Comparative Study of Lipid Profile, Oxidant, Antioxidant Levels and Thyroid Hormone Status in Normal and Abnormal Pregnancy

Abstract

Aim: The aim of the study is to evaluate thyroid status, Oxidative stress & lipid profile levels in abnormal and normal pregnancies. Material and Methods: The study includes 25 abnormal pregnant women, 25 normally healthy pregnant women. Ages ranged from 20 to 30 years. Thyroid status was estimated by ELISA method. For determination of oxidative stress Malandialdehyde (MDA) is estimated as oxidants by TBARS, Uric acid is estimated by pap method, cholesterol & HDL-C by CHOD-POD method, triglycerides by GPO-POD method. Results: In the present study, we observed that TSH is significantly increased compared to normal pregnancies TSH and FT4 are slightly decreased compared to normal pregnancies. In the present study cholesterol levels were increased in abnormal pregnancies compared to normal pregnancies and decrease in HDL cholesterol were observed in preeclamptic and eclamptic pregnant women. In the present study Hb levels were decreased in abnormal pregnancies compared to normal pregnancies. The levels of MDA and uric acid were significantly increased in abnormal pregnancies. The glucose (RBS) levels were increased compared to normal pregnancies. Conclusions: Altered Thyroid status which leads to hypothyroidism may be due to the loss of protein and protein bound hormones in urine in abnormal pregnancies compared with normals. Increased oxidative stress is due to increase in TSH levels which directly induces the pro-inflammatory cytokines. Study suggests that all abnormal pregnancies studied are associated with hypothyroidism.