@incollection{, 68C05648909D8A14349AA52E6B6B628F , author={{TapanBehl} and {Delhi University}}, journal={{Global Journal of Medical Research}}, journal={{GJMR}}2249-46180975-588810.34257/GJMR, address={Cambridge, United States}, publisher={Global Journals Organisation}1442936 } @incollection{b0, , title={{}} , author={{ SHLandis } and { TMurray } and { SBolden }} , journal={{Cancer statistics. CA: A Cancer Journal for Clinicians}} 49 1 , year={1999} } @incollection{b1, , title={{Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study}} , author={{ FBerrino } and { RDe Angelis } and { MSant }} , journal={{Lancet.Oncol}} 8 , year={2007} } @incollection{b2, , title={{Cancer statistics}} , author={{ RSiegel } and { JMa } and { ZZou } and { A }} , journal={{CA: A Cancer Journal for Clinicians}} 64 1 , year={2014} } @incollection{b3, , title={{Epidemiology of colorectal cancer}} , author={{ NBecker }} , journal={{Der. Radiologe}} 43 2 , year={2003} } @incollection{b4, , title={{}} , author={{ FJemal } and { MMBray } and { Center }} , journal={{Global cancer statistics. CA: A Cancer Journal for Clinicans}} 61 2 , year={2011} } @incollection{b5, , title={{How does colorectal cancer present? Symptoms, duration, and clues to location}} , author={{ SRMajumdar } and { RHFletcher } and { ATEvans }} , journal={{The American Journal of Gastroenterology}} 94 10 , year={1999} } @book{b6, , title={{The diagnosis of colorectal cancer in patients with symptoms: finding a needle in a haystack}} , author={{ RHFletcher }} , year={2009} 17 18 } @book{b7, , title={{Large bowel perforation: morbitiy and mortality. Techniques in Coloproctology}} , author={{ KBielecki } and { PKaminski } and { MKlukowski }} , year={2002} 6 } @incollection{b8, , title={{Understanding current guidelines for colorectal cancer screening: a casebased approach. Cleve}} , author={{ LKBianchi } and { CABurke }} , journal={{Clin. J. Med}} 75 6 } @incollection{b9, , title={{Red meat and colorectal cancer: a critical summary of prospective epidemiologic studies}} , author={{ DDAlexander } and { CACushing }} , journal={{Obes. Rev}} 12 5 , year={2011} } @incollection{b10, , title={{Diet and colorectal cancer}} , author={{ MCBoutron } and { MWilpart } and { JFaivre }} , journal={{European Journal of Cancer Prevention}} 2 , year={1991} , note={Suppl} } @incollection{b11, , title={{An Updated Review of the Epidemiological Evidence that Cigarette Smoking Increases Risk of Colorectal Cancer}} , author={{ EGiovannucci }} , journal={{Cancer Epidemiol. Biomarkers Prev}} 10 7 , year={2001} } @incollection{b12, , title={{Microbially produced acetaldehyde from ethanol may increase the risk of colon cancer via folate deficiency}} , author={{ NHomann } and { JTillonen } and { MSalaspuro }} , journal={{Int. J. Cancer}} 86 2 , year={2000} } @incollection{b13, , title={{Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study}} , author={{ AHWu } and { APaganini-Hill } and { RKRoss } and { BEHenderson }} , journal={{Br. J. Cancer}} 55 6 , year={1987} } @incollection{b14, , title={{Familial adenomatous polyposis}} , author={{ EHalf } and { DBercovich } and { PRozen }} , journal={{Orphanet Journal of Rare Diseases}} 4 22 , year={2009} } @book{b15, , title={{Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. The Lancet}} , author={{ SDolwani } and { SJones } and { DEccles }} , year={2003} 362 } @incollection{b16, , title={{Inherited colorectal cancer syndromes}} , author={{ RGryfe }} , journal={{Colorectal Cancer}} 22 4 , year={2009} } @incollection{b17, , title={{Genetic pathways in colorectal cancer: interest for the pathologist}} , author={{ FPiard } and { LMartin } and { CChapusot } and { TPonnelle } and { JFaivre }} , journal={{Ann. Pathol}} 22 4 , year={2002} } @incollection{b18, , title={{Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC}} , author={{ PJMorin } and { ABSparks } and { VKorinek }} , journal={{Science}} 275 5307 , year={1997} } @incollection{b19, , title={{Detection of point mutations of the Axin1 gene in colorectal cancers}} , author={{ LHJin } and { QJShao } and { WLuo }} , journal={{Int. J. Cancer}} 107 5 , year={2003} } @incollection{b20, , title={{Mai et Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signaling}} , author={{ WLiu } and { MDong }} , journal={{Nat. Genet}} 26 2 , year={2000} } @incollection{b21, , title={{Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells}} , author={{ PHatzis } and { LGVan Der Flier } and { MAVan Driel }} , journal={{Mol. Cell Biol}} 28 8 , year={2008} } @incollection{b22, , title={{Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alterWnt/Dvl/beta-catenin signaling}} , author={{ JGuo } and { TCagatay } and { GZhou }} , journal={{PloS One}} 4 11 e7982 , year={2009} } @book{b23, , title={{Colon cancer. In: DeVita, Hellman, and Rosenberg's cancer: principles and practice of oncology}} , author={{ SKLibutti } and { LBSaltz } and { JETepper }} , editor={V.T. DeVita Jr., T.S. Lawrence, S.A. Rosenberg} , year={2008} , publisher={Lippincott Williams & Wilkins} 1 , address={Philadelphia} } @incollection{b24, , title={{}} , author={{ CCompton } and { ETHawk } and { LGrochow } and { FLee } and { MRitter } and { JE }} , journal={{Abeloff's clinical oncology}} , note={Niederhuber. Colon cancer} } @book{b25, , title={{}} , author={{ MDAbeloff } and { JArmitage } and { JENiederhuber } and { MBKastan } and { GW }} } @book{b26, , author={{ Mckenna }} , title={{Philadelphia: Churchill Livingstone}} , year={2008} } @incollection{b27, , title={{}} , author={{ SDMarkowitz } and { DMDawson } and { JWillis } and { JKWillson }} , journal={{Focus on colon cancer. Cancer Cell}} 1 3 , year={2002} } @incollection{b28, , title={{Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer}} , author={{ TAndre } and { CBoni } and { LMounedji-Boudiaf }} , journal={{N. Engl. J. Med}} 350 23 , year={2004} } @incollection{b29, , title={{Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC?/? colon carcinoma}} , author={{ VKorinek } and { NBarker } and { PJMorin }} , journal={{Science}} 275 5307 , year={1997} } @book{b30, , title={{Biology of the adenomatous polyposis coli tumor suppressor}} , author={{ KHGoss } and { JGroden }} } @incollection{b31, , title={{Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression}} , author={{ MGPrieve } and { MLWaterman }} , journal={{Mol. Cell Biol}} 19 , year={1999} } @book{b32, , title={{Colorectal tumors. In: The genetic basis of human cancer}} , author={{ KWKinzler } and { BVogelstein }} , editor={B. Vogelstein and K.W.Kinzler} , year={2002} , publisher={McGraw-Hill} , address={New York} } @incollection{b33, , title={{p53, the cellular gatekeeper for growth and division}} , author={{ AJLevine }} , journal={{Cell}} 88 , year={1997} } @incollection{b34, , title={{Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas}} , author={{ SJBaker } and { ERFearon } and { JMNigro }} , journal={{Science}} 244 , year={1989} } @incollection{b35, , title={{p53 Gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis}} , author={{ SJBaker } and { ACPreisinger } and { JMJessup }} , journal={{Cancer Res}} 50 , year={1990} } @incollection{b36, , title={{MAD-related genes in the human}} , author={{ GJRiggins } and { SThiagalingam } and { ERozenblum }} , journal={{Nat. Genet}} 13 , year={1996} } @incollection{b37, , title={{The MAPK signaling pathways and colorectal cancer}} , author={{ JYFang } and { BCRichardson }} , journal={{The Lancet Oncology}} 6 5 , year={2005} } @incollection{b38, , title={{Prevalence of RAS gene mutations in human colorectal cancers}} , author={{ JLBos } and { ERFearon } and { SRHamilton }} , journal={{Nature}} 327 6120 , year={1987} } @incollection{b39, , title={{Hyperplastic and serrated polyps of the colorectum}} , author={{ MJO'brien }} , journal={{Gastroenterol. Clin. North. Am}} 36 4 , year={2007} } @incollection{b40, , title={{Mutations of the BRAF gene in human cancer}} , author={{ HDavies } and { GRBignell } and { CCox }} , journal={{Nature}} 417 6892 , year={2002} } @incollection{b41, , title={{High frequency of mutations of the PIK3CA gene in human cancers}} , author={{ YSamuels } and { ZWang } and { ABardelli }} , journal={{Science}} 304 5670 554 , year={2004} } @incollection{b42, , title={{Colorectal cancer: mutations in a signalling pathway}} , author={{ DWParsons } and { TLWang } and { YSamuels }} , journal={{Nature}} 436 7052 792 , year={2005} } @incollection{b43, , title={{Comparative lesion sequencing provides insights into tumor evolution}} , author={{ SJones } and { WDChen } and { GParmigiani } and { G }} , booktitle={{Proc. Natl. Acad. Sci. USA}} Natl. Acad. Sci. USA , year={2008} 105 } @incollection{b44, , title={{15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers}} , author={{ MYan } and { RMRerko } and { PPlatzer }} , booktitle={{Proc. Natl. Acad. Sci. USA}} Natl. Acad. Sci. USA , year={2004} 101 } @incollection{b45, , title={{The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis}} , author={{ GSteinbach } and { PMLynch } and { RK SPhillips }} , journal={{N. Engl. J. Med}} 342 , year={2000} } @incollection{b46, , title={{Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor}} , author={{ LBSaltz } and { NJMeropol } and { PJLoehrer } and { MNNeedle } and { JKopit } and { RJMayer }} , journal={{J.Clin. Oncol}} 22 7 , year={2004} } @incollection{b47, , title={{PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab}} , author={{ MJhawer } and { SGoel } and { AJWilson }} , journal={{Cancer Res}} 68 6 , year={2008} } @incollection{b48, , title={{Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer}} , author={{ HHurwitz } and { LFehrenbacher } and { WNovotny }} , journal={{N. Engl. J. Med}} 350 23 , year={2004} }