Pre-Emptive Intravenous Paracetamol and Lornoxicam in Third Molar Surgery

Can Eyigor; Esra Cagiran

Authors

Can Eyigor
Esra Cagiran

Keywords:

third molar; pre-emptive analgesia; lornoxicam; paracetamol

Abstract

Backgrounds: The objective of the present study was to compare the postoperative analgesic effects of pre-emptive intravenous (IV) paracetamol, lornoxicam and placebo following third molar surgery. Materials and Methods: This was a prospective, double-blind, randomized, placebo-controlled study where 50 patients had both of their identical impacted mandibular third molars impacted. Before the removal of the impacted third molar tooth on one side either of the two drug regimens (1 g paracetamol or 8 mg lornoxicam) administered preemptively and 15 days later second surgical approach was performed but this time for comparison the other drug regimen (which was not chosen initially) was carried out as the preemptive agent; and all of the operations were performed by the same surgeon. Diclofenac sodium up to 75 mg daily was provided as rescue medication. The postoperative rescue analgesic consumption was recorded and pain scores were evaluated with a Verbal Rating Scale (VRS) at 15,30 min and 1,2, 4, 6, 12, 24 h postoperatively. Results: There was a significant difference in mean second hour VRS scores between paracetamol and lornoxicam group in favor of the lornoxicam (p

Downloads

How to Cite

Pre-Emptive Intravenous Paracetamol and Lornoxicam in Third Molar Surgery. (2013). Global Journal of Medical Research, 13(15), 31-37. https://medicalresearchjournal.org/index.php/GJMR/article/view/

Download Citation

Author Biographies

Can Eyigor

Esra Cagiran is a researcher affiliated with the Department of Anesthesiology at Ege University Faculty of Medicine in Turkey. Her work encompasses pain management and local anesthesia, with notable studies on pre-emptive intravenous paracetamol and lornoxicam in third molar surgery, as well as allergies related to local anesthetics. With 18 publications and over 135 citations, her h-index of 6 and i10-index of 4 demonstrate her contributions to the field.

Esra Cagiran

Esra Cagiran is a researcher affiliated with the Department of Anesthesiology at Ege University Faculty of Medicine in Turkey. Her work encompasses pain management and local anesthesia, with notable studies on pre-emptive intravenous paracetamol and lornoxicam in third molar surgery, as well as allergies related to local anesthetics. With 18 publications and over 135 citations, her h-index of 6 and i10-index of 4 demonstrate her contributions to the field.

References

J. Savin, G. Ogden (1997) Third molar surgery-a preliminary report on aspects affecting quality of life in the early post-operative period Br J Oral Maxillofac Surg. 35, 246-253.

Clifford Woolf, Mun-Seng Chong (1993) Preemptive analgesia: treating postoperative pain by preventing the establishment of central sensitization Anesth Analg. 77(2), 362-379. https://doi.org/10.1213/00000539-199377020-00026

Tarek Samad, Kimberly Moore, Adam Sapirstein, Sara Billet, Andrew Allchorne, Stephen Poole, Joseph Bonventre, Clifford Woolf (2001) Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. 410(6827), 471-475. https://doi.org/10.1038/35068566

Clifford Woolf (1983) Evidence for a central component of postinjury pain hypersensitivity Nature. 306(5944), 686-688. https://doi.org/10.1038/306686a0

Forbes JA, Beaver WT, White EH, White RW, Neilson GB, Shackleford RW (1982) Diflunisal A new oral analgesic with an unusually long duration of action JAMA. 248, 2139.

E. Trampitsch, W. Pipam, M. Moertl, A. Sadjak, C. Dorn, R. Sittl, R. Likar (2003) Preemptive randomized, doubleblind study with lornoxicam in gynecological surgery. 17, 4-10.

A. Hein, C. Norlander, L. Blom, J. Jakobsson (2001) Is pain prophylaxis in minor gynaecological surgery of clinical value? A double blind placebo controlled study of paracetamol 1 g versus lornoxicam 8 mg given orally Ambul Surg. 9(2), 91-94. https://doi.org/10.1016/s0966-6532(01)00078-6

Z. Pektas, M. Sener, B. Bayram, T. Eroglu, N. Bozdogan, A. Donmez, G. Arslan, S. Uckan (2007) A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study. 36, 123-127.

Mohamed Amin, Daniel Laskin (1983) Prophylactic use of indomethacin for prevention of postsurgical complications after removal of impacted third molars Oral Surg Oral Med Oral Pathol. 55(5), 448-451. https://doi.org/10.1016/0030-4220(83)90227-x

W. Chiu, L. Cheung (2005) Efficacy of preoperative oral rofecoxib in pain control for third molar surgery. 99(6), 47-53. https://doi.org/10.1016/j.tripleo.2005.02.075

M. Nguyen, D. Graham, T. Gage, G. Griffiths (1999) Nonsteroidal anti-inflammatory drug use in dentistry: gastrointestinal implications Gen Dent. 47, 590-596.

P. Moller, S. Sindet-Pedersen, C. Petersen, G. Juhl, A. Dillenschneider, L. Skoglund (2005) Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery.Br J Anesth. 94(5), 642-648. https://doi.org/10.1093/bja/aei109

A. García, F. Sampedro, J. Rey, P. Vila, M. Martin (2000) Pell-Gregory classification is unreliable as a predictor of difficulty in extracting impacted lower third molars Br J Oral Maxillofac Surg. 38, 585-587.

J. Dahl, H. Kehlet (1993) The value of pre-emptive analge- sia in the treatment of postoperative pain Br J Anaesth. 70(4), 434-439. https://doi.org/10.1093/bja/70.4.434

K. Ong, R. Seymour, F. Chen, Vcl Ho (2004) Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. 33, 771-776.

Sener M, Pektas Z, Yılmaz I, Donmez A, Arslan G (2005) Comparison Of Preemptive Analgesic Effects Of A Single Dose Of Nonopioid Analgesics For Pain Management After Ambulatory Surgery: A Prospective, Randomized, Single-Blind Study İn Turkish Patients Cur Ther Res. 66(6), 541-551. https://doi.org/10.1016/j.curtheres.2005.12.001

Tump Morse Z (2006) Ibuprofen as a pre-emptive analgesic is as effective as rofecoxib for mandibular third molar surgery. 94, 59-63.

Ozlem Korkmaz Dilmen, Yusuf Tunali, Ozlem Cakmakkaya, Ercument Yentur, Ayse Tutuncu, Ercan Tureci, Mois Bahar (2010) Efficacy of intravenous paracetamol, metamizol and lornoxicam on postoperative pain and morphine consumption after lumbar disc surgery.Eur J Anaesthesiol. 27(5), 428-432. https://doi.org/10.1097/eja.0b013e32833731a4

M. Tyers, Hazel Haywood (1979) Effects of prostaglandins on peripheral nociceptors in acute inflammation Agents Actions. 6, 65-78.

Haglund B, von I (2006) Combining paracetamol with a selective cyclooxygenase-2 inhibitor for acute pain relief after third molar surgery: a randomized, double-blind, placebocontrolled study Eur J Oral Sci. 114(4), 293-301. https://doi.org/10.1111/j.1600-0722.2006.00365.x

J. Eur (2006) Juhl G, Norholt S, Tonnesen E, Hiesse-Provost O, Jensen T: Analgesic efficacy and safety of intravenous paracetamol (acetaminophen) administered as a 2 g starting dose following third molar surgery. 10, 371-377.