Determination of the Compound Biological Effectiveness (CBE) Factors based on the ISHIYAMA-IMAHORI Deterministic Parsing Model with the Dynamic PET Technique

Shintaro Ishiyama; Yoshio Imahori; Jun Itami; Hanna Koivunoro

Authors

Shintaro Ishiyama
Yoshio Imahori
Jun Itami
Hanna Koivunoro

Keywords:

boron neutron capture therapy, compound biological effectiveness, borono-phenylalanine, tumor, 10B(n, #x3B1;)7 li, sigmoid function

Abstract

Purpose: In defining the biological effects of the 10B (n, α)7Li neutron capture reaction, we have proposed a deterministic parsing model (ISHIYAMA-IMAHORI model) to determine the Compound Biological Effectiveness (CBE) factor in Borono-Phenyl-Alanine (BPA)-mediated Boron Neutron Capture Therapy (BNCT). In present paper, we Where, Nth and Nmax are the threshold value of boron concentration of N and saturation boron density and CBE0, F and n are given as 0.5, 8 and 3, respectively. In order to determine Nth and Nmax in the formula, sigmoid logistic function was employed for 10B concentration data, Db(t) obtained by dynamic PET technique. (2) Where, A, a and t0 are constants Results and Conclusion: From the application of sigmoid function to dynamic PET data, it is concluded that the Nth and Nmax for tissue and tumor are identified with the parameter constants in the sigmoid function in eq.(2) as; (3) And the calculated CBE factor values obtained from eq. (1), with Nth/Nmax.

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Determination of the Compound Biological Effectiveness (CBE) Factors based on the ISHIYAMA-IMAHORI Deterministic Parsing Model with the Dynamic PET Technique. (2015). Global Journal of Medical Research, 15(30), 1-5. https://medicalresearchjournal.org/index.php/GJMR/article/view/

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References

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