Abstract

Background: Stroke is the third cause of death and foremost cause of disability worldwide. Cerebrovascular accident or stroke is an emergency condition which require immediate procedure by a neurologist. Determination of extent of brain damage at the onset of the seizure is an appropriate action to determine therapy and prognosis. Increased serum neuron specific enolase can be expected to differentiating stroke types at the onset of the seizure. Aim: The goal of present study was to measure diagnostic value of serum neuron specific enolase in various types of cerebrovascular accident as well as to evaluate the clinical performance of neuron specific enolase in early diagnosis of cerebrovascular accident. Methods: A diagnostic case control study was conducted on 60 patients were admitted within 72 hours of onset of stroke in the department of neurology and department of medicine of PDVVPF#x2019;s Medical College and hospital Ahmednagar and 60 healthy age and sex matched volunteers formed the control group. Serum neuron specific enolase level was estimated by commercially available quantitative enzyme linked immune sorbent assay (ELISA) kit which based on biotin double antibody sandwich technology. Statistical analysis used: The student t test was used to compared patients and control. Receiver operating characteristic curve for neuron specific enolase was established to determined cut-off point. The sensitivity and specificity of neuron specific enolase for detection of cerebrovascular accident were analyzed. Results: serum neuron specific enolase (plt;0.05) concentrations was significantly higher in cerebrovascular accident than healthy controls. Sensitivity, specificity, positive predictive value and negative predictive value of neuron specific enolase for detection of cerebrovascular accident were 87.10%, 95.00%, 92.74% and 87.69%. The area under the receiver operating characteristic curve of neuron specific enolase in cerebrovascular accident was 0.84. Conclusion: Pres