The Effect of Oral Metronidazole in the Prevention of Preterm Labour among Pregnant women With Bacterial Vaginosis

Authors

  • Huda salihkhuder

Keywords:

metronidazole, preterm labour, bacterial vaginosis

Abstract

Aim of the study: To evaluatethe effectiveness of oral metronidazole in prevention of preterm labouramong pregnant women with bacterial vaginosis. Settings and study design: An experimental (longitudinalprospective) study done in Tikrit city between April 2011 and April 2012. Methods: A total number of 50 pregnant women in their midtrimester were included in the study, they received oral metronidazole 200 mg orally in two divided doses for 7 days,selection criteria include pregnant women with singleton viable pregnancy in midtrimester with intact membranes. Demographic profile and prolongation of pregnancy and neonatal outcome were recorded is special forms. Results: Oral metronidazole was not effective in prolongation of pregnancy despite its efficacy in eradicating bacterial vaginosis. Conclusion: Our findings suggest that second trimester screening and treatment of bacterial vaginosis during pregnancy with oral metronidazole is not effective regarding prolongation of pregnancy and preventing adverse neonatal outcome.

How to Cite

The Effect of Oral Metronidazole in the Prevention of Preterm Labour among Pregnant women With Bacterial Vaginosis. (2013). Global Journal of Medical Research, 13(10), 31-35. https://medicalresearchjournal.org/index.php/GJMR/article/view/

References

HauthJ Klebanoff M, Heine R (2004) Asymptomatic bacterial vaginosis in pregnancy with and without treatment. 190, 363-370.

BodnerB LeitichH, HussleinP (2003) Bacterial vaginosis as a risk factor for preterm delivery: A meta-analysis. 189(1), 139-147.

Paternoster D, MagginoT, AmbrosiniA (2004) Efficasy of an acidic vaginal gel on vaginal PH and interleukin-6 levels in low risk pregnant women. 15(3), 198-201.

J. Rosnes, Nichd Network (2002) Does vaginal PH or gram stain score alter the likelihood of successful metronidazole treatment of bacterial vaginosis during pregnancy. (6 Pt2), S228.

A. Shennan, CrawshawS, JonesG (2006) A randomized controlled trial of metronidazole for the prevention of preterm labour in women positive for cervicovaginal fetal fibronectin. 113(1), 65-74.

Steyn PS, Odendaal HJ, Grove D (2003) A randomised, double-blind placebo-controlled trial of ascorbic acid supplementation for the prevention of preterm labour. 23(2), 150-50.

Yudin MH, Landers DV, Meyn L (2003) Clinical and cervical cytokine response to treatment with oral or vaginal metronidazole for bacterial vaginosis during pregnancy. 102(3), 527-34.

HamadehSM DarwishA, MakaremMH (2007) Treatment options for bacterial vaginosis in patients at high risk of preterm labor and premature rupture of membranes. 33(6), 781-787.

G. Giuffrida, A. Mangiacasale (2006) Bacterial vaginosis in pregnancy.J of Obstet and Gynecol 2006. 28(12), 539-543.

Kurtzman J, Chandiramane M, Briley A Quantitative fetal fibronectin screening at 24 weeks substantially discriminates the risk of recurrent preterm delivery in asymptomatic patients with prior preterm labour. 199(6 Suppl 1), S10.

Fhraeus Larsson PG, ForsumU Late miscarriage and preterm labour after treatment with metronidazole. 113(6), 629-637.

Amsel R, Totten PA, Spiegel CA (1983) Non specificvaginitis Diagnostic criteria and microbial and epidemiological associations. 74, 14-22.

R. Nugent, M. Krohn, S. Hillier (1991) Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. 29, 297-301.

Rang P, Dale M (2007) Drugs used in treatment of infections and cancer. 2007, 700.

H. McDonald, P. Jolley, Pharm (1996) McDonald HM, Jolley PT, Pharm et al. Metronidazole treatment of bacterial vaginosis in pregnancy, and preterm birth. 4, 49.

J. Carey, KlebanoffM, HauthJ, R. Heine (2004) Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. 190, 363-370.

Ugwumadu A, Reid F, Hay P (2006) Oral metronidazole and histologic chorioamnionitis in women with abnormal vaginal flora. 107(4), 863-8.

R. Lamont, N. Fisk (1993) The role of infection in the pathogenesis of preterm labour. 10, 135-58.

The Effect of Oral Metronidazole in the Prevention of Preterm Labour among Pregnant Women with Bacterial Vaginosis

Published

2013-04-18

How to Cite

The Effect of Oral Metronidazole in the Prevention of Preterm Labour among Pregnant women With Bacterial Vaginosis. (2013). Global Journal of Medical Research, 13(10), 31-35. https://medicalresearchjournal.org/index.php/GJMR/article/view/