase oxygen\\
6. Improve the activity of red blood cells\\
Ethical Considerations\\
Not applicable.\end{longtable} \par
 
\caption{\label{tab_0}}\end{figure}
 		 		\backmatter  			 
\subsection[{Conflict of Interests}]{Conflict of Interests}\par
The authors declare no conflict of interest.			 			  				\begin{bibitemlist}{1}
\bibitem[Kamani and Razaghi ()]{b3}\label{b3} 	 		‘Application of Laser Blue Light With a Wavelength of 405 nm in the Treatment of Patients with the Virus COVID-19’.  		 			E Kamani 		,  		 			M Razaghi 		.  		 \xref{http://dx.doi.org/10.22037/jlms.v11i4.30498}{10.22037/jlms.v11i4.30498}.  		 \url{https://doi.org/10.22037/jlms.v11i4.30498}  	 	 		\textit{Journal of Lasers in Medical Sciences}  		2020. 11  (4)  p. .  	 
\bibitem[Li et al. ()]{b0}\label{b0} 	 		‘Coronavirus disease 2019 (COVID-19): current status and future perspectives Int’.  		 			H Li 		,  		 			S.-M Liu 		,  		 			X.-H Yu 		.  	 	 		\textit{J Antimicrob Agents}  		2020. p. 105951.  	 
\bibitem[Kamani ()]{b5}\label{b5} 	 		‘Effect of Low Level Yellow Laser Light 589nm on Virus Prevention Corona Virus (COVID-19)’.  		 			E Kamani 		.  		 JCR-2-112.  	 	 		\textit{OSP J Case Rep}  		2020. 2.  	 
\bibitem[Enwemekaa et al. ()]{b1}\label{b1} 	 		‘Light as a potential treatment for pandemic coronavirus infections: a perspective’.  		 			C S Enwemekaa 		,  		 			V V Bumahab 		,  		 			D S Masson-Meyersc 		.  		 \xref{http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A6152}{10.1164/ajrccm-conference.2019.199.1\textunderscore MeetingAbstracts.A6152}.  	 	 		\textit{J Photochem Photobiol B}  		2020. p. 111891.  	 
\bibitem[Mokmeli and Vetrici ()]{b2}\label{b2} 	 		‘Low level laser therapy as a modality to attenuate cytokine storm at multiple levels, enhance recovery, and reduce the use of ventilators in COVID-19’.  		 			S Mokmeli 		,  		 			M Vetrici 		.  		 \xref{http://dx.doi.org/10.29390/cjrt-2020-015}{10.29390/cjrt-2020-015}.  	 	 		\textit{Can J Respir Ther}  		2020. 56 p. .  	 
\bibitem[Razzaghi and Kamani ()]{b4}\label{b4} 	 		‘Role low-power blue laser with a wavelength of 405 nm in increasing the level of nitric oxide in increasing the resistance of cells to the virus (COVID-19) and its effect on virus (COVID-19) mortality in vitro’.  		 			M D Razzaghi 		,  		 			E Kamani 		.  	 	 		\textit{OSP J Case Rep}  		2020. 2  (3)  p. .  	 
\bibitem[Momenzadeh et al. ()]{b6}\label{b6} 	 		‘The Intravenous Laser Blood Irradiation in Chronic Pain and Fibromyalgia’.  		 			Sirous Momenzadeh 		,  		 			Mohammadzaki Abbasi 		,  		 			Asghar Ebadifar 		,  		 			Mohammadreza Aryani 		,  		 			Jafar Bayrami 		.  	 	 		\textit{Lasers Med Sci}  		2015. 6 p. .  	 
\end{bibitemlist}
 			 		 	 
\end{document}