Thrombocytopenia as a Clue of Vivax Malaria in Endemic Region, Sudan

Bakri Y. M. Nour

Authors

Bakri Y. M. Nour

Keywords:

vivax malaria; thrombocytopenia; sudan

Abstract

Reduction in circulating platelets is observed relatively frequently in cases of malaria due to P. vivax. 61 patients with confirmed vivax malaria were enrolled in this study and the platelets were counted by hematological analyzer. our study revealed that 77.1% had platelets count less than 150,000/ µl , thrombocytopenia grade 1 represent 43%, grade 2 represent 19.8%, grade 3 represent 9.8% and grade 4 represent 4.9%. Thrombocytopenia should be a consideration as a clue to the presence of malaria in endemic region.

Downloads

How to Cite

Thrombocytopenia as a Clue of Vivax Malaria in Endemic Region, Sudan. (2014). Global Journal of Medical Research, 14(50), 21-23. https://medicalresearchjournal.org/index.php/GJMR/article/view/

Download Citation

References

Guerra CA, Howes RE, Patil AP, Gething PW, Van TP, Temperley WH (2010) The international limits and population at risk of Plasmodium vivax transmission in 2009. 4, e774.

K. Mendis, B. Sina, P. Marchesini, R. Carter (2001) The neglected burden of Plasmodium vivax malaria. 64, 97-106.

Mueller I, Galinski MR, Baird JK, Carlton JM, Kochar DK (2009) Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite. 9(9), 555-566. https://doi.org/10.1016/s1473-3099(09)70177-x

Yohannes AM, Teklehaimanot A, Bergqvist Y, Ringwald P (2011) Confirmed Vivax Resistance to Chloroquine and Effectiveness of Artemether-Lumefantrine for the Treatment of Vivax Malaria in Ethiopia. 84, 137-140.

Safa Abdalla, Elfatih Malik, Kamil Ali (2007) Abdalla SI, Malik EM and Ali KM. The burden of malaria in Sudan: incidence, mortality and disability adjusted life years. 6(1), 97. https://doi.org/10.1186/1475-2875-6-97

Albadawi Abdelbagi, Talha (2014) Plasmodium vivax: Diagnosis, genotypes and antifolate resistance molecular markers.

Federal Ministry of Health (FMOH) (2013) National Malaria Control Program (NMCP) --The National Protocol for Treatment of Malaria - Federal Ministry of Health June 2013 - Khartoum- Sudan. 2.

Kanjaksha Ghosh, Kinjalka Ghosh (2007) Pathogenesis of anemia in malaria: a concise review. 101(6), 1463-1469. https://doi.org/10.1007/s00436-007-0742-1

CTCAE v3.0. http://www.ctep.cancer.gov/reporting/ctc.html

S. Wickramasinghe, S. Abdalla (2000) Blood and bone marrow changes in malaria. 13(2), 277-299. https://doi.org/10.1053/beha.1999.0072

Pal Makkar (2002) Plasmodium Vivax Malaria Presenting With Severe Thrombocytopenia. 6(5), 263-265.

P. Piguet, C. Kan, C. Vesin (2002) Thrombocytopenia in an animal model of malaria is associated with an increased caspase-mediated death of thrombocytes. 7(2), 91-98. https://doi.org/10.1023/a:1014341611412

Bansal Gupta NK, Jain UC (2013) Study of thrombocytopenia in patients of malaria. 3, 58-61. https://doi.org/10.4103/2229-5070.113914

S. Greisenegger, G. Endler, K. Hsieh, S. Tentschert, C. Mannhalter, W. Lalouschek (2004) Is Elevated Mean Platelet Volume Associated With a Worse Outcome in Patients With Acute Ischemic Cerebrovascular Events?. 35, 1688-1691.

Muhammad Akhtar, Sajid Jamil, Syed Amjad, Anjum Butt, Muhammad Farooq (2005) Association of malaria with thrombocytopenia. 11(4), 536-537. https://doi.org/10.21649/akemu.v11i4.1105

Z. Rehman, M. Alam, A. Mahmood, A. Mubarik, A. Sattar, K. Karamat (1999) Thrombocytopenia in acute malarial infection. 10, 9-11.

Daily JP, Waldron MA (2003) Case 22 - 2003: a 22 - year - old man with chills and fever after a stay in South America. 349, 287-95.

J. Am (2001) Oh M-D, Shin H, Shin D, et al: Clinical features of vivax malaria. 65, 143-146.

D. Kochar, A. Das, A. Kochar (2010) Thrombocytopenia inPlasmodium falciparum,Plasmodium vivaxand mixed infection malaria: A study from Bikaner (Northwestern India). 21(8), 623-627. https://doi.org/10.3109/09537104.2010.505308

Saurabh Srivastava, Sohaib Ahmad, Nadia Shirazi, Sanjiv Kumar Verma, Prashant Puri (2011) Retrospective analysis of vivax malaria patients presenting to tertiary referral centre of Uttarakhand. 117(2), 82-85. https://doi.org/10.1016/j.actatropica.2010.10.001

Peter George, Lobo Alexander (2010) A study on the clinical profile of complicated Plasmodium vivax mono-infections. 3(7), 560-562. https://doi.org/10.1016/s1995-7645(10)60135-6

F. Yousef Khan, A. Lutof, M. Yassin (2009) Imported malaria in Qatar: a one year hospitalbased study in 2005. 7(2), 111-117.

B. Gonz´alez, H. Rodulfo, M. Donato, M. Berrizbeitia, C., L. Gonz´alez (2009) Hematologic variations in patient with malaria caused by Plasmodium vivax before, during and after treatment. 50(2), 187-201.

R. Horstmann, M. Dietrich, U. Bienzle, H. Rasche (1991) Malaria-induced thrombocytopenia. 42, 157-164.

R. Trans (1989) Pukrittayakamee S., White N.J., Clemens R.,et al.Activation of the coagulation cascade in falciparum malaria. 83, 762-766.

Kakar A, Bhoi S, Prakash V, Kakar S (1999) Profound thrombocytopenia in Plasmodium vivax malaria. 35, 243-244.

S. Silva (2009) Avaliac¸˜ao da frequˆencia e dos fatores associados `a plaquetopenia causada pelo. Plasmodium vivax.

Anju Aggarwal, Suman Rath, Shashiraj (2005) Plasmodium vivax Malaria Presenting with Severe Thrombocytopenia. 51(2), 120-121. https://doi.org/10.1093/tropej/fmh107

M. Metanat, B. Sharifi-Mood (2010) Malaria vivax and severe thrombocytopenia in Iran. 5(3), 69-70.

A.Kumar, Shashirekha (2006) Thrombocytopenia-an indicator of acute vivax malaria. 49(4), 505-508.

Dhanpat Kumar Kochar, Gajanand Tanwar, Renu Agrawal, Shilpi Kochar, Gayatri Tanwar1, Kochar Swati, Falodia (2012) Tanwar, Renu Agrawal, Shilpi Kochar, Gayatri Tanwar1, Swati Kochar Falodia Platelet count and parasite density: Independent variable in Plasmodium vivax malaria. 2012, 191-192.