@incollection{, 5E73BAFDD55C70D6EA3936BCCEC57183 , author={{Herman S.Cheung} and {Carlos M.Carballosa} and {David J.Fernandez-Fidalgo} and {Herman S.Cheung} and {University of Miami, Coral Gables, FL}}, journal={{Global Journal of Medical Research}}, journal={{GJMR}}2249-46180975-588810.34257/GJMR, address={Cambridge, United States}, publisher={Global Journals Organisation}141111 } @incollection{b0, , title={{Mammalian nicotinic acetylcholine receptors: From structure to function}} , author={{ EXAlbuquerque } and { EF RPereira } and { MAlkondon } and { SWRogers }} , journal={{Physiological Reviews}} 89 1 , year={2009} } @incollection{b1, , title={{Factors affecting the fracture healing in treatment of tibial shaft fractures with circular external fixator}} , author={{ KBAlemdaro?lu } and { UTiftikçi } and { SIltar } and { NHAydo?an } and { TKara } and { DAtlihan } and { ASabri Ate?alp }} , journal={{Injury}} 40 11 , year={2009} } @incollection{b2, , title={{MicroRNAs: Genomics, biogenesis, mechanism, and function}} , author={{ DPBartel }} , journal={{Cell}} 116 2 , year={2004} } @book{b3, , title={{Nicotine chemistry, metabolism, kinetics and biomarkers. Handbook of Experimental Pharmacology}} , author={{ NLBenowitz } and { JHukkanen } and { IiiJacob } and { P }} , year={2009} 192 } @incollection{b4, , title={{Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers}} , author={{ NLBenowitz } and { IiiJacob } and { P }} , journal={{Clinical Pharmacology and Therapeutics}} 53 3 , year={1993} } @incollection{b5, , title={{Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism}} , author={{ NLBenowitz } and { IiiJacob } and { P }} , journal={{Clinical Pharmacology and Therapeutics}} 67 6 , year={2000} } @incollection{b6, , title={{Stable isotope studies of nicotine kinetics and bioavailability}} , author={{ NLBenowitz } and { IiiJacob } and { PDenaro } and { CJenkins } and { R }} , journal={{Clinical Pharmacology and Therapeutics}} 49 3 , year={1991} } @incollection{b7, , title={{Nicotine absorption and cardiovascular effects with smokeless tobacco use: Comparison Nicotine's Influence on Musculoskeletal Healing: A Review Featuring nAChRS and miRNA}} , author={{ NLBenowitz } and { HPorchet } and { LSheiner } and { IiiJacob } and { P }} , journal={{Global Journal of Medical Research}} , year={1988} } @incollection{b8, , title={{Tobacco smoking and chronic destructive periodontal disease}} , author={{ JBergström }} , journal={{Odontology / the Society of the Nippon Dental University}} 92 1 , year={2004} } @incollection{b9, , title={{Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family}} , author={{ JBoulter } and { JConnolly } and { EDeneris } and { DGoldman } and { SHeinemann } and { JPatrick }} , journal={{Proceedings of the National Academy of Sciences of the United States of America}} 84 21 , year={1987} } @incollection{b10, , title={{In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57B1/6J mice}} , author={{ DHBrunzell } and { DSRussell } and { MRPicciotto }} , journal={{Journal of Neurochemistry}} 84 6 , year={2003} } @incollection{b11, , title={{MicroRNAs in skeletal and cardiac muscle development}} , author={{ TECallis } and { J-Chen } and { D-Wang }} , journal={{DNA and Cell Biology}} 26 4 , year={2007} } @incollection{b12, , title={{Quitting smoking among adults-United States}} , journal={{Centers for Disease Control and Prevention (CDC)}} 60 , year={2011. 2001-2010} , note={MMWR Morb Mortal Wkly Rep} } @incollection{b13, , title={{The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration}} , author={{ AIChernyavsky } and { JArredondo } and { EKarlsson } and { IWessler } and { SAGrando }} , journal={{Journal of Biological Chemistry}} 280 47 , year={2005} } @incollection{b14, , title={{Nicotine induces the expression of early growth response-1 in human skin dermal fibroblasts}} , author={{ JEChoi } and { JNKim } and { SHJeong } and { SWSon }} , journal={{International Journal of Dermatology}} 49 2 , year={2010} } @incollection{b15, , title={{Mutational analysis of the charge selectivity filter of the ?7 nicotinic acetylcholine receptor}} , author={{ P-Corringer } and { SBertrand } and { J-Galzi } and { ADevillers-Thiéry } and { J-Changeux } and { DBertrand }} , journal={{Neuron}} 22 4 , year={1999} } @incollection{b16, , title={{Expression of neuronal acetylcholine receptor genes in vertebrate skeletal muscle during development}} , author={{ RACorriveau } and { SJRomano } and { WGConroy } and { LOliva } and { DKBerg }} , journal={{Journal of Neuroscience}} 15 2 , year={1995} } @incollection{b17, , title={{The nicotinic acetylcholine receptor: Structure and autoimmune pathology}} , author={{ BMConti-Tronconi } and { KEMclane } and { MARaftery } and { SAGrando } and { MPProtti }} , journal={{Critical Reviews in Biochemistry and Molecular Biology}} 29 2 , year={1994} } @incollection{b18, , title={{Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system}} , author={{ JADani } and { DBertrand }} , journal={{Annu Rev Pharmacol Toxicol}} 47 , year={2007} } @book{b19, , title={{Department of Health and Human Services. The health consequences of smoking: nicotine addiction. A Report of the Surgeon General}} , year={1988} } @incollection{b20, , title={{Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis}} , author={{ MEn-Nosse Lips, K. S. } and { SHartmann Lips, K. S. } and { KTrinkaus Lips, K. S. } and { VAlt Lips, K. S. } and { BStigler Lips, K. S. } and { CHeiss Lips, K. S. }} , journal={{Cell and Tissue Research}} 338 2 , year={January 15. 2014. 2009} } @incollection{b21, , title={{Current concepts in neuromuscular transmission}} , author={{ MJFagerlund } and { LIEriksson }} , journal={{British Journal of Anaesthesia}} 103 1 , year={2009} } @incollection{b22, , title={{Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4 +:CD8+ Tcell ratios are reversed by smoking cessation: Influence of bone mass on immune cell response to and recovery from smoke exposure}} , author={{ JSFusby } and { MDKassmeier } and { VLPalmer } and { GAPerry } and { DKAnderson } and { BTHackfort } and { ..Swanson } and { PC }} , journal={{Inhalation Toxicology}} 22 9 , year={2010} } @incollection{b23, , title={{Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic}} , author={{ J-Galzi } and { ADevillers-Thiery } and { NHussy } and { SBertrand } and { J-Changeux } and { DBertrand }} , journal={{Nature}} 359 6395 , year={1992} } @book{b24, , title={{Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: Regulatory implications}} , author={{ MLGoniewicz } and { PHajek } and { HMcrobbie }} , year={2013} } @incollection{b25, , title={{Repair and transplant of bone}} , author={{ AWHam } and { WRHarris }} , booktitle={{The Biochemistry and Physiology of Bone: Development and Growth}} , editor={ GHBourne } New York, NY , publisher={McGraw-Hill, Medical Pub. Division} , year={1971} } @incollection{b26, , title={{How a cigarette is smoked determines blood nicotine levels}} , author={{ RIHerning } and { RTJones } and { NLBenowitz } and { AHMines }} , journal={{Clinical Pharmacology and Therapeutics}} 33 1 , year={1983} } @incollection{b27, , title={{Functional nicotinic and muscarinic receptors on mesenchymal stem cells}} , author={{ MJHoogduijn } and { ACheng } and { PGGenever }} , journal={{Stem Cells and Development}} 18 1 , year={2009} } @incollection{b28, , title={{Chronic neonatal nicotine upregulates heteromeric nicotinic acetylcholine receptor binding without change in subunit mRNA expression}} , author={{ LZHuang } and { UHWinzer-Serhan }} , journal={{Brain Research}} 1113 1 , year={2006} } @incollection{b29, , title={{Metabolism and disposition kinetics of nicotine}} , author={{ JHukkanen } and { IiiJacob } and { PBenowitz } and { NL }} , journal={{Pharmacological Reviews}} 57 1 , year={2005} } @incollection{b30, , title={{Nicotinic acetylcholine receptors: From basic science to therapeutics}} , author={{ RHurst } and { HRollema } and { DBertrand }} , journal={{Pharmacology and Therapeutics}} 137 1 , year={2013} } @book{b31, , title={{The in vitro and in vivo effects of nicotine on bone}} , author={{ RKallala } and { JBarrow } and { SMGraham } and { NKanakaris } and { PVGiannoudis }} , year={2013} } @incollection{b32, , title={{Nicotine acts on growth plate chondrocytes to delay skeletal growth through the ?7 neuronal nicotinic acetylcholine receptor}} , author={{ AKawakita } and { KSato } and { HMakino } and { HIkegami } and { STakayama } and { YToyama } and { AUmezawa }} , journal={{PLoS ONE}} 3 12 , year={2008} } @incollection{b33, , title={{?7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A ?-amyloidinduced neurotoxicity}} , author={{ TKihara } and { SShimohama } and { HSawada } and { KHonda } and { TNakamizo } and { HShibasaki } and { ..Akaike } and { A }} , journal={{Journal of Biological Chemistry}} 276 17 , year={2001} } @incollection{b34, , title={{Effects of nicotine on proliferation and osteoblast differentiation in human alveolar bone marrow-derived mesenchymal stem cells}} , author={{ B-Kim } and { S-Kim } and { H-Kim } and { S-Lee } and { Y-Park } and { JLee } and { H-You }} , journal={{Life Sciences}} 90 3-4 , year={2012} } @incollection{b35, , title={{Nicotinic acetylcholine receptor ?7 and ?4 subunits contribute to nicotine-induced apoptosis in periodontal ligament stem cells}} , author={{ SYKim } and { KLKang } and { J-Lee } and { JSHeo }} , journal={{Molecules and Cells}} 33 4 , year={2012} } @incollection{b36, , title={{The effect of cigarette smoking on radiographic bone healing after elective foot surgery}} , author={{ KWKrannitz } and { HWFong } and { LMFallat } and { JKish }} , journal={{Journal of Foot and Ankle Surgery}} 48 5 , year={2009} } @incollection{b37, , title={{Direct effects of pure nicotine, cigarette smoke extract, swedish-type smokeless tobacco (snus) extract and ethanol on human normal endothelial cells and fibroblasts}} , author={{ NLaytragoon-Lewin } and { FBahram } and { LERutqvist } and { ITuresson } and { FLewin }} , journal={{Anticancer Research}} 31 5 , year={2011} } @incollection{b38, , title={{Influence of tobacco abstinence on the disposition kinetics and effects of nicotine}} , author={{ BLLee } and { NLBenowitz } and { IiiJacob } and { P }} , journal={{Clinical Pharmacology and Therapeutics}} 41 4 , year={1987} } @incollection{b39, , title={{Effects of nicotine on antioxidant defense enzymes and RANKL expression in human periodontal ligament cells}} , author={{ H-Lee } and { S-Pi } and { YKim } and { H-Kim } and { S-Kim } and { Y-Kim } and { ..Kim } and { E- }} , journal={{Journal of Periodontology}} 80 8 , year={2009} } @incollection{b40, , title={{Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells}} , author={{ S-Lee } and { K-Kang } and { S-Shin } and { YHerr } and { Y-Lee } and { E-Kim }} , journal={{Journal of Periodontal Research}} 47 3 , year={2012} } @incollection{b41, , title={{Nicotinic acetylcholine receptors in health and disease}} , author={{ JLindstrom }} , journal={{Molecular Neurobiology}} 15 2 , year={1997} } @book{b42, , title={{}} , author={{ RJLukas } and { J-Changeux } and { NLe Novère } and { EXAlbuquerque } and { DJ KBalfour } and { DKBerg }} } @incollection{b43, , title={{International union of pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits}} , author={{ SWonnacott }} , journal={{Pharmacological Reviews}} 51 2 , year={1999} } @incollection{b44, , title={{Influence of low-dose nicotine on bone healing}} , author={{ LMa } and { MHSham } and { LWZheng } and { LKCheung }} , journal={{Infection and Critical Care}} 70 6 , year={2011} , note={Journal of Trauma -Injury} } @book{b45, , title={{}} , author={{ KDMacklin } and { AD JMaus } and { EF RPereira } and { EXAlbuquerque } and { BMConti-Fine }} , year={1998} } @incollection{b46, , title={{Human vascular endothelial cells express functional nicotinic acetylcholine receptors}} , journal={{Journal of Pharmacology and Experimental Therapeutics}} 287 1 } @incollection{b47, , title={{The multiple faces of nicotine and its implications in tissue and wound repair}} , author={{ JWMartin } and { SSMousa } and { OShaker } and { SAMousa }} , journal={{Experimental Dermatology}} 18 6 , year={2009} } @incollection{b48, , title={{Nicotine preconditioning antagonizes activitydependent caspase proteolysis of a glutamate receptor}} , author={{ ELMeyer } and { LCGahring } and { SWRogers }} , journal={{Journal of Biological Chemistry}} 277 13 , year={2002} } @book{b49, , title={{Nicotine prevents glutamateinduced proteolysis of the microtubule-associated protein MAP-2 and glutamate neurotoxicity in primary cultures of cerebellar neurons}} , author={{ M-Miñana } and { CMontoliu } and { MLlansola } and { SGrisolía } and { VFelipo }} , year={1998} } @incollection{b50, , title={{}} , journal={{Neuropharmacology}} 37 7 } @incollection{b51, , title={{Nicotine effects on skin: Are they positive or negative}} , author={{ LMisery }} , journal={{Experimental Dermatology}} 13 11 , year={2004} } @incollection{b52, , title={{Maturation of the acetylcholine receptor in skeletal muscle: Regulation of the AChR ?-to-? switch}} , author={{ ACMissias } and { GCChu } and { BJKlocke } and { JRSanes } and { JPMerlie }} , journal={{Developmental Biology}} 179 1 , year={1996} } @incollection{b53, , title={{Dose released and absolute bioavailability of nicotine from a nicotine vapor inhaler}} , author={{ LMolander } and { ELunell } and { S-Andersson } and { FKuylenstierna }} , journal={{Clinical Pharmacology and Therapeutics}} 59 4 , year={1996} } @incollection{b54, , title={{Nicotine alters MicroRNA expression and hinders human adult stem cell regenerative potential}} , author={{ TKNg } and { CMCarballosa } and { DPelaez } and { HKWong } and { KWChoy } and { CPPang } and { HSCheung }} , journal={{Stem Cells and Development}} 22 5 , year={2013} } @incollection{b55, , title={{Relationship between smoking status and periodontal conditions: Findings from national databases in japan}} , author={{ MOjima } and { THanioka } and { KTanaka } and { EInoshita } and { HAoyama }} , journal={{Journal of Periodontal Research}} 41 6 , year={2006} } @incollection{b56, , title={{Single-channel currents of rat neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes}} , author={{ RLPapke } and { JBoulter } and { JPatrick } and { SHeinemann }} , journal={{Neuron}} 3 5 , year={1989} } @incollection{b57, , title={{The role of the ?4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine ?3-receptors}} , author={{ RLPapke } and { SFHeinemann }} , journal={{Journal of Physiology}} 440 , year={1991} } @incollection{b58, , title={{Chronic nicotine exposure attenuates proangiogenic activity on human umbilical vein endothelial cells}} , author={{ HSPark } and { KCho } and { YJPark } and { TLee }} , journal={{Journal of Cardiovascular Pharmacology}} 57 3 , year={2011} } @incollection{b59, , title={{Effect of nicotine on human umbilical vein endothelial cells (HUVECs) migration and angiogenesis}} , author={{ YJPark } and { TLee } and { JHa } and { IMJung } and { JKChung } and { SJKim }} , journal={{Vascular Pharmacology}} 49 1 , year={2008} } @incollection{b60, , title={{Increased nicotinic receptors in brains from smokers: Membrane binding and autoradiography studies}} , author={{ DCPerry } and { MIDávila-García } and { CAStockmeier } and { KJKellar }} , journal={{Journal of Pharmacology and Experimental Therapeutics}} 289 3 , year={1999} } @incollection{b61, , title={{Neuronal nicotinic acetylcholine receptor subunit knockout mice: Physiological and behavioral phenotypes and possible clinical implications}} , author={{ MRPicciotto } and { BJCaldarone } and { DHBrunzell } and { VZachariou } and { TRStevens } and { SLKing }} , journal={{Pharmacology and Therapeutics}} 92 2-3 , year={2001} } @incollection{b62, , title={{The musculoskeletal effects of smoking}} , author={{ SEPorter } and { ENHanleyJr }} , journal={{The Journal of the American Academy of Orthopaedic Surgeons}} 9 1 , year={2001} } @incollection{b63, , title={{Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research}} , author={{ GSPortugal } and { TJGould }} , journal={{Behavioural Brain Research}} 193 1 , year={2008} } @incollection{b64, , title={{Nicotine pharmacokinetics of nicoderm® (nicotine transdermal system) in women and obese men compared with normal-sized men}} , author={{ RDPrather } and { TGTu } and { CNRolf } and { JGorsline }} , journal={{Journal of Clinical Pharmacology}} 33 7 , year={1993} } @incollection{b65, , title={{Role of acetylcholine receptors in proliferation and differentiation of P19 embryonal carcinoma cells}} , author={{ RRResende } and { ASAlves } and { LR GBritto } and { HUlrich }} , journal={{Experimental Cell Research}} 314 7 , year={2008} } @incollection{b66, , title={{Expression of the nicotinic receptor ?7 gene in tendon and periosteum during early development}} , author={{ SJRomano } and { RACorriveau } and { RISchwarz } and { DKBerg }} , journal={{Journal of Neurochemistry}} 68 2 , year={1997} } @incollection{b67, , title={{The effect of nicotine on the mechanical properties of mesenchymal stem cells}} , author={{ JPRuiz } and { DPelaez } and { JDias } and { NMZiebarth } and { HSCheung }} , journal={{Cell Health and Cytoskeleton}} 4 , year={2012} } @incollection{b68, , title={{The nicotine inhaler clinical pharmacokinetics and comparison with other nicotine treatments}} , author={{ NGSchneider } and { REOlmstead } and { MAFranzon } and { ELunell }} , journal={{Clinical Pharmacokinetics}} 40 9 , year={2001} } @incollection{b69, , title={{Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells}} , author={{ IUSchraufstatter } and { RGDiscipio } and { SKKhaldoyanidi }} , journal={{Journal of Stem Cells}} 4 4 , year={2009} } @incollection{b70, , title={{Nicotinic receptor signaling in nonexcitable cells}} , author={{ GSharma } and { SVijayaraghavan }} , journal={{Journal of Neurobiology}} 53 4 , year={2002} } @incollection{b71, , title={{Dose-dependent effects of nicotine on proliferation and differentiation of human bone marrow stromal cells and the antagonistic action of vitamin C}} , author={{ YShen } and { H-Liu } and { X-Ying } and { S-Yang } and { P-Nie } and { S-Cheng } and { ..Xu } and { H- }} , journal={{Journal of Cellular Biochemistry}} 114 8 , year={2013} } @incollection{b72, , title={{Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation}} , author={{ DSilva } and { MCáceres } and { RArancibia } and { CMartínez } and { JMartínez } and { PCSmith }} , journal={{Journal of Periodontal Research}} 47 5 , year={2012} } @incollection{b73, , title={{The effects of smoking on fracture healing}} , author={{ ASloan } and { IHussain } and { MMaqsood } and { OEremin } and { MEl-Sheemy }} , journal={{Surgeon}} 8 2 , year={2010} } @incollection{b74, , title={{Effects of cigarette smoke on the immune system}} , author={{ MSopori }} , journal={{Nature Reviews Immunology}} 2 5 , year={2002} } @incollection{b75, , title={{Joint abuse liability review of nicotine nasal spray}} , author={{ RStevens }} , booktitle={{FDA Drug Abuse Advisory Committee Background Information}} , year={1994} , note={cited in NDA 18612} } @incollection{b76, , title={{Mechanisms for redox actions of nicotine and glutathione in cell culture, relevant to periodontitis}} , author={{ FTinti } and { MSoory }} , journal={{Scientific Reports}} 2 , year={2012} } @incollection{b77, , title={{Simultaneous determination of nicotine and cotinine in various human tissues using capillary gas chromatography/mass spectrometry}} , author={{ NUrakawa } and { TNagata } and { KKudo } and { KKimura } and { TImamura }} , journal={{International Journal of Legal Medicine}} 106 5 , year={1994} } @incollection{b78, , title={{Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro}} , author={{ ACVillablanca }} , journal={{Journal of Applied Physiology}} 84 6 , year={1998} } @incollection{b79, , title={{Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture}} , author={{ LMWalker } and { MRPreston } and { JLMagnay } and { PB MThomas } and { AJHaj }} , journal={{Bone}} 28 6 , year={2001} } @incollection{b80, , title={{Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex}} , author={{ TLWallace } and { DBertrand }} , journal={{Biochemical Pharmacology}} 85 12 , year={2013} } @book{b81, , title={{Functional expression of ?7 nicotinic acetylcholine receptors in human periodontal ligament fibroblasts and rat}} , author={{ X-Wang } and { Y-Liu } and { Q-Wang } and { MTsuruoka } and { KOhta } and { S-Wu } and { ..Inoue } and { T }} , year={2010} }