Participation of T, B and NKT Lymphocytes and CD1 Molecule in the Infection by Entamoeba histolytica in Mice

fabriciom19; magomes

Authors

fabriciom19
magomes

Keywords:

amebic colitis, Entamoeba histolytica, natural killer T lymphocytes

Abstract

Studies have shown that CD1 double negative mice (CD1d-/-) develop larger liver abscesses due to their inability to present amebic antigens to NK T lymphocytes. Therefore, we conducted flow cytometry studies to determine the frequency of NK T, CD4+ T, CD8+ T and B lymphocytes in mice with amebic colitis. The frequency of NK T, CD8+ T and B lymphocytes was reduced in the MLN of mice in the CTRL- CD1-/- and Eh-CD1-/- groups compared to the CTRL-WT and Eh-WT groups. There was also a significant decrease in the frequency of B lymphocytes in the spleens of the animals in the Eh-WT group when compared with the CTRL-CD1-/-, Eh- CD1-/- and CTRL-WT groups. The results of the flow cytometry analysis highlight the importance of NK T lymphocytes in the immune response of mice to amebic intestinal infection and the importance of CD1 molecules in the activation of T and B lymphocytes.

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Participation of T, B and NKT Lymphocytes and CD1 Molecule in the Infection by Entamoeba histolytica in Mice. (2015). Global Journal of Medical Research, 15(30), 7-13. https://medicalresearchjournal.org/index.php/GJMR/article/view/

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