A research was conducted to design and evaluate a highly functional 3-component composite fillerbinder for direct compression. Tapioca starch (NTS) was modified physically at molecular level by annealing and enzyme hydrolyzed to obtain microcrystalline tapioca starch(MCTS) which was coprocessed with LMH and microcrystalline cellulose (MCC) to yield Microcrystarcellac (MSCL). NTS was extracted from cassava tuber ( Mannihot esculenta crantz ) using a standard method. The powder suspensions were prepared in concentration of 40 %w/w in five separate conical flasks. The starch granules were annealed for 1 h and subsequently hydrolyzed with α-amylase at 58o and pH 7 for 1, 2, 3, 4, and 5 h in a water bath. The reaction was terminated and neutralized with 0.1 N HCL and 0.1 N NaOH respectively. The MCTS was washed, recovered by sedimentation and air dried at room temperature for 72 h.

How to Cite
SHITTU, A.O., OYI, A.R., ISAH, A.B., IBRAHIM, M.A, Dr.. Design and Evaluation of a 3-Component Composite Excipient “Microcrystarcellac” as a Filler-Binder for Direct Compression Tabletting and its Utilisation in the Formulation of Paracetamol And Ascor. Global Journal of Medical Research, [S.l.], v. 12, n. 7, aug. 2012. ISSN 2249-4618. Available at: <https://medicalresearchjournal.org/index.php/GJMR/article/view/302>. Date accessed: 13 june 2021.

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