@incollection{,
	
					
					
					3D8432DA594AAE6EC0E65A5D3D3719C1
				,
	author={{Dr. Ammar Abdulkareem Hadi} and {Faculty  of pharmacy, Babylon university}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}1322328
}

@incollection{b0,
	
	
		,
	title={{Cardiotoxicity of antineoplasic agents; onset, risk factors and clinical manifestation}}
		,
	author={{
			MLR?dulescu
		} and {
			CLDuncea
		} and {
			DR?dulescu
		} and {
			VMilitaru
		} and {
			APârv
		}}
		
		
		
		
	
	
		,
	journal={{Journal HVM Bioflux}}
		
			3
			2
			
			,
	year={2011}
		
	

}

@incollection{b1,
	
	
		,
	title={{Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation}}
		,
	author={{
			CMCoppin
		} and {
			MKGospodarowicz
		} and {
			KJames
		} and {
			IFTannock
		} and {
			BZee
		} and {
			JCarson
		} and {
			JPeter
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			LDSullivan
		}}
		
		
		
		
		
		
		
	
	
		,
	journal={{J. Clinical Oncology}}
		
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			11
			
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	year={1996}
		
	

}

@incollection{b2,
	
	
		,
	title={{Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer.The new. Engl}}
		,
	author={{
			PGRose
		} and {
			BNBundy
		} and {
			EBWatkins
		} and {
			JTThigpen
		} and {
			GDeppe
		} and {
			MAMaiman
		} and {
			DLClarke-Pearson
		} and {
			SInsalaco
		}}
		
		
		
		
		
		
		
	
	
		,
	journal={{J. Med}}
		
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			15
			
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	year={1999}
		
	

}

@book{b3,
	
	
		,
	title={{}}
		,
	author={{
			UGatzemeier
		} and {
			JVon Pawel
		} and {
			MGottfried
		} and {
			GTen Velde
		} and {
			KMattson
		} and {
			FDemarinis
		} and {
			PHarper
		} and {
			FSalvati
		} and {
			GRobinet
		} and {
			ALucenti
		} and {
			JBogarerts
		} and {
			GGallant
		}}
		
		
		
		
		
		
		
		
		
		
		
		
			,
	year={2000}
		
	

}

@incollection{b4,
	
	
		,
	title={{Phase III comparative study of high-dose cisplatin versus a combination of paclitaxel and cisplatin in patients with advanced non-smallcell lung cancer}}
	
	
		,
	journal={{J. Clinic. Oncol}}
		
			18
			
			,
	year={19}
		
	

}

@book{b5,
	
	
		,
	title={{}}
		,
	author={{
			PHoskins
		} and {
			EEisenhauer
		} and {
			IVergote
		} and {
			JDubuc-Lissoir
		} and {
			BFisher
		} and {
			RGrimshaw
		} and {
			AOza
		} and {
			MPlante
		} and {
			GStuart
		} and {
			JVermorken
		}}
		
		
		
		
		
		
		
		
		
		
			,
	year={2000}
		
	

}

@book{b6,
	
	
		,
	title={{Phase II feasibility study of sequential couplets of}}
		
	

}

@incollection{b7,
	
	
		,
	title={{Cisplatin/Topotecan followed by paciltaxel/cisplatin as primary treatment of advanced epithelial ovarian cancer}}
	
	
		,
	journal={{Clinical Oncology}}
		
			18
			24
			
			,
	publisher={American Society}
		
	

}

@book{b8,
	
	
		,
	title={{}}
		,
	author={{
			AS TPlanting
		} and {
			GCatimel
		} and {
			PH MDe Mulder
		} and {
			ADe Graeff
		} and {
			FHoppener
		} and {
			JVerweij
		} and {
			WOster
		}}
		
		
		
		
		
		
		
	

}

@incollection{b9,
	
	
		,
	title={{Toxic effects of cis-dichlorodiammine platinum in man}}
		,
	author={{
			DDVan-Hoff
		} and {
			RSchilsky
		} and {
			CMReichert
		}}
		
		
	
	
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	journal={{Cancer Treat. Rep}}
		
			63
			
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	year={1979}
		
	

}

@incollection{b10,
	
	
		,
	title={{Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects}}
		,
	author={{
			AFlorea
		} and {
			DBüsselberg
		}}
		
	
	
		,
	journal={{Cancers}}
		
			3
			1
			
			,
	year={2011}
		
	

}

@book{b11,
	
	
		,
	title={{}}
		,
	author={{
			AAAl-Majed
		} and {
			MMSayed-Ahmed
		} and {
			AAAl-Yahya
		} and {
			MAAleisa
		} and {
			SSAl-Rejaie
		} and {
			OAShabanah
		}}
		
		
		
		
		
		
			,
	year={2006}
		
	

}

@incollection{b12,
	
	
		,
	title={{Propionyl-L-carnitine prevents the progression of cisplatin induced cardiomyopathy in a carnitine-depleted rat model}}
	
	
		,
	journal={{Pharmacol. Res}}
		
			53
			
		
	

}

@incollection{b13,
	
	
		,
	title={{5-fluorouracil induced cardiotoxicity}}
		,
	author={{
			SShanmugasundaram
		} and {
			RBharathithasan
		} and {
			SElangovan
		}}
		
		
	
	
		,
	journal={{Indian Heart J}}
		
			54
			
			,
	year={2002}
		
	

}

@incollection{b14,
	
	
		,
	title={{Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats}}
		,
	author={{
			MIYousef
		} and {
			AASaad
		} and {
			LKEl-Shennawy
		}}
		
		
	
	
		,
	journal={{Food and Chemical Toxicology}}
		
			47
			
			,
	year={2009}
		
	

}

@incollection{b15,
	
	
		,
	title={{}}
		,
	author={{
			NIWeijl
		} and {
			GDHopman
		} and {
			AWipkink-Bakker
		} and {
			EGLentjes
		} and {
			HMBerger
		} and {
			FJCleton
		} and {
			SOsanto
		}}
		
		
		
		
		
		
	
	
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	journal={{Ann. Oncol}}
		
			9
			
			,
	year={1998}
		
	

}

@book{b16,
	
	
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	title={{}}
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	author={{
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		} and {
			LMGreggi Antunes
		} and {
			MLBianchi
		}}
		
		
		
			,
	year={2001}
		
	

}

@incollection{b17,
	
	
		,
	title={{Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats}}
	
	
		,
	journal={{Pharmacol. Res}}
		
			43
			
		
	

}

@incollection{b18,
	
	
		,
	title={{Nitric oxide contributes to adriamycin's antitumor effect}}
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	author={{
			DSLinds
		} and {
			MIKontaridis
		} and {
			PDEdwards
		} and {
			MDJosephs
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			LLMoldawer
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			EMCopeland
		}}
		
		
		
		
		
	
	
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	journal={{J. Surg. Res}}
		
			69
			
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	year={1997}
		
	

}

@book{b19,
	
	
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	title={{}}
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	author={{
			HIschiropoulos
		} and {
			LZhu
		} and {
			JSBeckman
		}}
		
		
		
			,
	year={1992}
		
	

}

@incollection{b20,
	
	
		,
	title={{Peroxynitrite formation from macrophagederived nitric oxide}}
	
	
		,
	journal={{Arch. Biochem. Biophys}}
		
			298
			
		
	

}

@book{b21,
	
	
		,
	title={{}}
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	author={{
			RRadi
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			JSBeckman
		} and {
			KMBush
		} and {
			BAFreeman
		}}
		
		
		
		
			,
	year={1991}
		
	

}

@incollection{b22,
	
	
		,
	title={{Peroxynitrite oxidation of sulfhydryls. The cytosolic potential of superoxide and nitric oxide}}
	
	
		,
	journal={{J. Biol. Chem}}
		
			266
			
		
	

}

@incollection{b23,
	
	
		,
	title={{Correlation between cyclosporine-induced nephrotoxicity in reduced nephron mass and expression of kidney injury molecule-1 and aquaporin-2 gene}}
		,
	author={{
			MEHong
		} and {
			JCHong
		} and {
			SStepkowski
		} and {
			BDKahan
		}}
		
		
		
	
	
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	journal={{Transplant. Proc}}
		
			37
			10
			
			,
	year={2005}
		
	

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	title={{}}
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	author={{
			Grraphpad
		}}
		
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	year={1993}
			,
	address={Philadelphia, PA, USA}
		
	

}

@incollection{b25,
	
	
		,
	title={{Toxic effects of cis-dichlorodiammine platinum in man}}
		,
	author={{
			DDVan-Hoff
		} and {
			RSchilsky
		} and {
			CMReichert
		}}
		
		
	
	
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	journal={{Cancer Treat. Rep}}
		
			63
			
			,
	year={1979}
		
	

}

@incollection{b26,
	
	
		,
	title={{Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine}}
		,
	author={{
			JSastry
		} and {
			SJKellie
		}}
		
	
	
		,
	journal={{Pediatr. Hematol. Oncol}}
		
			22
			
			,
	year={2005}
		
	

}

@book{b27,
	
	
		,
	title={{}}
		,
	author={{
			EEElawady
		} and {
			YMMoustafa
		} and {
			DAbo-Elmatty
		} and {
			M
		} and {
			RadwanA
		}}
		
		
		
		
		
			,
	year={2011}
		
	

}

@incollection{b28,
	
	
		,
	title={{Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies}}
	
	
		,
	journal={{Eur. J. Pharma}}
		
			650
			
		
	

}

@book{b29,
	
	
		,
	title={{}}
		,
	author={{
			JWang
		} and {
			DHe
		} and {
			QZhang
		} and {
			YHan
		} and {
			SJin
		} and {
			FQi
		}}
		
		
		
		
		
		
			,
	year={2009}
		
	

}

@book{b30,
	
	
		,
	title={{Resveratrol Protects Against Cisplatin-Induced Cardiotoxicity by Alleviating Oxidative Damage: Cancer biotherapy and radio pharmaceuticals}}
		
			6
			
		
	

}

@incollection{b31,
	
	
		,
	title={{Molecular replacement in cancer therapy: reversing cancer metabolic and mitochondrial dysfunction, fatigue and the adverse effects of cancer therapy}}
		,
	author={{
			KAConklin
		} and {
			GLNicolson
		}}
		
	
	
		,
	journal={{Curr. Cancer Ther. Rev}}
		
			4
			
			,
	year={2008}
		
	

}

@incollection{b32,
	
	
		,
	title={{Role of mitochondria in toxic oxidative stress}}
		,
	author={{
			MWFariss
		} and {
			CBChan
		} and {
			MPatel
		} and {
			BVan Houten
		} and {
			SOrrenius
		}}
		
		
		
		
	
	
		,
	journal={{Mol. Interv}}
		
			5
			2
			
			,
	year={2005}
		
	

}

@incollection{b33,
	
	
		,
	title={{Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria}}
		,
	author={{
			NASantos
		} and {
			CSBezerra
		} and {
			NMMartins
		} and {
			CCurti
		} and {
			MLBianchi
		} and {
			ACSantos
		}}
		
		
		
		
		
	
	
		,
	journal={{Cancer hemother. Pharmacol}}
		
			61
			1
			
			,
	year={2008}
		
	

}

@book{b34,
	
	
		,
	title={{}}
		,
	author={{
			NASantos
		} and {
			CSBezerra
		} and {
			NMMartins
		} and {
			CCurti
		} and {
			MLBianchi
		} and {
			ASantos
		}}
		
		
		
		
		
		
			,
	year={2007}
		
	

}

@incollection{b35,
	
	
		,
	title={{Cisplatininduced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in ratkidney mitochondria}}
	
	
		,
	journal={{Arch. Toxicol}}
		
			81
			7
			
		
	

}

@incollection{b36,
	
	
		,
	title={{A novel free radical scavenger, edarabone, protects againstcisplatin-induced acute renal damage in vitro and in vivo}}
		,
	author={{
			MSatoh
		} and {
			NKashihara
		} and {
			SFujimoto
		} and {
			HHorike
		} and {
			TTokura
		} and {
			TNamikoshi
		} and {
			TSasaki
		} and {
			HMakino
		}}
		
		
		
		
		
		
		
	
	
		,
	journal={{J. Pharmacol. Exp. Ther}}
		
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	year={2003}
		
	

}

@book{b37,
	
	
		,
	title={{}}
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	author={{
			JSKim
		} and {
			LHe
		} and {
			JJLemasters
		}}
		
		
		
			,
	year={2003}
		
	

}

@incollection{b38,
	
	
		,
	title={{Mitochondrial permeability transition: a common pathway to necrosis and apoptosis}}
	
	
		,
	journal={{Biochem. Biophys. Res. Commun}}
		
			304
			
		
	

}

@incollection{b39,
	
	
		,
	title={{Mitochondrial control of cell death}}
		,
	author={{
			GKroemer
		} and {
			JCReed
		}}
		
	
	
		,
	journal={{Nat. Med}}
		
			6
			
			,
	year={2000}
		
	

}

@incollection{b40,
	
	
		,
	title={{Cisplatin nephrotoxicity}}
		,
	author={{
			IArany
		} and {
			RLSafirstein
		}}
		
	
	
		,
	journal={{Semin. Nephrol}}
		
			23
			
			,
	year={2003}
		
	

}

@book{b41,
	
	
		,
	title={{}}
		,
	author={{
			KKarthikeyan
		} and {
			BRBai
		} and {
			SNDevaraj
		}}
		
		
		
			,
	year={2007}
		
	

}

@incollection{b42,
	
	
		,
	title={{Emerging approaches in preventing cardiovascular disease}}
		,
	author={{
			RPMason
		} and {
			MWalter
		} and {
			FTrumbore
		} and {
			M
		} and {
			WOlmsteadJr
		} and {
			E
		} and {
			GMason
		} and {
			P
		} and {
			E
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Cardiology}}
		
			31
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			,
	year={1999}
		
	

}