Increased TNF Serum Levels are Related to Highly Aggressive Behavior in Male Swiss Webster Mice
Keywords:
aggressive behavior, laboratory mice, cytokine levels
Abstract
Since the 1960 s, mouse behavior has been systematically studied in the laboratory environment; however, there is still no consensus regarding the causes of aggression in laboratory animals. The involvement of the immune response in aggressive animal behavior has not been well elucidated. Different studies have found that the levels of interferon alpha (IFN-α), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α) are elevated in depressogenic/anxiogenic models. The aim of this study is to assess the correlations of serum cytokine (TNF, IL-6 and IL-10) levels with patterns of aggressive behavior (PBA). Our results suggest that mice exhibiting anxiety-like and highly aggressive behaviors have increased TNF serum levels and slightly decreased IL-10 levels. Additionally, a direct correlation was observed between high PBA scores and increased levels of TNF. In conclusion, TNF is an important cytokine related to highly aggressive behavior in male Swiss Webster mice.
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References
David Benton, John Dalrymple-Alford, Paul Brain (1980) Comparisons of measures of dominance in the laboratory mouse. 28(4), 1274-1279. https://doi.org/10.1016/s0003-3472(80)80115-1
M. Birger, M. Swartz, D. Cohen, Y. Alesh, C. Grishpan, M. Kotelr (2003) Aggression: the testosterone-serotonin link Isr Med Assoc J. 5, 653-658.
Blanchard RJ, Hori K, Blanchard DC (1988) Social dominance and individual aggressiveness Aggress Behav. 14(3), 195-203. https://doi.org/10.1002/1098-2337(1988)14:3
Paula Bray, Richard Cotton (2003) Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms Hum Mutat. 21(6), 557-568. https://doi.org/10.1002/humu.10213
Edward Brodkin, Sarah Goforth, Angela Keene, John Fossella, Lee Silver (2002) Identification of quantitative trait Loci that affect aggressive behavior in mice J Neurosci. 22(3), 1165-1170. https://doi.org/10.1523/jneurosci.22-03-01165.2002
Emil Coccaro, Richard Kavoussi, Robert Trestman, Steven Gabriel, Thomas Cooper, Larry Siever (1997) Serotonin function in human subjects: intercorrelations among central 5- HT indices and aggressiveness Psychiatry Res. 73(1-2), 1-14. https://doi.org/10.1016/s0165-1781(97)00108-x
John Cryan, Andrew Holmes (2005) The ascent of mouse: advances in modelling human depression and anxiety Nat Rev Drug Discov. 4(9), 775-790. https://doi.org/10.1038/nrd1825
Dantzer R, Bluthe RM, Laye S, Bret-Dibat JL, Parnet P, Kelley KW (1998) Cytokines and sickness behavior. 840, 586-590.
Robert Dantzer (2001) Cytokine-induced sickness behavior: mechanisms and implications Ann N.Y Acad Sci. 933(1), 222-234. https://doi.org/10.1111/j.1749-6632.2001.tb05827.x
Lee Drickamer (2001) Urine marking and social dominance in male house mice (Mus musculus domesticus) Behav Processes. 53(1-2), 113-120. https://doi.org/10.1016/s0376-6357(00)00152-2
David Edwards, Farzad Nahai, Paige Wright (1993) Pathways linking the olfactory bulbs with the medial preoptic anterior hypothalamus are important for intermale aggression in mice Physiol Behav. 53(3), 611-615. https://doi.org/10.1016/0031-9384(93)90162-9
Amanda Ensminger, Philip Crowley (2007) Strangers and brothers: a paternity game between house mice Animal Behav. 74(1), 23-32. https://doi.org/10.1016/j.anbehav.2006.11.009
Gleason ED, Fuxjager MJ, Oyegbile TO, Marler CA (2009) Testosterone release and social context: when it occurs and why. 30, 460-469.
Kareen AM, Barnard CJ (1986) Kin recognition in mice: age, sex and parental effects Anita Behav. 34(6), 1814-1824. https://doi.org/10.1016/s0003-3472(86)80267-6
Kelley KW, Bluthe RM, Dantzer R, Zhou JH, Shen WH, Johnson RW (2003) Cytokine-induced sickness behavior. 17, S112-S118.
Jan Konsman, Patricia Parnet, Robert Dantzer (2002) Cytokine-induced sickness behaviour: mechanisms and implications. 25(3), 154-159. https://doi.org/10.1016/s0166-2236(00)02088-9
Krishnadas R, Cavanagh J (2012) Depression: an inflammatory illness?. 83, 495-502.
Nathalie Laflamme, Serge Rivest (2001) Toll-like receptor 4: The missing link of the cerebral innate immune response triggered by circulating gramnegative bacterial cell wall components FASEB J. 15(1), 155-163. https://doi.org/10.1096/fj.00-0339com
Liebenauer LL, Slotnick BM (1996) Social organization and aggression in a group of olfactory bulbectomized male mice. 60, 403-9.
McKinney WT (1989) Basis of development of animal models in psychiatry: an overview. 3-17.
G. Oliveira (2012) Comportamento Social de Camundongos em Biotérios de Experimentação In Mattraia VM & Oliveira GM (orgs) Comportamento de Camundongos em Biotério São Paulo 1ª ed. 2012, 137-167.
Ankur Patel, Allan Siegel, Steven Zalcman (2010) Lack of aggression and anxiolytic-like behavior in TNF receptor (TNF-R1 and TNF-R2) deficientmice. 24(8), 1276-1280. https://doi.org/10.1016/j.bbi.2010.05.005
Pellis SM, Pellis VC (1988) Identification of the possible origin of the body target that differentiates play fighting from serious fighting in Syrian Golden hamsters (Mesocricetus auratus). 14, 437-450.
Aric Prather, Mordechai Rabinovitz, Bruce Pollock, Francis Lotrich (2009) Cytokineinduced depression during IFN-alpha treatment: the role of IL-6 and sleep quality. 23(8), 1109-1116. https://doi.org/10.1016/j.bbi.2009.07.001
Raison CL, Borisov AS, Woolwine BJ (2010) Interferon-α effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. 15(5), 535-547. https://doi.org/10.1038/mp.2008.58
Charles Raison, Andrew Miller (2011) Is depression an inflammatory disorder? Curr Psychiatry Rep. 13(6), 467-475. https://doi.org/10.1007/s11920-011-0232-0
Serge Rivest (2003) Molecular insights on the cerebral innate immune system. 17(1), 13-19. https://doi.org/10.1016/s0889-1591(02)00055-7
M. Steimer (2011) Animal models of anxiety disorders in rats and mice: some conceptual issues Dialogues Clin Neurosci. 13(4), 495-506.
Lucien Steru, Raymond Chermat, Bernard Thierry, Pierre Simon (1985) The tail suspension test: a new method for screening antidepressants in mice Psychopharmacology (Berl). 85(3), 367-370. https://doi.org/10.1007/bf00428203
Edward Suarez, James Lewis, Cynthia Kuhn (2002) The relation of aggression, hostility, and anger to lipopolysaccharide-stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men. 16(6), 675-684. https://doi.org/10.1016/s0889-1591(02)00019-3
Weidt A, Sarah E, Hofmann G, Konig B (2008) Not only mate choice matters: fitness consequences of social partner choice in female house mice Animal Behav. 75(3), 801-808. https://doi.org/10.1016/j.anbehav.2007.06.017
Robert Yerkes (1913) The heredity of savageness and wildness in rats J.Anim Behav. 3(4), 286-296. https://doi.org/10.1037/h0073865
Raz Yirmiya (1996) Endotoxin produces a depressive-like episode in rats Brain Res. 711(1-2), 163-174. https://doi.org/10.1016/0006-8993(95)01415-2
Steven Zalcman, Allan Siegel (2006) Neurobiology of aggression and rage: Role of cytokines. 20(6), 507-514. https://doi.org/10.1016/j.bbi.2006.05.002
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2013-08-01
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