Use of Immunoglobulin G Enriched With IGM + IGA in Primigestant with Septic Shock: Case Report.

Jaime A. Machado-Bernal; María C. Espinosa-González; Hernán L. Valle-Calderón; Belkis X. Quant-Vergara

doi:10.34257/GJMRFVOL25IS1PG1

Authors

Jaime A. Machado-Bernal
María C. Espinosa-González
Hernán L. Valle-Calderón
Belkis X. Quant-Vergara

Keywords:

sepsis septic shock pregnancy infectious complications of pregnancy intensive care units intravenous immunoglobulins

Abstract

Sepsis is a condition that occurs when the body produces an unbalanced immune response to an infection. Septic shock is the most serious manifestation of this infection, which increases with aggravation of maternal and perinatal morbidity and mortality. Within the pharmacological therapeutic options, the cornerstone of this entity is broad-spectrum antibiotic therapy; however, there are other drugs that can be used as adjuvants in the context of sepsis and among them are immunoglobulins. Currently there is little scientific evidence about the use of immunoglobulins in pregnant patients and in Colombia there is only one case report published so far. The objective of this patient report is to present the case of a primipregnant woman with a pregnancy of 16.3 weeks diagnosed with septic shock who was administered immunoglobulin G enriched with IgM + IgA, which had an excellent response to the established treatment and satisfactory evolution. without presenting maternal or fetal adverse effects to the drug.

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How to Cite

Use of Immunoglobulin G Enriched With IGM + IGA in Primigestant with Septic Shock: Case Report. (2022). Global Journal of Medical Research, 22(E3), 9-15. https://doi.org/10.34257/GJMRFVOL25IS1PG1

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References

Mervyn Singer, Clifford Deutschman, Christopher Seymour, Manu Shankar-Hari, Djillali Annane, Michael Bauer, Rinaldo Bellomo, Gordon Bernard, Jean-Daniel Chiche, Craig Coopersmith, Richard Hotchkiss, Mitchell Levy, John Marshall, Greg Martin, Steven Opal, Gordon Rubenfeld, Tom Van Der Poll, Jean-Louis Vincent, Derek Angus (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). 315(8), 801.

Carolin Fleischmann, André Scherag, Neill Adhikari, Christiane Hartog, Thomas Tsaganos, Peter Schlattmann, Derek Angus, Konrad Reinhart (2016) Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. 193(3), 259-272.

J Barton, B Sibai (2014) Severe Sepsis and Septic Shock in Pregnancy. 34(1), 10-11.

Evans Fernández-Pérez, Salam Salman, Shanthan Pendem, J Farmer (2005) Sepsis during pregnancy. 33(Supplement), S286-S293.

L Say, D Chou, A Gemmill, Ö Tunçalp, A Moller, J Daniels (2014) Global causes of maternal death: a WHO systematic analysis. 2(6), 323-333.

Jeroen Van Dillen, Joost Zwart, Joke Schutte, Jos Van Roosmalen (2010) Maternal sepsis: epidemiology, etiology and outcome. 23(3), 249-254.

Lauren Plante, Luis Pacheco, Judette Louis (2019) SMFM Consult Series #47: Sepsis during pregnancy and the puerperium. 220(4), B2-B10.

Rainer Straub (2007) The Complex Role of Estrogens in Inflammation. 28(5), 521-574.

Giamarellos-Bourboulis Ej Tziolos, N Routsi, C Katsenos, C Tsangaris, I Pneumatikos, I Vlachogiannis, G Theodorou, V Prekates, A Antypa, E Koulouras, V Kapravelos, N Gogos, C Antoniadou, E Mandragos, K Armaganidis, A, Hellenic Sepsis, Study Group (2016) Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins. 22(6), 499-506.

Lucy Bowyer, Helen Robinson, Helen Barrett, Timothy Crozier, Michelle Giles, Irena Idel, Sandra Lowe, Karin Lust, Catherine Marnoch, Mark Morton, Joanne Said, Maggie Wong, Angela Makris (2017) SOMANZ guidelines for the investigation and management sepsis in pregnancy. 57(5), 540-551.

Ivan González Calderón, Favian Medina (2021) Manejo de la sepsis en el embarazo. Revisión de la literatura. 30(1), 22-28.

Loukas Kakoullis, Nikolaos-Dimitrios Pantzaris, Chiristina Platanaki, Maria Lagadinou, Eleni Papachristodoulou, Dimitrios Velissaris (2018) The use of IgM-enriched immunoglobulin in adult patients with sepsis. 47, 30-35.

Andrea Shields, Viviana De Assis, Torre Halscott (2021) Top 10 Pearls for the Recognition, Evaluation, and Management of Maternal Sepsis. 138(2), 289-304.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig Coopersmith, Craig French, Flávia Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie Prescott, Christa Schorr, Steven Simpson, W Wiersinga, Fayez Alshamsi, Derek Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven Mcgloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy (2021) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. 47(11), 1181-1247.

Royal College, Of Obstetricians, Gynaecologists (2012) Bacterial sepsis in pregnancy. (64).

Nicole Pfaff (2014) The New Hypertensive Guidelines for Pregnancy. 28(2), 91-93.

S Busani, E Damiani, I Cavazzuti, A Donati, M Girardis (2016) Intravenous immunoglobulin in septic shock: review of the mechanisms of action and metaanalysis of the clinical effectiveness. 82(5), 559-572.

S Izdes, N Altintas, A Eldem, H Ceyhan, O Kanbak (2011) Intravenous polyclonal IgM-enriched immunoglobulin therapy for resistant Acinetobacter sepsis in a pregnant patient with ARDS due to H1N1 infection. 20(1), 99-100.

S Al-Rawi, L Woodward, J Knight (2009) Puerperal streptococcal toxic shock syndrome treated with recombinant human activated protein C and intravenous immunoglobulin. 18, 169-172.

Olga Cuero-Vidal, Diego Moreno-Sánchez, María Torres-Bejarano, Johana Moreno-Drada (2016) Uso de inmunoglobulinas intravenosas en una paciente obstétrica con choque séptico: reporte de caso y revisión de la literatura. 67(4), 305.