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\textcolor{GJBlue}{\large\bfseries\abstractname\space} }{% \vskip8pt \textcolor{GJMediumGrey}{\rule{\textwidth}{2pt}} \vskip16pt } \usepackage[absolute,overlay]{textpos} \makeatother \usepackage{lineno} \linenumbers \begin{document} \author[1]{Abdullah Al Mamun} \affil[1]{ National Institute of ENT} \renewcommand\Authands{ and } \date{\small \em Received: 10 December 2013 Accepted: 2 January 2014 Published: 15 January 2014} \maketitle \begin{abstract} from July 2011 to December 2012,where all patients were admitted through out patient department. All patients were selected as per described criteria from the Department of Otolaryngology & Head-Neck Surgery, SSMCMH & BSMMU. Diagnosed the cases by detail history, clinical examination,investigations,analysed data presented by various tables, figures.Results: In this study mean age of the patients of solitary thyroid nodule was 35.6±13.54 years and the highest frequency (38%) was within 21-30 years of age with female predominance (78%). Thyroid swelling was the common presentation in all9100%) cases, some patients also presented with other symptoms like cervical lymphadenopathy 13(13%) cases, dysphagia 1(1%), dyspnoea 1(1%), hoarseness of voice 1(1%) case & no bone metastetic found. \end{abstract} \keywords{solitary thyroid nodule, papillary carcinoma, follicular carcinoma, medulary carcinoma.} \begin{textblock*}{18cm}(1cm,1cm) % {block width} (coords) \textcolor{GJBlue}{\LARGE Global Journals \LaTeX\ JournalKaleidoscope\texttrademark} \end{textblock*} \begin{textblock*}{18cm}(1.4cm,1.5cm) % {block width} (coords) \textcolor{GJBlue}{\footnotesize \\ Artificial Intelligence formulated this projection for compatibility purposes from the original article published at Global Journals. However, this technology is currently in beta. \emph{Therefore, kindly ignore odd layouts, missed formulae, text, tables, or figures.}} \end{textblock*} \let\tabcellsep& \section[{Introduction}]{Introduction}\par The solitary or isolated thyroid nodule may be defined as a discrete swelling in an otherwise impalpable gland. It is usually a benign lesion. It is common in clinical practice. The swelling is often noticed accidentally by the patient or drawn to her attention by a family member, neighbor, or a friend. The nodule may also be encountered as an incidental finding when a patient is examined for some unrelated disease. About 70\% discrete thyroid swellings are clinically isolated. Thyroid nodules are common and are among 3-4\% of the adult population in the UK and USA. They are 3-4 times more frequent in women than men. A nodule may be adenoma, cyst, multino-dular goiter, thyroiditis and thyroid cancer {\ref 2.} The importance of solitary thyroid nodule lies in the significant risk of malignancy compared with other( D D D D ) J Year 2014\par hyroid gland and its enlargement are known since the time of Hippocrates. Among the endocrine organs, diseases of the thyroid gland are the most common. A good number of diseases affect the thyroid gland and almost all of them presents with nodular thyroid swelling. Nodular goiter remains a problem of enormous magnitude all over the world, although exact data on incidence and prevalence are unavailable. In our country the national prevalence rate is 10-15\%, which indicates, the whole country is endemic. The endemicity varies from one place to another. The highest prevalence rate in Bangladesh is in the district of Rangpur and Jamalpur, the range varies from 21-30\%. Nodular thyroid disease is more prevalent than diffuse goitre. In a report from the thyroid clinic, Bangabondhu Sheikh MujibMedical Univecity, Dhaka 32.67\% of all thyroid patients had solitary nodules {\ref 1.} thyroid swelling. Many studies have been published on the risk of malignancy in patients with thyroid nodules; these studies show that the risk of malignancy is low, approximately 5\%, unless the patient has an underlying risk factor, such as a history of external neck irradiation {\ref 3.} If imaging investigations shows the nodule to be truly solitary, then the likelihood of it being malignant increases to about 5-20\% \hyperref[b3]{4} , of which papillary carcinoma comprises about 80\%, follicular carcinoma 10\% and medullary carcinoma 5\% \hyperref[b4]{5} , but in another study it showed papillary carcinoma comprises about 60\% and follicular carcinoma 18\% \hyperref[b5]{6} .\par Screening of large numbers of patients previously unsuspected of having goiter suggests that the incidence of the isolated thyroid nodule in the general population may be of the order of 4-7\% \hyperref[b6]{7} . A thyroid nodule larger than 1 cm in diameter is usually palpable. However, the detection of a nodule by palpation also depends on its location within the thyroid gland, on the structure of the patient's neck and on the experience of the examiner.\par It has been estimated that palpable thyroid nodules are present in 4-7\% of the population, but when examined by ultrasound, as many as 50-70\% of subjects with no history of thyroid disease have been found to have incidentally discovered thyroid nodules, many of which are not palpable \hyperref[b7]{8} . In addition, nodular thyroid disease is more common in the elderly, a population subgroup, which is steadily increasing \hyperref[b8]{9} .\par Laboratory investigations other than FNAC have limited role in finding out the nature of thyroid swelling. Isotope scan can demonstrate the functioning capacity of the nodule but cannot predict the histopathological character \hyperref[b9]{10} .\par Fine needle aspiration cytology (FNAC) is considered as the most reliable test for the diagnosis of thyroid nodules \hyperref[b11]{11} . Many investigators have tried to point out few ultrasonographic features in order to identify those lesions, which are at a higher risk of malignancy, especially in non-palpable thyroid nodules \hyperref[b12]{12} . Preoperative assessment of thyroid nodules is generally performed by radio-nuclide scanning and fine needle aspiration (FNA). FNA biopsy is described as the most preferred test that has improved selection of patients for thyroid surgery. Several studies have concluded that the risk of thyroid cancer is less with multiple nodules than with solitary nodules 13 , 14 but other studies have not found any difference in risk \hyperref[b15]{15} . It is becoming increasingly clear that high-resolution ultrasonography is better than physical examination9 or other imaging techniques \hyperref[b16]{16} in detecting thyroid nodules.\par This study has been carried out to find out the relative frequency of pathological types, incidence of malignancy in solitary thyroid nodule and its age \& sex variation. This study also carried out to review the existing protocol for the management of solitary thyroid nodules in our country and to assess the accuracy of the available diagnostic modalities for appropriate selection of patients II. \section[{Methods}]{Methods} \section[{Discussion}]{Discussion}\par This cross sectional study was done in the department of Otolaryngology \& Head-Neck surgery, Sir Salimullah Medical College Mitford Hospital and BSMMU, Dhaka from July 2011 to December 2012. For this study, 100 patients of STN were studied by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examinations.\par In our study mean age of the patients of solitary thyroid nodule was 35.6±13.54 years and the highest frequency (38\%) was within 21-30 years of age. Whereas in the study of Islam et al. 2009, showed the majority of the patients were within 21-40 yrs of age. In a study17 they found the age range of their patients were 11-70 years of age. The youngest patient in our study was a boy of 13 years with a papillary carcinoma and the oldest patients was a man of 75 years with medullary carcinoma. The youngest patient and oldest patients of this study both had been suffering from malignant thyroid disease, the extreme of ages show less incidence of thyroid disease but has a more chance to be malignant.\par In this series, out of 100 patients, male were 22 (22\%) and female were 78 (78\%). Male female ratio was 1: 3.54. In a study \hyperref[b17]{17} solitary thyroid nodules were more common in female, where male female ratio was 1:2.2. This female preponderance is reflected in all studies including the present. The cause of high male to female ratio in this series can be explained by most of the patients are from nonendemic area \hyperref[b18]{18} . Here we may recall the findings of Kilopatric et al. who found a female to male ratio of 4:1 in nonendemic area \hyperref[b19]{19} . It is due to fact that thyroid disorder is female prone owing to the presence of estrogen receptors in the thyroid tissue \hyperref[b5]{6} . In this study the commonest occupational group was house wife (68\%).\par All solitary nodules are not a single clinical entity. So it is very difficult to comments regarding the nature of solitary nodule purely on the basis of clinical ground. But hoarseness of voice, hard irregular nodule, palpable cervical lymph node, extreme of age, male sex are always suspicious for malignancy in solitary thyroid nodule \hyperref[b20]{20} . Regarding presenting complaints we have found that all of the patients with neck swelling presents within variable durations. Some patient also presented with other symptoms like cervical lymphadenopathy 13(13\%) cases, dysphagia 1(1\%), dyspnoea 1(1\%), hoarseness of voice 1(1\%) case \& no bone metastetic found. Among 18 malignant cases 10(55.56\%) cases presented within 2 years but out of 82 benign cases only 14(17.07\%) cases presented within 2 years. It is well supported by others studies \hyperref[b21]{21,}\hyperref[b22]{22} .Where duration of swelling prior to the presentation was from 6 months to 3 yrs \hyperref[b17]{17} .Nodular goiter with large swelling may be associated with difficulty in respiration or rarely in deglutition which is due to pressure on trachea or oesophagus \hyperref[b23]{23} .\par In this series we have seen that nodules were found more in right lobe than left. There is yet no reported predilection for any specific site and no reason has been put forward for such a predilection. Similar findings were noted by many authors \hyperref[b24]{24,}\hyperref[b25]{25} .We found 56 nodules in right lobe, 38 nodules in left lobe, 4 nodules in both lobes and 2 nodules in the junctional region between isthmus and one lobe.\par Firm nodules are the commonest form of solitary thyroid nodule. In this series of solitary thyroid nodules constituted 73\% firm, 6\% hard and 11\% cystic. Malignancy was found more in firm nodule 13(72.22\%). Islam et al. 2009, found majority of the nodules were firm (72.03\%), others were hard(16.95\%) and cystic (11.02\%). Malignant lesion was more common in hard nodule (70\%).) Here hardness of nodule was due to malignancy and inflammatory conditions. Among 6 hard nodules, 4 were diagnosed as malignancy and 2 were diagnosed histopatho -logically as thyroiditis. So hardness in not conclusive but an important indication for malignancy. Hardness and irregularity, due to calcification, may simulate carcinoma \hyperref[b5]{6} .\par Investigations are essential to establish preoperative physical, function status and cytopathological nature of solitary nodule of thyroid \hyperref[b26]{26} .\par All patients of this study have done thyroid hormone profile and show value within normal limit. Isotopes scanning of the thyroid gland were done to see the functional status of the nodule. We found most 96(96\%) of the nodules were cold \& 4(4\%) were warm nodule \& no hot nodule found. In our study out of 96 cold nodular goiters we found 18(18.75 \%) malignant \& no malignant case found from rest of 4 warm cases. In a study showed that on thyroid scan out of 40 patients (80\%) having cold nodule \&10 patients (20\%) had hot nodule \hyperref[b27]{27} . Most of the nodules were cold (66.10\%) among them 25.6\% cases were malignant, followed by warm (30.5\%) and hot (3.3\%) \hyperref[b28]{28} .\par Fine needle aspiration cytology (FNAC) is a very important, highly sensitive and minimally invasive preoperative diagnostic tool \hyperref[b23]{23} . According to a study FNAC is a gold standard for preoperative assessment of thyroid nodules. Early and accurate diagnosis reduces surgical intervention, morbidity and mortality \hyperref[b29]{29} . In our study of FNAC of STN we found colloid nodule 46\%, throiditis 2\%, colloid degeneration 6\%, cellular follicular lesion 30\%, papillary carcinoma 13\%, medullary carcinoma 1\% \& non conclusive 2\%. On FNAC majority of STN were benign with being more common17. FNAC cannot distinguish between follicular adenoma and follicular carcinoma. In our study sensitivity \& specificity of FNAC was 77.77\% \& 97\% respectively. Where other study showed sensitivity and specificity of FNAC was 90\% and 100\%, respectively \hyperref[b29]{29} . Basharat R etal. 2011, showed sensitivity \& specificity of FNAC 80\% \& 97.7\% respectively in her study. So FNAC is an important preoperative diagnostic tool for STN.\par Final diagnosis in this study was on the basis of histopathological reports record. Out of 100 cases, 54 cases (54\%) were proven as nodular goitre \& 2 \% were thyroiditis in non-neoplastic lesion \& in neoplastic lesion we found 26(26\%) was benign (follicular adenoma) and 18(18\%) cases were malignant. In our study among 18 malignant cases 15(83.33\%) were papillary carcinoma, 2(11.11\%) were follicular carcinoma and 1(5.55\%) case was medullary carcinoma. In a study 13.9\% of patients of STN was found to be malignant \hyperref[b30]{30} . A study showed that 13.33\% of STN were found to have malignant lesions \& 86.67\% were benign \hyperref[b31]{31} . Papillary carcinoma was the most common malignancy (50\%) found in his study. Male patients with solitary thyroid nodule showed a higher incidence of malignancy (17.65\%) as compared to females (11.63\%). In our study we found frequency of malignancy in case of male was 27.3\% \& in case of female 15.4 \%. Venkatachalapathy et al. 2012, found the incidence of malignancy in their series in STN was 18\%. Islam et al. 2009, in their study found 18.65\% of STN to be malignant \& out of them 16 (72.72\%) cases were papillary carcinoma, 4 (18.18\%) cases were follicular carcinoma and 2(9.1\%) cases were medullary carcinoma. It showed a clear predominance of papillary over follicular and medullary carcinoma. According to Watkinson (2000), frequency of papillary carcinoma is 80\% and follicular carcinoma is 10\%. Some study showed that papillary carcinoma comprises about 60\% of all thyroid cancer \hyperref[b32]{32} and follicular carcinoma comprises 18\% of all malignant thyroid neoplasm 6 . So, papillary carcinoma was more common among all thyroid malignancies in patients with solitary thyroid nodule. Ultrasonography is used to establish physical characteristics of nodule like the size, echo-structure (solid or cystic), shape and number of nodule(s), and extranodular thyroid tissue. In our study of ultrasonography we found 89(89\%) nodules were solid, 11(11\%) were cystic. In our study, out of 89 solid nodule 72(80.89\%) were benign \& 17(19.10\%) nodule were malignant and out of 11 cystic nodule 10(90.9\%) were benign \& 1 (9.1\%) was malignant. In our study, most of the benign \& malignant nodules were predominantly solid. Study showed the malignancy is significantly (p<0.001) more in solid than cystic solitary thyroid nodule. Our study correspond with a study where he showed of cystic thyroid lesions, 4\% were simple cysts, 82\% were degenerating benign adenomas or colloid nodules and 14\% were malignant compared with 23\% of solid lesions that were malignant \hyperref[b34]{33} . Cathy Crenshaw Doheny also mentioned In a web journal found that a solid thyroid nodule is more likely than a cystic nodule to be malignant \hyperref[b36]{34} . More than 90\% of all solid nodules, however, are benign. A study showed 9\% incidence of malignancy in solid nodules \& no malignancy in cystic nodules \hyperref[b37]{35} . Whereas other found incidence of carcin-oma in cystic lesion <2\% \hyperref[b38]{36} .\par As this study had been carried out over a limited period of time with a limited number of patients, it could not have been large enough to be of reasonable precision. All the facts and figures mentioned here may considerably vary from those of large series covering wide range of time, but still then, as the cases of this study were collected from tertiary level hospitals in our country, this study had some credentials in reflecting the facts regarding distribution and type of malignancy in solitary thyroid nodules. \section[{V. Conclusion}]{V. Conclusion}\par We have observed worldwide malignancy in STN ranging from 16-30\% \hyperref[b39]{37} . We found in our series containing 18\% malignancy in solitary thyroid nodule. So significant percentage of malignancy in STN is very important though it is a small nodular lesion. As small lesion of STN sometimes is overlooked so it is an important message to our fellows and practitioners to get appropriate medical attention for early diagnosis \& proper management to reduce the morbidity and mortality.\begin{figure}[htbp] \noindent\textbf{} \par \begin{longtable}{P{0.85\textwidth}} Abstract-Objective: To find out the incidence of malignancy in\\ patient with solitary thyroid nodule.\\ Methods: This cross-sectional study was carried out with 100\\ solitary thyroid nodular patients who admitted in\\ Otolaryngology \& Head-Neck Surgery Department of Sir\\ Salimullah Medical College Mitford Hospital (SSMCMH) \&\\ Bangabondhu Sheikh Mujib Medical Univercity (BSMMU),\\ Dhaka, from July 2011 to December 2012,where all patients\\ were admitted through out patient department. All patients\\ were selected as per described criteria from the Department\\ of Otolaryngology \& Head-Neck Surgery, SSMCMH \&\\ BSMMU. Diagnosed the cases by detail history, clinical\\ examination,investigations,analysed data presented by various\\ tables, figures.\\ showed\\ the malignancy is significantly (p<0.001) more in solid than\\ cystic solitary thyroid nodule. Final diagnosis in this study was\\ on the basis of histopathological reports record. Out of 100\\ cases, 54 cases (54\%) were proven as nodular goitre \& 2 \%\\ were thyroiditis in non-neoplastic lesion \& in neoplastic lesion\\ we found 26(26\%) was benign (follicular adenoma) and\\ 18(18\%) cases were malignant. In our study among 18\\ malignant cases 15 (83.33\%) were papillary carcinoma,\end{longtable} \par {\small\itshape [Note: Results: In this study mean age of the patients of solitary thyroid nodule was 35.6±13.54 years and the highest frequency (38\%) was within 21-30 years of age with female predominance (78\%). Thyroid swelling was the common presentation in all9100\%) cases, some patients also presented with other symptoms like cervical lymphadenopathy 13(13\%) cases, dysphagia 1(1\%), dyspnoea 1(1\%), hoarseness of voice 1(1\%) case \& no bone metastetic found. . In this series of solitary thyroid nodules constituted 73\% firm, 6\% hard and 11\% cystic. Malignancy was found more in firm nodule 13(72.22\%). Isotopes scanning of the thyroid gland were done to see the functional status of the nodule. We found most 96(96\%) of the nodules were cold \& 4(4\%) were warm nodule \& no hot nodule found. In our study out of 96 cold nodular goiters we found 18(18.75 \%) malignant \& no malignant case found from rest of 4 warm cases. In our study, out of 89 solid nodule 72(80.89\%) were benign \& 17(19.10\%) nodule were malignant and out of 11 cystic nodule 10(90.9\%) were benign \& 1 (9.1\%) was malignant. In this study, most of the benign \& malignant nodules were predominantly solid. Study]} \caption{\label{tab_0}}\end{figure} \begin{figure}[htbp] \noindent\textbf{1} \par \begin{longtable}{P{0.10636978579481399\textwidth}P{0.7359639233370913\textwidth}P{0.0028748590755355127\textwidth}P{0.004791431792559188\textwidth}} \tabcellsep \multicolumn{2}{l}{Study of Pathological Variations of Solitary Thyroid Nodule}\\ 2014\tabcellsep \tabcellsep \\ Year\tabcellsep \tabcellsep \\ 10\tabcellsep \tabcellsep \\ Volume XIV Issue III Version I\tabcellsep \multicolumn{3}{l}{Thyroid scan done to see functional status of gland like cold, warm \& hot nodule. FNAC findings were recorded \& then after surgery histopathology reports were recorded \& FNAC findings were compared with histopathological reports. Data were processed and}\\ Medical Research ( ) J\tabcellsep \multicolumn{3}{l}{analyzed by using computer based programmed SPSS-16 (Statistical Package for Social Sciences). The deviation. The qualitative data were analyzed by Pearson Chi-square(x 2 ) test with 95\% confidence interval to make inference. III. Results quantitative data were analyzed by mean, standard}\\ Global Journal of\tabcellsep \multicolumn{3}{l}{Age group(Years) Frequency Percentage 10-20 08 08.0 21-30 38 38.0 31-40 28 28.0 41-50 14 14.0 51-60 06 06.0 >60 06 06.0}\\ \tabcellsep Total\tabcellsep 100\tabcellsep 100.0\\ \tabcellsep \multicolumn{3}{l}{Mean(±SD)age=35.60(±13.54)yrs,13 -75 yrs}\\ © 2014 Global Journals Inc. (US)\tabcellsep \tabcellsep \end{longtable} \par \caption{\label{tab_1}Table 1 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{2} \par \begin{longtable}{P{0.5342857142857143\textwidth}P{0.1457142857142857\textwidth}P{0.17\textwidth}} \tabcellsep (n=100)\tabcellsep \\ \multicolumn{3}{l}{Occupation Frequency Percentage}\\ Service\tabcellsep 14\tabcellsep 14.0\\ Business\tabcellsep 02\tabcellsep 02.0\\ Housewife\tabcellsep 68\tabcellsep 68.0\\ Others\tabcellsep 16\tabcellsep 16.0\\ Total\tabcellsep 100\tabcellsep 100.0\end{longtable} \par \caption{\label{tab_2}Table 2 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{4} \par \begin{longtable}{P{0.6124223602484472\textwidth}P{0.11614906832298137\textwidth}P{0.12142857142857141\textwidth}} Sign and symptoms\tabcellsep Frequency\tabcellsep Percentage\\ Swelling in front of neck\tabcellsep 100\tabcellsep 100\\ Palpable cervical lymph nodes\tabcellsep 13\tabcellsep 13\\ Dysphagia\tabcellsep 01\tabcellsep 01\\ Dyspnoea\tabcellsep 01\tabcellsep 01\\ Hoarseness of voice\tabcellsep 01\tabcellsep 01\\ Bone pain\tabcellsep 00\tabcellsep 00\end{longtable} \par \caption{\label{tab_3}Table 4 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{5} \par \begin{longtable}{P{0.4697368421052632\textwidth}P{0.14912280701754385\textwidth}P{0.23114035087719298\textwidth}} Site\tabcellsep Frequency\tabcellsep Percentage\\ Right lobe\tabcellsep 56\tabcellsep 56.0\\ Left lobe\tabcellsep 38\tabcellsep 38.0\\ Both lobe\tabcellsep 04\tabcellsep 04.0\\ Isthmus with adjacent lobe\tabcellsep 02\tabcellsep 02.0\\ Total\tabcellsep 100\tabcellsep 100.0\end{longtable} \par {\small\itshape [Note: © 2014 Global Journals Inc. (US)]} \caption{\label{tab_4}Table 5 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{6} \par \begin{longtable}{P{0.20114503816793894\textwidth}P{0.26927480916030533\textwidth}P{0.21412213740458014\textwidth}P{0.1232824427480916\textwidth}P{0.042175572519083965\textwidth}} \tabcellsep \tabcellsep developed\tabcellsep \tabcellsep \\ Duration of nodule\tabcellsep \multicolumn{2}{l}{Histopathological findings}\tabcellsep \tabcellsep \\ development\tabcellsep \tabcellsep \tabcellsep Total\tabcellsep P value\\ \tabcellsep Benign n (\%)\tabcellsep Malignant n (\%)\tabcellsep \tabcellsep \\ < 1 yr\tabcellsep 10(12.19)\tabcellsep 06(33.33)\tabcellsep 16(16)\tabcellsep \\ 1-2 yrs 2-5 yrs\tabcellsep 14(17.07) 34(41.46)\tabcellsep 10(55.56) 02(11.11)\tabcellsep 24(24) 36(36)\tabcellsep 0.01 S\\ > 5 yrs\tabcellsep 24(29.26)\tabcellsep 00(00)\tabcellsep 24(24)\tabcellsep \\ Total\tabcellsep 82(100)\tabcellsep 18(100)\tabcellsep 100(100)\tabcellsep \end{longtable} \par {\small\itshape [Note: ?2 = 11.14, Values in parentheses are percentages]} \caption{\label{tab_5}Table 6 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{3} \par \begin{longtable}{P{0.42047872340425535\textwidth}P{0.11303191489361701\textwidth}P{0.12207446808510639\textwidth}P{0.14468085106382977\textwidth}P{0.04973404255319149\textwidth}} Histopathological findings\tabcellsep \tabcellsep \tabcellsep Sex\tabcellsep \\ \tabcellsep Total\tabcellsep Male\tabcellsep Female\tabcellsep P value\\ Malignant\tabcellsep 18(18)\tabcellsep 06(27.3)\tabcellsep 12(15.4)\tabcellsep \\ Benign\tabcellsep 82(82)\tabcellsep 16(72.7)\tabcellsep 66(84.6)\tabcellsep 0.21\\ Total\tabcellsep 100(100)\tabcellsep 22(100)\tabcellsep 78(100)\tabcellsep \\ \multicolumn{3}{l}{X 2 -0.94 Values in parentheses are percentages}\tabcellsep \tabcellsep \end{longtable} \par \caption{\label{tab_6}Table 3 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{7} \par \begin{longtable}{P{0.4702127659574468\textwidth}P{0.24716312056737585\textwidth}P{0.1326241134751773\textwidth}} Histopathological\tabcellsep Thyroid scan\tabcellsep \\ study\tabcellsep \tabcellsep \\ \tabcellsep Cold\tabcellsep Warm\\ Benign\tabcellsep 78(81.25)\tabcellsep 4(100)\\ Malignant\tabcellsep 18(18.75)\tabcellsep 00(00)\\ Total\tabcellsep 96(100)\tabcellsep 4(100)\\ \multicolumn{2}{l}{Values in parentheses are percentage}\tabcellsep \end{longtable} \par \caption{\label{tab_7}Table 7 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{8} \par \begin{longtable}{P{0.22508710801393728\textwidth}P{0.154006968641115\textwidth}P{0.15696864111498257\textwidth}P{0.10958188153310104\textwidth}P{0.20435540069686411\textwidth}} \multicolumn{3}{l}{Consistency Histopathological findings}\tabcellsep Total\tabcellsep \\ \tabcellsep Benign\tabcellsep Malignant\tabcellsep \tabcellsep ? 2 (P value)\\ \tabcellsep n(\%)\tabcellsep n(\%)\tabcellsep \tabcellsep \\ Soft\tabcellsep 08(9.75)\tabcellsep 00(00)\tabcellsep 08(08)\tabcellsep 0.81(0.37 ns )\\ Cystic\tabcellsep 10(12.19)\tabcellsep 01(5.55)\tabcellsep 11(11)\tabcellsep 0.16(0.34 ns )\\ Firm\tabcellsep 62(75.61)\tabcellsep 13(72.22)\tabcellsep 75(75)\tabcellsep 0.04(0.99 ns )\\ Hard\tabcellsep 02(2.43)\tabcellsep 04(22.22)\tabcellsep 06(06)\tabcellsep 8.26(0.009 S )\\ Total\tabcellsep 82(100)\tabcellsep 18(100)\tabcellsep 100(100)\tabcellsep \\ Chi-square test\tabcellsep \tabcellsep \tabcellsep \tabcellsep \end{longtable} \par \caption{\label{tab_8}Table 8 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{9} \par \begin{longtable}{P{0.15528846153846151\textwidth}P{0.4903846153846153\textwidth}P{0.09399038461538461\textwidth}P{0.11033653846153847\textwidth}} Diagnosis\tabcellsep \tabcellsep Number\tabcellsep Percentage\\ \tabcellsep Colloid nodule\tabcellsep 46\tabcellsep 46\\ Non neoplastic\tabcellsep Thyroiditis\tabcellsep 02\tabcellsep 02\\ \tabcellsep Colloid degeneration\tabcellsep 6\tabcellsep 6\\ \tabcellsep Cellular Follicular lesion\tabcellsep 30\tabcellsep 30\\ Neoplastic\tabcellsep Papillary carcinoma Medullary carcinoma\tabcellsep 13 01\tabcellsep 13 01\\ \tabcellsep Suspicious\tabcellsep 02\tabcellsep 02\\ Total\tabcellsep \tabcellsep 100\tabcellsep 100\end{longtable} \par \caption{\label{tab_9}Table 9 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{10} \par \begin{longtable}{P{0.15911330049261083\textwidth}P{0.17167487684729063\textwidth}P{0.32660098522167486\textwidth}P{0.08374384236453201\textwidth}P{0.10886699507389164\textwidth}} Diagnosis\tabcellsep \tabcellsep \tabcellsep Number\tabcellsep Percentage\\ Non neoplastic\tabcellsep Nodular goiter Thyroiditis\tabcellsep \tabcellsep 54 02\tabcellsep 54 02\\ Neoplastic\tabcellsep Benign\tabcellsep Follicular adenoma\tabcellsep 26\tabcellsep 26\\ \tabcellsep \tabcellsep Papillary carcinoma\tabcellsep 15\tabcellsep 15\\ \tabcellsep Malignant\tabcellsep \multicolumn{2}{l}{Follicular carcinoma 02}\tabcellsep 02\\ \tabcellsep \tabcellsep Medullary\tabcellsep 01\tabcellsep 01\\ \tabcellsep \tabcellsep carcinoma\tabcellsep \tabcellsep \\ Total\tabcellsep \tabcellsep \tabcellsep 100\tabcellsep 100\end{longtable} \par \caption{\label{tab_10}Table 10 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{11} \par \begin{longtable}{P{0.23852040816326528\textwidth}P{0.017346938775510204\textwidth}P{0.14311224489795918\textwidth}P{0.23852040816326528\textwidth}P{0.14744897959183673\textwidth}P{0.06505102040816327\textwidth}} FNAC findings\tabcellsep \tabcellsep \tabcellsep \multicolumn{2}{l}{Final histopathological findings}\\ \tabcellsep \tabcellsep Total\tabcellsep Benign\tabcellsep Malignant\tabcellsep P value\\ Malignant\tabcellsep cell\tabcellsep 84(84)\tabcellsep 80(97.56)\tabcellsep 04(22.22)\\ Absent Malignant cell\tabcellsep \tabcellsep 16(16)\tabcellsep 02(2.43)\tabcellsep 14(88.88)\tabcellsep <0.001 S\\ present\tabcellsep \tabcellsep \tabcellsep \tabcellsep \\ Total\tabcellsep \tabcellsep \multicolumn{2}{l}{100(100) 82(100)}\tabcellsep 18(100)\end{longtable} \par {\small\itshape [Note: ?2 = 56.85, Values in parentheses are percentages.]} \caption{\label{tab_11}Table 11 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{12} \par \begin{longtable}{P{0.47682926829268296\textwidth}P{0.16585365853658537\textwidth}P{0.2073170731707317\textwidth}} Histopathological findings\tabcellsep Frequency\tabcellsep Percent\\ Benign\tabcellsep 82\tabcellsep 82.0\\ Malignant\tabcellsep 18\tabcellsep 18.0\\ Total\tabcellsep 100\tabcellsep 100.0\end{longtable} \par \caption{\label{tab_12}Table 12 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{13} \par \begin{longtable}{P{0.5552419354838709\textwidth}P{0.13024193548387097\textwidth}P{0.16451612903225807\textwidth}} Type of malignancy\tabcellsep No of cases\tabcellsep Percent\\ Papillary carcinoma\tabcellsep 15\tabcellsep 83.33\\ Follicular carcinoma\tabcellsep 02\tabcellsep 11.11\\ Medullary carcinoma\tabcellsep 01\tabcellsep 5.55\\ Total\tabcellsep 18\tabcellsep 100\end{longtable} \par \caption{\label{tab_13}Table 13 :}\end{figure} \begin{figure}[htbp] \noindent\textbf{14} \par \begin{longtable}{P{0.3929245283018868\textwidth}P{0.16839622641509436\textwidth}P{0.12429245283018867\textwidth}P{0.10424528301886793\textwidth}P{0.06014150943396226\textwidth}} Histopathological\tabcellsep USG findings\tabcellsep \tabcellsep Total\tabcellsep P value\\ findings\tabcellsep Cystic\tabcellsep Solid\tabcellsep \tabcellsep \\ Malignant Benign\tabcellsep 01(09.1) 10(90.9)\tabcellsep 17(19.10) 72(80.89)\tabcellsep 18(18) 82(82)\tabcellsep <0.001 S\\ Total\tabcellsep 11(100)\tabcellsep 89(100)\tabcellsep 100(100)\tabcellsep \\ \multicolumn{4}{l}{?2 = 23.92, Values in parentheses are percentages}\tabcellsep \\ IV.\tabcellsep \tabcellsep \tabcellsep \tabcellsep \end{longtable} \par \caption{\label{tab_14}Table 14 :}\end{figure} \backmatter \begin{bibitemlist}{1} \bibitem[London (18/1-5/18/22)]{b33}\label{b33} \textit{}, London . 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