Introduction: Significant number of road accidents can be attributed to drug use and drunk driving globally. The increase in the number of road traffic accidents in a report by the Ghana National Road Safety Commission, calls for a review of drunk driving in the country. The study was conducted to determine the types and use of drugs by drivers in Ghana. This will determine the social and cultural factors that influence drug driving. Methodology: We developed and introduced a self administered questionnaire using a sample of 300 questionnaires. These were administered and carefully edited to ensure some level of consistency, clarity and reliability in the information gathered. Purposive sampling approach was used in the selection of commercial bus stations and cargo stations of selected regions depending on the locations of these stations and the population of vehicles. Backward elimination regression model-building technique was used in the selection of significant variable(s) into a fitted logistic regression model. Five percent statistical level of significance was required for a variable to stay in the model.