Merkel Cell Carcinoma : An Indian Experience

Dr. Biswanath Paul; Dr. Bhaskar Mitra; Dr. Mallika Pal; Dr. Tarak Nath Saha; Dr. Ashok Maiti

Authors

Dr. Biswanath Paul
Dr. Bhaskar Mitra
Dr. Mallika Pal
Dr. Tarak Nath Saha
Dr. Ashok Maiti

Keywords:

merkel cell carcinoma, neuroendocrine tumour, skin tumour

Abstract

Merkel cell carcinoma [MCC] is a rare neoplasm of skin with an aggressive behaviour and unfavourable prognosis. MCC mainly occurs in the elderly, in the sun exposed areas of skin. Indian's experiences regarding patients' profiles, clinical presentation, age of occurrence, pattern of tumour are very limited as well as challenging. This retrospective study was performed, in a tertiary care hospital in Paschim Medinipur, West Bengal, India, reviewing the cases of five patients. In our cases we try to elaborate data regarding the age of occurrences, presentation, and behaviour of tumour and prognosis of MCC. The patients' profiles, clinical presentation, age of occurrence & the tumour characteristics including histopathological and immunohistochemical profiles are similar to the cases presented in other parts of world.

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How to Cite

Merkel Cell Carcinoma : An Indian Experience. (2014). Global Journal of Medical Research, 14(21), 9-13. https://medicalresearchjournal.org/index.php/GJMR/article/view/

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References

Cyril Toker (1972) Trabecular Carcinoma of the Skin. 105(1), 107. https://doi.org/10.1001/archderm.1972.01620040075020

P. Ziprin, S. Smith, G. Salerno, R. Rosin (2000) Two cases of Merkel cell tumour arising in patients with chronic lymphocytic leukaemia. 142(3), 525-528. https://doi.org/10.1046/j.1365-2133.2000.03370.x

Pan, D. D. Naryan, S. Ariyan (2002) Merkel Cell Carcinoma: Five Case Reports Using Sentinel Lymph Node Biopsy and a Review of 110 New Cases. 110(5), 1259-1265. https://doi.org/10.1097/01.prs.0000025287.96915.88

R. Miller, C. Rabkin (1999) Merkel cell carcinoma and melanoma: etiological similarities and differences. 8(2), 153-158.

P. Savage, D. Constenla, C. Fisher, J. Thomas, M. Gore (1997) The natural history and management of Merkel cell carcinoma of the skin: A review of 22 patients treated at the Royal Marsden Hospital. 9(3), 164-167.

I. Penn, M. First (1999) Merkel's cell carcinoma in organ recipients: report of 41 cases. 68(11), 1717-1721.

J. Rosai (2004) Rosai J: Rosai and Ackerman's Surgical Pathology. 1.

Brenner, B. Sulken, A. Rakowsky, M. E. Feinmesser (2001) Second neoplasm in patients with merkel cell carcinoma. 91(7), 1358-1362.

Heath M, Jaimes N, Lemos B, Mostaghim A et al Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. 58(3), 375-381.

M. Van Gele, M. Kaghad, J. Leonard (2000) Mutation analysis of P73 and TP53 in Merkel cell carcinoma Br J Cancer. 82, 823-826.

Michael Haag, Frank Glass, Neil Fenske (1995) Merkel cell carcinoma: diagnosis and treatment Dermatol Surg. 21(8), 669-683. https://doi.org/10.1111/j.1524-4725.1995.tb00269.x

William Oʼconnor, David Brodland (1996) Merkel cell carcinoma Dermatol Surg. 22(3), 262-267. https://doi.org/10.1111/j.1524-4725.1996.tb00317.x

E. Silva, B. Mackay, H. Goepfert (1984) Endocrine carcinoma of the skin (Merkel cell carcinoma) Pathol Annu. 19, 1-30.

Smith. PD, Patterson. JW (2001) Merkel Cell Carcinoma (Neuroendocrine Carcinoma of the Skin). 115(Suppl 1), S68-S78.

(1980) Merkel cell neoplasms. 2, 101-119.

Walsh NM (2001) Primary neuroendocrine (Merkel cell) carcinoma of the skin. Morphologic diversity and implications thereof. 32, 680-689.

Hofler H, kerl H, Lackinger E, Helleis G, Denk H (1985) The intermediate filament cytoskeleton of cutaneous neuroendocrine carcinoma ( merkel cell tumour) Immunohistochemical and biochemical analysis. 406(3), 339-350. https://doi.org/10.1007/bf00704303

Byrd-Gloster AL, Khoor A, Glass LF (2000) Differential expression of thyroid transcription factor 1 in small cell lung carcinoma and Merkel cell tumor Hum Pathol. 31(1), 58-62. https://doi.org/10.1016/s0046-8177(00)80199-9

Hanly AJ, Elgart GW, Jorda M (2000) Analysis of thyroid transcription factor-1 and cytokeratin 20 separates Merkel cell carcinoma from small cell carcinoma of lung J Cutan Pathol. 27(3), 118-120. https://doi.org/10.1034/j.1600-0560.2000.027003118.x

D. Larsimont, A. Verhest (1996) Chromosome 6 trisomy as sole anomaly in a primary Merkel cell carcinoma. 428(4-5), 305-309.

Gancberg, D. Feoli, J. F. Hamels (2000) Trisomy 6 in Merkel cell carcinoma: a recurrent chromosomal aberration. 37(5), 445-451.

A. Vortmeyer, M. Merino, R. Boni, L. Liotta, A. Cavazzana, Z. Zhuang (1998) Genetic Changes Associated With Primary Merkel Cell Carcinoma. 109(5), 565-570.

J. Leonard, P. Leonard, J. Kearsley (1993) Chromosomes 1, 11, and 13 are frequently involved in karyotypic abnormalities in metastatic Merkel cell carcinoma. 67(1), 65-70. https://doi.org/10.1016/0165-4608(93)90046-o

B. Amo-Takyi, L. Tietze, K. Tory (1999) Diagnostic relevance of chromosomal in‐situ hybridization in Merkel cell carcinoma: targeted interphase cytogenetic tumour analyses. 34(2), 163-169.

D. Pectasides, M. Pectasides, T. Economopoulos (2006) Merkel cell cancer of the skin. 24, 1489-1495.

Eng TY, Boersma MG, Fuller CD, Cavanaugh SX, Valenzuela F, Herman TS (2004) Treatment of merkel cell carcinoma. 27(5), 510-515.

K. Boyse, E. Foley, V. Bradley, D. Scarborough (2004) Cutis 2004. 74, 350-356.

A. Senchenkov, S. Barnes, S. Moran (2007) Predictors of survival and recurrence in the surgical treatment of merkel cell carcinoma of the extremities. 1(3), 229-234.

Otley Mehrany K, Phillips Weenig RH, Roenigk RK (2002) A meta-analysis of the prognostic significance of sentinel lymph node status in Merkel cell carcinoma. 28(2), 113-117.

Lowe Bichakjian CK, Sandler Lao CD, Johnson Bradford CR (2007) Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management. 110, 1-12.

(2007) Merkel cell carcinomas. 21, 527-544.

Papamichail M, Nikolaidis I, Nikolaidis N, Glava C, Lentzas I, Marmagkiolis K, Karassavsa K, Digalakis M (2008) Merkel cell carcinoma of the upper extremity: Case report and an update. 6, 32.