A Prospective Single-Centre Randomised Controlled Study to Compare the Time to Healing of Partial Thickness Burn Wounds Treated with Versajet, Biobrane and Acticoat to Conventional Therapy

amuganza

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amuganza

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Abstract

Background: Burns in South Africa account for significant morbidity, mortality cost. Treatment options that could ease this burden require exploration. Objectives: The primary objective was to compare the time to healing of partial thickness burn wounds treated with Versajet, Biobrane and Acticoat to conventional therapy. Methods: A randomised, controlled, prospective study was undertaken. Results: One hundred and twenty one patients were randomised, and 96 were analysed. Median time to healing was slightly shorter for Biobrane-treated patients in the pediatric sub-group (21.7 [±9.0] versus 23.7 [±9.4], p=0.5361), and slightly longer in the adult sub-group (19 [12- 25] versus 18.5 [12-27], p=09695). Healing rates were higher for Biobrane-treated patients in the paediatric sub-group (84.6% versus 68.4%, p=0.197), and lower in the adult subgroup (78.3% versus 85.7%, p=0.487). . The absolute risk reduction (ARR) for Biobrane-treated patients in the paediatric sub-group was 0.16 (16%), yielding a number-needed-to-treat (NNT) of 6. The median number of dressing changes was significantly lower for Biobrane group in the adult and paediatric population (6.2 [±3.6], p=0.0003; and 7.6 [±4.8] versus 10.7 [=4.8], p=0.039). The mean cost per healed burn for Biobrane group was lower in the paediatric population (R111, 385 versus R143,917), and higher in the adult population (R54, 290 versus R90.175). Conclusion: Biobrane and Acticoat did not lead to a significant decrease in the time to healing, we believe the associated reduction in dressing changes to be important. Together with the obsereved cost reduction to heal partial thickness burns in children, we recommend this regime therapy in a paediatric setting, and have adapted our Standard of Care accordingly. We have identified a subgroup of adult patients who will benefit of the application of skin substitutes.

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A Prospective Single-Centre Randomised Controlled Study to Compare the Time to Healing of Partial Thickness Burn Wounds Treated with Versajet, Biobrane and Acticoat to Conventional Therapy. (2014). Global Journal of Medical Research, 14(52), 5-12. https://medicalresearchjournal.org/index.php/GJMR/article/view/

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