# Introduction ump in breast is common presentation in surgical practice. The lesions of the breast have diverse etiology and presentation may range from a benign tumour, cyst or a malignancy. 1 The dominant breast lumps are often defined as clinically benign breast lesions which are distinct, persistent and relatively unchanging and include fibroadenomas, gross cysts and galactoceles. 2 The diagnostic methods of palpable breast lumps should be rapid, inexpensive, most accurate and least invasive to evaluate and distinguish between benign and malignant lumps in outpatient clinics. Such methods benefits both patients and surgeons by promoting proper preoperative diagnosis and management and by limiting the unnecessary testing and procedures. 3,4 FNAC is a relatively simple, reliable, atraumatic, economical and complication free technique for the evaluation of mass lesions. It can also be easily repeated if an adequate aspirate is not obtained. FNAC has superseded the use of frozen section examination in the diagnosis and management of patients with breast cancer. 5 the biopsy of the palpable breast lesion based on the histological study of the tissue specimens can provide all the reliable information to the surgeon and oncologist for modern therapeutic strategy in decision making regarding the patients treatment. It permits the eventual use of neo adjuvant therapy. 6 It has found to have sensitivity ranging from 82% to 97.5% and specificity of more than 99%. 7 The studies regarding comparison of FNAC with Histopathology is scant in this part of the country. Hence, this study was undertaken to compare the results of FNAC and tru-cut biopsy in detection of breast lesion pathology. # II. # Materials and Methods A cross sectional study was undertaken to study the clinical profile and correlation between FNAC and Histopathology of breast lumps. This study was conducted in Department of Surgery of Basaveshwara Medical College and Hospital, Chitradurga. A total of 150 patients attending the outpatient department were chosen as study sample. Institutional ethical committee approval was obtained before the study. All the patients included as study sample were obtained the informed consent. All the patients aged more than 18 years presenting with breast lumps were included in the study. Patients with breast pain of any cause were excluded from the study. The patients thus selected were subjected for detailed history including general physical examination, systemic and local examination. The patients were also subjected for detailed laboratory work up including basic investigations. The sample was obtained by the help of ultrasound with all aseptic precautions. The sample was spread on the slide handed over to pathologist for staining and interpretation. The data thus obtained was entered in a predesigned proforma. The data was analysed using Statistical Package for social services (SPSS vs 18). The categorical variables were analysed using frequencies and percentages. The mean age of women in this study was 34.98 years. Majority of the women were aged 21 -30 years, 24.7% were aged between 31 -40 years, 14% were aged between less than 20 years. About 52% of the women had lump in left breast, 45.3% had lump in right breast and 4% had bilateral lump. The discharge from nipple was present in 4.7% of the patients and 12.7% had history loss of weight in this study. Only 2.7% of the women in this study had family history of breast disease in this study. Table no 2 shows the distribution of the study group according to the dimension of the lesion. About 53.3% of the women had lump measuring 1 -3 × 1 -3 cms, 22.7% had lump measuring 4 -6 × 4 -6 cms, 16% had lump measuring 4 -6 × 1 -3 cms and 7.3% had lump measuring 1 -3 × 4 -6 cms. In this study, 21.3% of the breast lumps were due to benign breast disease, 56.7% of the women had fibroadenoma of the breast, 14.7% had suspicious malignancy and 7.3% had features suggestive of malignancy. Women aged less than 20 years had benign breast disease and most of the women aged more than 40 years had FNAC features of suspicious malignancy. On comparison of FNAC findings with histopathology, about 17.3% of the patients in this study who were diagnosed as benign breast disease had fibro adenoma on histopathology, 12% with suspicious malignancy turned out as invasive duct carcinoma. ( D D D D ) I III. # Results IV. # Discussion Breast Lumps are common presentations to the surgical outpatient department. Breast lumps are common surgical problem in females. All breast lesions are not malignant but can also be benign. Majority of the benign breast lumps do not progress to cancer. 1 Hence the diagnostic method of palpable breast lump should be rapid, inexpensive, most accurate and least invasive and should be able to distinguish between benign and malignant lumps in the outpatient clinics. Such methods help the surgeons in early and accurate diagnosis and management and also help the patient in improving the prognosis. 3,4 Hence a cross sectional study was conducted in order to evaluate and compare the findings of FNAC in outpatient department. The mean age of the women with breast lump in this study was 34.98 years. Majority of the women belonged to 21 -40 years. In a study by Homesh et al, the mean age of the women who were subjected for FNAC was 33.36 years. 8 A study in Nepal, had shown that the age of patients ranged from 16 to 72 years and maximum number of patients were in the age group of 20 -40 years. 9 In contrast to this study, the mean age of the women in study was 46.12 years. 10 Left breast was commonly affected in this study than right breast. Left breast was affected in more than 50% of the patients in this study. In a study by Homesh et al, 8 right breast was involved in 50.3% of the women and left breast was involved in 40.7% of the women. The dimension of majority of the lesions in this study was between 1 -3 × 1 -3 cms. Mean size of the breast lumps in a study In Saudi Arabia was 3.47 cms with a range of 2 -10 cms in contrary to the findings of this study. 8 More than 50% of the palpable breast lumps were sized between 1 -2 cms. The decrease in size of the lesion in yielded inadequate aspirate in a study by Bajwa et al. 11 In another study, the size of lesion was Majority of the women with breast lump were found to have fibroadenoma in this study. It was followed by benign breast disease and feature suggestive or suspicious of malignancy. About 17.3% of the patients in this study who were diagnosed as benign breast disease had fibro adenoma, 12% with suspicious malignancy turned out as invasive duct carcinoma. In a study, Hirachand et al, have found that 64.2% cases with breast lump had fibro adenoma of the breast, 7.5% reported benign proliferative diseases of the breast and 16% reported to be having malignant breast lesions. There were 3.8% of the cases with epithelial hyperplasia with atypia, 3.8% with duct ectasia and 1.9% had phylloids tumour. The histopathology had shown that 64.2% were turned out to be fibro adenoma, 5.6% turned out to be fibrocystic disease, 3.8% had duct ectasia, 1.9% had phylloids tumour and 1.9% had chronic abscess. The FNAC was not correlated with the histopathological findings in three patients. 9 In a study by Bajwa et al, proliferative and neoplastic lesions accounted for 71% of the total samples in contrary to the results of our study. Fibroadenoma accounted for 48.1% of the cases, infiltrating ductal carcinoma was found in 26.6% of the cases. 11 in a study by Bukhari et al, benign lesions were found in 60% of the cases, 20% had inflammatory aspirates and 40% of the women with breast lump had benign proliferative lesions. 12 This study was mainly under taken to study the value of FNAC and histopathology in diagnosis of breast lumps. Breast lumps may range from simple benign tumors to invasive malignancy. Accurate and simple diagnostic measures can detect the nature of the lump at an earliest possible time and helps in early management can improve the prognosis. The results of this study had shown that, even though FNAC was considered as a simple, cost effective and easy method, it had low sensitivity in diagnosis compared to trucut biopsy. 1Profile of PatientsFrequency PercentageLess than 202114.0years21 -305234.7years31 -403724.7Age groupyears 41 -502013.3years51 -6074.7yearsMorethan138.760 yearsSide lesionofBilateral Right Left4 68 782.7 45.3 52.0DischargePresent74.7from nippleNo14395.3LossofPresent1912.7weightNo13187.3FamilyYes42.7historyofNo14697.3breastdiseaseTotal150100 2Dimension of LesionDimension of theBreadth of the lesionlesion (Length)1 -3 cms4 -6 cmsn (%)n (%)1 -3 cms80 (53.3)11 (7.3)4 -6 cms24 (16.0)34 (22.7)More than 7 cms01 (0.7)Total104 (69.3)46 (30.7) 3Age groupBenign breast diseaseFibroadenomaSuggestive ofSuspiciousmalignancymalignancyLess than 20 years3 (2.0)18 (12.0)21 -30 years17 (11.3)33 (22.0)2 (1.3)31 -40 years7 (4.7)26 (17.3)2 (1.3)2 (1.3)41 -50 years3 (2.0)8 (5.3)4 (2.7)5 (3.3)51 -60 years5 (3.3)2 (1.3)More than 60 years2 (1.3)11 (7.3)Total32 (21.3)85 (56.7)11 (7.3)22 (14.7) 4Year 2014Volume XIV Issue II Version I( ) IAge groupFibroadenomaInvasive ductLipomaPaget's disease ofPhylloidscarcinomanippletumourLess than 20 years21 (14.0)21 -30 years48 (32.0)2 (1.3)2 (1.3)31 -40 years31 (20.7)4 (2.7)2 (1.3)41 -50 years11 (7.3)9 (6.0)51 -60 years7 (4.7)More than 60 years7 (4.7)4 (2.7)2 (1.3)Total111 (74.0)29 (19.3)2 (1.3)4 (2.7)4 (2.7)The histopathological findings in this study had19.3% had invasive duct carcinoma, 2.7% had paget'sshown that, 74% of the patients had fibroadenoma,disease of nipple and phylloides tumour. 5FNAC resultsHistopathology findingsFibroadenomaInvasive ductLipomaPaget's diseasePhylloidsn (%)carcinoman (%)of nippletumourn (%)n (%)n (%)Benign breast disease26 (17.3)2 (1.3)4 (2.7)Fibro adenoma85 (56.7)Suggestive of malignancy11 (7.3)Suspicious malignancy18 (12.0)4 (2.7)Total111 (74.0)29 (19.3)2 (1.3)4 (2.7)4 (2.7) © 2014 Global Journals Inc. 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