@incollection{,
	
					
					
					73BEB7D01738AA4659BAFC79BAAD8FA9
				,
	author={{SantoshNagare}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}2132731
}

@book{b0,
	
	
		,
	title={{Pathophysiology of pain}}
		,
	author={{
			TW J M CVanderah
		}}
		
			,
	year={2007}
			91
			
		
	

}

@book{b1,
	
	
		,
	title={{General pathways of pain sensation and the major neurotransmitters involved in pain regulation}}
		,
	author={{
			MFYam
		}}
		
			,
	year={2018}
			19
			2164
		
	

}

@book{b2,
	
	
		,
	title={{Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway}}
		,
	author={{
			ABasbaum
			
				P.o.t.N.A.o.S. Fields
			
		} and {
			CClanton
			
				P.o.t.N.A.o.S. Fields
			
		} and {
			HJ
			
				P.o.t.N.A.o.S. Fields
			
		}}
		
		
		
			,
	year={1976}
			73
			
		
	

}

@book{b3,
	
	
		,
	title={{Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P}}
		,
	author={{
			THökfelt
		}}
		
			,
	year={1977}
			74
			
		
	

}

@book{b4,
	
	
		,
	title={{Pain pathways, and mechanisms of neuropathic pain}}
		,
	author={{
			OA J A N CDe Leon-Casasola
		}}
		
			,
	year={2007}
			23
		
	

}

@incollection{b5,
	
	
		,
	title={{Pathways of pain perception and modulation}}
		,
	author={{
			KRajneesh
		} and {
			RBolash
		}}
		
	
	
		,
	booktitle={{Fundamentals of Pain Medicine}}
				
			,
	publisher={Springer}
			,
	year={2018}
			
		
	

}

@incollection{b6,
	
	
		,
	title={{Central neuropathic pain syndromes}}
		,
	author={{
			JCWatson
		} and {
			PSandroni
		}}
		
	
	
		,
	booktitle={{Mayo clinic proceedings}}
				
			,
	publisher={Elsevier}
			,
	year={2016}
		
	

}

@book{b7,
	
	
		,
	title={{Understanding the etiology and management of HIV-associated peripheral neuropathy}}
		,
	author={{
			KStavros
		} and {
			DM J C H A RSimpson
		}}
		
		
			,
	year={2014}
			11
			
		
	

}

@book{b8,
	
	
		,
	title={{Mechanisms of disease: neuropathic pain-a clinical perspective}}
		,
	author={{
			RJ N C P NBaron
		}}
		
			,
	year={2006}
			2
			
		
	

}

@book{b9,
	
	
		,
	title={{J.o.t.n.s. Cavanagh, Vascular leakage in the dorsal root ganglia of the rat, studied with horseradish peroxidase}}
		,
	author={{
			JMJacobs
		} and {
			RMMacfarlane
		} and {
			JJ
		}}
		
		
		
			,
	year={1976}
			29
			
		
	

}

@book{b10,
	
	
		,
	title={{Impaired nociception and pain sensation in mice lacking the capsaicin receptor}}
		,
	author={{
			MJCaterina
		}}
		
			,
	year={2000}
			288
			
		
	

}

@book{b11,
	
	
		,
	title={{Postherpetic neuralgia: Topical lidocaine is effective in nociceptor-deprived skin}}
		,
	author={{
			GWasner
		}}
		
			,
	year={2005}
			252
			
		
	

}

@book{b12,
	
	
		,
	title={{VR1 protein expression increases in undamaged DRG neurons after partial nerve injury}}
		,
	author={{
			LHudson
		}}
		
			,
	year={2001}
			13
			
		
	

}

@book{b13,
	
	
		,
	title={{Preemptive analgesia I: physiological pathways and pharmacological modalities}}
		,
	author={{
			DJKelly
		} and {
			MAhmad
		} and {
			SJ J C
		}}
		
		
		
			,
	year={2001}
			48
			
		
	

}

@book{b14,
	
	
		,
	title={{p. and s. management, Update on the neurophysiology of pain transmission and modulation: focus on the NMDA-receptor}}
		,
	author={{
			GJ J JBennett
		}}
		
			,
	year={2000}
			19
			
		
	

}

@book{b15,
	
	
		,
	title={{Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain}}
		,
	author={{
			R.-RJi
		} and {
			CJ J N O DWoolf
		}}
		
		
			,
	year={2001}
			8
			
		
	

}

@book{b16,
	
	
		,
	title={{Extra-territorial pain in rats with a peripheral mononeuropathy: mechanohyperalgesia and mechano-allodynia in the territory of an uninjured nerve}}
		,
	author={{
			MTal
		} and {
			GJ J PBennett
		}}
		
		
			,
	year={1994}
			57
			
		
	

}

@book{b17,
	
	
		,
	title={{Upregulation of dorsal root ganglion ?2? calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats}}
		,
	author={{
			ZDLuo
		}}
		
			,
	year={2001}
			21
			
		
	

}

@book{b18,
	
	
		,
	title={{Pathogen recognition and innate immunity}}
		,
	author={{
			SAkira
		} and {
			SUematsu
		} and {
			OJ CTakeuchi
		}}
		
		
		
			,
	year={2006}
			124
			
		
	

}

@book{b19,
	
	
		,
	title={{Toll-like receptor 7 contributes to neuropathic pain by activating NF-?B in primary sensory neurons}}
		,
	author={{
			LHe
		}}
		
			,
	year={2020}
			87
			
		
	

}

@book{b20,
	
	
		,
	title={{TLR8 and its endogenous ligand miR-21 contribute to neuropathic pain in murine DRG}}
		,
	author={{
			Z.-JZhang
		}}
		
			,
	year={2018}
			215
			
		
	

}

@book{b21,
	
	
		,
	title={{TLR8 in the Trigeminal Ganglion Contributes to the Maintenance of Trigeminal Neuropathic Pain in Mice}}
		,
	author={{
			L.-XZhao
		}}
		
			2020
			
		
	

}

@book{b22,
	
	
		,
	title={{TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation}}
		,
	author={{
			X.-JLiu
		}}
		
			,
	year={2016}
			6
			
		
	

}

@book{b23,
	
	
		,
	title={{Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain}}
		,
	author={{
			ZChen
		}}
		
			,
	year={2019}
			116
			
		
	

}

@book{b24,
	
	
		,
	title={{Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate}}
		,
	author={{
			MGSanna
		}}
		
			,
	year={2004}
			279
			
		
	

}

@book{b25,
	
	
		,
	title={{The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1}}
		,
	author={{
			KJanes
		}}
		
			,
	year={2014}
			289
			
		
	

}

@book{b26,
	
	
		,
	title={{A.i.b.r. Spiegel, Sphingosine-1-phosphate signaling: a novel target for simultaneous adjuvant treatment of triple-negative breast cancer and chemotherapy-induced neuropathic pain}}
		,
	author={{
			SKSingh
		} and {
			SJ
		}}
		
		
			,
	year={2020}
			75
			100670
		
	

}

@book{b27,
	
	
		,
	title={{Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn}}
		,
	author={{
			SDoolen
		}}
		
			,
	year={2018}
			159
			224
		
	

}

@book{b28,
	
	
		,
	title={{P2X 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury}}
		,
	author={{
			MTsuda
		}}
		
			,
	year={2003}
			424
			
		
	

}

@book{b29,
	
	
		,
	title={{Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury}}
		,
	author={{
			TYamashita
		}}
		
			,
	year={2016}
			11
			e0165189
		
	

}

@book{b30,
	
	
		,
	title={{Fibronectin/integrin system is involved in P2X4 receptor upregulation in the spinal cord and neuropathic pain after nerve injury}}
		,
	author={{
			MTsuda
		}}
		
			,
	year={2008}
			56
			
		
	

}

@book{b31,
	
	
		,
	title={{P2X4 receptor function in the nervous system and current breakthroughs in pharmacology}}
		,
	author={{
			LStokes
		}}
		
			,
	year={2017}
			8
			291
		
	

}

@book{b32,
	
	
		,
	title={{Cellular and molecular mechanisms of pain}}
		,
	author={{
			AIBasbaum
		}}
		
			,
	year={2009}
			139
			
		
	

}

@book{b33,
	
	
		,
	title={{PARP-1-regulated TNF-? expression in the dorsal root ganglia and spinal dorsal horn contributes to the pathogenesis of neuropathic pain in rats}}
		,
	author={{
			YGao
		}}
		
			,
	year={2020}
			88
			
		
	

}

@book{b34,
	
	
		,
	title={{The role of poly (ADP-ribose) polymerase-1 in rheumatoid arthritis}}
		,
	author={{
			SGarcía
		} and {
			CJ M O IConde
		}}
		
		
			,
	year={2015. 2015}
		
	

}

@book{b35,
	
	
		,
	title={{CCL2 is a key mediator of microglia activation in neuropathic pain states}}
		,
	author={{
			MAThacker
		}}
		
			,
	year={2009}
			13
			
		
	

}

@book{b36,
	
	
		,
	title={{Ryk receptors on unmyelinated nerve fibers mediate excitatory synaptic transmission and CCL2 release during neuropathic pain induced by peripheral nerve injury}}
		,
	author={{
			QOYang
		}}
		
			,
	year={2017}
			13
			1744806917709372
		
	

}

@book{b37,
	
	
		,
	title={{Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic painin vivo and in vitro evidence}}
		,
	author={{
			APiotrowska
		}}
		
			,
	year={2016}
			297
			
		
	

}

@book{b38,
	
	
		,
	title={{Novel hybrid compounds, opioid agonist+ melanocortin 4 receptor antagonist, as efficient analgesics in mouse chronic constriction injury model of neuropathic pain}}
		,
	author={{
			JStarnowska-Sokó?
		}}
		
			,
	year={2020}
			178
			108232
		
	

}

@book{b39,
	
	
		,
	title={{Novel analogs of bifunctional ligands for opioid and melanocortin 4 receptor, in Peptides for Youth}}
		,
	author={{
			VVKulkarni
		}}
		
			,
	year={2009}
			,
	publisher={Springer}
			
		
	

}

@book{b40,
	
	
		,
	title={{Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain}}
		,
	author={{
			APiotrowska
		}}
		
			,
	year={2021}
			162
			432
		
	

}

@book{b41,
	
	
		,
	title={{Neuropathic pain: a possible role for the melanocortin system?}}
		,
	author={{
			DHVrinten
		}}
		
			,
	year={2001}
			429
			
		
	

}

@book{b42,
	
	
		,
	title={{Chronic blockade of melanocortin receptors alleviates allodynia in rats with neuropathic pain}}
		,
	author={{
			DHVrinten
		}}
		
			,
	year={2001}
			93
			
		
	

}