Effect of Trichopus Zeylanicus Leaf Extract on Acute Stress Induced Anxiety in Mice

D. Yashwanth Kumar

Authors

D. Yashwanth Kumar

Keywords:

acute restraint stress, anxiety and trichopus zeylanicus

Abstract

Trichopus zeylanicus Gaertn. (Dioscoreaceae) [TZ] leaf is traditionally used as a general health tonic in tribal regions of south India. In the present study the effect of alcoholic extract of TZ leaves was evaluated on acute stress induced anxiety in mice at oral doses of 100 mg/kg, 250 mg/kg and 500 mg/kg. Acute stress was induced by restraint stress method and the stressed rodents were evaluated in light and dark model and elevated plus maze. The extract at the doses of 250 mg/kg and 500 mg/kg showed a significant increase in the number of crossings and reduced time spent in the dark chamber in light and dark model. Further, it significantly reduced the time spent in the closed arm in elevated plus maze as compared to stressed mice. Moreover, TZ significantly reduced stress induced increased plasma corticosterone levels and hyperglycemia in rats.

Downloads

How to Cite

Effect of Trichopus Zeylanicus Leaf Extract on Acute Stress Induced Anxiety in Mice. (2013). Global Journal of Medical Research, 13(20), 1-4. https://medicalresearchjournal.org/index.php/GJMR/article/view/

Download Citation

References

G. Dawson, M. Tricklebank (1995) Use of the elevated plus maze in the search for novel anxiolytic agents Trends Pharmacol. 16, 33-36.

D. Evans, A. Subramoniam, S. Rajasekharan, P. Pushpangadan (2002) Effect of Trichopus zeylanicus leaf extract on the energy metabolism in mice during exercise and at rest. 34, 32-37.

Glick D., Recllich DV. (1964) Fluorimetric determination of cortisol. 74, 653.

Madhu Kalia (2005) Neurobiological basis of depression: an update. 54(5), 24-27. https://doi.org/10.1016/j.metabol.2005.01.009

S. Kulkarni (1999) New Drug Discovery Process. 135-137.

Anbrin Masood, Basudeb Banerjee, V. Vijayan, Arunabha Ray (2003) Modulation of stress-induced neurobehavioral changes by nitric oxide in rats. 458(1-2), 135-139. https://doi.org/10.1016/s0014-2999(02)02688-2

S. Moraa, R. Millan, H. Lungenstrass, G. D´ıaz-V´eliz, J. Mor´an, M. Herrera-Ruiz, J. Tortoriello (2006) The hydroalcoholic extract of Salvia elegans induces anxiolytic and antidepressant-like effects in rats. 106(1), 76-81. https://doi.org/10.1016/j.jep.2005.12.004

D. Philip, F. Joan, R. Peter (1994) Clinical Chemistry in Diagnosis and Treatment. 195.

Naila Rasheed, Ethika Tyagi, Ausaf Ahmad, Kiran Siripurapu, Shawon Lahiri, Rakesh Shukla, Gautam Palit (2008) Rasheed, N., Tyagi, E., Ahmad, A., Siripurapu, K.B., Lahiri, S., Shukla, R., Palit, G. 2008. Involvement of monoamines and proinflammatory cytokines in mediating the anti-stress effects of Panax quinquefolium. 117(2), 257-262. https://doi.org/10.1016/j.jep.2008.01.035

P. Riebling, G. Walker (1975) Extraction and extractives. 1509-1522.

A. Sharma, P. Pushpangadan, C. Chopra (1989) Adaptogenic activity of seeds of Trichopus zeylanicus gaertn, the ginseng of kerala. 8(3&4), 212-219.

A. Subramoniam, V. Madhavachandran, S. Rajasekharan, P. Pushpangadan (1997) Aphrodisiac property of Trichopus zeylanicus extract in male mice. 57, 21-7.