Preliminary Investigation on Anti Typhoid Properties of Acacia Nilotica Leaf Extract

Sarkiyayi S.

Authors

Sarkiyayi S.

Keywords:

typhoid fever, anti typhoid, acacia nilotica, salmonella typhi and ld

Abstract

Anti typhoid properties of methanol leaves extract of Acacia nilotica was investigated. The phytochemical screenings for detection of the presence of bioactive constituents were carried out. Among other parameters investigated include LD50 of the leaves extract, inoculation of mice with Salmonella typhi parasites treating them with leave extract of Acacia nilotica followed by widal tests. The phytochemical screening of the methanol leave extract of Acacia nilotica revealed the presence of alkaloid, anthraquinone, carbohydrates, cardiac glycosides, flavonoid, saponin, tannins and terpens. The leaves extract of Acacia nilotica has possess some acute toxicity effect on animals (mice) at a dose of (LD50) 288.5mg/kg. The plant extract produced inhibitory activities against Salmonella typhi. It is interesting to note the widal test titer valve was found to be 140 for the treated group while the untreated group had titer value of 1160, suggesting that the plant leaves extract was effective as anti typhoid agent against salmonella typhi on mice infected with typhoid parasites. The extract demonstrated high activity against Salmonella typhi, bacterial typhoid causing agent.

Downloads

How to Cite

Preliminary Investigation on Anti Typhoid Properties of Acacia Nilotica Leaf Extract. (2013). Global Journal of Medical Research, 13(8), 11-15. https://medicalresearchjournal.org/index.php/GJMR/article/view/

Download Citation

Author Biography

Sarkiyayi S.

Sarkiyayi S. is a researcher affiliated with Modibbo Adama University of Technology in Yola, Adamawa State, Nigeria. With a focus on microbiology and toxicology, he has contributed to studies on the anti-typhoid properties of Acacia nilotica leaf extract, heavy metal contamination in vegetables, and toxicological assessments of Ceiba pentandra. He has published 15 works, accumulating 155 citations, with an h-index of 6 and an i10-index of 3, reflecting his growing impact in the field.

References

D. Akinpelu, D. Kolawole (2004) Phytochemcials and antimicrobial activity of leaf extract of Piiositigma thoriningi (Schum). 7, 64-70.

F. Aussie (2006) the properties of Acacia spices and their uses Journal of clinical microbiology. 152-185.

N. Azu, R. Onyeagba (2007) Antimicrobial properties of extracts of Allium cepa (onions) and Zingiber officinale (ginger) on Escherichia coli, and Bacillus subtilis. 3(2), 277-286. https://doi.org/10.5580/1f5e

T. Ayogu, E. Amadi (2009) Studies On The Antibacterial Activities Of Medicinal Plants On Typhoid Fever Organism. 7(2). https://doi.org/10.5580/ee0

Cooke FJ, Wain J, Threlfall EJ (2006) "Flouoroquinolone resistance in salmonella typhi. 353-354.

B. Ivanoff, M. Levinc (1997) Typhoid fever: continuing challenges from a resilient bacterial foe. 95(3), 129-142. https://doi.org/10.1016/s0020-2452(97)81367-x

S. Leume (1999) Multidrug resistant salmonella enteric serotype typhimurium associated with pest and Rodent. 356(1), 21-28.

Dietrich Lorke (1983) A new approach to practical acute toxicity testing. 54(4), 275-287. https://doi.org/10.1007/bf01234480

A. Sofowara (2003) Phytochemical Screening of Nigerian Medicinal Plants Part 11. 44, 234-246.

S. Sarkiyayi, J. Karago, R. Hassan (2011) Studies on Anti Typhoid Properties of Aqueous Methanol Leaves Extract of Albizia ferruginea (Musase) International Journal of Biochemistry Research & Review. 1(1), 24-30. https://doi.org/10.9734/ijbcrr/2011/167

G. Trease, W. Evans (1983) Textbook of Pharmacognosy. 1-100.

K. Vivek, S. Nandini, S. Anitha (2010) Anti Typhoid activity of aqueous extract of fruit peel Citrus sinensis. (2), 49-59.