Effect of Diallyl Disulphide on Protein and Lipid Glycation, and Lipid Peroxidation in Brain of Alloxan Diabetic Rats

Dr. Vickram; Kashinath R T; Dr. Vijay V

Authors

Dr. Vickram
Kashinath R T
Dr. Vijay V

Keywords:

diallyl disulphide, protein glycation, lipid glycation, diabetic encephalopathy

Abstract

Non enzymatic glycosylation of proteins and lipids is the main initiating factor for the pathophysiology of chronic diabetic complications. This glycation is more prevalent in insulin independent tissues like brain, kidney, RBCs, etc. Diallyl disulphide (DADS), the principle compound of garlic oil, is well known for its antihyperglycemic, antihyperlipidemic, anticarcinogenic and antibiotic properties. Hence a study was undertaken to assess the anti-glycation properties of DADS, in alloxan diabetic brain tissue, thereby to establish any usefulness of DADS in prevention of central nervous system complications in diabetes mellitus like diabetic dementia or diabetic encephalopathy. The current study showed a significant decrease (p

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Effect of Diallyl Disulphide on Protein and Lipid Glycation, and Lipid Peroxidation in Brain of Alloxan Diabetic Rats. (2013). Global Journal of Medical Research, 13(30), 7-11. https://medicalresearchjournal.org/index.php/GJMR/article/view/

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Author Biographies

Dr. Vickram

Dr. R. T. Kashinath is a Professor in the Department of Biochemistry at Subbaiah Institute of Medical Sciences in Shimoga, Karnataka, India. He holds an M.Sc. and Ph.D. in Biochemistry (Medical Faculty) and is a Fellow of the Indian College of Surgeons (FICS).

Kashinath R T

Dr. Kashinath R.T. is a biochemist with an MSc in Biochemistry, a PhD in Biochemistry (Medical Faculty), and is a Fellow of the International College of Surgeons (FICS). His research focuses on diabetes, cardiovascular risks, and lipoproteins. He has served as Professor and Head of the Department of Biochemistry at Subbaiah Institute of Medical Sciences & Research Center, and as Director of R&D at SUIMS. He has published 14 papers and has an h-index of 3.

Dr. Vijay V

Dr. Vijay V is an Associate Professor in the Department of Biochemistry at Vijayanagara Institute of Medical Sciences, Bellary, India. He holds an MSc in Biochemistry, a Ph.D. in Biochemistry (Medical Faculty), and a Fellowship (FICS). His research focuses on diabetes mellitus, particularly alterations in membrane phospholipid/cholesterol ratio, glycated proteins, and lipid profiles in diabetic subjects. He has published extensively on the effects of organosulfur compounds like diallyl disulphide in experimental diabetes and hepatoma models. As a reviewer for the Global Journal of Medical Research since 2012, he contributes to the advancement of medical biochemistry. With 74 publications and over 470 citations, his h-index stands at 10 and i10-index at 12, reflecting his impact in the field of endocrinology and metabolism.

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