@incollection{,
	
					
					
					6F0481F32FAEABB350014B76B8BCD5E1
				,
	author={{LiangZhou} and {GuanjingZhang} and {ZhiyanXu} and {KhrystynaPronyuk} and {XingmingChen} and {E-Techco Information Technologies Co.Ltd}},
	journal={{Global Journal of Medical Research}},
	journal={{GJMR}}2249-46180975-588810.34257/GJMR,
	address={Cambridge, United States},
	publisher={Global Journals Organisation}1521726
}

@incollection{b0,
	
	
		,
	title={{Role of reactive oxygen species in the pathogenesis of diabetic nephropathy}}
		,
	author={{
			HHa
		} and {
			IAHwang
		} and {
			JHPark
		} and {
			HBLee
		}}
		
		
		
	
	
		,
	journal={{Diabetes Research and Clinical Practice}}
		
			82
			
			,
	year={2008}
		
	

}

@book{b1,
	
	
		,
	title={{International Diabetes Federation. IDF Diabetes Atlas Update Poster}}
				Brussels, Belgium
		
			,
	year={2014}
		
	
	,
	note={6th ed.; International Diabetes Federation}

}

@incollection{b2,
	
	
		,
	title={{Molecular mechanisms underlying diabetic nephropathy}}
		,
	author={{
			AMSheridan
		}}
	
	
		,
	journal={{Nephrology Rounds}}
		
			4
			8
			,
	year={2006}
		
	

}

@incollection{b3,
	
	
		,
	title={{Pathogenesis of diabetic nephropathy}}
		,
	author={{
			AArya
		} and {
			SAggarwal
		} and {
			HNYadav
		}}
		
		
	
	
		,
	journal={{Int J Pharm Pharm Sci}}
		
			2
			4
			
			,
	year={2010}
		
	

}

@incollection{b4,
	
	
		,
	title={{Diabetic nephropathy: important pathophysiologic mechanisms}}
		,
	author={{
			GSoldatos
		} and {
			MECooper
		}}
		
	
	
		,
	journal={{Diabetes Research And Clinical Practice}}
		
			82
			
			,
	year={2008}
		
	

}

@incollection{b5,
	
	
		,
	title={{Advanced glycation end-products: iImplications for Diabetic and non-diabetic nephropathies}}
		,
	author={{
			MDaroux
		} and {
			GPrevost
		} and {
			HMaillard-Lefebvre
		} and {
			CGaxatte
		} and {
			VDD'agati
		} and {
			AMSchmidt
		} and {
			EBoulanger
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Diabetes & Metabolism}}
		
			36
			
			,
	year={2010}
		
	

}

@book{b6,
	
	
		,
	title={{}}
		,
	author={{
			ADash
		} and {
			RMaiti
		} and {
			TK ABandakkanavar
		} and {
			BLPandey
		}}
		
		
		
		
		
			Novel Drug Treatment for Diabetic Nephropathy
		
	

}

@incollection{b7,
	
	
		,
	title={{}}
		,
	author={{
			HongKong
		}}
	
	
		,
	journal={{J Nephrol}}
		
			13
			1
			
			,
	year={2011}
		
	

}

@incollection{b8,
	
	
		,
	title={{Recent Advances in Pharmacotherapy for Diabetic Nephropathy: Current Perspectives and Future Directions}}
		,
	author={{
			PBalakumar
		} and {
			MKArora
		} and {
			SSGanti
		} and {
			JReddy
		} and {
			MSingh
		}}
		
		
		
		
	
	
		,
	journal={{Pharmacological Research}}
		
			60
			
			,
	year={2009}
		
	

}

@incollection{b9,
	
	
		,
	title={{Molecular mechanisms in the pathogenesis of diabetic nephropathy: an update}}
		,
	author={{
			MKArora
		} and {
			UKSingh
		}}
		
	
	
		,
	journal={{Vascular Pharmacology}}
		
			58
			
			,
	year={2013}
		
	

}

@incollection{b10,
	
	
		,
	title={{Vascular Complications of Diabetes: Mechanisms of injury and protective factors}}
		,
	author={{
			CRask-Madsen
		} and {
			. & GLKing
		}}
		
	
	
		,
	journal={{Cell Metabolism}}
		
			17
			
			,
	year={2013}
		
	

}

@incollection{b11,
	
	
		,
	title={{The role of tubular injury in diabetic nephropathy}}
		,
	author={{
			CJMagri
		} and {
			SFava
		}}
		
	
	
		,
	journal={{European Journal of Internal Medicine}}
		
			20
			
			,
	year={2009}
		
	

}

@incollection{b12,
	
	
		,
	title={{The role of TGF-? and epithelial-to mesenchymal transition in diabetic nephropathy}}
		,
	author={{
			CEHills
		} and {
			PESquires
		}}
		
	
	
		,
	journal={{Cytokine & Growth Reviews}}
		
			22
			
			,
	year={2011}
		
	

}

@incollection{b13,
	
	
		,
	title={{Advanced glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but now retinopathy}}
		,
	author={{
			SChabroux
		} and {
			FCanoui-Poitrine
		} and {
			SReffet
		} and {
			GMills-Joncour
		} and {
			EMordlon
		} and {
			CColin
		} and {
			CThivolet
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Diabetes & Metabolism}}
		
			36
			
			,
	year={2010}
		
	

}

@incollection{b14,
	
	
		,
	title={{Advanced glycation end products and oxidative stress in Type 2 Diabetes Mellitus}}
		,
	author={{
			KNowotny
		} and {
			T
		} and {
			JungHohn
		}}
		
		
	
	
		,
	journal={{Biomolecules}}
		
			5
			
			,
	year={2015}
		
	

}

@incollection{b15,
	
	
		,
	title={{Expression of advanced glycation endproduces and their cellular receptor RAGE in diabetic nephropathy and non-diabetic renal disease}}
		,
	author={{
			NTanji
		} and {
			GSMarkowitz
		} and {
			CFu
		} and {
			TKislinger
		} and {
			ATaguchi
		} and {
			MPischetsrieder
		} and {
			DStern
		} and {
			AMSchmidt
		} and {
			VDD'agati
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{J Am Soc Nephrol}}
		
			11
			
			,
	year={2000}
		
	

}

@incollection{b16,
	
	
		,
	title={{Relationship between the expression of advanced glycation end-products (AGE) and the receptor for AGE (RAGE) mRNA in diabetic nephropathy}}
		,
	author={{
			DSuzuki
		} and {
			MToyoda
		} and {
			NYamamoto
		} and {
			MMiyauchi
		} and {
			MKatoh
		} and {
			MKimura
		} and {
			MMaruyama
		} and {
			MHonma
		} and {
			TUmezono
		} and {
			MYagame
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Intern Med}}
		
			45
			
			,
	year={2006}
		
	

}

@incollection{b17,
	
	
		,
	title={{Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications}}
		,
	author={{
			SYamagishi
		} and {
			KNakamura
		} and {
			TMatsui
		} and {
			SUeda
		} and {
			KFukami
		} and {
			SOkuda
		}}
		
		
		
		
		
	
	
		,
	journal={{Expert Opin Invest Drugs}}
		
			17
			
			,
	year={2008}
		
	

}

@incollection{b18,
	
	
		,
	title={{Development and prevention of advanced diabetic nephropathy in RAGE overexpressing mice}}
		,
	author={{
			YYamamoto
		} and {
			IKato
		} and {
			TDoi
		} and {
			HYonekura
		} and {
			SOhashi
		}}
		
		
		
		
	
	
		,
	journal={{J Clin Invest}}
		
			108
			
			,
	year={2001}
		
	

}

@book{b19,
	
	
		,
	title={{}}
		,
	author={{
			TSoulis
		} and {
			MECooper
		} and {
			DVranes
		} and {
			RBucala
		} and {
			GJerums
		}}
		
		
		
		
		
	
	,
	note={Effects of aminoguanidine in preventing}

}

@incollection{b20,
	
	
		,
	title={{Diabetic Nephropathy: Causative and Protective Factors experimental diabetic nephropathy are related to the duration of treatment}}
	
	
		,
	journal={{Kidney Int}}
		
			50
			
			,
	year={1996}
		
	

}

@incollection{b21,
	
	
		,
	title={{The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes}}
		,
	author={{
			JMForbes
		} and {
			VThallas
		} and {
			MCThomas
		} and {
			HWFounds
		} and {
			WCBurns
		} and {
			GJerums
		} and {
			MECooper
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Faseb J}}
		
			17
			12
			
			,
	year={2003}
		
	

}

@incollection{b22,
	
	
		,
	title={{The RAGE axis: a Fundamental mechanism signaling danger to the vulnerable vasculature}}
		,
	author={{
			SFYan
		} and {
			RRamasamy
		} and {
			AMSchemidt
		}}
		
		
	
	
		,
	journal={{Circ. Res}}
		
			106
			
			,
	year={2010}
		
	

}

@incollection{b23,
	
	
		,
	title={{Protein kinase C and lipid signaling for sustained cellular responses}}
		,
	author={{
			YNishizuka
		}}
	
	
		,
	journal={{FASEB J}}
		
			9
			
			,
	year={1995}
		
	

}

@incollection{b24,
	
	
		,
	title={{D-Saccharic acid 1, 4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-?B and PKC signaling}}
		,
	author={{
			SBhattacharya
		} and {
			PManna
		} and {
			RGachhui
		} and {
			PCSil
		}}
		
		
		
	
	
		,
	journal={{Toxicology and Applied Pharmacology}}
		
			267
			
			,
	year={2013}
		
	

}

@book{b25,
	
	
		,
	title={{Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes. Diabetes Care}}
		,
	author={{
			REGilbert
		} and {
			SAKim
		} and {
			KRTuttle
		} and {
			GLBakris
		} and {
			RDToto
		} and {
			JBMcgill
		}}
		
		
		
		
		
		
			,
	year={2007}
			30
			
		
	

}

@incollection{b26,
	
	
		,
	title={{The effect of ruboxistaurin on nephropathy in type 2 diabetes}}
		,
	author={{
			KRTuttle
		} and {
			GLBakris
		} and {
			RDToto
		} and {
			JBMcgill
		} and {
			KHu
		} and {
			PWAnderson
		}}
		
		
		
		
		
	
	
		,
	journal={{Diabetes Care}}
		
			28
			
			,
	year={2005}
		
	

}

@incollection{b27,
	
	
		,
	title={{Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation}}
		,
	author={{
			YSong
		} and {
			CLi
		} and {
			LCai
		}}
		
		
	
	
		,
	journal={{Exp. Mol. Patholo}}
		
			76
			
			,
	year={2004}
		
	

}

@incollection{b28,
	
	
		,
	title={{Transforming growth factor-?/connective tissue growth factor axis in the kidney}}
		,
	author={{
			WQi
		} and {
			XMChen
		} and {
			PPoronnik
		} and {
			CAPollock
		}}
		
		
		
	
	
		,
	journal={{The International Journal of Biochemistry & Cell Biology}}
		
			40
			
			,
	year={2008}
		
	

}

@incollection{b29,
	
	
		,
	title={{Advanced glycosylation end products up-regulate connective tissue growth factor (Insulin-like growth factor-binding protein-related protein 2) in human fibroblasts: A potential mechanism for expansion of extracellular matrix in diabetes mellitus}}
		,
	author={{
			SMTwigg
		} and {
			MMChen
		} and {
			AHJoly
		} and {
			SDChakrapani
		} and {
			JTsubaki
		} and {
			HSKim
		} and {
			YOh
		} and {
			RGRosenfeld
		}}
		
		
		
		
		
		
		
	
	
		,
	journal={{Endocrinology}}
		
			142
			
			,
	year={2001}
		
	

}

@incollection{b30,
	
	
		,
	title={{Angiotensin ? induces connective tissue growth factor gene expression via calcineurin-dependent pathways}}
		,
	author={{
			PFinckenberg
		} and {
			KInkinen
		} and {
			JAhonen
		} and {
			SMerasto
		} and {
			MLouhelainen
		} and {
			HVapaatalo
		} and {
			DMüller
		} and {
			DGanten
		} and {
			FLuft
		} and {
			EMervaala
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{American Journal of Pathology}}
		
			163
			
			,
	year={2003}
		
	

}

@incollection{b31,
	
	
		,
	title={{Clinical significance of inflammatory and fibrogenic cytokines in diabetic nephropathy}}
		,
	author={{
			HO EMesallamy
		} and {
			HHAhmed
		} and {
			AABassyouni
		} and {
			ASAhmed
		}}
		
		
		
	
	
		,
	journal={{Clinical Biochemistry}}
		
			45
			
			,
	year={2012}
		
	

}

@incollection{b32,
	
	
		,
	title={{Connective tissue growth factor (CTGF) expression modulates response to high glucose}}
		,
	author={{
			Lr James
		} and {
			HLe
		} and {
			Doherty
		}}
		
		
	
	
		,
	journal={{Plos One}}
		
			8
			8
			,
	year={2013}
		
	

}

@incollection{b33,
	
	
		,
	title={{Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor Trk A}}
		,
	author={{
			NAWahab
		} and {
			BSWeston
		} and {
			RMMason
		}}
		
		
	
	
		,
	journal={{J. Am. Soc. Nephrol}}
		
			16
			
			,
	year={2005}
		
	

}

@incollection{b34,
	
	
		,
	title={{Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis}}
		,
	author={{
			HYokoi
		} and {
			MMukoyama
		} and {
			TNagae
		} and {
			KMori
		} and {
			TSuganami
		} and {
			KSawai
		} and {
			TYoshioka
		} and {
			MKoshikawa
		} and {
			TNishida
		} and {
			MTakigawa
		} and {
			ASugawara
		} and {
			KNakao
		}}
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{J. Am. Soc. Nephrol}}
		
			15
			
			,
	year={2004}
		
	

}

@incollection{b35,
	
	
		,
	title={{Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuria}}
		,
	author={{
			SGAdler
		} and {
			SSchwartz
		} and {
			MEWilliams
		} and {
			CArauz-Pacheco
		} and {
			WKBolton
		}}
		
		
		
		
	
	
		,
	journal={{Clin. J. Am. Soc. Nephrol}}
		
			5
			8
			
			,
	year={2010}
		
	

}

@incollection{b36,
	
	
		,
	title={{Molecular basis of NF-?B signaling}}
		,
	author={{
			JNapetschnig
		} and {
			& HWu
		}}
		
	
	
		,
	journal={{Annu Rev Biophys}}
		
			42
			
			,
	year={2013}
		
	

}

@incollection{b37,
	
	
		,
	title={{NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy}}
		,
	author={{
			SMezzano
		} and {
			CAros
		} and {
			ADroguett
		} and {
			MEBurgos
		} and {
			LArdiles
		} and {
			CFlores
		} and {
			HSchneider
		} and {
			MRuiz-Ortega
		} and {
			&JEgido
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Nephrol. Dial. Transplant}}
		
			19
			10
			
			,
	year={2004}
		
	

}

@incollection{b38,
	
	
		,
	title={{Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury}}
		,
	author={{
			WLiu
		} and {
			XZhang
		} and {
			PLiu
		} and {
			XShen
		} and {
			TLan
		} and {
			WLi
		} and {
			QJiang
		} and {
			XXie
		} and {
			&HHuang
		}}
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Eur. J. Pharmacol}}
		
			638
			
			,
	year={2010}
		
	

}

@incollection{b39,
	
	
		,
	title={{Role of high glucose-induced nuclear factor-kappa B activation in monocyte chemoattractant protein-1 expression by mesangial cells}}
		,
	author={{
			HHa
		} and {
			MRYu
		} and {
			YJChoi
		} and {
			MKitamura
		} and {
			HBLee
		}}
		
		
		
		
	
	
		,
	journal={{J. Am. Soc. Nephrol}}
		
			13
			
			,
	year={2002}
		
	

}

@incollection{b40,
	
	
		,
	title={{From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines}}
		,
	author={{
			BFSchrijvers
		} and {
			ASDe Vriese
		} and {
			AFlyvbjerg
		}}
		
		
	
	
		,
	journal={{Endocr Rev}}
		
			25
			6
			
			,
	year={2004}
		
	

}

@incollection{b41,
	
	
		,
	title={{Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells}}
		,
	author={{
			TOkado
		} and {
			YTerada
		} and {
			HTanaka
		} and {
			SInoshita
		} and {
			ANakao
		} and {
			SSasaki
		}}
		
		
		
		
		
	
	
		,
	journal={{Kidney int}}
		
			62
			
			,
	year={2002}
		
	

}

@incollection{b42,
	
	
		,
	title={{Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB}}
		,
	author={{
			RPNagarajan
		} and {
			FChen
		} and {
			WLi
		} and {
			EVig
		} and {
			MAHarrington
		} and {
			HNakshatri
		} and {
			YChen
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Biochem J}}
		
			348
			
			,
	year={2000}
		
	

}

@incollection{b43,
	
	
		,
	title={{Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-?B}}
		,
	author={{
			JChiu
		} and {
			HFarhangkhoee
		} and {
			SChakrabarti
		}}
		
		
	
	
		,
	journal={{Nutrition}}
		
			25
			
			,
	year={2009}
		
	

}

@incollection{b44,
	
	
		,
	title={{Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-?B signaling pathway in rat glomerular mesangial cells}}
		,
	author={{
			XXie
		} and {
			JPeng
		} and {
			KHuang
		} and {
			JHuang
		} and {
			XYShen
		} and {
			PLiu
		} and {
			HHuang
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Mol Cell Endocrinol}}
		
			362
			
			,
	year={2012}
		
	

}

@incollection{b45,
	
	
		,
	title={{Beneficial effect of lycopene on anti-diabetic nephropathy through diminishing inflammatory response and oxidative stress}}
		,
	author={{
			YGuo
		} and {
			YLiu
		} and {
			Wang
		}}
		
		
	
	
		,
	journal={{Food Funct}}
		
			,
	year={2015}
		
	

}

@incollection{b46,
	
	
		,
	title={{Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease}}
		,
	author={{
			MScatena
		} and {
			LLiaw
		} and {
			CMGiachelli
		}}
		
		
	
	
		,
	journal={{Arterioscler Thromb Vasc Biol}}
		
			27
			
			,
	year={2007}
		
	

}

@book{b47,
	
	
		,
	title={{Osteopontin in diabetic nephropathy: signpost or road? Kideny international}}
		,
	author={{
			JG DHeuer & M
		} and {
			Breyer
		}}
		
		
			,
	year={2010}
			77
			
		
	

}

@incollection{b48,
	
	
		,
	title={{Critical role for osteopontin in diabetic nephropathy}}
		,
	author={{
			SBNicholas
		} and {
			JLiu
		} and {
			JKim
		} and {
			YRen
		} and {
			ARCollins
		} and {
			LNguyen
		} and {
			WAHsueh
		}}
		
		
		
		
		
		
	
	
		,
	journal={{Kidney International}}
		
			77
			
			,
	year={2010}
		
	

}

@incollection{b49,
	
	
		,
	title={{Molecular profiling of diabetic mouse kidney reveals novel genes linked to glomerular disease}}
		,
	author={{
			KSusztak
		} and {
			EBöttinger
		} and {
			ANovetsky
		} and {
			DLiang
		} and {
			YZhu
		} and {
			ECiccone
		} and {
			DWu
		} and {
			SDunn
		} and {
			PMccue
		} and {
			KSharma
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Diabetes}}
		
			53
			
			,
	year={2004}
		
	

}

@incollection{b50,
	
	
		,
	title={{The role of osteopontin in the development of albuminuria}}
		,
	author={{
			JLorenzen
		} and {
			RShah
		} and {
			ABiser
		} and {
			SAStaicu
		} and {
			TNiranjan
		} and {
			AMGarcia
		} and {
			AGruenwald
		} and {
			DBThomas
		} and {
			IFShatat
		} and {
			KSupe
		} and {
			RPWoroniecki
		} and {
			KSusztak
		}}
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{J Am Soc Nephrol}}
		
			19
			
			,
	year={2008}
		
	

}

@incollection{b51,
	
	
		,
	title={{Analysis of differential gene expression in stretched podocytes: osteopontin enhances adaptation of podocytes to mechanical stress}}
		,
	author={{
			NEndlich
		} and {
			MSunohara
		} and {
			WNietfeld
		} and {
			EWWolski
		} and {
			DSchiwek
		} and {
			BKränzlin
		} and {
			NGretz
		} and {
			WKriz
		} and {
			HEickhoff
		} and {
			KEndlich
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{FASEB J}}
		
			16
			
			,
	year={2002}
		
	

}

@incollection{b52,
	
	
		,
	title={{Osteopontin mediates hypoxia-induced proliferation of cultured mesangial cells: role of PKC and p38 MAPK}}
		,
	author={{
			CPSodhi
		} and {
			DBattle
		} and {
			ASahai
		}}
		
		
	
	
		,
	journal={{Kidney int}}
		
			58
			
			,
	year={2000}
		
	

}

@incollection{b53,
	
	
		,
	title={{High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-?B/NADPH oxidase/ROS pathway, which is inhibited by resveratrol}}
		,
	author={{
			LZhang
		} and {
			SPang
		} and {
			BDeng
		} and {
			LQian
		} and {
			JChen
		} and {
			JZou
		} and {
			JZheng
		} and {
			L
		} and {
			Yang
		} and {
			CZhang
		} and {
			XChen
		} and {
			ZLiu
		} and {
			YLe
		}}
		
		
		
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Int J Biochem Cell Biol}}
		
			44
			
			,
	year={2012}
		
	

}

@incollection{b54,
	
	
		,
	title={{Oxidative stress as a major culprit in kidney disease in diabetes}}
		,
	author={{
			JMForbes
		} and {
			MTCoughlan
		} and {
			MECooper
		}}
		
		
	
	
		,
	journal={{Diabetes}}
		
			57
			6
			
			,
	year={2008}
		
	

}

@incollection{b55,
	
	
		,
	title={{Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice}}
		,
	author={{
			MLBrezniceanu
		} and {
			FLiu
		} and {
			CCWei
		} and {
			STran
		} and {
			SSachetelli
		} and {
			SLZhang
		} and {
			DFGuo
		} and {
			JGFilep
		} and {
			JRIngelfinger
		} and {
			JSChan
		}}
		
		
		
		
		
		
		
		
		
	
	
		,
	journal={{Kidney Int}}
		
			71
			
			,
	year={2007}
		
	

}

@incollection{b56,
	
	
		,
	title={{Oxidative stress in diabetic nephropathy}}
		,
	author={{
			NKashihara
		} and {
			YHaruna
		} and {
			VKKondeti
		} and {
			YSKanwar
		}}
		
		
		
	
	
		,
	journal={{Curr. Med. Chem}}
		
			17
			
			,
	year={2010}
		
	

}

@incollection{b57,
	
	
		,
	title={{Schizandrin prevents damage of murine mesangial cells via blocking NADPH oxidase-induced ROS signaling in high glucose}}
		,
	author={{
			SJeong
		} and {
			SJKim
		} and {
			THKwon
		} and {
			KYYu
		} and {
			SYKim
		}}
		
		
		
		
	
	
		,
	journal={{Food and Chemical Toxicology}}
		
			50
			
			,
	year={2012}
		
	

}

@incollection{b58,
	
	
		,
	title={{Long-term dietary antioxidant cocktail supplementation effectively reduces renal inflammation in diabetic mice}}
		,
	author={{
			NYPark
		} and {
			SKPark
		} and {
			&YLim
		}}
		
		
	
	
		,
	journal={{Br. J. Nutr}}
		
			106
			10
			
			,
	year={2011}
		
	

}

@incollection{b59,
	
	
		,
	title={{NADPH Oxidases, reactive oxygen species, and the kidney: Friend and Foe}}
		,
	author={{
			MSedeek
		} and {
			Nasrallah
		} and {
			& RlTouyz
		} and {
			Hebert
		}}
		
		
		
	
	
		,
	journal={{J Am Nephrol}}
		
			24
			
			,
	year={2013}
		
	

}

@incollection{b60,
	
	
		,
	title={{Reactive oxygen species in diabetic nephropathy: friend or foe?}}
		,
	author={{
			TBondeva
		} and {
			& GWolf
		}}
		
	
	
		,
	journal={{Nephrol. Dial. Transplant}}
		
			29
			11
			
			,
	year={2014}
		
	

}

@incollection{b61,
	
	
		,
	title={{Regression of microalbuminuria in type 1 diabetes}}
		,
	author={{
			BAPerkins
		} and {
			LHFicociello
		} and {
			KHSilva
		}}
		
		
	
	
		,
	journal={{N Engl J Med}}
		
			348
			
			,
	year={2003}
		
	

}

@incollection{b62,
	
	
		,
	title={{The molecular biology of axon guidance}}
		,
	author={{
			MTessier-Lavigne
		} and {
			CSGoodman
		}}
		
	
	
		,
	journal={{Science}}
		
			274
			
			,
	year={1996}
		
	

}

@incollection{b63,
	
	
		,
	title={{The netrin receptor UNC5B promotes angiogenesis in specific vascular beds}}
		,
	author={{
			SNavankasattusas
		} and {
			KJWhitehead
		} and {
			ASuli
		} and {
			LKSorensen
		} and {
			AHLim
		} and {
			JZhao
		}}
		
		
		
		
		
	
	
		,
	journal={{Development}}
		
			135
			
			,
	year={2008}
		
	

}

@incollection{b64,
	
	
		,
	title={{Netrin-1 and kidney injury. 1. Netrin-1 protects against ischemia-reperfusion injury of the kidney}}
		,
	author={{
			Ww
		} and {
			WBWang
		} and {
			&GReeves
		} and {
			Ramesh
		}}
		
		
		
	
	
		,
	journal={{Am J Physiol Renal Physiol}}
		
			294
			4
			
			,
	year={2008}
		
	

}

@incollection{b65,
	
	
		,
	title={{Partial netrin-1 deficiency aggravates acute kidney injury}}
		,
	author={{
			AGrenz
		} and {
			JHDalton
		} and {
			JDBauerle
		} and {
			ABadulak
		} and {
			DRidyard
		}}
		
		
		
		
	
	
		,
	journal={{PloS One}}
		
			6
			5
			e14812
			,
	year={2011}
		
	

}

@book{b66,
	
	
		,
	title={{Role of netrin-1 beyone the brain: from biomarker of tissue injury to therapy for inflammatory disease}}
		,
	author={{
			GRamesh
		}}
		
			,
	year={2012}
			2
			
		
	
	,
	note={Recent pat biomark}

}

@incollection{b67,
	
	
		,
	title={{Type 2 diabetes mellitus as inflammatory disease}}
		,
	author={{
			DZozulinska & B. Wierusz-Wysocka
		}}
	
	
		,
	journal={{Diabetes Research and Clinical Practice}}
		
			74
			
			,
	year={2006}
		
	

}

@incollection{b68,
	
	
		,
	title={{Kidney proximal tubular epithelial-specific overexpression of netrin-1 suppression of COX-2-mediated PGE2 production in streptozotocin-induced diabetic mice}}
		,
	author={{
			RMohamed
		} and {
			CJayakumar
		} and {
			PVRanganathan
		} and {
			VGanapahty
		} and {
			GRamesh
		}}
		
		
		
		
	
	
		,
	journal={{Am J Pathol}}
		
			181
			
			,
	year={2012}
		
	

}

@incollection{b69,
	
	
		,
	title={{Protective role for netrin-1 during diabetic nephropathy}}
		,
	author={{
			ETak
		} and {
			DRidyard
		} and {
			ABadulak
		} and {
			AGiebler
		} and {
			UShabeka
		} and {
			TWerner
		}}
		
		
		
		
		
	
	
		,
	journal={{J Mol Med}}
		
			91
			
			,
	year={2013}
		
	

}

@book{b70,
	
	
		,
	author={{
			YXSu
		} and {
			HCDeng
		} and {
			MXZhang
		} and {
			JLong
		} and {
			ZGPeng
		}}
		
		
		
		
		,
	title={{Adiponectin inhibits PDGF-induced}}
				
	

}

@incollection{b71,
	
	
		,
	title={{Diabetic Nephropathy: Causative and Protective Factors mammalian target of rapamycin-mediated survival pathway by adenosine 5-Monophosphate-activated protein kinase}}
	
	
		,
	journal={{Horm Metab Res}}
		
			44
			
			,
	year={2012}
		
	

}

@incollection{b72,
	
	
		,
	title={{Adiponectin effects on the kidney}}
		,
	author={{
			NSweiss
		} and {
			&KSharma
		}}
		
	
	
		,
	journal={{Best Practice & Research Clinical Endocrinology & Metabolism}}
		
			
			,
	year={2013}
		
	

}

@incollection{b73,
	
	
		,
	title={{Adiponectin and adiponectin receptors}}
		,
	author={{
			TKadowaki
		} and {
			& TYamauchi
		}}
		
	
	
		,
	journal={{Endocrine Reviews}}
		
			26
			3
			
			,
	year={2005}
		
	

}

@incollection{b74,
	
	
		,
	title={{Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes}}
		,
	author={{
			XFang
		} and {
			& GSweeney
		}}
		
	
	
		,
	journal={{Biochemical Society Transactions}}
		
			34
			5
			
			,
	year={2006}
		
	

}

@incollection{b75,
	
	
		,
	title={{Adiponectinreduces proteinuria in streptozotocin-induced diabetic Wistar rats}}
		,
	author={{
			SNakamaki
		} and {
			HSatoh
		} and {
			AKudoh
		} and {
			YHayashi
		} and {
			HHirai
		} and {
			TWatanabe
		}}
		
		
		
		
		
	
	
		,
	journal={{Exp. Biol. Med}}
		
			236
			5
			
			,
	year={2011}
		
	

}

@book{b76,
	
	
		,
	title={{Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice}}
		,
	author={{
			KOhashi
		} and {
			HIwatani
		} and {
			SKihara
		}}
		
		
		
	

}

@incollection{b77,
	
	
		,
	title={{}}
	
	
		,
	journal={{Arteriosclerosis, Thrombosis, and Vascular Biology}}
		
			27
			9
			
			,
	year={2007}
		
	

}

@incollection{b78,
	
	
		,
	title={{Adiponectin regulates albuminuria and podocytes function in mice}}
		,
	author={{
			KSharma
		} and {
			SRamachandrarao
		} and {
			GQiu
		}}
		
		
	
	
		,
	journal={{The journal of Clinical Investigation}}
		
			118
			5
			
			,
	year={2008}
		
	

}

@incollection{b79,
	
	
		,
	title={{Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocytes apoptosis}}
		,
	author={{
			BIsermann
		} and {
			IAVinnikov
		} and {
			TMadhusudhan
		} and {
			SHerzog
		} and {
			MKashif
		}}
		
		
		
		
	
	
		,
	journal={{Nat Med}}
		
			13
			11
			
			,
	year={2007}
		
	

}

@incollection{b80,
	
	
		,
	title={{Decreased activated protein C levels are inversely associated with the urinary albumin excretion rate in patients with type 2 diabetes}}
		,
	author={{
			WLi
		} and {
			Lin
		} and {
			He
		}}
		
		
	
	
		,
	journal={{Clin. Lab}}
		
			60
			2
			
			,
	year={2014}
		
	

}

@incollection{b81,
	
	
		,
	title={{Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66shc}}
		,
	author={{
			FBock
		} and {
			KShahzad
		} and {
			HJWang
		} and {
			SStoyanov
		} and {
			JWolter
		} and {
			WDong
		}}
		
		
		
		
		
	
	
		,
	journal={{PNAS}}
		
			110
			2
			
			,
	year={2013}
		
	

}

@incollection{b82,
	
	
		,
	title={{Activated protein C and diabetic nephropathy}}
		,
	author={{
			REGilbert
		} and {
			PAMarsden
		}}
		
	
	
		,
	journal={{N ENGL J MED}}
		
			358
			15
			
			,
	year={2008}
		
	

}

@incollection{b83,
	
	
		,
	title={{Exogenous activated protein C inhibits the progression of diabetic nephropathy}}
		,
	author={{
			PGil-Bernabe
		} and {
			CND'alessandro-Gabazza
		} and {
			MToda
		} and {
			DBoveda
		} and {
			Ruiz
		}}
		
		
		
		
	
	
		,
	journal={{J Thromb Haemost}}
		
			10
			3
			
			,
	year={2012}
		
	

}

@incollection{b84,
	
	
		,
	title={{Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitrix oxide synthase function in obesity-associated insulin resistance}}
		,
	author={{
			KNaruse
		} and {
			CRask-Madsen
		} and {
			NTakahara
		} and {
			SWHa
		} and {
			KSuzuma
		}}
		
		
		
		
	
	
		,
	journal={{Diabetes}}
		
			55
			
			,
	year={2006}
		
	

}

@incollection{b85,
	
	
		,
	title={{Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: A specific vascular action of insulin}}
		,
	author={{
			KKuboki
		} and {
			ZYJiang
		} and {
			NTakahara
		} and {
			SWHa
		}}
		
		
		
	
	
		,
	journal={{Circulation}}
		
			101
			
			,
	year={2000}
		
	

}

@incollection{b86,
	
	
		,
	title={{Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: a possible explanation for impaired collateral formation in cardiac tissue}}
		,
	author={{
			EChou
		} and {
			LSuzuma
		} and {
			KJWay
		} and {
			DOpland
		} and {
			ACClermont
		}}
		
		
		
		
	
	
		,
	journal={{Circulation}}
		
			105
			
			,
	year={2002}
		
	

}

@incollection{b87,
	
	
		,
	title={{FoxOs intergrate pleiotropic actions of insulin in vascular endothelium protect mice from atherosclerosis}}
		,
	author={{
			KTsuchiya
		} and {
			JTanaka
		} and {
			YShuiqing
		} and {
			CLWelch
		} and {
			RADepinho
		}}
		
		
		
		
	
	
		,
	journal={{Cell Metab}}
		
			15
			
			,
	year={2012}
		
	

}

@incollection{b88,
	
	
		,
	title={{Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells}}
		,
	author={{
			CHermann
		} and {
			BAssmus
		} and {
			CUrbich
		} and {
			AMZeiher
		} and {
			SDimmeler
		}}
		
		
		
		
	
	
		,
	journal={{Arterioscler. Thromb. Vasc. Biol}}
		
			20
			
			,
	year={2000}
		
	

}

@incollection{b89,
	
	
		,
	title={{Activation of protein kinase C isoforms and its impact on diabetic complications}}
		,
	author={{
			P &Geraldes
		} and {
			GLKing
		}}
		
	
	
		,
	journal={{Circ. Res}}
		
			106
			
			,
	year={2010}
		
	

}

@incollection{b90,
	
	
		,
	title={{Glomerular-specific protein kinase C-?-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity}}
		,
	author={{
			YMima
		} and {
			MOhshiro
		} and {
			MKitada
		} and {
			Matsumoto
		}}
		
		
		
	
	
		,
	journal={{Kidney international}}
		
			79
			8
			
			,
	year={2011}
		
	

}

@incollection{b91,
	
	
		,
	title={{Insulin signaling to the glomerular podocytes is critical for normal kidney function}}
		,
	author={{
			GIWelsh
		} and {
			LGHale
		} and {
			VEremina
		} and {
			MJeansson
		} and {
			YMaezawa
		}}
		
		
		
		
	
	
		,
	journal={{Cell metab}}
		
			12
			
			,
	year={2010}
		
	

}