Comparative Analysis of Adverse drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients
Keywords:
tuberculosis, adverse drug reactions, dots
Abstract
This study describes the occurrences of adverse drug reactions (ADRs) caused by anti tubercular (TB) drugs employed in Directly Observed Treatment Short Course (DOTS) from ten years of ADR data (from 2002 to 2012) reported in various articles. The frequency of each type of ADR was analyzed and compared. A total of 10,219 patients were studied. Among them, 8,047 (78.75%) patients demonstrated positive responses to at least one type of ADR. Dermatological reactions predominated among the ADRs which occurred in 4389 (42.95%) patients followed by hepatotoxicity in 1634 (15.99%) cases. Female patients were more prone to ADRs as compared to the male patients. The occurrence of ADRs is mainly attributed to the combination therapy along with the prolonged medication period. A colossal amount of ADRs were observed during the study which must be monitored and managed properly throughout the DOTS therapy in order to prevent life-threatening harmful effects.
Downloads
- Article PDF
- TEI XML Kaleidoscope (download in zip)* (Beta by AI)
- Lens* NISO JATS XML (Beta by AI)
- HTML Kaleidoscope* (Beta by AI)
- DBK XML Kaleidoscope (download in zip)* (Beta by AI)
- LaTeX pdf Kaleidoscope* (Beta by AI)
- EPUB Kaleidoscope* (Beta by AI)
- MD Kaleidoscope* (Beta by AI)
- FO Kaleidoscope* (Beta by AI)
- BIB Kaleidoscope* (Beta by AI)
- LaTeX Kaleidoscope* (Beta by AI)
How to Cite
References
K. Chhetri, A. Saha, S. Verma, S. Palaian, P. Mishra, P. Shankar (2008) A study of adverse drug reactions caused by first line anti-tubercular drugs used in Directly Observed Treatment, Short course (DOTS) therapy in western Nepal, Pokhara.
L. Begum, A. Nahar, M. Mosharrof Hossain, D. Islam, Saha (2006) A comparative study on the adverse effects of two antituberculosis drugs regimen in initial two-month treatment period.
L. Tak, K. Acharya, G. Gowarinath, P. Rao Padma, Subish Safety Evaluation Of Antitubercular Therapy Under Revised National Tuberculosis Control Programme In India. 1395-1401.
F. Kurniawati, S. Sulaiman, S. Gillani Adverse Drug Reactions of Primary Antituberculosis Drugs Among Tuberculosis Patients Treated in Chest Clinic. 1331-1338.
J. Jeong, B. Jung, M. Kim, J. Lim, D. Ha, S. Cho (2009) The Influence of Adverse Drug Reactions on First-line Anti-tuberculosis Chemotherapy in the Elderly Patients. 67(4), 325. https://doi.org/10.4046/trd.2009.67.4.325
J. Furin, C. Mitnick, S. Shin, J. Bayona, M. Becerra, J. Singler (2001) et al. Occurrence of serious adverse effects in patients receiving community-based therapy for multidrug-resistant tuberculosis. 5(7), 648-655.
E. K Gholami, G. Hajiabdolbagh Mi (2006) Evaluation of anti-tuberculosis induced adverse reactions in hospitalized patients. 4(3), 134-138.
K. Tripathi (2008) Essentials of Medical Pharmacology by Jaypee Brothers Medical Publishers, India, 6th edition 2008.
NTP http://www.ban.searo.who.int/en/Section15/Section16_25.htm
P. Kishore, S. Palaian, P. Ojha, P. Shankar (2008) Pattern of Adverse drug Reactions Experienced by Tuberculosis Patients in A tertiary Care Teaching Hospital in Nepal. 21.
D. Pillai, Behera (2008) Influence of Honey on Adverse Reactions Due to Anti-Tubercular Drugs in Pulmonary Tuberculosis Patients. 2.
(2007) Rang & Dale: A textbook of pharmacology by Elsevier, 6th edition, 2007.
(2012) Global Tuberculosis Control 2012. http://www.who.int/tb/publications/global_report/
Published
2013-09-12
Issue
Section
License
Copyright (c) 2013 Authors and Global Journals Private Limited
This work is licensed under a Creative Commons Attribution 4.0 International License.