@incollection{,
	
					
					
					59EF165C695998AD01BDE576F8B3B2E5
				,
	author={{Paul ChidokaChikezie} and {Imo State University, Owerri, Imo State, Nigeria}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}146512
}

@incollection{b0,
	
	
		,
	title={{Studies on human erythrocyte glutathione-S transferase from HbAA, HbAS and HbSS subjects}}
		,
	author={{
			EOAnosike
		} and {
			AAUwakwe
		} and {
			MonanuMo
		} and {
			GIEkeke
		}}
		
		
		
	
	
		,
	journal={{Biochima Biomedica Acta}}
		
			50
			
			,
	year={1991}
		
	

}

@incollection{b1,
	
	
		,
	title={{Enzymatic conjugation with 1-chloro-2,-4-dinitrobenzene. The fate of glutathione conjugates in erythrocytes and the effect of glutathione depletion on hemoglobin}}
		,
	author={{
			YCAwasthi
		} and {
			HJGarg
		} and {
			DDDao
		} and {
			CAPartridge
		} and {
			SKSrivastiva
		}}
		
		
		
		
	
	
		,
	journal={{Blood}}
		
			58
			4
			
			,
	year={1981}
		
	

}

@incollection{b2,
	
	
		,
	title={{Biochemical changes in and liver of albino rats exposed to petroleum samples (gasoline, kerosene, and crude petroleum)}}
		,
	author={{
			EOAyalogu
		} and {
			NHIgboh
		} and {
			EBDede
		}}
		
		
	
	
		,
	journal={{Journal of Applied Science and Environmental Management}}
		
			5
			1
			
			,
	year={2001}
		
	

}

@book{b3,
	
	
		,
	title={{Gradwohl's Clinical Laboratory Methods and Diagnosis}}
		,
	author={{
			JDBaure
		}}
		,
	editor={Sonnenwirth AC, Jarett L, (Eds). St. Louis Mosby. MO}
		
			,
	year={1980}
			
		
	
	,
	note={Laboratory investigation of hemoglobin}

}

@incollection{b4,
	
	
		,
	title={{Oxidative stress in malarial -infected erythrocytes host -parasite interactions}}
		,
	author={{
			KBecker
		} and {
			LTilley
		} and {
			JLVennerstron
		} and {
			DRoberts
		} and {
			SRogerson
		} and {
			HGinsburg
		}}
		
		
		
		
		
	
	
		,
	journal={{International Journal of Parasitology}}
		
			34
			
			,
	year={2004}
		
	

}

@incollection{b5,
	
	
		,
	title={{Glutathione Stransferases: biomedical applications}}
		,
	author={{
			GJBeckett
		} and {
			JDHayes
		}}
		
	
	
		,
	journal={{Advanced Clinical Chemistry}}
		
			30
			
			,
	year={1993}
		
	

}

@incollection{b6,
	
	
		,
	title={{The role of glutathione dependent enzyme in drug resistance}}
		,
	author={{
			SMBlack
		} and {
			CRWolf
		}}
		
	
	
		,
	journal={{Pharmacological Therapeutics}}
		
			51
			
			,
	year={1991}
		
	

}

@incollection{b7,
	
	
		,
	title={{Genetic heterogeneity of the human glutathione transferases; a complex of gene families}}
		,
	author={{
			PBoard
		} and {
			MCoggan
		} and {
			PJohnston
		} and {
			VRoss
		} and {
			TSuzuki
		} and {
			GWebb
		}}
		
		
		
		
		
	
	
		,
	journal={{Pharmacological Therapeutics}}
		
			48
			3
			
			,
	year={1990}
		
	

}

@incollection{b8,
	
	
		,
	title={{Role of glutathione-S transferase in heme transport}}
		,
	author={{
			TDBoyer
		} and {
			EOslen
		}}
		
	
	
		,
	journal={{Biochemical Pharmacology}}
		
			42
			
			,
	year={1991}
		
	

}

@incollection{b9,
	
	
		,
	title={{Access to hematin: the basis of chloroquine resistance}}
		,
	author={{
			PGBray
		} and {
			MMungthin
		} and {
			RGRidley
		} and {
			SAWard
		}}
		
		
		
	
	
		,
	journal={{Molecular Pharmacology}}
		
			54
			
			,
	year={1998}
		
	

}

@book{b10,
	
	
		,
	title={{}}
		,
	author={{
			FCarmagnol
		} and {
			PMSinet
		} and {
			JRapin
		} and {
			JeromeH
		}}
		
		
		
		
			,
	year={1981}
		
	

}

@book{b11,
	
	
		,
	title={{Glutathione S-transferase of human red blood cells}}
		
	

}

@incollection{b12,
	
	
		,
	title={{values in normal subjects and in two pathological circumstances: hyperbilirubinemia and impaired renal function}}
	
	
		,
	journal={{Clin ica Chima Acta}}
		
			117
			
		
	

}

@book{b13,
	
	
		,
	title={{District laboratory practice in tropical countries}}
		,
	author={{
			MCheesbrough
		}}
		
			,
	year={1998}
			,
	publisher={Cambridge University Press}
			
			,
	address={Cambridge}
		
	

}

@book{b14,
	
	
		,
	title={{Membrane stability and methaemoglobin content of}}
		,
	author={{
			PCChikezie
		} and {
			ARAkuwudike
		} and {
			CMChikezie
		}}
		
		
		
			,
	year={2012}
		
	

}

@incollection{b15,
	
	
		,
	title={{Comparative study of glutathione Stransferase activity of three human erythrocyte genotypes infected with Plasmodium falciparum}}
		,
	author={{
			PCChikezie
		} and {
			CMChikezie
		} and {
			AAUwakwe
		} and {
			CCMonago
		}}
		
		
		
	
	
		,
	journal={{Journal of Applied Science and Environmental Management}}
		
			13
			3
			
			,
	year={2009}
		
	

}

@incollection{b16,
	
	
		,
	title={{Glutathione S-transferase activity of human erythrocytes incubated in aqueous solution of five antimalarial drugs}}
		,
	author={{
			PCChikezie
		}}
	
	
		,
	journal={{Free Radical and Antioxidants}}
		
			1
			2
			
			,
	year={2011}
		
	

}

@incollection{b17,
	
	
		,
	title={{Plasmodium berghei; Implication of intracellular glutathione and related enzymes inchloroquine resistance in vivo}}
		,
	author={{
			VLDubois
		} and {
			DfnPlatel
		} and {
			PaulyGTribouley
		} and {
			DJ
		}}
		
		
		
	
	
		,
	journal={{Experimental Parasitology}}
		
			81
			
			,
	year={1995}
		
	

}

@incollection{b18,
	
	
		,
	title={{Clinical pharmacokinetics and metabolism of chloroquine: focus on recent developments}}
		,
	author={{
			JDucharme
		} and {
			RFarinotti
		}}
		
	
	
		,
	journal={{Clinical Pharmacokinetics}}
		
			31
			
			,
	year={1996}
		
	

}

@incollection{b19,
	
	
		,
	title={{Pooled analysis and metaanalysis of glutathione S-transferase M1 and bladder cancer: A HUGE review}}
		,
	author={{
			LSEngel
		} and {
			ETaioli
		} and {
			RPfeiffer
		} and {
			MGarcia-Closas
		} and {
			PMMarcus
		}}
		
		
		
		
	
	
		,
	journal={{American Journal of Epidemiology}}
		
			156
			
			,
	year={2002}
		
	

}

@book{b20,
	
	
		,
	title={{}}
		,
	author={{
			LMForrester
		} and {
			JDHayes
		} and {
			RMillis
		} and {
			DBarnes
		} and {
			ALHarris
		} and {
			JJSchlager
		} and {
			GPowis
		} and {
			CRWolf
		}}
		
		
		
		
		
		
		
		
			,
	year={1990}
		
	

}

@incollection{b21,
	
	
		,
	title={{Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue}}
	
	
		,
	journal={{Carcinogenesis}}
		
			11
			
		
	

}

@incollection{b22,
	
	
		,
	title={{Changes in some cytoplasmic enzymes from red cells fractionated into age groups by centrifugation in Ficoll TM /Triosil TM gradients. Comparison of normal human and patients with Duchenne muscular dystrophy}}
		,
	author={{
			DAGalbraith
		} and {
			DCWatts
		}}
		
	
	
		,
	journal={{Biochemical Journal}}
		
			191
			
			,
	year={1980}
		
	

}

@incollection{b23,
	
	
		,
	title={{Over expression of erythrocyte glutathione S-transferase in uremia and dialysis}}
		,
	author={{
			FGalli
		} and {
			SRovidati
		} and {
			SBenedettis
		} and {
			UBuoncristiani
		} and {
			CCovarelli
		} and {
			AFloridi
		} and {
			FCanestrari
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Clinical Chemistry}}
		
			45
			
			,
	year={1999}
		
	

}

@book{b24,
	
	
		,
	title={{}}
		,
	author={{
			WHHabig
		} and {
			MJPabst
		} and {
			WBJacoby
		}}
		
		
		
			,
	year={1974}
		
	

}

@incollection{b25,
	
	
		,
	title={{Glutathione S-transferases: the first enzymatic step in mercapturic acid formation}}
	
	
		,
	journal={{Journal of Biological Chemistry}}
		
			249
			
		
	

}

@incollection{b26,
	
	
		,
	title={{Binding of heme by glutathione S-transferase: The first step in mercapturic acid formation}}
		,
	author={{
			JWHarvey
		} and {
			EBeutler
		}}
		
	
	
		,
	journal={{Journal of Biological Chemistry}}
		
			245
			
			,
	year={1982}
		
	

}

@incollection{b27,
	
	
		,
	title={{Glutathione S-transferase of the malaria parasite Plasmodium falciparum characterization of a potential drug target}}
		,
	author={{
			PHarwaldt
		} and {
			SRahlfs
		} and {
			KBecker
		}}
		
		
	
	
		,
	journal={{Biological Chemistry}}
		
			383
			
			,
	year={2002}
		
	

}

@incollection{b28,
	
	
		,
	title={{The glutathione Stransferase superfamily. Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance}}
		,
	author={{
			JDHayes
		} and {
			DJPulford
		}}
		
	
	
		,
	journal={{Critical Review of Biochemistry and Molecular Biology}}
		
			30
			
			,
	year={1995}
		
	

}

@incollection{b29,
	
	
		,
	title={{Plasmodum falciparum glutathione S-transferase structural and mechanistic studies on ligand binding and enzyme inhibition}}
		,
	author={{
			NHiller
		} and {
			FritzWolf
		} and {
			KDeponte
		} and {
			MWende
		} and {
			WZimmerman
		} and {
			HBecker
		} and {
			K
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Protein Science}}
		
			15
			
			,
	year={2006}
		
	

}

@incollection{b30,
	
	
		,
	title={{Comparative study of the status of a biomarker of lipid peroxidation (malondialdehyde) in patients with Plasmodium falciparum and Plasmodium vivaxmalaria infection}}
		,
	author={{
			OBIdonije
		} and {
			OFestus
		} and {
			OOkhiai
		} and {
			UAkpamu
		}}
		
		
		
	
	
		,
	journal={{Asian Journal of Biological Science}}
		
			4
			
			,
	year={2011}
		
	

}

@incollection{b31,
	
	
		,
	title={{Glutathione-S transferase: A group of multifunctional detoxification proteins}}
		,
	author={{
			WBJacoby
		}}
	
	
		,
	booktitle={{Advances in Enzymology (Meister A. (Ed) John}}
				
			,
	year={1976}
		
	

}

@book{b32,
	
	
		,
	title={{}}
		,
	author={{
			WileyInterscience
		}}
		
			40
			
			,
	address={New York}
		
	

}

@incollection{b33,
	
	
		,
	title={{Modifications in the activities of membrane-bound enzymes during in vivo ageing of human and rabbit erythrocytes}}
		,
	author={{
			KKamber
		} and {
			APoyiagi
		} and {
			GDelikonstantinos
		}}
		
		
	
	
		,
	journal={{Comparative Biochemistry and Physiology B}}
		
			77
			
			,
	year={1984}
		
	

}

@book{b34,
	
	
		,
	author={{
			RAKavishe
		} and {
			JBKoenderink
		} and {
			MBMccall
		} and {
			WHPeters
		} and {
			BMulder
		} and {
			CCHermsen
		} and {
			RWSauerwein
		} and {
			FGRussel
		} and {
			JAVan Der Ven
		}}
		
		
		
		
		
		
		
		
		,
	title={{Severe Plasmodium falciparum malaria in Cameroon: Associated with the glutathione S-transferase M1 null genotype}}
				
			,
	year={2006}
		
	

}

@incollection{b35,
	
	
		,
	title={{}}
	
	
		,
	journal={{American Journal of Tropical Medicine and Hygiene}}
		
			75
			5
			
		
	

}

@incollection{b36,
	
	
		,
	title={{Binding of non-substrate ligand to glutathione-S-transferase from human erythrocyte}}
		,
	author={{
			JNKetley
		} and {
			Habig
		} and {
			WBJacoby
		}}
		
		
	
	
		,
	journal={{Archive of Biochemistry and Biophysics}}
		
			188
			
			,
	year={1975}
		
	

}

@book{b37,
	
	
		,
	title={{}}
		,
	author={{
			ELiebau
		} and {
			BBergmann
		} and {
			AMCampbell
		} and {
			PTeesdale-Spittle
		} and {
			PMBrophy
		} and {
			KLuersen
		} and {
			RWalter
		}}
		
		
		
		
		
		
		
			,
	year={2002}
		
	

}

@incollection{b38,
	
	
		,
	title={{The glutathione S-transferase from Plasmodium falciparum}}
	
	
		,
	journal={{Molecular Biochemistry and Parasitology}}
		
			124
			
		
	

}

@incollection{b39,
	
	
		,
	title={{Glutathione transferases-structure and catalytic activity}}
		,
	author={{
			BMannervik
		} and {
			UHDanielson
		}}
		
	
	
		,
	journal={{CRC Critical Review of Biochemistry}}
		
			23
			
			,
	year={1988}
		
	

}

@incollection{b40,
	
	
		,
	title={{In vitro activities and mechanism of resistance to antifol antimalarial drugs}}
		,
	author={{
			WKMilhous
		} and {
			FWNorman
		} and {
			JeanHb
		} and {
			EDRobert
		}}
		
		
		
	
	
		,
	journal={{Antimicrobial Agents Chemotherapy}}
		
			
			,
	year={1985. 1985}
		
	

}

@incollection{b41,
	
	
		,
	title={{Variability of glutathione S-transferase ? in human liver and plasma}}
		,
	author={{
			TpjMulder
		} and {
			DACourt
		} and {
			WhmPeters
		}}
		
		
	
	
		,
	journal={{Clinical Chemistry}}
		
			45
			
			,
	year={1999}
		
	

}

@book{b42,
	
	
		,
	title={{Erythrocyte glutathione S-transferase as a marker of oxidative stress at birth. Archive of}}
		,
	author={{
			VmeNeefjes
		} and {
			CtaEvelo
		} and {
			LgmBears
		} and {
			CEBlanco
		}}
		
		
		
		
			,
	year={1999}
		
	

}

@incollection{b43,
	
	
		,
	title={{Theligandin (non-substrate) binding site of human pi class glutathione transferase is located in the electrophile binding sited (H-Site)}}
		,
	author={{
			AJOakley
		} and {
			LoBellow
		} and {
			MNucceteli
		} and {
			MMazzetti
		} and {
			APParker
		} and {
			MW
		}}
		
		
		
		
		
	
	
		,
	journal={{Journal of Molecular Biology}}
		
			291
			
			,
	year={1999}
		
	

}

@incollection{b44,
	
	
		,
	title={{Levels of parasitaemia and changes in some liver enzymes among malarial infected patients in Edo-Delta Region of Nigeria}}
		,
	author={{
			IOnyesom
		} and {
			NOnyemakonor
		}}
		
	
	
		,
	journal={{Current Research Journal of Biological Science}}
		
			3
			2
			
			,
	year={2011}
		
	

}

@incollection{b45,
	
	
		,
	title={{Evaluation of oxidative stress, antioxidant and thyroid hormone status in patients with diabetes mellitus}}
		,
	author={{
			PPasupathi
		} and {
			VChandrasekar
		} and {
			USKumar
		}}
		
		
	
	
		,
	journal={{Journal of Medicine}}
		
			10
			
			,
	year={2009}
		
	

}

@incollection{b46,
	
	
		,
	title={{Oxidative stress and antioxidant defense mechanism in Plasmodium vivax malaria before and after chloroquine treatment}}
		,
	author={{
			KSarin
		} and {
			AKumar
		} and {
			APrakash
		} and {
			ASharma
		}}
		
		
		
	
	
		,
	journal={{International Journal of Malaria}}
		
			30
			3
			
			,
	year={1993}
		
	

}

@incollection{b47,
	
	
		,
	title={{Deferiprone (L1) Chelates pathologic iron deposits from membranes of intact thalasaemic and sickle red blood cells both in vitro and in vivo}}
		,
	author={{
			OShalev
		} and {
			TRepka
		} and {
			AGoldfarb
		} and {
			LGrinberg
		} and {
			AAbrahamov
		} and {
			NFOlievieri
		}}
		
		
		
		
		
	
	
		,
	journal={{Blood}}
		
			86
			
			,
	year={1995}
		
	

}

@incollection{b48,
	
	
		,
	title={{Decreased glutathione S-transferase activity: Diagnostic and protective role in vivax malaria}}
		,
	author={{
			MSohail
		} and {
			AKaul
		} and {
			MRaziuddin
		} and {
			TAdak
		}}
		
		
		
	
	
		,
	journal={{Clinical Biochemistry}}
		
			40
			5-6
			
			,
	year={2007}
		
	

}

@incollection{b49,
	
	
		,
	title={{Glutathione-Stransferase activity in malarial parasites}}
		,
	author={{
			PSrivastava
		} and {
			SKPuri
		} and {
			KKKamboj
		} and {
			VCPandey
		}}
		
		
		
	
	
		,
	journal={{Tropical Medicine and International Health}}
		
			4
			4
			
			,
	year={1999}
		
	

}

@incollection{b50,
	
	
		,
	title={{The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity}}
		,
	author={{
			STsakiris
		} and {
			AGiannoulia-Karantana
		} and {
			ISimintzi
		} and {
			KHSchulpis
		}}
		
		
		
	
	
		,
	journal={{Pharmacological Research}}
		
			53
			
			,
	year={2005}
		
	

}

@book{b51,
	
	
		,
	title={{World medical association declaration of Helsinki ethical principles for medical research involving human subjects. 52nd WMA General Assembly}}
		,
	author={{
			Wma
		}}
		
			,
	year={2000}
			,
	address={Edinburgh, Scotland}
		
	

}

@book{b52,
	
	
		,
	title={{}}
		,
	author={{
			PlmZusterzeel
		} and {
			WldNelen
		} and {
			MJRoelofs
		} and {
			WhmPeters
		} and {
			HJBlom
		} and {
			EapSteegers
		}}
		
		
		
		
		
		
			,
	year={2000}
		
	

}

@incollection{b53,
	
	
		,
	title={{Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss}}
	
	
		,
	journal={{Molecular Human Reproduction}}
		
			6
			5
			
		
	

}