@incollection{, 2F5A70F089DDD53FC63478D81B11476A , author={{M.Esteban-Blanco} and {González-Fernández} and {V.Villar-Suárez} and {University of León-Universidad de León}}, journal={{Global Journal of Medical Research}}, journal={{GJMR}}2249-46180975-588810.34257/GJMR, address={Cambridge, United States}, publisher={Global Journals Organisation}2113141 } @book{b0, , title={{}} , author={{ TFAlamin }} } @incollection{b1, , title={{The mechanisms of pain from intervertebral discs}} , author={{ VAgarwal }} , booktitle={{The lumbar intervertebral disc}} , editor={ FMPhillips CLauryssen } , year={2010} } @book{b2, , title={{?id=y5V1xNN6ZToC &printsec=frontcover&dq=books+T5he+Lumbar +Intervertebral+Disc&hl=es&sa=X&ved=0ahUKE wiN597JxdzkAhWIBG6MBHaD2CdAQ6AEILTAA# v=onepage&q=books The Lumbar Intervertebral Disc&f=false. Accessed}} , year={19 Sep 2019} } @incollection{b3, , title={{Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs}} , author={{ JISive } and { PBaird } and { MJeziorsk } and { AWatkins } and { JAHoyland } and { AJFreemont }} , journal={{J Clin Pathol -Mol Pathol}} 55 , year={2002} } @incollection{b4, , title={{Pathology and possible mechanisms of nervous system response to disc degeneration}} , author={{ HBrisby }} 10.2106/JBJS.E.01282 , journal={{J Bone Joint Surg Am}} 88 2 , year={2006} , note={Suppl} } @book{b5, , title={{What is Intervertebral Disc Degeneration, and What Causes It?}} , author={{ MAAdams } and { PJRoughley }} } @incollection{b6, , title={{Role of cytokines in intervertebral disc degeneration: pain and disc-content}} , author={{ VMakarand } and { IrvingRisbud } and { Shapiro }} 10.1038/nrrheum.2013.160.Role , journal={{Nat Rev Rheumatol}} 10 , year={2015} } @incollection{b7, , title={{A role for TNF? in intervertebral disc degeneration: A non-recoverable catabolic shift}} , author={{ DPurmessur } and { BAWalter } and { PJRoughley } and { DMLaudier } and { ACHecht } and { JIatridis }} , journal={{Biochem Biophys Res Commun}} 433 , year={2013} } @incollection{b8, , title={{The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc}} , author={{ KLPhillips } and { NChiverton } and { ALMichael } and { AACole } and { LMBreakwell } and { GHaddock } and { RABunning } and { AKCross } and { Lmc }} 10.1089/ten.TEA.2011.0360 , journal={{Biomaterials}} 12 , year={2006} } @book{b9, , title={{Cytokine expression in the epidural space: A model of noncompressive disc herniation-induced inflammation. Spine (Phila Pa 1976)}} , author={{ JMCuéllar } and { PMBorges } and { VGCuéllar } and { AYoo } and { GJScuderi } and { DCYeomans }} , year={2013} 38 } @book{b10, , title={{TNF-Alpha in Nucleus Pulposus Induces Sensory Nerve Growth. Spine (Phila Pa 1976)}} , author={{ SHayashi } and { ATaira } and { GInoue } and { TKoshi } and { TIto } and { MYamashita }} 10.1097/BRS.0b013e318178e5ea , year={2008} 33 } @book{b11, , title={{The Natural History of Age-related Disc Degeneration. Spine (Phila Pa 1976)}} , author={{ BVernon-Roberts } and { RJMoore } and { RDFraser }} 10.1097/BRS.0b013e31815b64d2 , year={2007} 32 } @incollection{b12, , title={{Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials}} , author={{ DOehme } and { TGoldschlager } and { PGhosh } and { J VRosenfeld } and { GJenkin }} doi:10.1155/ 2015/946031 , journal={{Stem Cells Int}} 946031 , year={2015. 2015} } @incollection{b13, , title={{Multipotent Mesenchymal Stem Cell Treatment for Discogenic Low Back Pain and Disc Degeneration}} , author={{ JZeckser } and { MWolff } and { JTucker } and { JGoodwin }} 10.1155/2016/3908389 , journal={{Stem Cells Int}} 3908389 , year={2016. 2016} } @incollection{b14, , title={{Proteomic comparison of the secreted factors of mesenchymal stem cells from bone marrow, adipose tissue and dental pulp}} , author={{ YTachida } and { HSakurai } and { JOkutsu }} , journal={{J Proteomics Bioinform}} 8 , year={2016} } @incollection{b15, , title={{Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease}} , author={{ SHRanganath } and { OLevy } and { MSInamdar } and { JMKarp }} 10.1016/j.stem.2012.02.005 , journal={{Cell Stem Cell}} 10 , year={2012} } @incollection{b16, , title={{The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine}} , author={{ LPk } and { SKandoi } and { RMisra } and { SV } and { KRVerma } and { RS }} , journal={{Cytokine and Growth Factor Reviews}} 46 , year={2019} } @incollection{b17, , title={{Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase}} , author={{ SPiera-Velazquez } and { SAJimenez } and { DGStokes }} , journal={{Arthritis Rheum}} 46 , year={2002} } @incollection{b18, , title={{Cocktail of Hyaluronic Acid and Human Amniotic Mesenchymal Cells Effectively Repairs Cartilage Injuries in Sodium Iodoacetate-Induced Osteoarthritis Rats}} , author={{ A-TWang } and { Q-FZhang } and { N-XWang } and { C-YYu } and { R-MLiu } and { YLuo }} 10.3389/fbioe.2020.00087 , journal={{Front Bioeng Biotechnol}} 8 , year={2020} } @incollection{b19, , title={{Why are MSCs therapeutic? New data: new insight}} , author={{ ACaplan }} 10.1002/path.2469 , journal={{J Pathol}} 217 , year={2009} } @incollection{b20, , title={{Adipose-derived adult stem cells: Isolation, characterization, and differentiation potential}} , author={{ JMGimble } and { FGuilak }} doi:10.1080/ 14653240310003026 , journal={{Cytotherapy}} 5 , year={2003} } @incollection{b21, , title={{Human adiposederived stem cells: isolation, characterization and applications in surgery}} , author={{ MLocke } and { JWindsor } and { PRDunbar }} 10.1111/j.1445-2197.2009.04852.x.21 , booktitle={{Papavassiliou AG, Pneumaticos SG, Evangelopoulos DS}} , year={2009. 2014; 20 JULY-DECEMBER 2014} 79 , note={Mol Med} } @incollection{b22, , title={{Identification of cell proliferation zones, progenitor cells and a potential stem cell niche in the intervertebral disc region: A study in four species}} , author={{ HBHenriksson } and { MThornemo } and { CKarlsson } and { OHägg } and { KJunevik } and { ALindahl }} 10.1097/BRS.0b013e3181a95ad2 , journal={{Spine}} 34 , year={1976. 2009} , publisher={Phila} } @book{b23, , title={{Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc. Spine (Phila Pa 1976)}} , author={{ KSingh } and { KMasuda } and { EjmaThonar } and { HSAn } and { GCs-Szabo }} 10.1097/BRS.0b013e31818e5ddd , year={2009} 34 } @incollection{b24, , title={{Mechanics and biology in intervertebral disc degeneration: A vicious circle}} , author={{ PpaVergroesen } and { IKingma } and { KSEmanuel } and { RjwHoogendoorn } and { TJWelting } and { BJVan Royen }} , journal={{Osteoarthritis and Cartilage}} 23 , year={2015} } @incollection{b25, , title={{Discogenic Back Pain: Literature Review of Definition}} , author={{ KFujii } and { MYamazaki } and { JDKang } and { M VRisbud } and { SKCho } and { SAQureshi }} doi:10.1002/ jbm4.10180 , journal={{Diagnosis, and Treatment. JBMR Plus}} 3 e10180 , year={2019} } @incollection{b26, , title={{Inflammation in intervertebral disc degeneration and regeneration}} , author={{ MMolinos } and { CRAlmeida } and { JCaldeira } and { CCunha } and { RMGonçalves } and { MABarbosa }} doi:10.1098/ rsif.2015.0429 , journal={{J R Soc Interface}} 12 20150429 , year={2015} } @incollection{b27, , title={{Immunomodulation of mesenchymal stem cells in discogenic pain}} , author={{ LMiguélez-Rivera } and { SPérez-Castrillo } and { MlmlGonzález-Fernández } and { JgjggPrieto-Fernández } and { MemeLópez-González } and { JGarcía-Cosamalón }} 10.1016/j.spinee.2017.09.002 , journal={{Spine J}} 18 , year={2018} } @incollection{b28, , title={{Human mesenchymal stem cells stimulated by TNF-?, LPS, or hypoxia produce growth factors by an NF?B-but not JNK-dependent mechanism}} , author={{ PRCrisostomo } and { YWang } and { TAMarkel } and { MWang } and { TLahm } and { DRMeldrum }} , journal={{Am J Physiol -Cell Physiol}} 294 , year={2008} } @incollection{b29, , title={{Human mesenchymal stem cell coculture modulates the immunological properties of human intervertebral disc tissue fragments in vitro}} , author={{ ABertolo } and { TThiede } and { NAebli } and { MBaur } and { SJFerguson } and { JStoyanov }} , journal={{Eur Spine J}} 20 , year={2011} } @incollection{b30, , title={{Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis}} , author={{ XLi } and { MEllman } and { PMuddasani } and { Jh-CWang } and { GCs-Szabo } and { AJVan Wijnen }} 10.1002/art.24258 , journal={{Arthritis Rheum}} 60 , year={2009} } @incollection{b31, , title={{The pro-and anti-inflammatory properties of the cytokine interleukin}} , author={{ JScheller } and { AChalaris } and { DSchmidt-Arras } and { Rose-John } and { S }} , journal={{Biochim Biophys Acta -Mol}} 6 } @incollection{b32, , title={{}} doi:10.1016/ j.bbamcr.2011.01.034 , journal={{Cell Res}} 1813 , year={2011} } @incollection{b33, , title={{Bone marrow-derived mesenchymal stem cellsecreted IL-8 promotes the angiogenesis and growth of colorectal cancer}} , author={{ JWang } and { YWang } and { SWang } and { JCai } and { JShi } and { XSui }} , journal={{Oncotarget}} 6 , year={2015} } @book{b34, , title={{mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine (Phila Pa 1976)}} , author={{ SHAhn } and { YWCho } and { MWAhn } and { SHJang } and { YKSohn } and { HSKim }} 10.1097/00007632-200205010-00005 , year={2002} 27 } @incollection{b35, , title={{Regulation of interferon-? gene expression}} , author={{ HAYoung }} , journal={{Journal of Interferon and Cytokine Research}} 16 , year={1996} } @incollection{b36, , title={{Enhanced Immunosuppressive Properties of Human Mesenchymal Stem Cells Primed by Interferon-?}} , author={{ DSKim } and { IKJang } and { MWLee } and { YJKo } and { DHLee } and { JWLee }} 10.1016/j.ebiom.2018.01.002 , journal={{EBioMedicine}} 28 , year={2018} } @incollection{b37, , title={{Nerve growth factor expression and innervation of the painful intervertebral disc}} , author={{ AJFreemont } and { AWatkins } and { LeMaitre } and { CBaird } and { PJeziorska } and { MKnight } and { Mtn }} , journal={{J Pathol}} 197 , year={2002} } @incollection{b38, , title={{Connective tissue growth factor expression in human intervertebral disc: Implications for angiogenesis in intervertebral disc degeneration}} , author={{ RAli } and { LeMaitre } and { CLRichardson } and { SMHoyland } and { JAFreemont } and { AJ }} , journal={{Biotech Histochem}} 83 , year={2008} } @incollection{b39, , title={{Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain}} , author={{ JGarcía-Cosamalón } and { MEValle } and { MGCalavia } and { OGarcía-Suárez } and { ALópez-Muñiz } and { JOtero }} , journal={{Journal of Anatomy}} 217 , year={2010} } @incollection{b40, , title={{NEUROTROPHINS: Mediators and Modulators of Pain}} , author={{ SPezet } and { SBMcmahon }} , journal={{Annu Rev Neurosci}} 29 , year={2006} } @book{b41, , title={{}} , author={{ LMiguélez-Rivera } and { SPérez-Castrillo } and { MLGonzález-Fernández } and { JGPrieto-Fernández } and { MELópez-González } and { JGarcía-Cosamalón }} }