Tranexamic Acid for Postpartum Haemorrhage: A Review

Authors

  • Suzanne Davis

Keywords:

tranexamic acid, pregnancy, cesarean section, postpartum haemorrhage, bleeding, maternal mortality

Abstract

Post partum haemorrhage is the main cause of maternal mortality worldwide. Tranexamic acid is a cheap, easy to use and relatively safe medication that is gaining popularity as a management option for obstetric haemorrhage. It is already widely used to limit bleeding in trauma and many major surgeries. This review examines the evidence surrounding its use to control bleeding at the time of delivery.

How to Cite

Tranexamic Acid for Postpartum Haemorrhage: A Review. (2014). Global Journal of Medical Research, 14(5), 27-29. https://medicalresearchjournal.org/index.php/GJMR/article/view/

References

Foreman Hogan MC, Ahn Naghavi M, Makela Wang M, Lozano Lopez AD (2010) Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millenium Development Goal 5. 375, 1609-1623.

World Health Organization, U.N.C.F, United Nations Population Fund, World Bank (2007) Maternal Mortality in 2005. Estimates developed by WHO, UNICEF, UNFPA, and The World Bank.

Natalia Novikova, G. Hofmeyr (2011) Novikova N, Hofmeyr GJ: Tranexamic acid for preventing postpartum haemorrhage. 7, 7872. https://doi.org/10.1002/14651858.cd007872.pub2

Dunn CJ, Goa KL (1999) Tranexamic acid: a review of its use in surgery and other indications.Drugs. 57(6), 1005-1032.

Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L (2013) The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. (10).

Wellington K, Wagstaff AJ (2003) Tranexamic acid: a review of its use in the management of menorrhagia Drugs. 63(13), 1417-1433.

Department of Reproductive Health and Research, World Health Organization Geneva: WHO Library Cataloguing- in-Publication Data NLM classification: WQ.

H. Abdel-Aleem, T. Alhusaini, M. Abdel-Aleem, M. Menoufy, A. Gülmezoglu (2013) Effectiveness of tranexamic acid on blood loss in patients undergoing elective cesarean section: randomized clinical trial. 26(17), 1705-1709.

Upasana Goswami, Sushmita Sarangi, Sunali Gupta, Savita Babbar (2013) Comparative evaluation of two doses of tranexamic acid used prophylactically in anemic parturients for lower segment cesarean section: A double-blind randomized case control prospective trial. 7(4), 427. https://doi.org/10.4103/1658-354x.121077

M. Gohel, P. Patel, G. Ashoo, P. Desai (2007) Efficacy of Tranexamic Acid in Decreasing Blood Loss during and after Cesarean Section: A Randomized Case Controlled Prospective Study. 57, 227-230.

Ming-Ying Gai, Lian-Fang Wu, Qi-Feng Su, Karin Tatsumoto (2004) Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. 112(2), 154-157. https://doi.org/10.1016/s0301-2115(03)00287-2

Gungorduk K, Yıldırım G, Asıcıoğlu O, Gungorduk OC, Sudolmus S, Ark C (2011) Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: A prospective, randomized, double-blind, placebo-controlled study Am J Perinatol. 28, 233-240.

Movafegh A, Eslamian L, Dorabadi A (2011) Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. 115, 224-6.

Gao XuJ, Ju Y (2013) Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial Arch Gynecol Obstet. 287(3), 463-468.

A. Shahid, A. Khan (2013) Tranexamic acid in decreasing blood loss during and after caesarean section. 23(7), 459-462.

Sentürk MB, Cakmak Y, Yildiz G, Yildiz P (2013) Tranexamic acid for cesarean section: a doubleblind, placebo-controlled, randomized clinical trial.Arch Gynecol Obstet. 287(4), 641-645.

(2011) High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. R117.

(2012) Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators.Antifibrinolytic drugs for acute traumatic injury. 4896.

(2010) The WOMAN trial (World Maternal Antifibrinolytic Trial): Tranexamic acid for the treatment of post partum haemorrhage: An international randomized, double blind placebo controlled trial. 11(1), 40. https://doi.org/10.1186/1745-6215-11-40

Tranexamic Acid for Postpartum Haemorrhage: A Review

Published

2014-02-07

How to Cite

Tranexamic Acid for Postpartum Haemorrhage: A Review. (2014). Global Journal of Medical Research, 14(5), 27-29. https://medicalresearchjournal.org/index.php/GJMR/article/view/