@incollection{,
	
					
					
					3B920F3222319DF1C4B017EA1EE3A428
				,
	author={{YujiAkiyama} and {Saitama Medical University}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}152715
}

@incollection{b0,
	
	
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	title={{A novel vasoconstrictor peptide produced by vascular endothelial cells}}
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	author={{
			MYanagisawa
		} and {
			HKurihara
		} and {
			SKimura
		} and {
			YTomobe
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			MKobayashi
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			YMitsui
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}

@incollection{b1,
	
	
		,
	title={{Bosentan A review of its use in the management of digital ulcers associated with systemic sclerosis}}
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			SDhillon
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	journal={{Drugs}}
		
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			14
			
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	year={2009}
		
	

}

@incollection{b2,
	
	
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	title={{Clinical characteristics and survival of Japanese patients with connective tissue disease and pulmonary arterial hypertension: a singlecenttre cohort}}
		,
	author={{
			YShirai
		} and {
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			51
			10
			
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	year={2012}
		
	

}

@incollection{b3,
	
	
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	title={{Microcirculation Society Multicentre Group for the Study of Vascular Acrosyndromes. Controlled multicenter double blind trial of an oral analog of prostacyclin in the treatment of primary Raynaud's phenomenon}}
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	author={{
			MVayssairat
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			French
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			23
			
			,
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}

@incollection{b4,
	
	
		,
	title={{Bosentan therapy for patients with severe Raynaud's phenomenon in systemic sclerosis}}
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	author={{
			MEHettema
		} and {
			DZhang
		} and {
			HBootsma
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		}}
		
		
		
	
	
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			66
			
			,
	year={2007}
		
	

}

@incollection{b5,
	
	
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	title={{Effects of bosentan of the skin lesions: an observational study from a single center in Japan}}
		,
	author={{
			MFunauchi
		} and {
			KKishimoto
		} and {
			HShimizu
		} and {
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	journal={{Rheumatol Int}}
		
			29
			
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}

@incollection{b6,
	
	
		,
	title={{Bosentan treatment for Raynaud's phenomenon and skin fibrosis in patients with systemic sclerosis and pulmonary arterial hypertension: An open-label, observational, retrospective study}}
		,
	author={{
			NGiordano
		} and {
			LPuccetti
		} and {
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			23
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	year={2010}
		
	

}

@incollection{b7,
	
	
		,
	title={{Effect of the dual endothelin receptor antagonist bosentan on Raynaud's phenomenon secondary to systemic sclerosis: a double-blind prospective, randomized, placebo-controlled pilot study}}
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	author={{
			VANguyen
		} and {
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		} and {
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	journal={{Rheumatology}}
		
			49
			3
			
			,
	year={2010}
		
	

}

@incollection{b8,
	
	
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	title={{Bosentan improves skin perfusion of hands in patients with systemic sclerosis with pulmonary arterial hypertension}}
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	author={{
			ERosato
		} and {
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		} and {
			FBorghese
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@incollection{b9,
	
	
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	title={{Assessment of digital vascular structure and function in response to bosentan in patients with systemic sclerosis-related Raynaud's phenomenon}}
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	author={{
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	journal={{Rheumatology}}
		
			46
			
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}

@incollection{b10,
	
	
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	title={{Efficacy of ambrisentan in the treatment of digital ulcers in patients with systemic sclerosis: a preliminary study}}
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			52
			
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}

@incollection{b11,
	
	
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	title={{Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classication of systemic sclerosis (scleroderma)}}
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@incollection{b12,
	
	
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	title={{The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE)}}
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@incollection{b13,
	
	
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			1
			
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}

@incollection{b14,
	
	
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	title={{Polymyositis and dermatomyositis}}
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@incollection{b15,
	
	
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	title={{Controlled double-blind trial of nifedipine in the treatment of Raynaud's phenomenon}}
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	author={{
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@incollection{b16,
	
	
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	title={{Treatment of Raynaud's phenomenon with the selective serotonin reuptake inhibitor fluoetine}}
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	author={{
			BColeiro
		} and {
			SEMarshall
		} and {
			CPDenton
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	journal={{Rheumatology}}
		
			40
			
			,
	year={2001}
		
	

}

@incollection{b17,
	
	
		,
	title={{The combination therapy with sarpoglerate hydrochloride and kampo medicine (Oren-gedoku-to or Toki-shakuyaku-san) for Raynaud's phenomenon}}
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	author={{
			YAkiyama
		} and {
			SOhno
		} and {
			TAsaoka
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			TKatagiri
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	journal={{Jpn Soc Orient Med}}
		
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	year={2001}
		
	
	,
	note={in Japanese}

}

@incollection{b18,
	
	
		,
	title={{Successful treatment of severe Raynaud's phenomenon with bosentan in four patients with systemic sclerosis}}
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	author={{
			MRamos-Casals
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			PBrito-Zeron
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			NNardi
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	journal={{Rheumatology}}
		
			43
			
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}

@incollection{b19,
	
	
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	title={{Successful treatment of patients with severe secondary Raynaud's phenomenon with the endothelin receptor antagonist bosentan}}
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	author={{
			NSelenko-Gebauer
		} and {
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		} and {
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	journal={{Rheumatology}}
		
			45
			
			,
	year={2006}
		
	

}

@incollection{b20,
	
	
		,
	title={{Efficacy of tadalafil in secondary Raynaud's phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial}}
		,
	author={{
			PDShenoy
		} and {
			SKumar
		} and {
			LKJha
		} and {
			SKChoudhary
		} and {
			USingh
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			RMisra
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	journal={{Rheumatology}}
		
			49
			12
			
			,
	year={Dec2010}
		
	

}

@incollection{b21,
	
	
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	title={{Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud's phenomenon: systemic review and meta-analysis of randomized trials}}
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	author={{
			MRoustit
		} and {
			SBlaise
		} and {
			YAllanore
		} and {
			PHCarpentier
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			ECaglayan
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			JLCracowski
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		,
	journal={{Ann Rheum Dis}}
		
			72
			
			,
	year={2013}
		
	

}

@incollection{b22,
	
	
		,
	title={{Macitentan slows down the dermal fibrotic process in systemic sclerosis: in vitro findings}}
		,
	author={{
			CCorallo
		} and {
			CCPecetti
		} and {
			MIglarz
		} and {
			NVolpi
		} and {
			DFranci
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			AMontella
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			27
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	year={2013}
		
	

}