Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form

B. Mohammed Ishaq; Hindustan Abdul Ahad; Shaik Muneer; S. Praveena

Authors

B. Mohammed Ishaq
Hindustan Abdul Ahad
Shaik Muneer
S. Praveena

Keywords:

atomoxetine hydrochloride, spectrophotometric, ringbom#x2019;s plot, pharmaceutical formulations

Abstract

Simple, rapid and sensitive spectrophotometric procedure was developed for the analysis of atomoxetine hydrochloride (ATH) in pure form as well as in pharmaceutical formulations. The method was based on the reaction of ATH with gold (III) chloride in the pH range 3.5-4.5 forming violet colored complex solution, showing absorption maxima at 550 nm. The linear plot indicates that Beer's law is obeyed in the range of 5 - 80 μg/ml of atomoxetine hydrochloride. The molar absorptivity and Sandell's sensitivity are 3.77 x 103M and 0.0774 µg cm-2 respectively. The standard deviation of the method for ten determinations ATH is 9.9827 x 103. The correlation coefficient (r2) of the experimental data of the calibration plot is 0.9997. The effective range of concentration for accurate determination of ATH as ascertained from Ringbom's plot and it is 10 - 80 μg/ml.

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How to Cite

Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and Tablet Dosage Form. (2013). Global Journal of Medical Research, 13(30), 69-72. https://medicalresearchjournal.org/index.php/GJMR/article/view/

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Author Biography

B. Mohammed Ishaq

B. Mohammed Ishaq is a dedicated pharmaceutical researcher based in India, affiliated with Balaji College of Pharmacy and Jawaharlal Nehru Technological University Anantapur. His work spans analytical chemistry and bioanalytical method development, with notable contributions including a colourimetric assay for atomoxetine hydrochloride and a sensitive LC-MS/MS method for escitalopram in human plasma. With 26 publications, 72 citations, an h-index of 4, and an i10-index of 1, his research has made a measurable impact in the field of pharmaceutical analysis. His academic profile is further recognized through his OpenAlex identifier (A5110283883), reflecting his ongoing commitment to advancing drug analysis and quality control.

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