Simple UV Spectrophotometric Assay of Atorvastatin API Formulation and their Comparative Study
Keywords:
atorvastatin, assay, uv pectrophotometry
Abstract
A rapid, simple, accurate, and economical least time consuming rosuvastatin spectrophotometric method has been developed for the assay of atorvastatin and then compare assay of brand available in Karachi,Pakistan. The assay is based on the ultraviolet UV absorbance maxima at about 244nm wavelength of atorvastatin using methanol as solvent. A sample of drug was dissolved in methanol to produce a solution containing atorvastatin. Similarly, a sample of ground tablets of different brand were extracted with methanol and diluted with the same methanol. The absorbance of sample preparation was measured at 244 nm against the solvent blank and the assay was determined by comparing with the absorbance of available brand. The method can be applied for the routine QC quantitation of atorvastatin in tablet formulation and active.
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References
Jonathan Tobert (2003) Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. 2(7), 517-526.
P Jones, M Davidson, E Stein, H Bays, J Mckenney, E Miller (2003) Unknown Title. 92, 152-160.
M Caslake, G Stewart, S Day, E Daly (2003) Unknown Title. 171, 245-253.
J Mckenney, Am (2005) Unknown Title. 62, 1033-1047.
Kwang Koh, Michael Quon, Seung Han, Wook-Jin Chung, Jeong Ahn, Yiel-Hea Seo, Moon Kang, Tae Ahn, In Choi, Eak Shin (2004) Additive Beneficial Effects of Losartan Combined With Simvastatin in the Treatment of Hypercholesterolemic, Hypertensive Patients. 110(24), 3687-3692.
Najma Sultana, M Arayne, Safila Naveed (2010) Simultaneous Determination of Captopril and Statins in API, Pharmaceutical Formulations and in Human Serum by RP‐HPLC. 57(3A), 378-383.
Najma Sultana, M Arayne, Shabana Shah, Nighat Shafi, Safila Naveed (2010) Simultaneous Determination of Prazosin, Atorvastatin, Rosuvastatin and Simvastatin in API, Dosage Formulations and Human Serum by RP‐HPLC. 57(6), 1286-1292.
N Sultana, M Arayne, Safila Naveed (2011) Validated Method for the Simultaneous Determination of Lisinopril, Pravastatin, Atorvastatin and Rosuvastatin in API, Formulations and Human Serum by RP-HPLC. 29, 1216-1220.
Najma Sultana, M Arayne, Safila Naveed (2011) SIMULTANEOUS DETERMINATION OF ENALAPRIL AND STATIN'S IN PHARMACEUTICAL FORMULATIONS BY RP-HPLC. 56(3), 734-737.
M Arayne, N Sultana, Arman, Tabassum Saeeda, Nadir Ali, Safila Naveed (2012) Simultaneous LC Determination of Rosuvastatin, Lisinopril, Captopril, and Enalapril in API, Pharmaceutical Dosage Formulations, and Human Serum Medicinal.
Published
2014-06-03
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